ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.25789/YMJ.2021.73.19ymj-512Research ArticleАКТУАЛЬНАЯ ТЕМАACTUAL TOPICКогнитивные нарушения у пациентов, перенесших COVID-19Cognitive impairment in patients after COVID-19https://orcid.org/0000-0002-7709-3917ГалкинС. А.GalkinS. A.

Галкин Станислав Алексеевич – аспирант

Galkin Stanislav A., PhD Student

s01091994@yandex.ruhttps://orcid.org/0000-0002-3951-395XПешковскаяА. Г.PeshkovskayaA. G.

Пешковская Анастасия Григорьевна – м.н.с.

Peshkovskaya Anastasia G., Researcher

https://orcid.org/0000-0001-7078-323XИвановаС. А.IvanovaS. A.

Иванова Светлана Александровна – д.м.н., проф., зав. лаб., зам. директора по научной работе

Ivanova Svetlana A., DM, Professor, Head of the Laboratory of Molecular Genetics and Biochemistry, Deputy Director for Science

Tomsk

https://orcid.org/0000-0002-1052-855XБоханН. А.BokhanN. A.

Бохан Николай Александрович – д.м.н., проф., акад. РАН, директор НИИ психического здоровья;

зав. Кафедрой

Bokhan Nikolay A., DM, Professor, Аcademician of the Russian Academy of Sciences academician, RAS, Director;

head of the Department of psychiatry, psychotherapy, narcology with the course med. the psychology

Tomsk

НИИ психического здоровья, Томский НИМЦ РАНРоссияMental Health Research Institute, Tomsk NRMCRussian FederationНИИ психического здоровья, Томский НИМЦ РАН; ГБОУ ВПО СибГМУ Минздрава РоссииРоссияMental Health Research Institute; Siberian State Medical University of RussiaRussian Federation202127042025016972Copyright © Галкин С.А., Пешковская А.Г., Иванова С.А., Бохан Н.А., 20252025Галкин С.А., Пешковская А.Г., Иванова С.А., Бохан Н.А.Galkin S.A., Peshkovskaya A.G., Ivanova S.A., Bokhan N.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/512

Проведена оценка изменений уровня когнитивных функций у пациентов, перенесших COVID–19. Анализ более 30 современных научных исследований за 2019–2021 гг. показал, что у пациентов, перенесших новую коронавирусную инфекцию в различной степени тяжести, происходят значительные изменения уровня когнитивного функционирования в виде снижения памяти, исполнительных функций, внимания и т.д.

The assessment of changes in the level of cognitive functions in patients who underwent COVID-19 was carried out. The analysis of more than 30 modern scientific studies for 2019-2021 showed that patients who had the new coronavirus infection of varying severity, there are significant changes in the level of cognitive functioning in the form of a decrease in memory, executive functions, attention, etc.

