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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ymj</journal-id><journal-title-group><journal-title xml:lang="ru">Якутский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Yakut Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1813-1905</issn><issn pub-type="epub">2312-1017</issn><publisher><publisher-name>ЯНЦ КМП</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.25789/YMJ.2021.73.03</article-id><article-id custom-type="elpub" pub-id-type="custom">ymj-463</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL RESEARCH</subject></subj-group></article-categories><title-group><article-title>Нарушения эмоциональной сферы у пациентов с болезнью двигательного нейрона в РС(Я)</article-title><trans-title-group xml:lang="en"><trans-title>Emotional disorders in patients with motor neuron disease in the Republic of Sakha (Yakutia)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Давыдова</surname><given-names>Т. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Davydova</surname><given-names>T. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Давыдова Татьяна Кимовна - к.м.н., в.н.с., руковод.;</p><p>зав. лаб.</p></bio><bio xml:lang="en"><p>Davydova Tatyana Kimovna, MD, PhD, Leading Researcher, Head;</p><p>Head of the Laboratory of Neurodegenerative Diseases</p><p>Yakutsk</p></bio><email xlink:type="simple">tanya.davydova.56@inbox.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шадрина</surname><given-names>С. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Shadrina</surname><given-names>S. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шадрина Светлана Семеновна - с.н.с.</p></bio><bio xml:lang="en"><p>Shadrina Svetlana Semyonovna, Senior Researcher, Research Laboratory of Cell Technologies and Regenerative Medicine</p><p>Yakutsk</p></bio><email xlink:type="simple">svetlana.maksimo@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шнайдер</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Schneider</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шнайдер Наталья Алексеевна - д.м.н., проф., в.н.с.</p><p>г. Санкт-Петербург;</p><p>в.н.с.</p></bio><bio xml:lang="en"><p>Schneider Natalya Alekseevna, MD, DSc, Professor, Leading Researcher Center for Personalized Psychiatry and Neurology</p><p>St. Petersburg;</p><p>660022, Krasnoyarsk</p></bio><email xlink:type="simple">NASchnaider@yandex.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гончарова</surname><given-names>П. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Goncharova</surname><given-names>P. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гончарова Полина Сергеевна - невролог-ординатор</p><p>г. Санкт-Петербург</p></bio><bio xml:lang="en"><p>Goncharova Polina Sergeevna, neurologist-resident of the Center for Personalized Psychiatry and Neurology</p><p>St. Petersburg</p></bio><email xlink:type="simple">po.gon4arova@yandex.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Насырова</surname><given-names>Р. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Nasyrova</surname><given-names>R. F.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Насырова Регина Фаритовна - д.м.н., гл.н.с., руковод.</p><p>г. Санкт-Петербург</p></bio><bio xml:lang="en"><p>Nasyrova Regina F., MD, PhD, Chief Researcher, Head</p><p>St. Petersburg</p></bio><email xlink:type="simple">reginaf@bekhterev.ru</email><xref ref-type="aff" rid="aff-5"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Центр нейродегенеративных заболеваний;&#13;
ЯНЦ КМП</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Center for Neurodegenerative Diseases;&#13;
YSC KMP</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>НИЛ СВФУ им. М.К. Аммосова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>North-Eastern Federal University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Нац. мед. исследов. центр психиатрии и неврологии им. В.М. Бехтерева Минздрава России;&#13;
