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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ymj</journal-id><journal-title-group><journal-title xml:lang="ru">Якутский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Yakut Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1813-1905</issn><issn pub-type="epub">2312-1017</issn><publisher><publisher-name>ЯНЦ КМП</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.25789/YMJ.2021.73.18</article-id><article-id custom-type="elpub" pub-id-type="custom">ymj-511</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>АКТУАЛЬНАЯ ТЕМА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ACTUAL TOPIC</subject></subj-group></article-categories><title-group><article-title>Эпидемиологические и клинические аспекты сердечно-сосудистых заболеваний при новой коронавирусной инфекции</article-title><trans-title-group xml:lang="en"><trans-title>Epidemiological and clinical aspects of cardiovascular diseases in new coronavirus infection</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0010-9850</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Софронова</surname><given-names>С. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Sofronova</surname><given-names>S. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Софронова Саргылана Ивановна – к.м.н., гл.н.с. - руковод. Отдела</p></bio><bio xml:lang="en"><p>Sofronova Sargylana Ivanovna, PhD, Chief Researcher</p><p>The Republic of Sakha (Yakutia), Yakutsk, Yaroslavskogo, 6/3</p></bio><email xlink:type="simple">sara2208@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кириллина</surname><given-names>М. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Kirillina</surname><given-names>M. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кириллина Мария Петровна – к.б.н., в.н.с. – руковод. лаб.</p></bio><bio xml:lang="en"><p>Kirillina Maria Petrovna, PhD, Leading Researcher</p><p>The Republic of Sakha (Yakutia), Yakutsk, Yaroslavskogo, 6/3</p></bio><email xlink:type="simple">kirillinamp@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Николаев</surname><given-names>В. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Nikolaev</surname><given-names>V. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Николаев Вячеслав Михайлович – к.б.н., гл.н.с. - руковод. Отдела</p></bio><bio xml:lang="en"><p>Nikolaev Vyacheslav Mikhailovich, PhD, Chief Researcher</p><p>The Republic of Sakha (Yakutia), Yakutsk, Yaroslavskogo, 6/3</p></bio><email xlink:type="simple">Nikolaev1126@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4817-5315</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Романова</surname><given-names>А. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Romanova</surname><given-names>A. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Романова Анна Николаевна – д.м.н., директор</p></bio><bio xml:lang="en"><p>Romanova Anna Nikolaevna, MD, director</p><p>The Republic of Sakha (Yakutia), Yakutsk, Yaroslavskogo, 6/3</p></bio><email xlink:type="simple">ranik@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9243-6623</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кононова</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kononova</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кононова Ирина Васильевна – к.м.н., с.н.с.</p></bio><bio xml:lang="en"><p>Kononova Irina Vasilievna, Researcher</p><p>The Republic of Sakha (Yakutia), Yakutsk, Yaroslavskogo, 6/3</p></bio><email xlink:type="simple">irinakon.07@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Якутский научный центр комплексных медицинских проблем</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Yakut science centre of complex medical problems</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>27</day><month>04</month><year>2025</year></pub-date><volume>0</volume><issue>1</issue><fpage>64</fpage><lpage>69</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Софронова С.И., Кириллина М.П., Николаев В.М., Романова А.Н., Кононова И.В., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Софронова С.И., Кириллина М.П., Николаев В.М., Романова А.Н., Кононова И.В.</copyright-holder><copyright-holder xml:lang="en">Sofronova S.I., Kirillina M.P., Nikolaev V.M., Romanova A.N., Kononova I.