когнитивные функциикогнитивный дефицитисполнительные функциипамятьвниманиеновая коронавирусная инфекцияCOVID–19cognitive functionscognitive deficitsexecutive functionsmemoryattentionnew coronavirus infectionCOVID-19Исследование проведено в рамках выполнения гос. задания, тема №0550–2019–0007.ReferencesВзаимосвязь когнитивных нарушений с клиническими особенностями алкогольной зависимости / С.А. Галкин, А.Г. Пешковская, О.В. Рощина [и др.] // Якутский медицинский журнал. – 2020. – №2. – С. 62–65. doi:10.25789/YMJ.2020.70.19.Galkin S.A. The relationship of cognitive disorders with clinical features of alcohol dependence / S. A. Galkin, A. G. Peshkovskaya, O. V. Roshchina et al. // Yakut medical journal. – 2020. – №2. – Р. 62–65. doi:10.25789/YMJ.2020.70.19.A Case of COVID–19 With Memory Impairment and Delayed Presentation as Stroke / A. Garg, A. Marji, S. Goyal [et al.] // Cureus. – 2020. – №8. – P. e10025. doi:10.7759/cureus.10025.A Case of COVID–19 With Memory Impairment and Delayed Presentation as Stroke / A. Garg, A. Marji, S. Goyal [et al.] // Cureus. – 2020. – №8. – P. e10025. doi:10.7759/cureus.10025.Ardila A. Executive dysfunction in COVID–19 patients / A. Ardila, D. Lahiri // Diabetes Metab Syndr. – 2020. – №5. – Р. 1377–1378. doi:10.1016/j.dsx.2020.07.032.Ardila A. Executive dysfunction in COVID–19 patients / A. Ardila, D. Lahiri // Diabetes Metab Syndr. – 2020. – №5. – Р. 1377–1378. doi:10.1016/j.dsx.2020.07.032.Baker H.A. The 'third wave': impending cognitive and functional decline in COVID–19 survivors / H.A. Baker, S.A. Safavynia, L.A. Evered // Br J Anaesth. – 2021. – №1. – Р. 44–47. doi:10.1016/j.bja.2020.09.045.Baker H.A. The 'third wave': impending cognitive and functional decline in COVID–19 survivors / H.A. Baker, S.A. Safavynia, L.A. Evered // Br J Anaesth. – 2021. – №1. – Р. 44–47. doi:10.1016/j.bja.2020.09.045.Characteristics and outcomes of 21 critically ill patients with COVID–19 in Washington State / M. Arentz, E. Yim, L. Klaff [et al.] // JAMA. – 2020. – №323. – Р. 1612. doi:10.1001/jama.2020.4326.Characteristics and outcomes of 21 critically ill patients with COVID–19 in Washington State / M. Arentz, E. Yim, L. Klaff [et al.] // JAMA. – 2020. – №323. – Р. 1612. doi:10.1001/jama.2020.4326.Chronic traumatic encephalopathy: neurodegeneration following repetitive concussive and subconcussive brain trauma / C.M. Baugh, J.M. Stamm, D.O. Riley [et al.] // Brain Imaging Behav. – 2012. – №2. – P. 244–254. doi:10.1007/s11682–012–9164–5.Chronic traumatic encephalopathy: neurodegeneration following repetitive concussive and subconcussive brain trauma / C.M. Baugh, J.M. Stamm, D.O. Riley [et al.] // Brain Imaging Behav. – 2012. – №2. – P. 244–254. doi:10.1007/s11682–012–9164–5.COVID–19–associated acute hemorrhagic necrotizing encephalopathy: CT and MRI features / N. Poyiadji, G. Shahin, D. Noujaim [et al.] // Radiology. – 2020. – №2. – P. 119–120. doi:10.1148/radiol.2020201187.COVID–19–associated acute hemorrhagic necrotizing encephalopathy: CT and MRI features / N. Poyiadji, G. Shahin, D. Noujaim [et al.] // Radiology. – 2020. – №2. – P. 119–120. doi:10.1148/radiol.2020201187.Dementia care in times of COVID–19: experience at Fundacio ACE in Barcelona / A. Benaque, M.J. Gurruchaga, C. Abdelnour [et al.] // Spain. J. Alzheimers Dis. – 2020. – №1. – Р. 33–40. doi:10.3233/jad–200547Dementia care in times of COVID–19: experience at Fundacio ACE in Barcelona / A. Benaque, M.J. Gurruchaga, C. Abdelnour [et al.] // Spain. J. Alzheimers Dis. – 2020. – №1. – Р. 33–40. doi:10.3233/jad–200547Frequent neurocognitive deficits after recovery from mild COVID–19 / M.S. Woo, J. Malsy, J. Pöttgen [et al.] // Brain Communications. – 2020. – №2. – P. fcaa205. doi:10.1093/braincomms/fcaa205Frequent neurocognitive deficits after recovery from mild COVID–19 / M.S. Woo, J. Malsy, J. Pöttgen [et al.] // Brain Communications. – 2020. – №2. – P. fcaa205. doi:10.1093/braincomms/fcaa205Functional and cognitive outcomes after COVID–19 delirium / B.C. McLoughlin, A. Miles, T.E. Webb [et al.] // Eur. Geriatr. Med. – 2020. – №5. – P. 