Красноярский ГМУ им. проф. В.Ф. Войно-Ясенецкого</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal State Budgetary Institution National Medical Research Center for Psychiatry and Neurology named after V.M. Bekhterev, Ministry of Health of Russia;&#13;
Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>Нац. мед. исследов. центр психиатрии и неврологии им. В.М. Бехтерева Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>FSBI National Medical Research Center for Psychiatry and Neurology named after I.I. V.M. Bekhterev, Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru"><institution>Центр персонализированной психиатрии и неврологии Нац. мед. исследов. центра психиатрии и неврологии им. В.М. Бехтерева Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Center for Personalized Psychiatry and Neurology of the FSBI ‘National Medical Research Center for Psychiatry and Neurology named after V.I. V.M. Bekhterev’ Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>27</day><month>04</month><year>2025</year></pub-date><volume>0</volume><issue>1</issue><fpage>12</fpage><lpage>15</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Давыдова Т.К., Шадрина С.С., Шнайдер Н.А., Гончарова П.С., Насырова Р.Ф., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Давыдова Т.К., Шадрина С.С., Шнайдер Н.А., Гончарова П.С., Насырова Р.Ф.</copyright-holder><copyright-holder xml:lang="en">Davydova T.K., Shadrina S.S., Schneider N.A., Goncharova P.S., Nasyrova R.F.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://ymj.elpub.ru/jour/article/view/463">https://ymj.elpub.ru/jour/article/view/463</self-uri><abstract><p>В статье описано исследование пациентов с болезнью двигательного нейрона (БДН) и членов их семей по госпитальной шкале Hospital Anxiety and Depression Scale (HADS). Исследованы частота встречаемости и тяжесть тревоги и депрессии у пациентов с БДН и членов их семей.</p></abstract><trans-abstract xml:lang="en"><p>The article describes a study of patients with motor neuron disease (MND) and their families using the Hospital Anxiety and Depression Scale (HADS). The frequency and severity of anxiety and depression in patients with MND and their family members were studied.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>болезни двигательного нейрона</kwd><kwd>боковой амиотрофический склероз</kwd><kwd>тревога</kwd><kwd>депрессия</kwd><kwd>госпитальная шкала тревоги и депрессии</kwd><kwd>HADS</kwd></kwd-group><kwd-group xml:lang="en"><kwd>motor neuron diseases</kwd><kwd>amyotrophic lateral sclerosis</kwd><kwd>anxiety</kwd><kwd>depression</kwd><kwd>hospital anxiety and depression scale</kwd><kwd>HADS</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Яхно Н.Н. Синдром БАС – деменция лобного типа / Н.Н. Яхно, М.С. Головкова, И.С. Пpеобpаженская // Неврологический журнал.2002;4:12-18.</mixed-citation><mixed-citation xml:lang="en">Yakhno N.N. ALS syndrome - dementia of the frontal type / N.N. Yakhno, M.S. Golovkova, I.S. Pereobpazhenskaya // Neurological journal. - 2002; 4: 12-18.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Brooks BR, MillerRG, SwasM [et al]. El- Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis.Amyotroph. Lateral scler. Other Motor Neuron Disord. - 2000; Vol. 1 (5): 293-299.</mixed-citation><mixed-citation xml:lang="en">Brooks BR, MillerRG, SwasM [et al]. El- Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis.Amyotroph. Lateral scler. Other Motor Neuron Disord. - 2000; Vol. 1 (5): 293-299.