ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.25789/YMJ.20201.73.26ymj-520Research ArticleНАУЧНЫЕ ОБЗОРЫ И ЛЕКЦИИSCIENTIFIC REVIEWS AND LECTURESРоль генов лептина и рецептора лептина при развитии детского ожиренияThe role of leptin genes and leptin receptor genes in the development of child obesityКочетоваО. В.KochetovaO. V.

Кочетова Ольга Владимировна – к.б.н., н.с.

Kochetova Olga Vladimirovna - Candidate of Biological Sciences Research Institute of Biochemistry and Genetics

olga_mk78@mail.ruШангарееваЗ. А.ShangareevaZ. A.

Шангареева Зиля Асгатовна – к.м.н., доцент

Shangareeva Zilya Asgatovna - Candidate of Medical Sciences, Associate Professor

ВиктороваТ. В.ViktorovaT. V.

Викторова Татьяна Викторовна – д.м.н., проф., зав. Кафедрой

Viktorova Tatyana Viktorovna - Doctor of Medical Sciences, Prof., Head. Department

КорытинаГ. Ф.KorytinaG. F.

Корытина Гульназ Фаритовна – д.б.н., с.н.с., зав. лаб.

Korytina Gulnaz Faritovna - Doctor of Biological Sciences, Senior Researcher, Head. lab.

Институт биохимии и генетики Уфимского ФИЦ РАНРоссияUfa Federal Research Center of the Russian Academy of SciencesRussian FederationБашкирский ГМУРоссияBashkir State Medical UniversityRussian FederationБГМУРоссияBSMURussian FederationИБГ УФИЦ РАНРоссияFSBSRI UFRC RASRussian Federation2021270420250197100Copyright © Кочетова О.В., Шангареева З.А., Викторова Т.В., Корытина Г.Ф., 20252025Кочетова О.В., Шангареева З.А., Викторова Т.В., Корытина Г.Ф.Kochetova O.V., Shangareeva Z.A., Viktorova T.V., Korytina G.F.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/520

Проведена оценка роли полиморфных вариантов генов лептина (LEP rs2167270) и рецептора лептина (LEPR rs1137100) при развитии детского ожирения и пищевого поведения. Ассоциации с развитием ожирения при сравнении детских групп между собой не выявлено. Вместе с тем установлена ассоциация полиморфного локуса гена LEP (rs2167270) по следующим шкалам опросника CEBQ: «удовольствие от еды, EF», «медлительность в приеме пищи, SE» и уровнем глюкозы. Для локуса rs1137100 гена LEPR ассоциации показаны с такими антропометрическими показателями, как масса тела при рождении, в настоящее время, Z-score, с уровнем перцентилей.

The role of polymorphic variants of leptin (LEP rs2167270) and leptin receptor (LEPR rs1137100) genes in the development of child obesity and eating behavior was estimated. There was no association with the development of obesity when comparing children's groups with each other. At the same time, the association of LEP (rs2167270) was established according to the following scales of the CEBQ questionnaire: “pleasure of eating, EF”, “slowness in eating, SE” and glucose level. For the rs1137100 locus of the LEPR gene, the associations are shown with such anthropometric parameters as birth weight, weight at present, Z-score, and percentile level.

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The authors declare that there are no conflicts of interest present.