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://ymj.elpub.ru/jour/article/view/511">https://ymj.elpub.ru/jour/article/view/511</self-uri><abstract><p>Представлен обзор литературных данных об эпидемиологических и клинических аспектах сердечно-сосудистых заболеваний при новой коронавирусной инфекции. Результаты исследований многих авторов показывают, что тропизм новой коронавирусной инфекции к сердечно-сосудистой системе проявляется через рецепторы ACE2, иммунное, цитокиновое воспаление, повышение коагуляционной активности и т.д. Эти патофизиологические характеристики особенно проявляются при сопутствующей сердечно-сосудистой патологии, приводя к декомпенсации имеющейся патологии и нередко к летальному исходу. Таким образом, сердечно-сосудистые заболевания являются опасным фактором риска развития фатальных последствий при текущей пандемической ситуации.</p></abstract><trans-abstract xml:lang="en"><p>A review of the literature data on the epidemiological and clinical aspects of cardiovascular diseases in the new coronavirus infection is presented. Summarizing the results of studies by many authors, we state that the tropism of the new coronavirus infection to the cardiovascular system is manifested through ACE2 receptors, immune, cytokine inflammation, increased coagulation activity. These pathophysiological characteristics are especially manifested in concomitant cardiovascular pathology, leading to decompensation of the existing pathology and often death. Thus, cardiovascular disease is a dangerous risk factor for the development of fatal consequences in the current pandemic situation.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>SARS-CoV-2</kwd><kwd>COVID-19</kwd><kwd>сердечно-сосудистые заболевания</kwd><kwd>ACE2</kwd><kwd>артериальная гипертензия</kwd><kwd>миокардит</kwd><kwd>аритмия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>SARS-CoV-2</kwd><kwd>COVID-19</kwd><kwd>cardiovascular disease</kwd><kwd>ACE2</kwd><kwd>arterial hypertension</kwd><kwd>myocarditis</kwd><kwd>arrhythmia</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">https://стопкоронавирус.рф</mixed-citation><mixed-citation xml:lang="en">https://стопкоронавирус.рф</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Annakan V Navaratnam. Patient factors and temporal trends associated with COVID-19 in-hospital mortality in England: an observational study using administrative data/ Annakan V Navaratnam, William K Gray, Jamie Day [et al.] // The Lancet Respiratory Medicine, Published: February 15, 2021. https://doi.org/10.1016/S2213-2600(20)30579-8</mixed-citation><mixed-citation xml:lang="en">Annakan V Navaratnam. Patient factors and temporal trends associated with COVID-19 in-hospital mortality in England: an observational study using administrative data/ Annakan V Navaratnam, William K Gray, Jamie Day [et al.] // The Lancet Respiratory Medicine, Published: February 15, 2021. https://doi.org/10.1016/S2213-2600(20)30579-8</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Arentz M. Characteristics and outcomes of 21 critically ill patients with COVID-19 in Washington State / M, Arentz, E. Yim, L. Klaff // JAMA. 2020;323:1612–1614.</mixed-citation><mixed-citation xml:lang="en">Arentz M. Characteristics and outcomes of 21 critically ill patients with COVID-19 in Washington State / M, Arentz, E. Yim, L. Klaff // JAMA. 2020;323:1612–1614.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Argulian E. Right ventricular dilation in hospitalized patients with COVID-19 infection / E. Argulian, K. Sud, B. Vogel [et al.] // JACC Cardiovasc Imaging. Published online. - May 15, 2020. doi:10.1016/j.jcmg.2020.05.010</mixed-citation><mixed-citation xml:lang="en">Argulian E. Right ventricular dilation in hospitalized patients with COVID-19 infection / E. Argulian, K. Sud, B. Vogel [et al.] // JACC Cardiovasc Imaging. Published online. - May 15, 2020. doi:10.1016/j.jcmg.2020.05.010</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Bourgonje A.R. Angiotensin-converting enzyme 2 (ACE2), SARS-CoV-2 and the pathophysiology of coronavirus disease 2019 (COVID-19) / A.R.Bourgonje, A.E.Abdulle, W. Timens [et al.] // J Pathol.