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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ymj</journal-id><journal-title-group><journal-title xml:lang="ru">Якутский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Yakut Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1813-1905</issn><issn pub-type="epub">2312-1017</issn><publisher><publisher-name>ЯНЦ КМП</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.25789/YMJ.2023.84.30</article-id><article-id custom-type="elpub" pub-id-type="custom">ymj-375</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>НАУЧНЫЕ ОБЗОРЫ И ЛЕКЦИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>SCIENTIFIC REVIEWS AND LECTURES</subject></subj-group></article-categories><title-group><article-title>Роль провоспалительных цитокинов в развитии хронического дискогенного болевого синдрома</article-title><trans-title-group xml:lang="en"><trans-title>The role of proinflammatory cytokines in the development of chronic discogenic pain syndrome</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3565-8657</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ашхотов</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Ashkhotov</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ашхотов Азамат Вячеславович – невролог-исследователь</p></bio><bio xml:lang="en"><p>Ashkhotov  Azamat Vyacheslavovich – neurologist-researcher</p><p> St. Petersburg</p></bio><email xlink:type="simple">ashkhotov.v@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2840-837X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шнайдер</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Shnaider</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шнайдер  Наталья Алексеевна – д.м.н., проф., гл.н.с.;  в.н.с</p></bio><bio xml:lang="en"><p>Shnaider  Natalya Alekseevna – Doctor of Medical Sciences, Prof., Chief Researcher</p><p>St. Petersburg</p></bio><email xlink:type="simple">naschnaider@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4378-1308</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Трефилова</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Trefilova</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Трефилова Вера Васильевна – аспирант; невролог</p><p>г. Санкт-Петербург</p></bio><bio xml:lang="en"><p>Trefilova Vera Vasilievna – graduate student</p></bio><email xlink:type="simple">vera.v.trefilova@yandex.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2001-6432</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Новицкий</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Novitsky</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Новицкий  Максим Александрович – невролог</p><p>г. Санкт-Петербург</p></bio><bio xml:lang="en"><p>Novitsky Maxim Aleksandrovich – neurologist</p><p>Krasnoyarsk</p></bio><email xlink:type="simple">maximnovitsky93@gmail.com</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8493-0058</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Петрова</surname><given-names>М. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Petrova</surname><given-names>M. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Петрова Марина Михайловна – д.м.н., проф.</p></bio><bio xml:lang="en"><p>Petrova Marina Mikhailovna – Doctor of Medical Sciences, Prof.</p></bio><email xlink:type="simple">stk99@yandex.ru</email><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1874-9434</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Насырова</surname><given-names>Р. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Nasyrova</surname><given-names>R. F.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Насырова  Регина Фаритовна – д.м.н., гл.н.с.