ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.25789/YMJ.2021.75.22ymj-549Research ArticleНАУЧНЫЕ ОБЗОРЫ И ЛЕКЦИИSCIENTIFIC REVIEWS AND LECTURESКлеточные и молекулярные механизмы действия нейростероидов в различных отделах центральной нервной системы (Ч. 2)Cellular and molecular mechanisms of action of neurosteroids in various parts of the central nervous system (Part 2)https://orcid.org/0000-0003-4639-6365ДмитренкоД. В.DmitrenkoD. V.

Дмитренко Диана Викторовна – д.м.н., зав. кафедрой

Dmitrenko Diana Viktorovna - Advanced Doctor in Medical Sciences, head of medical genetics and clinical neurophysiology department

mart2802@yandex.ruhttps://orcid.org/0000-0003-2748-3164ЗобоваС. Н.ZobovaS. N.

Зобова Светлана Николаевна – к.м.н., н.с.

Zobova Svetlana Nikolaevna - Ph.D. of Medical Sciences, research officer

SNZobova@yandex.ruhttps://orcid.org/0000-0001-8142-4283РукшаТ. Г.RukshaT. G.

Рукша Татьяна Геннадьевна – д.м.н., проф., зав. кафедрой

Ruksha Tatyana Gennadievna - Advanced Doctor in Medical Sciences, professor, head of pathophysiology and clinical pathophysiology department

tatyana_ruksha@mail.ruhttps://orcid.org/0000-0001-8844-0622ПрусоваТ. И.PrusovaT. I.

Прусова Татьяна Игоревна – студентка, лаборант

Prusova Tatyana Igorevna - student, laboratory assistant of medical genetics and clinical neurophysiology department

ta_prusova@mail.ruhttps://orcid.org/0000-0002-9678-6719УсольцеваА. А.UsoltsevaA. A.

Усольцева Анна Александровна – клинич. ординатор, лаборант

Usoltseva Anna Alexandrovna - clinical resident, laboratory assistant of medical genetics and clinical neurophysiology department

a.usoltseva@list.ruИПО ФГБОУ ВО «КрасГМУ им. проф. В.Ф. Войно-Ясенецкого» МЗ РФРоссияV.F. Voyno-Yasenetsky Krasnoyarsk State Medical UniversityRussian FederationИПО ФГБОУ ВО «КрасГМУ им. проф. В.Ф. Войно-Ясенецкого» МЗ РФРоссияScientific Research Institute of Medical Problems of the North and medical genetics laboratory of V.F. Voyno-Yasenetsky Krasnoyarsk State Medical UniversityRussian Federation202127042025038591Copyright © Дмитренко Д.В., Зобова С.Н., Рукша Т.Г., Прусова Т.И., Усольцева А.А., 20252025Дмитренко Д.В., Зобова С.Н., Рукша Т.Г., Прусова Т.И., Усольцева А.А.Dmitrenko D.V., Zobova S.N., Ruksha T.G., Prusova T.I., Usoltseva A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/549

Нейростероиды, или нейроактивные стероиды, – это класс эндогенных соединений, синтезирующихся в нервной ткани и или способных оказывать модулирующее влияние на функциональную активность головного мозга, в том числе это стероиды, образующиеся в надпочечниках и гонадах, проникающие через гематоэнцефалический барьер и оказывающие влияние на функционирование центральной нервной системы в норме и при патологии. Вторая часть обзора посвящена многообразию особенностей секреции, механизмов действия и описанию мишеней для воздействия четырех нейростероидов на различных этапах онтогенеза крыс: прогестерона, аллопрегнанолона, дегидроэпиандростерона и дегидроэпиандростерона сульфата.

Neurosteroids (or neuroactive steroids) are a class of endogenous compounds which are synthesized in nervous tissue or\and able to modulate the brain functional activity, the class also includes steroids from gonads or adrenals, which are capable of migrating through the blood brain barrier to achieve their biological targets. The second part of the review is focused on describing multiply features of synthesis, functioning of such neurosteroids as progesterone, allopregnanolone, dehydroepiandrosterone and dehydroepiandrosterone sulfate as well as their targets, synthesized analogs.

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The authors declare that there are no conflicts of interest present.