- 2020 Jul; No 251(3). – P.228-248. doi: 10.1002/path.5471</mixed-citation><mixed-citation xml:lang="en">Bourgonje A.R. Angiotensin-converting enzyme 2 (ACE2), SARS-CoV-2 and the pathophysiology of coronavirus disease 2019 (COVID-19) / A.R.Bourgonje, A.E.Abdulle, W. Timens [et al.] // J Pathol.- 2020 Jul; No 251(3). – P.228-248. doi: 10.1002/path.5471</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Caforio A.L.Current state of knowledge on aetiology, diagnosis, management, and therapy of myocarditis: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases / A.L. Caforio, S. Pankuweit, E. Arbustini // Eur Heart J. 2013;34:2636–2648.</mixed-citation><mixed-citation xml:lang="en">Caforio A.L.Current state of knowledge on aetiology, diagnosis, management, and therapy of myocarditis: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases / A.L. Caforio, S. Pankuweit, E. Arbustini // Eur Heart J. 2013;34:2636–2648.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Center for Disease Control and Prevention. Hypertension statistics and maps. https://www.cdc.gov/bloodpressure/statistics_maps.htm</mixed-citation><mixed-citation xml:lang="en">Center for Disease Control and Prevention. Hypertension statistics and maps. https://www.cdc.gov/bloodpressure/statistics_maps.htm</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Center for Disease Control and Prevention. Diabetes data and statistics. https://www.cdc.gov/diabetes/data/index.html</mixed-citation><mixed-citation xml:lang="en">Center for Disease Control and Prevention. Diabetes data and statistics. https://www.cdc.gov/diabetes/data/index.html</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Center for Disease Control and Prevention. Overweight &amp; obesity - data &amp; statistics. https://www.cdc.gov/obesity/data/index.html</mixed-citation><mixed-citation xml:lang="en">Center for Disease Control and Prevention. Overweight &amp; obesity - data &amp; statistics. https://www.cdc.gov/obesity/data/index.html</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Chen L. The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARSCoV-2 / L. Chen, X. Li, M. Chen, Y. Feng, C. Xiong // Cardiovasc Res. 2020;116(6):1097-1100. doi:10.1093/cvr/cvaa078</mixed-citation><mixed-citation xml:lang="en">Chen L. The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARSCoV-2 / L. Chen, X. Li, M. Chen, Y. Feng, C. Xiong // Cardiovasc Res. 2020;116(6):1097-1100. doi:10.1093/cvr/cvaa078</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Clerkin K.J. COVID-19 and cardiovascular disease / K.J. Clerkin, J.A. Fried, J. Raikhelkar // Circulation. 2020;141:1648–1655.</mixed-citation><mixed-citation xml:lang="en">Clerkin K.J. COVID-19 and cardiovascular disease / K.J. Clerkin, J.A. Fried, J. Raikhelkar // Circulation. 2020;141:1648–1655.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Coomes E.A. Interleukin-6 in COVID-19: A systemic review and meta-analysis / E.A. Coomes, H. Haghbayan // Rev. Med. Virol. 2020; e2141. DOI: 10.1002/rmv.2141.</mixed-citation><mixed-citation xml:lang="en">Coomes E.A. Interleukin-6 in COVID-19: A systemic review and meta-analysis / E.A. Coomes, H. Haghbayan // Rev. Med. Virol. 2020; e2141. DOI: 10.1002/rmv.2141.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Cunningham J.W. Clinical Outcomes in Young US Adults Hospitalized With COVID-19 / J.W. Cunningham, M. Vaduganathan, B.L. Claggett [et al.] // JAMA Intern Med. 2020. Sep 9. doi: 10.1001/jamainternmed.2020.5313</mixed-citation><mixed-citation xml:lang="en">Cunningham J.W. Clinical Outcomes in Young US Adults Hospitalized With COVID-19 / J.W. Cunningham, M. Vaduganathan, B.L. Claggett [et al.] // JAMA Intern Med. 2020. Sep 9. doi: 10.1001/jamainternmed.2020.5313</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Driggin E, Madhavan MV, Bikdeli B [et al.] Cardiovascular Considerations for Patients, Health Care Workers, and Health Systems During the COVID-19 Pandemic / Driggin E, Madhavan MV, Bikdeli B [et al.] // J Am Coll Cardiol 2020;75(18):2352-2371. https://doi.org/10.1016/j.jacc.2020.03.031</mixed-citation><mixed-citation xml:lang="en">Driggin E, Madhavan MV, Bikdeli B [et al.] Cardiovascular Considerations for Patients, Health Care Workers, and Health Systems During the COVID-19 Pandemic / Driggin E, Madhavan MV, Bikdeli B [et al.] // J Am Coll Cardiol 