ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.25789/YMJ.2022.78.03ymj-49Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHИндивидуальные различия числа копий митохондриальной ДНК: роль социально-демографических параметровIndividual differences in the number of mitochondrial DNA copies: the effect of socio-demographic factorsЕникееваР. Ф.EnikeevaR. F.

Еникеева Рената Фануровна – к.б.н., н.с.

Enikeeva Renata Fanurovna – Candidate of Biological Sciences, researcher

enikeevarf@gmail.comКазанцеваА. В.KazantsevaA. V.

Казанцева Анастасия Валерьевна – к.б.н., с.н.с.

Kazantseva Anastasia Valeryevna – Candidate of Biological Sciences, senior researcher

ДавыдоваЮ. Д.DavydovaYu. D.

Давыдова Юлия Дмитриевна – м.н.с.

DavydovaA Yulia Dmitrievna – junior researcher

МустафинР. Н.MustafinR. N.

Мустафин Рустам Наилевич – к.м.н., доцент

Mustafin Rustam Nailevich – Ph.D., Associate Professor

ЛобасковаМ. М.LobaskovaM. M.

Лобаскова Марина Михайловна – к.психол.н., с.н.с.

Lobaskova Marina Mikhailovna – Candidate of Psychology, senior researcher

МалыхС. Б.MalykhS. B.

Малых Сергей Борисович – д.психол.н., проф., действительный член РАО, зав. лаб.

Malykh Sergey Borisovich – Doctor of Psychology, professor, Fellow Member of RAE, Head of the lab.

https://orcid.org/0000-0001-9633-6374КовасЮ. В.KovasY. V.

Ковас Юлия Владимировна – PhD, проф. генетики и психологии, директор Международной лаборатории междисциплинарных исследований индивидуальных различий в обучении (InLab) в колледже ГолдсмитResearcher ID (WOS): L-7116-2019

Autor ID (Scopus): 8680670800

KOVAS Yulia Vladimirovna – PhD, Professor of Genetics and Psychology, Director of the International Laboratory for Interdisciplinary Studies of Individual Differences in Learning (InLab) at Goldsmith College

Researcher ID (WAS): L7116-2019

Author ID (Scopus): 8680670800

ХуснутдиноваЭ. К.KhusnutdinovaE. K.

Хуснутдинова Эльза Камилевна – д.б.н., проф., чл.-корр. РАО, директор

KhusnutdinovaElsa Kamilevna – Doctor of Biological Sciences, Professor, Corresponding Member of the Russian Academy of Sciences, Director

Институт биохимии и генетики Уфимского ФИЦ РАНРоссияInstitute of Biochemistry and Genetics of Ufa FIT RASRussian FederationБашкирский ГМУРоссияBashkir State Medical UniversityRussian FederationПсихологический институт Российской академии образованияРоссияPsychological Institute of the Russian Academy of EducationRussian FederationУниверситет ЛондонаВеликобританияUniversity of LondonUnited KingdomИнститут биохимии и генетики Уфимского ФИЦ РАНРоссияInstitute of Biochemistry and Genetics of the Ufa AIC RASRussian Federation202203022025021316Copyright © Еникеева Р.Ф., Казанцева А.В., Давыдова Ю.Д., Мустафин Р.Н., Лобаскова М.М., Малых С.Б., Ковас Ю.В., Хуснутдинова Э.К., 20252025Еникеева Р.Ф., Казанцева А.В., Давыдова Ю.Д., Мустафин Р.Н., Лобаскова М.М., Малых С.Б., Ковас Ю.В., Хуснутдинова Э.К.Enikeeva R.F., Kazantseva A.V., Davydova Y.D., Mustafin R.N., Lobaskova M.M., Malykh S.B., Kovas Y.V., Khusnutdinova E.K.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/49

Вариации числа копий мтДНК обусловлены комплексным воздействием различных средовых факторов, включая химический, биологический или физиологический стресс, возраст, особенности эмбрионального развития. Однако к настоящему времени остается неизвестным, какие факторы и в каком возрасте оказывают наиболее значимый эффект на изменение числа копий мтДНК и приводят к большей аллостатической нагрузке. Исходя из этого, целью данной работы являлась оценка вовлеченности различных социально-демографических параметров в формирование межиндивидуальных вариаций числа копий мтДНК у здоровых индивидов 18–25 лет. В рамках данного исследования были выявлены эффекты жестокого обращения в детстве и возраста на индивидуальные различия в числе копий митохондриальной ДНК.