</p></bio><bio xml:lang="en"><p>Nasyrova Regina Faritovna – Doctor of Medical Sciences, Chief Researcher, Department of Neurology </p><p>St. Petersburg</p></bio><email xlink:type="simple">regina_nmrcpn@mail.ru</email><xref ref-type="aff" rid="aff-6"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Институт персонализированной психиатрии и неврологии НМИЦ ПН им.В.М. Бехтерева</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.M. Bekhterev Institute of Personalized Psychiatry and Neurology SMRC PN</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Институт персонализированной психиатрии и неврологии НМИЦ ПН им.В.М. Бехтерева; Центр коллективного пользования «Молекулярные и клеточные технологии», КрасГМУ им. проф. В.Ф. Войно-Ясенецкого</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.M. Bekhterev Institute of Personalized Psychiatry and Neurology SMRC PN</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Институт персонализированной психиатрии и неврологии НМИЦ ПН им.В.М. Бехтерева; Госпиталь для ветеранов войн</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.M. Bekhterev Institute of Personalized Psychiatry and Neurology SMRC PN</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>Госпиталь для ветеранов войн</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Center for Collective Use Molecular and Cellular Technologies, V.F. Voino-Yasenetsky Krasnoyarsk State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru"><institution>Центр коллективного пользования «Молекулярные и клеточные технологии», КрасГМУ им. проф. В.Ф. Войно-Ясенецкого</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Center for Collective Use Molecular and Cellular Technologies, V.F. Voino-Yasenetsky Krasnoyarsk State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-6"><aff xml:lang="ru"><institution>Институт персонализированной психиатрии и неврологии НМИЦ ПН им.В.М. Бехтерева</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Hospital for War Veterans</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>14</day><month>02</month><year>2025</year></pub-date><volume>0</volume><issue>4</issue><fpage>128</fpage><lpage>134</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ашхотов А.В., Шнайдер Н.А., Трефилова В.В., Новицкий М.А., Петрова М.М., Насырова Р.Ф., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Ашхотов А.В., Шнайдер Н.А., Трефилова В.В., Новицкий М.А., Петрова М.М., Насырова Р.Ф.</copyright-holder><copyright-holder xml:lang="en">Ashkhotov A.V., Shnaider N.A., Trefilova V.V., Novitsky M.A., Petrova M.M., Nasyrova R.F.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://ymj.elpub.ru/jour/article/view/375">https://ymj.elpub.ru/jour/article/view/375</self-uri><abstract><p>Целью данного обзора является обновление уровня знаний врачей-неврологов о роли провоспалительных цитокинов в развитии и хронизации дискогенного болевого синдрома у пациентов с дегенерацией межпозвонковых дисков.</p></abstract><trans-abstract xml:lang="en"><p>The purpose of this review is to update the knowledge of neurologist doctors about the role of pro-inflammatory cytokines in the evelopment and chronicity of discogenic pain syndrome in patients with intervertebral disc degeneration.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>цитокины</kwd><kwd>цитокиновый статус</kwd><kwd>дегенерация межпозвонковых дисков</kwd><kwd>биомаркеры</kwd><kwd>хроническое воспаление</kwd><kwd>дискогенный болевой синдром</kwd></kwd-group><kwd-group xml:lang="en"><kwd>cytokines</kwd><kwd>cytokine status</kwd><kwd>disk degeneration</kwd><kwd>biomarker</kwd><kwd>chronic inflammation</kwd><kwd>discogenic pain syndrome</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Дегенеративе дистрофические заболевания позвоночника / Луцик А.А., Садова, М.А., Крутько А.В. и др. / Клинические рекомендации Общероссийской общественной организации "Ассоциация травматологов и ортопедов России" (АТОР). Новосибирск;2012:264.