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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ymj</journal-id><journal-title-group><journal-title xml:lang="ru">Якутский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Yakut Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1813-1905</issn><issn pub-type="epub">2312-1017</issn><publisher><publisher-name>ЯНЦ КМП</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.25789/YMJ.2021.73.10</article-id><article-id custom-type="elpub" pub-id-type="custom">ymj-475</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>МЕТОДЫ ДИАГНОСТИКИ И ЛЕЧЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>METHODS OF DIAGNOSIS AND TREATMENT</subject></subj-group></article-categories><title-group><article-title>Метаболические изменения у детей с патологией печени</article-title><trans-title-group xml:lang="en"><trans-title>Metabolic changes in children with liver pathology</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рыбочкина</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Rybochkina</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Рыбочкина Анна Витальевна – врач гастроэнтеролог</p></bio><bio xml:lang="en"><p>Rybochkina Anna Vitalievna – gastroenterologist</p><p>8-920- 577-50-32, 677014, RS (Y), Yakutsk city</p></bio><email xlink:type="simple">a.rybochkina@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дмитриева</surname><given-names>Т. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Dmitrieva</surname><given-names>T. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дмитриева Татьяна Геннадьевна – д.м.н., проф.</p></bio><bio xml:lang="en"><p>Dmitrieva Tatyana Gennadievna, doctor of medical sciences, professor of pediatrics and children's surgery department</p><p>8-914-231-08-39</p></bio><email xlink:type="simple">dtg63@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Климова</surname><given-names>Т. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Klimova</surname><given-names>T. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Климова Татьяна Михайловна – к.м.н., доцент;</p><p>с.н.с.</p></bio><bio xml:lang="en"><p>Klimova Tatyana Mikhailovna, candidate of medical Sciences, associate Professor of the Department of pharmacology and pharmacy</p><p>8-914-233-67-24</p></bio><email xlink:type="simple">biomedykt@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фонарева</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Fonareva</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Фонарева Евдокия Андреевна – студентка</p></bio><bio xml:lang="en"><p>Fonareva Evdokia Andreyevna, 6-year student</p><p>8-924-621-45-33</p></bio><email xlink:type="simple">lady.prinses@mail.ru</email><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">РБ№1-НЦМ – ПЦ<country>Россия</country></aff><aff xml:lang="en">SAI RS(Y) ‘RB №1-NCM-РС’<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">СВФУ им. М.К. Аммосова<country>Россия</country></aff><aff xml:lang="en">NEFU named after M.K. Ammosov<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru">СВФУ им. М.К. Аммосова;&#13;
ЯНЦ КМП<country>Россия</country></aff><aff xml:lang="en">NEFU named after M.K. Ammosov<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru">МИ ПО СВФУ им. М.К. Аммосова<country>Россия</country></aff><aff xml:lang="en">MI NEFU. M.K. Ammosov<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>27</day><month>04</month><year>2025</year></pub-date><volume>0</volume><issue>1</issue><fpage>36</fpage><lpage>39</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Рыбочкина А.В., Дмитриева Т.Г., Климова Т.М., Фонарева Е.А., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Рыбочкина А.В., Дмитриева Т.Г., Климова Т.М., Фонарева Е.А.</copyright-holder><copyright-holder xml:lang="en">Rybochkina A.V., Dmitrieva T.G., Klimova T.M., Fonareva E.A.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://ymj.elpub.ru/jour/article/view/475">https://ymj.elpub.ru/jour/article/view/475</self-uri><abstract><p>Исследованы метаболические изменения у детей с патологией печени с клинических и лабораторно-инструментальных позиций. Целью исследования послужило изучение биохимических и метаболических показателей у детей и подростков с ожирением и патологией печени на территории РС(Я). По этнической принадлежности установлено, что поражение печени преобладало у детей монголоидной расы. Определены маркеры, позволяющие идентифицировать поражение печени у детей на ранней стадии.</p></abstract><trans-abstract xml:lang="en"><p>Metabolic changes in children with liver pathology were studied from clinical and laboratory-instrumental positions. The aim of the study was to investigate biochemical and metabolic parameters in children and adolescents with obesity and liver pathology in the Republic of Sakha (Yakutia). According to ethnicity, it was found that liver damage prevailed in children of the Mongoloid race. Markers have been identified that allow identifying liver damage in children at an early stage.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>дети</kwd><kwd>ожирение</kwd><kwd>патология печени</kwd><kwd>метаболические изменения</kwd><kwd>ROC-анализ</kwd></kwd-group><kwd-group xml:lang="en"><kwd>children</kwd><kwd>obesity</kwd><kwd>liver pathology</kwd><kwd>metabolic changes</kwd><kwd>ROC analysis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Алешина Е.И. Стеатоз печени и стеатоз поджелудочной железы как две мишени метаболического синдрома у детей / Е.И. Алешина, В.П. Новикова, В.А. Гурьева // Экспериментальная и клиническая гастроэнтерология. -2014. -№108 (8). -С.16-20.</mixed-citation><mixed-citation xml:lang="en">Aleshina E.I. Hepatic steatosis and steatosis of the pancreas as two targets 8of the metabolic syndrome in children / E.I. Aleshina, V.P. 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