Differences in mtDNA copy-number are caused by a complex effect of various environmental factors including chemical, biological or physiological stress, age, and embryonic development. However, to date it remains unknown, which factors and at what age have the most significant impact on mtDNA copy-number and cause greater allostatic load. Therefore, the present study aims to assess the involvement of various socio-demographic parameters in manifesting mtDNA copy-number in healthy individuals aged 18-25 years (N=1065). Within the framework of this study the effects of childhood maltreatment and age on individual differences in mitochondrial DNA copy number were revealed.

митохондриальная ДНКмитохондриясредовые факторымитохондриальная теория старенияаллостатическая нагрузкаmitochondrial DNAmitochondriaenvironmental factorsmitochondrial theory of agingallostatic loadРабота выполнена при финансовой поддержке гранта Российского научного фонда (проект № 17–78–30028) в части сбора психологических данных и биологических образцов, мегагранта Правительства РФ (проект № 075-15-2021-595) в части статистической обработки и биоинформатического анализа данных, мегагранта Правительства Республики Башкортостан в части генотипирования изученных вариантов.ReferencesФомченко Н.Е. Биологическая роль митохондрий в старении организма/ Н.Е. Фомченко, Е.В. Воропаев, А.В. Скачков //Проблемы здоровья и экологии. -2015; -4 (46): 8-13.Fomchenko N.E. The biological role of mitochondria in the aging of the body/ Fomchenko N.E., Voropaev E.V., Skachkov А.V. 2015; 4 (46): 8-13. doi.org/10.51523/2708–6011.2015-12-4-2Bersani F, Morley С, Lindqvist С, et al. Mitochondrial DNA copy number is reduced in male combat veterans with PTSD. Progress in neuro-psychopharmacology & biological psychiatry. 2016; 64:10–17. doi: 10.1016/j.pnpbp.2015.06.012Bersani F, Morley С, Lindqvist С, et al. Mitochondrial DNA copy number is reduced in male combat veterans with PTSD. Progress in neuro-psychopharmacology & biological psychiatry. 2016; 64:10–17. doi: 10.1016/j.pnpbp.2015.06.012Cai N, Chang S, Li Y, et al. Molecular signatures of major depression. Current biology. 2015; 9 (25): 1146–1156. doi: 10.1016/j.cub.2015.03.008Cai N, Chang S, Li Y, et al. Molecular signatures of major depression. Current biology. 2015; 9 (25): 1146–1156. doi: 10.1016/j.cub.2015.03.008Calvo SE, Clauser KR, Mootha VK, et al. MitoCarta2.0: an updated inventory of mammalian mitochondrial proteins. Nucleic Acids Research. 2016; 44: D1251. doi: 10.1093/nar/gkv1003Calvo SE, Clauser KR, Mootha VK, et al. MitoCarta2.0: an updated inventory of mammalian mitochondrial proteins. Nucleic Acids Research. 2016; 44: D1251. doi: 10.1093/nar/gkv1003Clay M, Deng JJ, Bai Y, et al. Number matters: control of mammalian mitochondrial DNA copy number. Journal of genetics and genomics. 2009; 3 (36):125. doi: 10.1016/S1673-8527(08)60099-5Clay M, Deng JJ, Bai Y, et al. Number matters: control of mammalian mitochondrial DNA copy number. Journal of genetics and genomics. 2009; 3 (36):125. doi: 10.1016/S1673-8527(08)60099-5Ding J., Sidore C., Butler TJ, et al. Assessing Mitochondrial DNA Variation and Copy Number in Lymphocytes of ~2,000 Sardinians Using Tailored Sequencing Analysis Tools. PLoS Genetics. 