</mixed-citation><mixed-citation xml:lang="en">Degenerative-dystrophic diseases of the spine / Lutsik A.A., Sadova, M.A., Krutko A.V. [et al.]. Clinical recommendations of the All-Russian public organization ‘Association of Traumatologists and Orthopedists of Russia’ (ATOR). Novosibirsk; 2012:264.2.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Сорокин Ю.Н. Боль в спине и дегенерация межпозвонковых дисков в Международной классификации болезней 11-го пересмотра / Журнал неврологии и психиатрии имени С.С. Корсаковой. 2019;119(8):153 159 https://doi.org/10.17116/jnevro2019119081153.3</mixed-citation><mixed-citation xml:lang="en">Sorokin Yu.N. Back Pain and Intervertebral Disc Degeneration in the International Classification of Diseases 11th Revision / S. Korsakov Journal of Neurology and Psychiatry 2019; 119(8): 153 159 (https://doi.org/10.17116/ineuro2019119081153.3.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Cabal-Hierro L., Lazo P.S. Signal transduction by tumor necrosis factor receptors. Cell Signal 2012;24:1297–1305. doi: 10.1016/j.cellsig.2012.02.006.</mixed-citation><mixed-citation xml:lang="en">Cabal-Hierro L., Lazo P.S. Signal transduction by tumor necrosis factor receptors. Cell Signal 2012;24:1297–1305. doi: 10.1016/j.cellsig.2012.02.006.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Patil P., Niedernhofer L.J., Robbins P.D. [et al.] Cellular senescence in intervertebral disc aging and degeneration. Curr Mol Biol Rep. 2018;4(4): 180–190. doi: 10.1007/s40610-018-0108-8.</mixed-citation><mixed-citation xml:lang="en">Patil P., Niedernhofer L.J., Robbins P.D. [et al.] Cellular senescence in intervertebral disc aging and degeneration. Curr Mol Biol Rep. 2018;4(4): 180–190. doi: 10.1007/s40610-018-0108-8.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Cua D.J., Tato C.M. / Innate IL-17-producing cells: The sentinels of the immune system. Nat. Rev. Immunol. 2010;10:479–489. doi: 10.1038/nri2800.</mixed-citation><mixed-citation xml:lang="en">Cua D.J., Tato C.M. / Innate IL-17-producing cells: The sentinels of the immune system. Nat. Rev. Immunol. 2010;10:479–489. doi: 10.1038/nri2800.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Shneider N.A., Ashhotov A.V., Trefilova V.V. [et al.] Cytokine imbalance as a biomarker of inter-vertebral disk degeneration. Cytokine imbalance as a biomarker of intervertebral disk degeneration. Int J Mol Sci. 2023;24(3):2360. doi: 10.3390/ijms24032360.</mixed-citation><mixed-citation xml:lang="en">Shneider N.A., Ashhotov A.V., Trefilova V.V. [et al.] Cytokine imbalance as a biomarker of inter-vertebral disk degeneration. Cytokine imbalance as a biomarker of intervertebral disk degeneration. Int J Mol Sci. 2023;24(3):2360. doi: 10.3390/ijms24032360.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Shneider N.A., Khasanova A.K., Strelnik A.I. [et al.] Cytokine imbalance as a biomarker of thera-peutic resistance to antipsychotics. Int. J. Mol. Sci. 2022; 23:x. https://doi.org/10.3390/xxxxx.</mixed-citation><mixed-citation xml:lang="en">Shneider N.A., Khasanova A.K., Strelnik A.I. [et al.] Cytokine imbalance as a biomarker of thera-peutic resistance to antipsychotics. Int. J. Mol. Sci. 2022; 23:x. https://doi.org/10.3390/xxxxx.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Likhitpanichkul M., Torre O.M., Gruen J. [et al.]. Do mechanical strain and TNF-α interact to amplify pro-inflammatory cytokine production in human annulus fibrosus cells? J. Biomech. 2016;49: 1214–1220. doi: 10.1016/j.jbiomech.2016.02.029.</mixed-citation><mixed-citation xml:lang="en">Likhitpanichkul M., Torre O.M., Gruen J. [et al.]. Do mechanical strain and TNF-α interact to amplify pro-inflammatory cytokine production in human annulus fibrosus cells? J. Biomech. 2016;49: 1214–1220. doi: 10.1016/j.jbiomech.2016.02.029.