ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.25789/YMJ.2021.75.08ymj-535Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHЭффективность оценки экспрессии генов гомеобокса в прогнозировании исходов программ вспомогательных репродуктивных технологийEfficiency of homeobox gene expression assessment for predicting outcomes of assisted reproductive technology programhttps://orcid.org/0000-0001-6929-0892ЧухнинаЕ. Г.ChukhninaE. G.

Чухнина Елена Галиевна – аспирант

Челябинск

Chukhnina Elena Galievna – Postgraduate at Department of Pathological Anatomy and Forensic Medicine

Chelyabinsk

chuhninaeg@yandex.ruhttps://orcid.org/0000-0003-0800-3380ВоропаеваЕ. Е.VoropaevaE. E.

Воропаева Екатерина Евгеньевна – д.м.н., доцент, проф.

Челябинск

Voropaeva Ekaterina Evgenievna – MD, associate professor, professor of the Department of Pathological Anatomy and Forensic Medicine

Chelyabinsk

https://orcid.org/0000-0002-4512-3421КазачковЕ. Л.KazachkovE. L.

Казачков Евгений Леонидович – д.м.н., проф., зав. Кафедрой

Челябинск

Kazachkov Evgeny Leonidovich – MD, Professor, Head, Department of Pathological Anatomy and Forensic Medicine

Chelyabinsk

https://orcid.org/0000-0002-1672-7058КазачковаЭ. А.KazachkovaE. A.

Казачкова Элла Алексеевна – д.м.н., проф.

Челябинск

Kazachkova Ella Alekseevna – MD, Professor of the Department of Obstetrics and Gynecology

Chelyabinsk

https://orcid.org/0000-0003-3883-3967ПолинаМ. Л.PolinaM. L.

Полина Мирослава Леонидовна – к.м.н., врач акушер-гинеколог

Москва

Polina Miroslava Leonidovna – PhD in Medical Sciences, Gynecologist

Moscow

ДугласН. И.DouglasN. I.

Дуглас Наталья Ивановна – д.м.н., зав. кафедрой ПОВ

Douglas Natalya Ivanovna – Grand PhD in Medical Sciences, Head of the Department of Obstetrics and Gynecology

Yakutsk

ФГБОУ ВО «Южно-Уральский ГМУ» Минздрава РоссииРоссияFSBEI HE SUSMU of the Ministry of Health of RussiaRussian FederationМедицинский центр женского здоровьяРоссияWomen's Health Medical CenterRussian FederationМедицинский институт «Северо-Восточного федеральн. ун-та им. М.К. Аммосова»РоссияMedical Institute of North-Eastern Federal University named M.K. AmmosovRussian Federation202127042025033337Copyright © Чухнина Е.Г., Воропаева Е.Е., Казачков Е.Л., Казачкова Э.А., Полина М.Л., Дуглас Н.И., 20252025Чухнина Е.Г., Воропаева Е.Е., Казачков Е.Л., Казачкова Э.А., Полина М.Л., Дуглас Н.И.Chukhnina E.G., Voropaeva E.E., Kazachkov E.L., Kazachkova E.A., Polina M.L., Douglas N.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/535

Выполнен анализ влияния экспрессии HOXA10 и HOXA11 в строме эндометрия женщин позднего репродуктивного возраста с трубным фактором бесплодия на исходы программ вспомогательных репродуктивных технологий.Выявлена тенденция к статистически значимому снижению экспрессии НОХА11 в строме эндометрия при эффективных попытках лечения бесплодия.С помощью метода ROC (Receiver operator characteristic) анализа и расчетов площади под ROC–кривой определены благоприятные уровни экспрессии HOXA11 для успешной имплантации бластоцисты и живорождения у бесплодных женщин с собственными и донорскими ооцитами.

An analysis of the effect of HOXA10 and HOXA11 expression in the endometrial stroma of late reproductive women with tubal infertility factor on the outcomes of assisted reproductive technology (ART) programs was performed.There was a tendency to a statistically significant decrease in the expression of HOXA11 in the endometrial stroma during effective attempts to treat infertility.Using the ROC (Receiver operator characteristic) method of analysis and calculations of the area under the ROC curve (AUC), it was found out that favorable levels of HOXA11 expression for successful blastocyst implantation and live births in infertile women with their own and donor oocytes.

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The authors declare that there are no conflicts of interest present.