2015; 7 (11): 1005306. doi: 10.1371/journal.pgen.1005306Ding J., Sidore C., Butler TJ, et al. Assessing Mitochondrial DNA Variation and Copy Number in Lymphocytes of ~2,000 Sardinians Using Tailored Sequencing Analysis Tools. PLoS Genetics. 2015; 7 (11): 1005306. doi: 10.1371/journal.pgen.1005306Kazantseva A, Davydova Yu, Enikeeva R, et al. AVPR1A main effect and OXTR-by-environment interplay in individual differences in depression level. Heliyon. 2020:10 (6): e05240. doi: 10.1016/j.heliyon. 2020.e05240Kazantseva A, Davydova Yu, Enikeeva R, et al. AVPR1A main effect and OXTR-by-environment interplay in individual differences in depression level. Heliyon. 2020:10 (6): e05240. doi: 10.1016/j.heliyon. 2020.e05240Lee W, Johnson J, Gough DJ, et al. Mitochondrial DNA copy number is regulated by DNA methylation and demethylation of POLGA in stem and cancer cells and their differentiated progeny. Cell Death & Disease. 2015; 2 (6): e1664–e1664. doi: 10.1038/cddis.2015.34Lee W, Johnson J, Gough DJ, et al. Mitochondrial DNA copy number is regulated by DNA methylation and demethylation of POLGA in stem and cancer cells and their differentiated progeny. Cell Death & Disease. 2015; 2 (6): e1664–e1664. doi: 10.1038/cddis.2015.34Liu X, Longchamps RJ, Wiggins KL, et al. Association of mitochondrial DNA copy number with cardiometabolic diseases. Cell Genomics. 2021; 1:100006. doi: 10.1016/j.xgen.2021.100006Liu X, Longchamps RJ, Wiggins KL, et al. Association of mitochondrial DNA copy number with cardiometabolic diseases. Cell Genomics. 2021; 1:100006. doi: 10.1016/j.xgen.2021.100006Loeb LA, Wallace DC, Martin GM. The mitochondrial theory of aging and its relationship to reactive oxygen species damage and somatic mtDNA mutations. Proceedings of the National Academy of Sciences. 2005; 52 (102):18769–18770. doi: 10.1073/pnas.0509776102Loeb LA, Wallace DC, Martin GM. The mitochondrial theory of aging and its relationship to reactive oxygen species damage and somatic mtDNA mutations. Proceedings of the National Academy of Sciences. 2005; 52 (102):18769–18770. doi: 10.1073/pnas.0509776102Picard M. Blood mitochondrial DNA copy number: What are we counting? Mitochondrion. 2021; 60:1–11. doi: 10.1016/j.mito.2021.06.010Picard M. Blood mitochondrial DNA copy number: What are we counting? Mitochondrion. 2021; 60:1–11. doi: 10.1016/j.mito.2021.06.010Picard M, Juster RP, McEwen BS. Mitochondrial allostatic load puts the «gluc» back in glucocorticoids. Nature reviews. Endocrinology. 2014: 5 (10): 303–310. doi: 10.1038/nrendo.2014.22Picard M, Juster RP, McEwen BS. Mitochondrial allostatic load puts the «gluc» back in glucocorticoids. Nature reviews. Endocrinology. 2014: 5 (10): 303–310. doi: 10.1038/nrendo.2014.22Picard M, McEwen BS. Psychological Stress and Mitochondria: A Systematic Review. Psychosomatic medicine. 2018; 2 (80): 141. doi: 10.1097/PSY.0000000000000545Picard M, McEwen BS. Psychological Stress and Mitochondria: A Systematic Review. Psychosomatic medicine. 2018; 2 (80): 141. doi: 10.1097/PSY.0000000000000545Ridout KK, Khan M, Ridout SJ. Adverse Childhood Experiences Run Deep: Toxic Early Life Stress, Telomeres, and Mitochondrial DNA Copy Number, the Biological Markers of Cumulative Stress. BioEssays: news and reviews in molecular, cellular and developmental biology. 