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Dudli S., Haschtmann D., Ferguson S.J. Fracture of the vertebral endplates; but not equienergetic impact load, promotes disc degeneration in vitro. J. Orthop. Res. 2012;30:809–816. doi: 10.1002/jor.21573.</mixed-citation><mixed-citation xml:lang="en">Dudli S., Haschtmann D., Ferguson S.J. Fracture of the vertebral endplates; but not equienergetic impact load, promotes disc degeneration in vitro. J. Orthop. Res. 2012;30:809–816. doi: 10.1002/jor.21573.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Effects of secreted factors inculture medium of annulus fibrosus cells on microvascular endothelial cells: Elucidating the possible pathomechanisms of matrixdegradation and nerve in-growth in disc degeneration / Moon H.J., Yurube T., Lozito T.P. [et al.] / Osteoarthr. Cartil. 2014;22:344–354. doi: 10.1016/j.joca.2013.12.008.</mixed-citation><mixed-citation xml:lang="en">Effects of secreted factors inculture medium of annulus fibrosus cells on microvascular endothelial cells: Elucidating the possible pathomechanisms of matrixdegradation and nerve in-growth in disc degeneration / Moon H.J., Yurube T., Lozito T.P. [et al.] / Osteoarthr. Cartil. 2014;22:344–354. doi: 10.1016/j.joca.2013.12.008.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Wang S.L., Yu Y.L., Tang C.L. [et al.]. Effects of TGF-β1 and IL-1β on expression of ADAMTS enzymes and TIMP-3 in human intervertebral disc degeneration. Exp. Ther. Med. 2013;6:1522-1526. doi: 10.3892/etm.2013.1348.</mixed-citation><mixed-citation xml:lang="en">Wang S.L., Yu Y.L., Tang C.L. [et al.]. Effects of TGF-β1 and IL-1β on expression of ADAMTS enzymes and TIMP-3 in human intervertebral disc degeneration. Exp. Ther. Med. 2013;6:1522-1526. doi: 10.3892/etm.2013.1348.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Deng X., Zhao F., Kang B. [et al.]. Elevated interleukin-6 expression levels are associated with in-tervertebral disc degeneration. Exp. Ther. Med. 2016;11:1425–1432. doi: 10.3892/etm.2016.3079.</mixed-citation><mixed-citation xml:lang="en">Deng X., Zhao F., Kang B. [et al.]. Elevated interleukin-6 expression levels are associated with in-tervertebral disc degeneration. Exp. Ther. Med. 2016;11:1425–1432. doi: 10.3892/etm.2016.3079.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Klawitter M., Hakozaki M., Kobayashi H. [et al.]. Expression and regulation of toll-like receptors (TLRs) in human intervertebral disc cells. Eur. Spine J. 2014;23:1878–1891. doi: 10.1007/s00586-014-3442-4.</mixed-citation><mixed-citation xml:lang="en">Klawitter M., Hakozaki M., Kobayashi H. [et al.]. Expression and regulation of toll-like receptors (TLRs) in human intervertebral disc cells. Eur. Spine J. 2014;23:1878–1891. doi: 10.1007/s00586-014-3442-4.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Liu X.W., Kang J., Fan X.D. [et al.]. Expression and significance of VEGF and p53 in rat degener-ated intervertebral disc tissues. Asian Pac. J. Trop. Med. 2013;6:404–406. doi: 10.1016/S1995-7645(13)60047-4.</mixed-citation><mixed-citation xml:lang="en">Liu X.W., Kang J., Fan X.D. [et al.]. Expression and significance of VEGF and p53 in rat degener-ated intervertebral disc tissues. Asian Pac. J. Trop. Med. 2013;6:404–406. doi: 10.1016/S1995-7645(13)60047-4.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Yamamoto J., Maeno K., Takada T. [et al.]. Fas ligand plays an important role for the production of pro-inflammatory cytokines in intervertebral disc nucleus pulposus cells. J. Orthop. Res. 2013;31:608–615. doi: 10.1002/jor.22274.</mixed-citation><mixed-citation xml:lang="en">Yamamoto J., Maeno K., Takada T. [et al.]. Fas ligand plays an important role for the production of pro-inflammatory cytokines in intervertebral disc nucleus pulposus cells. J. Orthop. Res. 2013;31:608–615. doi: 10.1002/jor.22274.