ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.25789/YMJ.2021.73.25ymj-519Research ArticleНАУЧНЫЕ ОБЗОРЫ И ЛЕКЦИИSCIENTIFIC REVIEWS AND LECTURESСигнальные функции жирных кислот в плацентеSignaling functions of fatty acids in the placentahttps://orcid.org/0000-0002-1024-1532ИшутинаН. А.IshutinaN. A.

Ишутина Наталия Александровна – д.б.н., в.н.с.

г. Благовещенск

Ishutina Nataliа A. – PhD, D.Sc. (Biol.), Leading Staff Scientist of Laboratory of Mechanisms of Etiopathogenesis and Recovery Processes of the Respiratory System at NonSpecific Lung Diseases

22 Kalinina Str., Blagoveshchensk, 675000

ishutina-na@mail.ruhttps://orcid.org/0000-0003-0212-0201АндриевскаяИ. А.AndrievskayaI. A.

Андриевская Ирина Анатольевна – д.б.н., проф. РАН

г. Благовещенск

Andrievskaya Irina A. – PhD, D.Sc. (Biol.), Professor RANS, Head of Laboratory of Mechanisms of Etiopathogenesis and Recovery Processes of the Respiratory System at Non-Specific Lung Diseases

22 Kalinina Str., Blagoveshchensk, 675000

irina-andrievskaja@rambler.ruhttps://orcid.org/0000-0001-9112-5893ГерманМ. Н.GermanM. N.

Герман Марина Николаевна – лаборант-исследователь

г. Благовещенск

German Marina N. – Research Assistant at the Laboratory of Mechanisms of Etiopathogenesis and Recovery Processes of the Respiratory System at Non-Specific Lung Diseases

22 Kalinina Str., Blagoveshchensk, 675000

marina.german.1975@mail.ruФГБНУ «Дальневосточный научный центр физиологии и патологии дыхания»РоссияFar Eastern Scientific Center of Physiology and Pathology of RespirationRussian Federation202127042025019297Copyright © Ишутина Н.А., Андриевская И.А., Герман М.Н., 20252025Ишутина Н.А., Андриевская И.А., Герман М.Н.Ishutina N.A., Andrievskaya I.A., German M.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/519

Проведен анализ современных достижений о механизмах сигнальной трансдукции жирных кислот (ЖК) в плаценте в базах данных PubMed, Google Scholar. В настоящем обзоре обобщены современные представления о системах сигнальной трансдукции в плаценте, активируемых ЖК. Показано их действие на мембранные и ядерные рецепторы, а также участие в сопряженных с G-протеин-связанными рецепторами (GPCR) процессах децидуализации и модуляции воспаления в плаценте. Описаны эффекты рецепторов, активируемых пероксисомным пролифератором (PPAR) γ, опосредованных ЖК в плаценте. Особое внимание уделено Toll-опосредованным воспалительным (TLR) сигнальным путям ЖК в плаценте. Суммированы данные исследований по изучению влияния ЖК на экспрессию генов, вовлеченных в ангиогенез в плаценте.

This review summarizes the current understanding of FA-activated signal transduction systems in the placenta in the data PubMed, Google Scholar. Their effect on membrane and nuclear receptors, as well as their participation in the processes of decidualization and modulation of inflammation in the placenta, associated with G-protein-coupled receptors, have been shown. The effects of peroxisome proliferator-activated receptors mediated FAs in the placenta are described. Particular attention is paid to the Toll-mediated inflammatory signaling pathways of the FAs in the placenta. Research data on the effect of FAs on the expression of genes involved in placenta angiogenesis are summarized.

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The authors declare that there are no conflicts of interest present.