857–862. doi:10.1007/s41999–020–00353–8Functional and cognitive outcomes after COVID–19 delirium / B.C. McLoughlin, A. Miles, T.E. Webb [et al.] // Eur. Geriatr. Med. – 2020. – №5. – P. 857–862. doi:10.1007/s41999–020–00353–8Hampshire A. Cognitive deficits in people who have recovered from COVID–19 relative to controls: An N=84,285 online study / A. Hampshire // medRxiv. – 2020. – №10. – P. 96–103. doi:10.1101/2020.10.20.20215863Hampshire A. Cognitive deficits in people who have recovered from COVID–19 relative to controls: An N=84,285 online study / A. Hampshire // medRxiv. – 2020. – №10. – P. 96–103. doi:10.1101/2020.10.20.20215863Hosey M.M. Survivorship after COVID–19 ICU stay / M.M. Hosey, D.M. Needham // Nat Rev Dis Primers. – 2020. – №6. – Р. 60. doi:10.1038/s41572–020–0201–1Hosey M.M. Survivorship after COVID–19 ICU stay / M.M. Hosey, D.M. Needham // Nat Rev Dis Primers. – 2020. – №6. – Р. 60. doi:10.1038/s41572–020–0201–1Immediate and long–term consequences of COVID–19 infections for the development of neurological disease / M.T. Heneka, D. Golenbock, E. Latz [et al.] // Alz. Res. Therapy. – 2020. – №12. – Р. 69. doi:10.1186/s13195–020–00640–3Immediate and long–term consequences of COVID–19 infections for the development of neurological disease / M.T. Heneka, D. Golenbock, E. Latz [et al.] // Alz. Res. Therapy. – 2020. – №12. – Р. 69. doi:10.1186/s13195–020–00640–3Impact of SARS–CoV–2 infection on neurodegenerative and neuropsychiatric diseases: a delayed pandemic / P.J. Serrano–Castro, G. Estivill–Torrús, P. Cabezudo–García [et al.] // Neurologia. – 2020. – №4. – Р. 245–251. doi:10.1016/j.nrl.2020.04.002.Impact of SARS–CoV–2 infection on neurodegenerative and neuropsychiatric diseases: a delayed pandemic / P.J. Serrano–Castro, G. Estivill–Torrús, P. Cabezudo–García [et al.] // Neurologia. – 2020. – №4. – Р. 245–251. doi:10.1016/j.nrl.2020.04.002.Inflammation induced by infection potentiates tau pathological features in transgenic mice / M. Sy, M. Kitazawa, R. Medeiros [et al.] // Am. J. Pathol. – 2011. – №178. – Р. 2811–2822. doi:10.1016/j.ajpath.2011.02.012.Inflammation induced by infection potentiates tau pathological features in transgenic mice / M. Sy, M. Kitazawa, R. Medeiros [et al.] // Am. J. Pathol. – 2011. – №178. – Р. 2811–2822. doi:10.1016/j.ajpath.2011.02.012.Jurado M.B. The elusive nature of executive functions: a review of our current understanding / M.B. Jurado, M. Rosselli // Neuropsychol Rev. – 2007. – №3. – P. 213–233. doi:10.1007/s11065–007–9040–z.Jurado M.B. The elusive nature of executive functions: a review of our current understanding / M.B. Jurado, M. Rosselli // Neuropsychol Rev. – 2007. – №3. – P. 213–233. doi:10.1007/s11065–007–9040–z.Long–Term Cognitive Impairment after Critical Illness / P.P. Pandharipande, T.D. Girard, J.C. Jackson [et al.] // N Engl J Med. – 2013. – №369. – Р. 1306–1316. doi:10.1056/NEJMoa1301372Long–Term Cognitive Impairment after Critical Illness / P.P. Pandharipande, T.D. Girard, J.C. Jackson [et al.] // N Engl J Med. – 2013. – №369. – Р. 1306–1316. doi:10.1056/NEJMoa1301372Long–term neuroinflammation induced by influenza A virus infection and the impact on hippocampal neuron morphology and function / S. Hosseini, E. Wilk, K. Michaelsen–Preusse [et al.] // J. Neurosci. – 2018. – №38. – P. 3060–3080. doi:10.1523/JNEUROSCI.1740–17.2018.Long–term neuroinflammation induced by influenza A virus infection and the impact on hippocampal neuron morphology and function / S. Hosseini, E. Wilk, K. Michaelsen–Preusse [et al.] // J. Neurosci. – 2018. – №38. – P. 3060–3080. doi:10.1523/JNEUROSCI.1740–17.2018.Medium–term effects of SARS–CoV–2 infection on multiple vital organs, exercise capacity, cognition, quality of life and mental health, post–hospital discharge / B. Raman, M. Cassar, E.M. Tunnicliffe [et al.] // medRxiv Preprint. – 2020. – №5. – P. 126. doi:10.1101/2020.10.15.20205054Medium–term effects of SARS–CoV–2 infection on multiple vital organs, exercise capacity, cognition, quality of life and mental health, post–hospital discharge / B. Raman, M. Cassar, E.M. Tunnicliffe [et