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Gawri R., Rosenzweig D.H., Krock E. [et al.]. High mechanical strain of primary intervertebral disc cells promotes secretion of inflammatory factors associated with disc degeneration and pain. Arthritis Res. Ther. 2014;16:R21. doi: 10.1186/ar4449.</mixed-citation><mixed-citation xml:lang="en">Gawri R., Rosenzweig D.H., Krock E. [et al.]. High mechanical strain of primary intervertebral disc cells promotes secretion of inflammatory factors associated with disc degeneration and pain. Arthritis Res. Ther. 2014;16:R21. doi: 10.1186/ar4449.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Shneider N.A., Ashhotov A.V., Trefilova V.V. [et al.]. High-Tech methods of cytokine imbalance correction in intervertebral disc degeneration. Int. J. Mol. Sci. 2023;24:13333. https://doi.org/10.3390/ijms241713333.</mixed-citation><mixed-citation xml:lang="en">Shneider N.A., Ashhotov A.V., Trefilova V.V. [et al.]. High-Tech methods of cytokine imbalance correction in intervertebral disc degeneration. Int. J. Mol. Sci. 2023;24:13333. https://doi.org/10.3390/ijms241713333.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Studer R.K., Vo N., Sowa G. [et al.]. Human nucleus pulposus cells react to IL-6: Independent ac-tions and amplification of response to IL-1 and TNF-α. Spine 2011;36:593–599. doi: 10.1097/BRS.0b013e3181da38d5.</mixed-citation><mixed-citation xml:lang="en">Studer R.K., Vo N., Sowa G. [et al.]. Human nucleus pulposus cells react to IL-6: Independent ac-tions and amplification of response to IL-1 and TNF-α. Spine 2011;36:593–599. doi: 10.1097/BRS.0b013e3181da38d5.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">He W.S., Zou M.X., Yan Y.G. [et al.]. Interleukin-17A promotes human disc degeneration by inhib-iting autophagy through the activation of the phosphatidylinositol 3-kinase/Akt/Bcl2 signaling path-way. World Neurosurg. 2020;143:215-223. doi: 10.1016/j.wneu.2020.07.117.</mixed-citation><mixed-citation xml:lang="en">He W.S., Zou M.X., Yan Y.G. [et al.]. Interleukin-17A promotes human disc degeneration by inhib-iting autophagy through the activation of the phosphatidylinositol 3-kinase/Akt/Bcl2 signaling path-way. World Neurosurg. 2020;143:215-223. doi: 10.1016/j.wneu.2020.07.117.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Xue H., Yao Y., Wang, X. [et al.]. Interleukin-21 is associated with the pathogenesis of lumbar disc herniation. Iran J. Allergy Asthma Immunol. 2015;14:509–518.</mixed-citation><mixed-citation xml:lang="en">Xue H., Yao Y., Wang, X. [et al.]. Interleukin-21 is associated with the pathogenesis of lumbar disc herniation. Iran J. Allergy Asthma Immunol. 2015;14:509–518.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Intervertebral disk degeneration and repair / Dowdell J., Erwin M., Choma T. [et al.] / Neurosurgery. 2017;80(3S):46-54. doi: 10.1093/neuros/nyw078.</mixed-citation><mixed-citation xml:lang="en">Intervertebral disk degeneration and repair / Dowdell J., Erwin M., Choma T. [et al.] / Neurosurgery. 2017;80(3S):46-54. doi: 10.1093/neuros/nyw078.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Lin X., Lin Q., Ye J.-J. Role of IL-17 in Nucleus Pulposus Cell Proliferation and Metabolism Cul-tured In Vitro / Asian Pac. J. Trop. Med. 2015;8:41–47. doi: 10.1016/S1995-7645(14)60185-1.</mixed-citation><mixed-citation xml:lang="en">Lin X., Lin Q., Ye J.-J. Role of IL-17 in Nucleus Pulposus Cell Proliferation and Metabolism Cul-tured In Vitro / Asian Pac. J. Trop. Med. 2015;8:41–47. doi: 10.1016/S1995-7645(14)60185-1.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Moen G.-H., Moen A., Schistad E.I. [et al.]. Local up-regulation of interferon-γ (IFN-γ) following disc herniation is involvedin the inflammatory response underlying acute lumbar radicular pain. Cy-tokine 2017;97:181–186. doi: 10.1016/j.cyto.2017.06.005.