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Białkowska J., Mroczkowska D., Huflejt M.E. [et al] Complex treatment of amyotrophiclateral sclerosis patient. Acta Clin Croat. - 2019 Dec; 58(4): 757–766.doi: 10.20471/acc.2019.58.04.24</mixed-citation><mixed-citation xml:lang="en">Białkowska J., Mroczkowska D., Huflejt M.E. [et al] Complex treatment of amyotrophiclateral sclerosis patient. Acta Clin Croat. - 2019 Dec; 58(4): 757–766.doi: 10.20471/acc.2019.58.04.24</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Benbrika S., Desgranges B., Eustache F. [et al.] Cognitive, Emotional and Psychological Manifestations in Amyotrophic Lateral Sclerosis at Baseline and Overtime: A Review. Front Neurosci. 2019; 13: 951.Published online 2019 Sep 10. doi: 10.3389/fnins.2019.00951</mixed-citation><mixed-citation xml:lang="en">Benbrika S., Desgranges B., Eustache F. [et al.] Cognitive, Emotional and Psychological Manifestations in Amyotrophic Lateral Sclerosis at Baseline and Overtime: A Review. Front Neurosci. 2019; 13: 951.Published online 2019 Sep 10. doi: 10.3389/fnins.2019.00951</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Cheng HWB,Chan OM, Chan CHR [et al]. End-of-life Characteristics and Palliative Care Provision for Patients With Motor Neuron Disease.Am J. Hosp. Palliat Care. - 2018; Jun. 35 (6): 847-851. DOI: 10.1177 / 1049909117735832. Epub 2017 Oct 15.</mixed-citation><mixed-citation xml:lang="en">Cheng HWB,Chan OM, Chan CHR [et al]. End-of-life Characteristics and Palliative Care Provision for Patients With Motor Neuron Disease.Am J. Hosp. Palliat Care. - 2018; Jun. 35 (6): 847-851. DOI: 10.1177 / 1049909117735832. Epub 2017 Oct 15.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Carvalho T.L., Sanguinette de Almeida L.M., Araujo Lorega K.M.[et al] Depression and anxiety in individuals with amyotrophic lateral sclerosis: a systematic review Trends in Psychiatry and Psychotherapy January March 2016;38(1):1-5. doi: 10.1590/2237-6089-2015-0030.</mixed-citation><mixed-citation xml:lang="en">Carvalho T.L., Sanguinette de Almeida L.M., Araujo Lorega K.M.[et al] Depression and anxiety in individuals with amyotrophic lateral sclerosis: a systematic review Trends in Psychiatry and Psychotherapy January March 2016;38(1):1-5. doi: 10.1590/2237-6089-2015-0030.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Chen D., Guo X., Zheng Z. [et al.] Depression and anxiety in amyotrophic lateral sclerosis: correlations between the distress of patients and caregivers.Muscle Nerve. 2015 Mar;51(3):353-7. doi: 10.1002/mus.24325. Epub 2015 Jan 6</mixed-citation><mixed-citation xml:lang="en">Chen D., Guo X., Zheng Z. [et al.] Depression and anxiety in amyotrophic lateral sclerosis: correlations between the distress of patients and caregivers.Muscle Nerve. 2015 Mar;51(3):353-7. doi: 10.1002/mus.24325. Epub 2015 Jan 6</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Godoy L.,Prado R., Santos Bicalho I.C. [et al.]. Depression and anxiety in a case series of amyotrophic lateral sclerosis: frequency and association with clinical features. Einstein (Sao Paulo). 2017;15(1):58-60. doi: 10.1590/S1679-45082017AO3870.</mixed-citation><mixed-citation xml:lang="en">Godoy L.,Prado R., Santos Bicalho I.C. [et al.]. Depression and anxiety in a case series of amyotrophic lateral sclerosis: frequency and association with clinical features. Einstein (Sao Paulo). 2017;15(1):58-60. doi: 10.1590/S1679-45082017AO3870.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Hirano A, Kurland LT, Krooth RS. Parkinsonism-dementia complex, an endemic disease on the island of Guam. I. Clinical features. Brain. 1961a; Vol. 84: 642-661.</mixed-citation><mixed-citation xml:lang="en">Hirano A, Kurland LT, Krooth RS. Parkinsonism-dementia complex, an endemic disease on the island of Guam. I. Clinical features. Brain. 1961a; Vol. 84: 642-661.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Leighton DJ,Newton J, Stephenson LJ [et al.].Changing epidemiology of motor neurone disease in Scotland. J.Neurol. 2019; Apr.266(4): 817-825. DOI: 10.1007/s00415-019-09190-7. Epub.2019 Feb. 25, CARE-MND Consortium.