2018; 9 (40): e1800077. doi: 10.1002/bies.201800077Ridout KK, Khan M, Ridout SJ. Adverse Childhood Experiences Run Deep: Toxic Early Life Stress, Telomeres, and Mitochondrial DNA Copy Number, the Biological Markers of Cumulative Stress. BioEssays: news and reviews in molecular, cellular and developmental biology. 2018; 9 (40): e1800077. doi: 10.1002/bies.201800077Tyrka AR, Parade SH, Price LH, et al. Alterations of Mitochondrial DNA Copy Number and Telomere Length with Early Adversity and Psychopathology. Biological psychiatry. 2016; 2 (79): 78. doi: 10.1016/j.biopsych.2014.12.025Tyrka AR, Parade SH, Price LH, et al. Alterations of Mitochondrial DNA Copy Number and Telomere Length with Early Adversity and Psychopathology. Biological psychiatry. 2016; 2 (79): 78. doi: 10.1016/j.biopsych.2014.12.025Wang L, Lv H, 1, Ji P, et al. Mitochondrial DNA copy number is associated with risk of head and neck squamous cell carcinoma in Chinese population. Cancer Medicine. 2018; 6 (7): 2776. doi: 10.1002/cam4.1452Wang L, Lv H, 1, Ji P, et al. Mitochondrial DNA copy number is associated with risk of head and neck squamous cell carcinoma in Chinese population. Cancer Medicine. 2018; 6 (7): 2776. doi: 10.1002/cam4.1452Zhang L, Zhou R, Li X et al. Stress-induced change of mitochondria membrane potential regulated by genomic and non-genomic GR signaling: a possible mechanism for hippocampus atrophy in PTSD. Medical hypotheses. 2006; 6 (66): 1205–1208. doi: 10.1016/j.mehy.2005.11.041Zhang L, Zhou R, Li X et al. Stress-induced change of mitochondria membrane potential regulated by genomic and non-genomic GR signaling: a possible mechanism for hippocampus atrophy in PTSD. Medical hypotheses. 2006; 6 (66): 1205–1208. doi: 10.1016/j.mehy.2005.11.041Zhang R, Wang Y, Ye K et al. Independent impacts of aging on mitochondrial DNA quantity and quality in humans. BMC Genomics. 2017; 1 (18): 890. doi: 10.1186/s12864-017-4287-0Zhang R, Wang Y, Ye K et al. Independent impacts of aging on mitochondrial DNA quantity and quality in humans. BMC Genomics. 2017; 1 (18): 890. doi: 10.1186/s12864-017-4287-0Zhao H, Chang D, Ye Y. Associations of blood mitochondrial DNA copy number with social-demographics and cancer risk: results from the Mano-A-Mano Mexican American Cohort. Oncotarget. 2018; № 39 (9): 25491. doi: 10.18632/oncotarget.25321Zhao H, Chang D, Ye Y. Associations of blood mitochondrial DNA copy number with social-demographics and cancer risk: results from the Mano-A-Mano Mexican American Cohort. Oncotarget. 2018; № 39 (9): 25491. doi: 10.18632/oncotarget.25321Ziada AS, Smith MSR, Côté HCF. Updating the Free Radical Theory of Aging. Frontiers in Cell and Developmental Biology. 2020; 8: 908. doi: 10.3389/fcell.2020.575645Ziada AS, Smith MSR, Côté HCF. Updating the Free Radical Theory of Aging. Frontiers in Cell and Developmental Biology. 2020; 8: 908. doi: 10.3389/fcell.2020.575645Mustafin RN, Khusnutdinova EK, Kazantseva AV et al. Epigenetics of aggressive behavior. Russian Journal of Genetics. 2019; 55 (9):1051–1060. doi: 10.1134/S0016675819090091Mustafin RN, Khusnutdinova EK, Kazantseva AV et al. Epigenetics of aggressive behavior. Russian Journal of Genetics. 2019; 55 (9):1051–1060. doi: 10.1134/S0016675819090091

The authors declare that there are no conflicts of interest present.