</mixed-citation><mixed-citation xml:lang="en">Moen G.-H., Moen A., Schistad E.I. [et al.]. Local up-regulation of interferon-γ (IFN-γ) following disc herniation is involvedin the inflammatory response underlying acute lumbar radicular pain. Cy-tokine 2017;97:181–186. doi: 10.1016/j.cyto.2017.06.005.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Martinon F., Burns K., Tschopp J. The inflammasome: A molecular platform triggering activation of inflammatory caspases andprocessing of proIL-beta / Mol. Cell. 2002;10:417–426. doi: 10.1016/s1097-2765(02)00599-3.</mixed-citation><mixed-citation xml:lang="en">Martinon F., Burns K., Tschopp J. The inflammasome: A molecular platform triggering activation of inflammatory caspases andprocessing of proIL-beta / Mol. Cell. 2002;10:417–426. doi: 10.1016/s1097-2765(02)00599-3.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Rigal J., Leglise A., Barnetche T. [et al.]. Meta-analysis of the effects of genetic polymorphisms on intervertebral disc degeneration. Eur. Spine J. 2017;26:2045–2052. doi: 10.1007/s00586-017-5146-z.</mixed-citation><mixed-citation xml:lang="en">Rigal J., Leglise A., Barnetche T. [et al.]. Meta-analysis of the effects of genetic polymorphisms on intervertebral disc degeneration. Eur. Spine J. 2017;26:2045–2052. doi: 10.1007/s00586-017-5146-z.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Molecular basic of pharmacotherapy of cytokine imbalance as a component of intervertebral disc de-generation treatment / Shnayder N.A., Ashkhotov A.V., Trefilova V.V. [et al.] / Int J Mol Sci. 2023;24(9):7692. doi: 10.3390/ijms24097692.</mixed-citation><mixed-citation xml:lang="en">Molecular basic of pharmacotherapy of cytokine imbalance as a component of intervertebral disc de-generation treatment / Shnayder N.A., Ashkhotov A.V., Trefilova V.V. [et al.] / Int J Mol Sci. 2023;24(9):7692. doi: 10.3390/ijms24097692.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Murata Y., Onda A., Rydevik B. Changes in pain behavior and histologic changescaused by applica-tion of tumor necrosis factor-alpha to the dorsal root ganglion in rats / Spine 2006;31:530–535. doi: 10.1097/01.brs.0000201260.10082.23.</mixed-citation><mixed-citation xml:lang="en">Murata Y., Onda A., Rydevik B. Changes in pain behavior and histologic changescaused by applica-tion of tumor necrosis factor-alpha to the dorsal root ganglion in rats / Spine 2006;31:530–535. doi: 10.1097/01.brs.0000201260.10082.23.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Nagase H., Visse R., Murphy G. Structure and function of matrix metalloproteinases and TIMPs / Cardiovasc. Res. 2006;69:562–573. doi: 10.1016/j.cardiores.2005.12.002.</mixed-citation><mixed-citation xml:lang="en">Nagase H., Visse R., Murphy G. Structure and function of matrix metalloproteinases and TIMPs / Cardiovasc. Res. 2006;69:562–573. doi: 10.1016/j.cardiores.2005.12.002.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Lan T., Shiyu-Hu Shen Z., Yan B. [et al.] New insights into the interplay between miRNAs and au-tophagy in the aging ofintervertebral discs. Ageing Res. Rev. 2021;65:101227. doi: 10.1016/j.arr.2020.101227.</mixed-citation><mixed-citation xml:lang="en">Lan T., Shiyu-Hu Shen Z., Yan B. [et al.] New insights into the interplay between miRNAs and au-tophagy in the aging ofintervertebral discs. Ageing Res. Rev. 2021;65:101227. doi: 10.1016/j.arr.2020.101227.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Ojala J.O., Sutinen E.M. The role of interleukin-18, oxidative stress and metabolic syndrome in Alz-heimer’s disease / J. Clin Med. 2017;6:55. doi: 10.3390/jcm6050055.</mixed-citation><mixed-citation xml:lang="en">Ojala J.O., Sutinen E.M. The role of interleukin-18, oxidative stress and metabolic syndrome in Alz-heimer’s disease / J. Clin Med. 2017;6:55. doi: 10.3390/jcm6050055.