al.] // medRxiv Preprint. – 2020. – №5. – P. 126. doi:10.1101/2020.10.15.20205054Neurologic features in severe SARS–CoV–2 infection / J. Helms, S. Kremer, H. Merdji [et al.] // N Engl J Med. – 2020. – №23. – Р. 2268–2270. doi:10.1056/NEJMc2008597.Neurologic features in severe SARS–CoV–2 infection / J. Helms, S. Kremer, H. Merdji [et al.] // N Engl J Med. – 2020. – №23. – Р. 2268–2270. doi:10.1056/NEJMc2008597.Neurological complications of coronavirus disease (COVID–19): encephalopathy / A. Filatov, P. Sharma, F. Hindi [et al.] // Cureus. – 2020. – №3. – P. e7352. doi: 10.7759/cureus.7352.Neurological complications of coronavirus disease (COVID–19): encephalopathy / A. Filatov, P. Sharma, F. Hindi [et al.] // Cureus. – 2020. – №3. – P. e7352. doi: 10.7759/cureus.7352.Neurological manifestations of hospitalized patients with COVID–19 in Wuhan, China: a retrospective case series study / L. Mao, M. Wang, S. Chen [et al.] // JAMA Neurol. – 2020. – №6. – P. 683–690. doi:10.1001/jamaneurol.2020.1127.Neurological manifestations of hospitalized patients with COVID–19 in Wuhan, China: a retrospective case series study / L. Mao, M. Wang, S. Chen [et al.] // JAMA Neurol. – 2020. – №6. – P. 683–690. doi:10.1001/jamaneurol.2020.1127.Ritchie K. The cognitive consequences of the COVID–19 epidemic: collateral damage / K. Ritchie, D. Chan, T. Watermeyer. // Brain Communications. – 2020. – №2. – P. 51. doi: 10.1093/braincomms/fcaa069Ritchie K. The cognitive consequences of the COVID–19 epidemic: collateral damage / K. Ritchie, D. Chan, T. Watermeyer. // Brain Communications. – 2020. – №2. – P. 51. doi: 10.1093/braincomms/fcaa069Self–reported depressive symptoms and memory complaints in survivors five years after ARDS / N. Adhikari, C.M. Tansey, M.P. McAndrews [et al.] // Chest. – 2011. – №140. – Р. 1484–1493. doi:10.1378/chest.11–1667.Self–reported depressive symptoms and memory complaints in survivors five years after ARDS / N. Adhikari, C.M. Tansey, M.P. McAndrews [et al.] // Chest. – 2011. – №140. – Р. 1484–1493. doi:10.1378/chest.11–1667.The adult respiratory distress syndrome cognitive outcomes study / M.E. Mikkelsen, J.D. Christie, P.N. Lanken [et al.] // Am. J. Respir. Crit. Care Med. – 2012. – №185. – Р. 1307–1315. doi:10.1164/rccm.201111–2025OC.The adult respiratory distress syndrome cognitive outcomes study / M.E. Mikkelsen, J.D. Christie, P.N. Lanken [et al.] // Am. J. Respir. Crit. Care Med. – 2012. – №185. – Р. 1307–1315. doi:10.1164/rccm.201111–2025OC.The landscape of cognitive function in recovered COVID–19 patients / H. Zhou, S. Lu, J. Chen [et al.] // J Psychiatr Res. – 2020. – №129. – Р. 98–102. doi:10.1016/j.jpsychires.2020.06.022.The landscape of cognitive function in recovered COVID–19 patients / H. Zhou, S. Lu, J. Chen [et al.] // J Psychiatr Res. – 2020. – №129. – Р. 98–102. doi:10.1016/j.jpsychires.2020.06.022.Two–year cognitive, emotional and quality of life outcomes in acute respiratory distress syndrome / R.O. Hopkins, L.K. Weaver, D. Collingridge [et al.] // Am. J. Respir. Crit. Care Med. – 2005. – №171. – Р. 340–347. doi:10.1164/ajrccm.172.6.958.Two–year cognitive, emotional and quality of life outcomes in acute respiratory distress syndrome / R.O. Hopkins, L.K. Weaver, D. Collingridge [et al.] // Am. J. Respir. Crit. Care Med. – 2005. – №171. – Р. 340–347. doi:10.1164/ajrccm.172.6.958.Wilcox C. Characterizing Cognitive Impairment in Patients Recovered from COVID–19 / C. Wilcox // J Psychiatr Res. – 2020. – №129. – P. 98. doi:10.1016/j.jpsychires.2020.06.022.Wilcox C. Characterizing Cognitive Impairment in Patients Recovered from COVID–19 / C. Wilcox // J Psychiatr Res. – 2020. – №129. – P. 98. doi:10.1016/j.jpsychires.2020.06.022.Ye M. Encephalitis as a clinical manifestation of COVID–19 / M. Ye, Y. Ren, T. Lv // Brain Behav Immun. – 2020. – №88. – P. 945–946. doi:10.1016/j.bbi.2020.04.017.Ye M. Encephalitis as a clinical manifestation of COVID–19 / M. Ye, Y. Ren, T. Lv // Brain Behav Immun. – 2020. – №88. – P. 945–946. doi:10.1016/j.bbi.2020.04.017.

The authors declare that there are no conflicts of interest present.