2020;75(18):2352-2371. https://doi.org/10.1016/j.jacc.2020.03.031</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Epidemiology Working Group for Ncip Epidemic Response CCfDC, Prevention. [The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China]. Zhonghua Liu Xing Bing Xue Za Zhi. 2020;41(2):145-151. https://doi.org/10.3760/cma.j.issn.0254-6450.2020.02.003</mixed-citation><mixed-citation xml:lang="en">Epidemiology Working Group for Ncip Epidemic Response CCfDC, Prevention. [The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China]. Zhonghua Liu Xing Bing Xue Za Zhi. 2020;41(2):145-151. https://doi.org/10.3760/cma.j.issn.0254-6450.2020.02.003</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Felix Kwenandar. Coronavirus disease 2019 and cardiovascular system: A narrative review / Felix Kwenandar, Karunia Valeriani Japar, Vika Damay [et al.] // Int J Cardiol Heart Vasc. 2020 Jun 3;29:100557. doi: 10.1016/j.ijcha.2020.100557</mixed-citation><mixed-citation xml:lang="en">Felix Kwenandar. Coronavirus disease 2019 and cardiovascular system: A narrative review / Felix Kwenandar, Karunia Valeriani Japar, Vika Damay [et al.] // Int J Cardiol Heart Vasc. 2020 Jun 3;29:100557. doi: 10.1016/j.ijcha.2020.100557</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Gro S. SARS-CoV-2 receptor ACE2-dependent implications on the cardiovascular system: From basic science to clinical implications / S. Gro, C. Jahn, S. Cushman [et al.] // J Mol Cell Cardiol. 2020 Jul;144:47-53. doi:10.1016/j.yjmcc.2020.04.031</mixed-citation><mixed-citation xml:lang="en">Gro S. SARS-CoV-2 receptor ACE2-dependent implications on the cardiovascular system: From basic science to clinical implications / S. Gro, C. Jahn, S. Cushman [et al.] // J Mol Cell Cardiol. 2020 Jul;144:47-53. doi:10.1016/j.yjmcc.2020.04.031</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Henry B.M. Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-analysis / B.M. Henry, M.H.C. de Oliveira, S. Benoit [et al.] // Clin. Chem. Lab. Med. 2020; 58 (7): 1021–1028. DOI: 10.1515/ cclm-2020-0369.</mixed-citation><mixed-citation xml:lang="en">Henry B.M. Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-analysis / B.M. Henry, M.H.C. de Oliveira, S. Benoit [et al.] // Clin. Chem. Lab. Med. 2020; 58 (7): 1021–1028. DOI: 10.1515/ cclm-2020-0369.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Huang C. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China / C. Huang, Y. Wang, X. Li [et al.] // Lancet 2020; 395: 497–506</mixed-citation><mixed-citation xml:lang="en">Huang C. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China / C. Huang, Y. Wang, X. Li [et al.] // Lancet 2020; 395: 497–506</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Inciardi R.M. Cardiac involvement in a patient with coronavirus disease 2019 (COVID-19) / R.M. Inciardi, L. Lupi, G. Zaccone // JAMA Cardiol. 2020;5:819–824.</mixed-citation><mixed-citation xml:lang="en">Inciardi R.M. Cardiac involvement in a patient with coronavirus disease 2019 (COVID-19) / R.M. Inciardi, L. Lupi, G. Zaccone // JAMA Cardiol. 2020;5:819–824.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Imam Z. Older age and comorbidity are independent mortality predictors in a large cohort of 1305 COVID-19 patients in Michigan, United States / Z. Imam, F. Odish, I. Gill [et al.] // J Intern Med. 2020;288(4):469–76. https://doi.org/10.1111/joim.13119.</mixed-citation><mixed-citation xml:lang="en">Imam Z. Older age and comorbidity are independent mortality predictors in a large cohort of 1305 COVID-19 patients in Michigan, United States / Z. Imam, F. Odish, I. Gill [et al.] // J Intern Med. 2020;288(4):469–76. https://doi.org/10.1111/joim.13119.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Januzzi J.L. Troponin and BNP use in COVID-19 / J.L. Januzzi // Cardiology Magazine. March. 2020;18 https://www.acc.org/latest-in-cardiology/articles/2020/03/18/15/25/troponin-andbnp-use-in-covid19</mixed-citation><mixed-citation xml:lang="en">Januzzi J.L. Troponin and BNP use in COVID-19 / J.L. Januzzi // Cardiology Magazine. March. 2020;18 https://www.acc.org/latest-in-cardiology/articles/2020/03/18/15/25/troponin-andbnp-use-in-covid19</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Kang S.J. Age-related morbidity and mortality among patients with COVID-19 / S.L. Kang, S.I. Jung // Infect Chemother. 