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Xie J., Li B., Zhang P. [et al.]. Osteogenic protein-1 attenuates the inflammatory cytokine-induced NP cell senescence through regulating the ROS/NF-κB pathway. Biomed. Pharmacother. 2018; 99:431-437. doi: 10.1016/j.biopha.2018.01.053.</mixed-citation><mixed-citation xml:lang="en">Xie J., Li B., Zhang P. [et al.]. Osteogenic protein-1 attenuates the inflammatory cytokine-induced NP cell senescence through regulating the ROS/NF-κB pathway. Biomed. Pharmacother. 2018; 99:431-437. doi: 10.1016/j.biopha.2018.01.053.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Zador F., Joca S., Nagy-Grocz G. [et al.]. Pro-inflammatory cytokines: potential links between the endocannabinoid system and the kynurenine pathway in depression. Int. J. Mol. Sci. 2021;22:5903. doi: 10.3390/ijms22115903.</mixed-citation><mixed-citation xml:lang="en">Zador F., Joca S., Nagy-Grocz G. [et al.]. Pro-inflammatory cytokines: potential links between the endocannabinoid system and the kynurenine pathway in depression. Int. J. Mol. Sci. 2021;22:5903. doi: 10.3390/ijms22115903.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Pro-inflammatory interleukin-18 increases Alzheimer’s disease-associated amyloid-beta production in human neuron-like cells / Sutinen E.M., Pirttila T., Anderson G. [et al.] / J. Neuroinflamm. 2012;9: 199. doi: 10.1186/1742-2094-9-199.</mixed-citation><mixed-citation xml:lang="en">Pro-inflammatory interleukin-18 increases Alzheimer’s disease-associated amyloid-beta production in human neuron-like cells / Sutinen E.M., Pirttila T., Anderson G. [et al.] / J. Neuroinflamm. 2012;9: 199. doi: 10.1186/1742-2094-9-199.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Bai Z., Liu W., He D. [et al.]. Protective effects of autophagy and NFE2L2 on reactive oxygen spe-cies-induced pyroptosis of human nucleus pulposus cells. Aging. 2020;12(8):7534-7548. doi: 10.18632/aging.103109.</mixed-citation><mixed-citation xml:lang="en">Bai Z., Liu W., He D. [et al.]. Protective effects of autophagy and NFE2L2 on reactive oxygen spe-cies-induced pyroptosis of human nucleus pulposus cells. Aging. 2020;12(8):7534-7548. doi: 10.18632/aging.103109.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Adamczak S.E., de Rivero Vaccari J.P., Dale G. [et al.]. Pyroptotic neuronal cell death mediated by the AIM2 in-flammasome. J. Cereb. Blood Flow Metab. 2014;34:621–629. doi: 10.1038/jcbfm.2013.236.</mixed-citation><mixed-citation xml:lang="en">Adamczak S.E., de Rivero Vaccari J.P., Dale G. [et al.]. Pyroptotic neuronal cell death mediated by the AIM2 in-flammasome. J. Cereb. Blood Flow Metab. 2014;34:621–629. doi: 10.1038/jcbfm.2013.236.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Qazi B.S., Tang K., Qazi A. Recent advances in underlying pathologies provide insight into interleu-kin-8 expression-mediatedinfammation and angiogenesis / Int. J. Inflam. 2011;2011:908468. doi: 10.4061/2011/908468.</mixed-citation><mixed-citation xml:lang="en">Qazi B.S., Tang K., Qazi A. Recent advances in underlying pathologies provide insight into interleu-kin-8 expression-mediatedinfammation and angiogenesis / Int. J. Inflam. 2011;2011:908468. doi: 10.4061/2011/908468.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Weber K.T., Alipui D.O., Sison C.P. [et al.]. Serum levels of theproinflammatory cytokine interleu-kin-6 vary based on diagnoses in individuals with lumbar intervertebral disc diseases. ArthritisRes. Ther. 2016;18:3. doi: 10.1186/s13075-015-0887-8.</mixed-citation><mixed-citation xml:lang="en">Weber K.T., Alipui D.O., Sison C.P. [et al.]. Serum levels of theproinflammatory cytokine interleu-kin-6 vary based on diagnoses in individuals with lumbar intervertebral disc diseases. ArthritisRes. Ther. 2016;18:3. doi: 10.1186/s13075-015-0887-8.