ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.25789/YMJ.2025.89.21ymj-434Research ArticleНАУЧНЫЕ ОБЗОРЫSCIENTIFIC REVIEWSРадиальный рубец молочной железы как маска злокачественного новообразованияRadial scar of the breast as a mask of malignant neoplasmshttps://orcid.org/0000-0001-7260-4629ПилькевичН. Б.PilkevichN. B.

Пилькевич Наталья Борисовна – д.м.н., проф.

308015, г. Белгород, ул. Победы, д. 85 

pilkevich@bsuedu.ruhttps://orcid.org/0000-0002-0887-2378ХабибуллинР. Р.KhabibullinR. R.

Хабибуллин Руслан Равильевич – ст. препод.; зав. патологоанатомич. отд. иммуногистохимии, Белгородское патологоанатомическое бюро

308015, г. Белгород, ул. Победы, д. 85 

habibullin@bsuedu.ruhttps://orcid.org/0000-0003-4410-9318МарковскаяВ. А.MarkovskayaV. A.

Марковская Вера Александровна – к.б.н., зав. кафедрой

308015, г. Белгород, ул. Победы, д. 85 

markovskaya@bsuedu.ruhttps://orcid.org/0009-0003-3288-9289ЯворскаяО. В.YavorskayaO. V.

Яворская Ольга Владимировна – препод. медицинского колледжа Медицинского ин-та

308015, г. Белгород, ул. Победы, д. 85 

yavorskaya@bsuedu.ruhttps://orcid.org/0009-0001-3087-0037СмирноваА. П.SmirnovaA. P.

Смирнова Анастасия Павловна – студентка

308015, г. Белгород, ул. Победы, д. 85 

1330007@bsuedu.ruБелгородский гос. национальн. исслед. ун-т, Медицинский ин-тRussian Federation202521032025019093Copyright © Пилькевич Н.Б., Хабибуллин Р.Р., Марковская В.А., Яворская О.В., Смирнова А.П., 20252025Пилькевич Н.Б., Хабибуллин Р.Р., Марковская В.А., Яворская О.В., Смирнова А.П.Pilkevich N.B., Khabibullin R.R., Markovskaya V.A., Yavorskaya O.V., Smirnova A.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/434

С целью изучения радиального рубца как маски злокачественного новообразования проведен анализ литературы. Выявлено, что сложность диагностики радиального рубца вызвана его морфологическим сходством со злокачественным новообразованием и сопутствующими внутрипротоковыми эпителиальными пролиферациями. Для исключения злокачественного новообразования и внутрипротоковых пролифераций используют иммуногистохимическую визуализацию неповрежденного слоя миоэпителиальных клеток, а также клеточную гетерогенность внутрипротоковых пролифератов с помощью таких маркеров, как р63, базальные цитокератины, гладкомышечный актин, базальные цитокератины и рецептор эстрогена. Установлено, что в случае сочетания радиального рубца с атипией или другими поражениями молочной железы высокого риска повышается вероятность его трансформации в злокачественные поражения молочной железы.

In order to study the radial scar as a mask of malignancy, a literature review was conducted. It was found that the difficulty in diagnosing the radial scar is due to its morphological similarity to a malignancy and associated intraductal epithelial proliferations. To exclude a malignancy and intraductal proliferations, immunohistochemical visualization of the intact myoepithelial cell layer is used, as well as cellular heterogeneity of intraductal proliferations using markers such as p63, basal cytokeratins, smooth muscle actin, basal cytokeratins, and estrogen receptor. It was found that in the case of a combination of a radial scar with atypia or other high-risk lesions of the mammary gland, the likelihood of its transformation into malignant lesions of the mammary gland increases.

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The authors declare that there are no conflicts of interest present.