</mixed-citation><mixed-citation xml:lang="en">Leighton DJ,Newton J, Stephenson LJ [et al.].Changing epidemiology of motor neurone disease in Scotland. J.Neurol. 2019; Apr.266(4): 817-825. DOI: 10.1007/s00415-019-09190-7. Epub.2019 Feb. 25, CARE-MND Consortium.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Lee Y-J, Lee G-W,Seo W-S [et al]. Neurofeedback Treatment on Depressive Symptoms and Functional Recovery in Treatment-Resistant Patients with Major Depressive Disorder: an Open-Label Pilot Study.J Korean Med Sci. 2019 Nov 4; 34(42): e287. Published online 2019 Oct 24. doi: 10.3346/jkms.2019.34.e287</mixed-citation><mixed-citation xml:lang="en">Lee Y-J, Lee G-W,Seo W-S [et al]. Neurofeedback Treatment on Depressive Symptoms and Functional Recovery in Treatment-Resistant Patients with Major Depressive Disorder: an Open-Label Pilot Study.J Korean Med Sci. 2019 Nov 4; 34(42): e287. Published online 2019 Oct 24. doi: 10.3346/jkms.2019.34.e287</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Müller HP, GorgesM, Del Tredici K. The same cortico-efferent tract involvement in progressive bulbar palsy and in 'classical' ALS: A tract of interest-based MRI study. Neuroimage Clin. 2019;24:101979. DOI: 10.1016/j.nicl.2019.101979. Epub 2019 Aug 9.</mixed-citation><mixed-citation xml:lang="en">Müller HP, GorgesM, Del Tredici K. The same cortico-efferent tract involvement in progressive bulbar palsy and in 'classical' ALS: A tract of interest-based MRI study. Neuroimage Clin. 2019;24:101979. DOI: 10.1016/j.nicl.2019.101979. Epub 2019 Aug 9.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Motataianu A., Andone S., Radu C. [et al.]. Predictors of Depression in Caucasian Patients with Amyotrophic Lateral Sclerosis in Romania. Brain Sci. 2020 Aug; 10(8): 470.Published online 2020 Jul 22. doi: 10.3390/brainsci10080470</mixed-citation><mixed-citation xml:lang="en">Motataianu A., Andone S., Radu C. [et al.]. Predictors of Depression in Caucasian Patients with Amyotrophic Lateral Sclerosis in Romania. Brain Sci. 2020 Aug; 10(8): 470.Published online 2020 Jul 22. doi: 10.3390/brainsci10080470</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Norris FN, Shepherd R, Denys E [et al.].Onset, natural history and outcome in idiopathic adult motor neuron disease. J.Neurol.Sci. 1993; 118:48-55.</mixed-citation><mixed-citation xml:lang="en">Norris FN, Shepherd R, Denys E [et al.].Onset, natural history and outcome in idiopathic adult motor neuron disease. J.Neurol.Sci. 1993; 118:48-55.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Roos E, Mariosa D, Ingre C, Lundholm C, Wirdefeldt K, Roos PM. [et al.]. Depression in amyotrophic lateral sclerosis. Neurology. 2016; 86(24):2271–7. 10.1212/WNL.0000000000002671</mixed-citation><mixed-citation xml:lang="en">Roos E, Mariosa D, Ingre C, Lundholm C, Wirdefeldt K, Roos PM. [et al.]. Depression in amyotrophic lateral sclerosis. Neurology. 2016; 86(24):2271–7. 10.1212/WNL.0000000000002671</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Saberi S., Stauffer J.E., Schulte D.J.[et al]. Neuropathology of Amyotrophic Lateral Sclerosis and Its Variants. Neurol Clin. 2015 Nov;33(4):855-76. doi: 10.1016/j.ncl.2015.07.012.</mixed-citation><mixed-citation xml:lang="en">Saberi S., Stauffer J.E., Schulte D.J.[et al]. Neuropathology of Amyotrophic Lateral Sclerosis and Its Variants. Neurol Clin. 2015 Nov;33(4):855-76. doi: 10.1016/j.ncl.2015.07.012.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">WijesekeraLC,Leigh PN. Amyotrophic lateral sclerosis. Orphanet J.Rare Dis. 2009; Feb. 3, 4:3. DOI: 10.1186/1750-1172-4-3.</mixed-citation><mixed-citation xml:lang="en">WijesekeraLC,Leigh PN. Amyotrophic lateral sclerosis. Orphanet J.Rare Dis. 2009; Feb. 3, 4:3. DOI: 10.1186/1750-1172-4-3.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