2020;52(2):154–64.</mixed-citation><mixed-citation xml:lang="en">Kang S.J. Age-related morbidity and mortality among patients with COVID-19 / S.L. Kang, S.I. Jung // Infect Chemother. 2020;52(2):154–64.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Kevin J Clerkin. COVID-19 and Cardiovascular Disease / Kevin J Clerkin, Justin A Fried, Jayant Raikhelkar [et al.] // Circulation. 2020 May 19;141(20):1648-1655. doi:10.1161/CIRCULATIONAHA.120.046941.</mixed-citation><mixed-citation xml:lang="en">Kevin J Clerkin. COVID-19 and Cardiovascular Disease / Kevin J Clerkin, Justin A Fried, Jayant Raikhelkar [et al.] // Circulation. 2020 May 19;141(20):1648-1655. doi:10.1161/CIRCULATIONAHA.120.046941.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Kim I.C. COVID-19-related myocarditis in a 21-year-old female patient / I.C. Kim, J.Y. Kim, H.A. Kim, S. Han // Eur Heart J. 2020;41:1859.</mixed-citation><mixed-citation xml:lang="en">Kim I.C. COVID-19-related myocarditis in a 21-year-old female patient / I.C. Kim, J.Y. Kim, H.A. Kim, S. Han // Eur Heart J. 2020;41:1859.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Kociol R.D. Recognition and initial management of fulminant myocarditis: a scientific statement from the American Heart Association / R.D. Kociol, L.T. Cooper, J.C. Fang // Circulation. 2020; 141:e69–e92.</mixed-citation><mixed-citation xml:lang="en">Kociol R.D. Recognition and initial management of fulminant myocarditis: a scientific statement from the American Heart Association / R.D. Kociol, L.T. Cooper, J.C. Fang // Circulation. 2020; 141:e69–e92.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Komarowska I. Hepatocyte growth factor receptor c-Met instructs T cell cardiotropism and promotes t cell migration to the heart via autocrine chemokine release / I. Komarowska, D. Coe, G. Wang // Immunity. 2015;42:1087–1099.</mixed-citation><mixed-citation xml:lang="en">Komarowska I. Hepatocyte growth factor receptor c-Met instructs T cell cardiotropism and promotes t cell migration to the heart via autocrine chemokine release / I. Komarowska, D. Coe, G. Wang // Immunity. 2015;42:1087–1099.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Lee D.W. Current concepts in the diagnosis and management of cytokine release syndromeBl / D.W. Lee, R. Gardner, D.L. Porter. Blood. 2014;124:188–195.</mixed-citation><mixed-citation xml:lang="en">Lee D.W. Current concepts in the diagnosis and management of cytokine release syndromeBl / D.W. Lee, R. Gardner, D.L. Porter. Blood. 2014;124:188–195.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Li S. Clinical and pathological investigation of patients with severe COVID-19 / S. Li, L. Jiang, X. Li [et al.] // JCI Insight. 2020;5(12):138070. Published 2020 Jun 18. doi: 10.1172/jci.insight.138070</mixed-citation><mixed-citation xml:lang="en">Li S. Clinical and pathological investigation of patients with severe COVID-19 / S. Li, L. Jiang, X. Li [et al.] // JCI Insight. 2020;5(12):138070. Published 2020 Jun 18. doi: 10.1172/jci.insight.138070</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Liu K. Clinical characteristics of novel coronavirus cases in tertiary hospitals in Hubei Province / K. Liu, Y.Y. Fang, Y. Deng // Chin Med J. 2020;133:1025–1031.</mixed-citation><mixed-citation xml:lang="en">Liu K. Clinical characteristics of novel coronavirus cases in tertiary hospitals in Hubei Province / K. Liu, Y.Y. Fang, Y. Deng // Chin Med J. 2020;133:1025–1031.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Lu R. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding / R. Lu, X. Zhao, J. Li [et al.] // Lancet. 2020; 395: 565–574.</mixed-citation><mixed-citation xml:lang="en">Lu R. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding / R. Lu, X. Zhao, J. Li [et al.] // Lancet. 2020; 395: 565–574.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Novel Coronavirus (2019-nCoV) global situation reports; World Health Organization. https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports</mixed-citation><mixed-citation xml:lang="en">Novel Coronavirus (2019-nCoV) global situation reports; World Health Organization. https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Peretto G. Ventricular arrhythmias in myocarditis: characterization and relationships with myocardial inflammation / G. Peretto, S. Sala, S. Rizzo // J Am Coll Cardiol. 