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Yang M., Peng Y., Liu W. [et al.] . Sirtuin 2 expression suppresses oxidative stress and senescence of nucleus pulposus cells through inhibition of the p53/p21 pathway. Biochem. Biophys. Res. Commun. 2019;513(3):616-622. doi: 10.1016/j.bbrc.2019.03.200.</mixed-citation><mixed-citation xml:lang="en">Yang M., Peng Y., Liu W. [et al.] . Sirtuin 2 expression suppresses oxidative stress and senescence of nucleus pulposus cells through inhibition of the p53/p21 pathway. Biochem. Biophys. Res. Commun. 2019;513(3):616-622. doi: 10.1016/j.bbrc.2019.03.200.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Brown S., Rodrigues S., Sharp C. [et al.]. Staying connected: structural integration at the interverte-bral disc-vertebra interface of human lumbar spines. Eur Spine J. 2017;26(1):248–258. doi: 10.1007/s00586-016-4560-y.</mixed-citation><mixed-citation xml:lang="en">Brown S., Rodrigues S., Sharp C. [et al.]. Staying connected: structural integration at the interverte-bral disc-vertebra interface of human lumbar spines. Eur Spine J. 2017;26(1):248–258. doi: 10.1007/s00586-016-4560-y.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Tchetina E.V., Markova G.A. Regulation of energy metabolism in the growth plate and osteoarthritic chondrocytes / Rheumatol. Int. 2018;386:1963–1974. doi: 10.1007/s00296-018-4103-4.</mixed-citation><mixed-citation xml:lang="en">Tchetina E.V., Markova G.A. Regulation of energy metabolism in the growth plate and osteoarthritic chondrocytes / Rheumatol. Int. 2018;386:1963–1974. doi: 10.1007/s00296-018-4103-4.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Nurgaliev Z.A., Shneider N.A, Trefilova V.V. [et al.]. The Frequency of Low Back Pain. Personal-ized Psychiatry and Neurology 2023;3(1):28-41. https://doi.org/10.52667/2712-9179-2023-3-1-28-41.</mixed-citation><mixed-citation xml:lang="en">Nurgaliev Z.A., Shneider N.A, Trefilova V.V. [et al.]. The Frequency of Low Back Pain. Personal-ized Psychiatry and Neurology 2023;3(1):28-41. https://doi.org/10.52667/2712-9179-2023-3-1-28-41.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Li Y., Samartzis D., Campbell D.D. [et al.]. Two subtypes of intervertebral disc degeneration distin-guished by large-scale population-based study. Spine J. 2016;(9):1079-89. doi: 10.1016/j.spinee.2016.04.020.</mixed-citation><mixed-citation xml:lang="en">Li Y., Samartzis D., Campbell D.D. [et al.]. Two subtypes of intervertebral disc degeneration distin-guished by large-scale population-based study. Spine J. 2016;(9):1079-89. doi: 10.1016/j.spinee.2016.04.020.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Harper E.G., Guo C., Rizzo H. [et al.]. Th17 cytokinesstimulate CCL20 expression in keratinocytes in vitro and in vivo: Implications for psoriasis pathogenesis. J. Invest. Dermatol. 2009;129:2175–2183. doi: 10.1038/jid.2009.65.</mixed-citation><mixed-citation xml:lang="en">Harper E.G., Guo C., Rizzo H. [et al.]. Th17 cytokinesstimulate CCL20 expression in keratinocytes in vitro and in vivo: Implications for psoriasis pathogenesis. J. Invest. Dermatol. 2009;129:2175–2183. doi: 10.1038/jid.2009.65.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Wang H., Ding W., Yang D. Different concentrations of 17β-estradiol modulates apoptosis induced by interleukin-1β in rat annulus fibrosus cells / Mol. Med. Rep. 2014;10:2745–2751. doi: 10.3892/mmr.2014.2514</mixed-citation><mixed-citation xml:lang="en">Wang H., Ding W., Yang D. Different concentrations of 17β-estradiol modulates apoptosis induced by interleukin-1β in rat annulus fibrosus cells / Mol. Med. Rep. 2014;10:2745–2751. doi: 10.3892/mmr.2014.2514</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru"></mixed-citation><mixed-citation xml:lang="en"></mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