2020;75:1046–1057.</mixed-citation><mixed-citation xml:lang="en">Peretto G. Ventricular arrhythmias in myocarditis: characterization and relationships with myocardial inflammation / G. Peretto, S. Sala, S. Rizzo // J Am Coll Cardiol. 2020;75:1046–1057.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Peretto G. Arrhythmias in myocarditis: state of the art / G. Peretto, S. Sala, S. Rizzo // Heart Rhythm. 2019;16:793–801.</mixed-citation><mixed-citation xml:lang="en">Peretto G. Arrhythmias in myocarditis: state of the art / G. Peretto, S. Sala, S. Rizzo // Heart Rhythm. 2019;16:793–801.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Richardson S. Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area / S. Richardson, J.S. Hirsch, M. Narasimhan [et al.] // JAMA 2020. https://doi.org/10.1001/jama.2020.6775</mixed-citation><mixed-citation xml:lang="en">Richardson S. Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area / S. Richardson, J.S. Hirsch, M. Narasimhan [et al.] // JAMA 2020. https://doi.org/10.1001/jama.2020.6775</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Rokni M. Immune responses and pathogenesis of SARS-CoV-2 during an outbreak in Iran: Comparison with SARS and MERS / M. Rokni, V. Ghasemi, Z. Tavakoli // Rev Med Virol. 2020;30(3): e2107. doi:10.1002/rmv.2107</mixed-citation><mixed-citation xml:lang="en">Rokni M. Immune responses and pathogenesis of SARS-CoV-2 during an outbreak in Iran: Comparison with SARS and MERS / M. Rokni, V. Ghasemi, Z. Tavakoli // Rev Med Virol. 2020;30(3): e2107. doi:10.1002/rmv.2107</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Sala S. Acute myocarditis presenting as a reverse Tako-Tsubo syndrome in a patient with SARS-CoV-2 respiratory infection / S. Sala, G. Peretto, M. Gramegna // Eur Heart J. 2020;41:1861–1862.</mixed-citation><mixed-citation xml:lang="en">Sala S. Acute myocarditis presenting as a reverse Tako-Tsubo syndrome in a patient with SARS-CoV-2 respiratory infection / S. Sala, G. Peretto, M. Gramegna // Eur Heart J. 2020;41:1861–1862.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Sato R. A review of sepsis-induced cardiomyopathy / R. Sato, M. Nasu // J Intensive Care. 2015;3:48.</mixed-citation><mixed-citation xml:lang="en">Sato R. A review of sepsis-induced cardiomyopathy / R. Sato, M. Nasu // J Intensive Care. 2015;3:48.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Shi S. Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan, China / M. Qin, B. Shen [et al.] // JAMA Cardiol.2020. https://doi.org/10.1001/jamacardio.2020.0950</mixed-citation><mixed-citation xml:lang="en">Shi S. Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan, China / M. Qin, B. Shen [et al.] // JAMA Cardiol.2020. https://doi.org/10.1001/jamacardio.2020.0950</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Siddhartha Dan, Mohit Pant, Sushil Kumar Upadhyay. The Case Fatality Rate in COVID-19 Patients With Cardiovascular Disease: Global Health Challenge and Paradigm in the Current Pandemic / Siddhartha Dan, Mohit Pant, Sushil Kumar Upadhyay // Curr Pharmacol Rep. 2020 Sep 15;1-10. doi: 10.1007/s40495-020-00239-0</mixed-citation><mixed-citation xml:lang="en">Siddhartha Dan, Mohit Pant, Sushil Kumar Upadhyay. The Case Fatality Rate in COVID-19 Patients With Cardiovascular Disease: Global Health Challenge and Paradigm in the Current Pandemic / Siddhartha Dan, Mohit Pant, Sushil Kumar Upadhyay // Curr Pharmacol Rep. 2020 Sep 15;1-10. doi: 10.1007/s40495-020-00239-0</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Sukrit Narula. Plasma ACE2 and risk of death or cardiometabolic diseases: a case-cohort analysis / Sukrit Narula, Salim Yusuf, Michael Chong [et al.] // The Lancet. 2020; Vol. 396, No. 10256: 968–976. DOI: 10.1016/S0140-6736(20)31964-4</mixed-citation><mixed-citation xml:lang="en">Sukrit Narula. Plasma ACE2 and risk of death or cardiometabolic diseases: a case-cohort analysis / Sukrit Narula, Salim Yusuf, Michael Chong [et al.] // The Lancet. 2020; Vol. 396, No. 10256: 968–976. DOI: 10.1016/S0140-6736(20)31964-4</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Szekely Y. The spectrum of cardiac manifestations in coronavirus disease 2019 (COVID19)—a systematic echocardiographic study / Y. Szekely, Y. Lichter, P. Taieb [et al.] // Circulation. 2020;142(4):342-353. doi:10.1161/CIRCULATIONAHA.120.047971</mixed-citation><mixed-citation xml:lang="en">Szekely Y. The spectrum of cardiac manifestations in coronavirus disease 2019 (COVID19)—a systematic echocardiographic study / Y. Szekely, Y. Lichter, P. Taieb [et al.] // Circulation. 2020;142(4):342-353. doi:10.1161/CIRCULATIONAHA.120.047971</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Tegally H. Emergence and rapid spread of a new severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) lineage with multiple spike mutations in South Africa / H. Tegally, E. Wilkinson, M. Giovanetti [et al.] // MedRxiv. 2020; (published online Dec 22.) (preprint). https://doi.org/10.1101/2020.12.21.20248640</mixed-citation><mixed-citation xml:lang="en">Tegally H. Emergence and rapid spread of a new severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) lineage with multiple spike mutations in South Africa / H. Tegally, E. Wilkinson, M. Giovanetti [et al.] // MedRxiv. 2020; (published online Dec 22.) (preprint). https://doi.org/10.1101/2020.12.21.20248640</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Tian W. Predictors of mortality in hospitalized COVID-19 patients: A systematic review and meta-analysis / W. Tian, W. Jiang, J. Yao [et al.] // J. Med. Virol. 2020; 92 (10):1875–1883. DOI: 10.1002/jmv.26050.</mixed-citation><mixed-citation xml:lang="en">Tian W. Predictors of mortality in hospitalized COVID-19 patients: A systematic review and meta-analysis / W. Tian, W. Jiang, J. Yao [et al.] // J. Med. Virol. 2020; 92 (10):1875–1883. DOI: 10.1002/jmv.26050.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Udomsinprasert W. Circulating Levels of Interleukin-6 and Interleukin-10, But Not Tumor Necrosis Factor-Alpha, as Potential Biomarkers of Severity and Mortality for COVID-19: Systematic Review with Meta-analysis / W. Udomsinprasert, J. Jittikoon, S. Sangroongruangsri, U. Chaikledkaew // J Clin Immunol. 2021 Jan;41(1):11-22. doi: 10.1007/s10875-020-00899-z.</mixed-citation><mixed-citation xml:lang="en">Udomsinprasert W. Circulating Levels of Interleukin-6 and Interleukin-10, But Not Tumor Necrosis Factor-Alpha, as Potential Biomarkers of Severity and Mortality for COVID-19: Systematic Review with Meta-analysis / W. Udomsinprasert, J. Jittikoon, S. Sangroongruangsri, U. Chaikledkaew // J Clin Immunol. 2021 Jan;41(1):11-22. doi: 10.1007/s10875-020-00899-z.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Volz E. Transmission of SARS-CoV-2 lineage B.1.1.7 in England: insights from linking epidemiological and genetic data. medRxiv. 2021; (published online Jan 4.) / E. Volz, S. Mishra, M. Chand [et al.] (preprint). https://doi.org/10.1101/2020.12.30.20249034</mixed-citation><mixed-citation xml:lang="en">Volz E. Transmission of SARS-CoV-2 lineage B.1.1.7 in England: insights from linking epidemiological and genetic data. medRxiv. 2021; (published online Jan 4.) / E. Volz, S. Mishra, M. Chand [et al.] (preprint). https://doi.org/10.1101/2020.12.30.20249034</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Wan S. Characteristics of lymphocyte subsets and cytokines in peripheral blood of 123 hospitalized patients with 2019 novel coronavirus pneumonia (NCP) / S. Wan, Q. Yi, S. Fan [et al.] // MedRxiv. 2020. doi:10.1101/2020.02.10.20021832</mixed-citation><mixed-citation xml:lang="en">Wan S. Characteristics of lymphocyte subsets and cytokines in peripheral blood of 123 hospitalized patients with 2019 novel coronavirus pneumonia (NCP) / S. Wan, Q. Yi, S. Fan [et al.] // MedRxiv. 2020. doi:10.1101/2020.02.10.20021832</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Wang D. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China / D. Wang, B. Hu, C. Hu [et al.] // JAMA. 2020;323:1061–1069. https://doi.org/10.1001/jama.2020.1585</mixed-citation><mixed-citation xml:lang="en">Wang D. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China / D. Wang, B. Hu, C. Hu [et al.] // JAMA. 2020;323:1061–1069. https://doi.org/10.1001/jama.2020.1585</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Xiong T.Y. Coronaviruses and the cardiovascular system: acute and long-term implications / T.Y. Xiong, S. Redwood, B. Prendergast, M. Chen // Eur Heart J 2020;41(19):1798-1800. https://doi.org/10.1093/eurheartj/ehaa231</mixed-citation><mixed-citation xml:lang="en">Xiong T.Y. Coronaviruses and the cardiovascular system: acute and long-term implications / T.Y. Xiong, S. Redwood, B. Prendergast, M. Chen // Eur Heart J 2020;41(19):1798-1800. https://doi.org/10.1093/eurheartj/ehaa231</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Yanez N.D. COVID-19 mortality risk for older men and women / N.D. Yanez, N.S. Weiss, J.A. Romand [et al.] // BMC Public Health 20, 1742 (2020). https://doi.org/10.1186/s12889-020-09826-8</mixed-citation><mixed-citation xml:lang="en">Yanez N.D. COVID-19 mortality risk for older men and women / N.D. Yanez, N.S. Weiss, J.A. Romand [et al.] // BMC Public Health 20, 1742 (2020). https://doi.org/10.1186/s12889-020-09826-8</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Ying-Ying Zheng. COVID-19 and the cardiovascular system / Ying-Ying Zheng, Yi-Tong Ma, Jin-Ying Zhang, Xiang Xie // Nat Rev Cardiol. 2020 May;17(5):259-260. doi: 10.1038/s41569-020-0360-5.</mixed-citation><mixed-citation xml:lang="en">Ying-Ying Zheng. COVID-19 and the cardiovascular system / Ying-Ying Zheng, Yi-Tong Ma, Jin-Ying Zhang, Xiang Xie // Nat Rev Cardiol. 2020 May;17(5):259-260. doi: 10.1038/s41569-020-0360-5.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Yu C.M. Cardiovascular complications of severe acute respiratory syndrome /C.M. Yu, R.S. Wong, E.B. Wu [et al.] // Postgrad Med J 2006;82(964):140-4. https://doi.org/10.1136/pgmj.2005.037515</mixed-citation><mixed-citation xml:lang="en">Yu C.M. Cardiovascular complications of severe acute respiratory syndrome /C.M. Yu, R.S. Wong, E.B. Wu [et al.] // Postgrad Med J 2006;82(964):140-4. https://doi.org/10.1136/pgmj.2005.037515</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Zeng J-H. First case of COVID-19 infection with fulminant myocarditis complication: case report and insights / J-H. Zeng, Y-X. Liu, J. Yuan // Published online April 10. Infection. 2020 doi: 10.1007/s15010-020-01424-5.</mixed-citation><mixed-citation xml:lang="en">Zeng J-H. First case of COVID-19 infection with fulminant myocarditis complication: case report and insights / J-H. Zeng, Y-X. Liu, J. Yuan // Published online April 10. Infection. 2020 doi: 10.1007/s15010-020-01424-5.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang J.J. Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China / J.J. Zhang, X. Dong, Y.Y. Cao [et al.] // Allergy. - 2020; 75(7):1730-1741. doi:10.1111/all.14238</mixed-citation><mixed-citation xml:lang="en">Zhang J.J. Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China / J.J. Zhang, X. Dong, Y.Y. Cao [et al.] // Allergy. - 2020; 75(7):1730-1741. doi:10.1111/all.14238</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang Q. Clinical trial analysis of 2019-nCoV therapy registered in China J Med Virol / Q. Zhang, Y. Wang, C. Qi [et al.]. – No 92 (2020), P. 540-545</mixed-citation><mixed-citation xml:lang="en">Zhang Q. Clinical trial analysis of 2019-nCoV therapy registered in China J Med Virol / Q. Zhang, Y. Wang, C. Qi [et al.]. – No 92 (2020), P. 540-545</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Zhao D. Epidemiology of cardiovascular disease in China: current features and implications / D. Zhao, J. Liu, M. Wang [et al.] // Nat Rev Cardiol 2019;16(4):203-212. https://doi.org/10.1038/s41569-018-0119-4</mixed-citation><mixed-citation xml:lang="en">Zhao D. Epidemiology of cardiovascular disease in China: current features and implications / D. Zhao, J. Liu, M. Wang [et al.] // Nat Rev Cardiol 2019;16(4):203-212. https://doi.org/10.1038/s41569-018-0119-4</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Zheng Y.Y. COVID-19 and the cardiovascular system / Y.Y. Zheng, Y.T. Ma, J.Y. Zhang, X. Xie // Nat Rev Cardiol 2020;17(5):259-260. https://doi.org/10.1038/s41569-020-0360-5</mixed-citation><mixed-citation xml:lang="en">Zheng Y.Y. COVID-19 and the cardiovascular system / Y.Y. Zheng, Y.T. Ma, J.Y. Zhang, X. Xie // Nat Rev Cardiol 2020;17(5):259-260. https://doi.org/10.1038/s41569-020-0360-5</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
