ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.25789/YMJ.2023.84.17ymj-352Research ArticleГИГИЕНА, САНИТАРИЯ, ЭПИДЕМИОЛОГИЯ И МЕДИЦИНСКАЯ ЭКОЛОГИЯHYGIENE, SANITATION, EPIDEMIOLOGY AND MEDICAL ECOLOGYВыявление вируса папилломы человека высокого канцерогенного риска у женщин в рамках II этапа пилотного проекта «ОНКОПОИСКСАХА.РФ» в ЯкутииDetection of high-risk human papilloma virus in women within the framework of the second stage of the pilot project "ОНКОПОИСКСАХА.РФ" in Yakutiahttps://orcid.org/0000-0003-2592-5125АфанасьеваЛ. Н.AfanasyevaL. N.

Афанасьева  Лена Николаевна – к.м.н., доцент 

Afanasyeva  Lena Nikolaevna – PhD, Associate Professor

lenanik2007@mail.ruhttps://orcid.org/0000-0003-0269-8943ФилипповЭ. В.FilippovE. V.

Филиппов Эдуард Васильевич – к.б.н., зав. молекуляр.-биологич. лаб.

Filippov  Eduard Vasilyevich – PhD in Biology, Head of Molecular Biology Laboratory 

Edy73@mail.ruhttps://orcid.org/0000-0002-2024-6062ФилипповаГ. В.FilippovaG. V.

Филиппова Галина Валерьевна – к.б.н., биолог пат.-анатом. лаб.; с.н.с. Ин-та биологич. проблем криолитозоны   

 Filippova Galina Valerievna – PhD in Biology, Pathological and Anatomical laboratory; Senior Re-searcher of the Institute for Biological Problems of Cryolithozone 

nureeva@mail.ruhttps://orcid.org/0000-0002-2758-155XНикифоровП. В.NikiforovP. V.

Никифоров Петр Владимирович – директор; доцент 

Nikiforov  Petr Vladimirovich – Deputy Chief Physician; Associate Professor

niccifforof@mail.ruНиколаеваТ. И.NikolaevaT. I.

Николаева Татьяна Ивановна – к.м.н., гл. врач; доцент СВФУ

Nikolaeva Tatyana Ivanovna – PhD in Medicine, Chief Physician; Associate Professor 

nti_nika@mail.ruЛарионоваН. А.LarionovaN. A.

Ларионова Наталья Абдраимжан – зав. цитологич. лаб.

Larionova  Natalya Abdraim-zhan – Head of the Cytological Laboratory  

larionovanataliaa@gmail.comСтручковаМ. С.StruchkovaM. S.

Стручкова Моника Сергеевна – врач-гинеколог-онколог

Struchkova Monika Sergeevna – oncogynecologist of the Department of Oncogynecology

monicas313@mail.ruСеверо-Восточный федеральн. ун-т им. М.К. Аммосова, министр здравоохранения РС(Я)РоссияM.K. Ammosov North-Eastern Federal UniversityRussian FederationЯкутский республиканский онкологический диспансерРоссияState Budgetary Institution of the Republic of Sakha (Yakutia) Yakut Republican Oncological DispensaryRussian FederationЯРОД; ФИЦ ЯНЦ СО РАНРоссияState Budgetary Institution of the Yakut Republic of Sakha (Yakutia) Yakut Republican Oncological Dispensary; Siberian Branch of Russian Academy of SciencesRussian FederationЯРМИАЦ; СВФУРоссияState Budgetary Institution of the Republic of Sakha (Yakutia) Yakut Republican Oncology Dispensary; Federal State Autonomous Educational Institution of Higher Education M.K. Ammosov North-Eastern Federal UniversityRussian FederationЯРОД; СВФУРоссияState Budgetary Institution of the Republic of Sakha (Yakutia) Yakut Republican Oncology Dispensary; Federal State Autonomous Educational Institution of Higher Education M.K. Ammosov North-Eastern Federal UniversityRussian FederationЯРОДРоссияState Budgetary Institution of the State Budgetary Institution of the Republic of Sakha (Yakutia) Yakut Republican Oncological DispensaryRussian FederationЯРОДРоссияBudgetary Institution of the Republic of Sakha (Yakutia) Yakut Republican Oncology DispensaryRussian Federation202310022025046874Copyright © Афанасьева Л.Н., Филиппов Э.В., Филиппова Г.В., Никифоров П.В., Николаева Т.И., Ларионова Н.А., Стручкова М.С., 20252025Афанасьева Л.Н., Филиппов Э.В., Филиппова Г.В., Никифоров П.В., Николаева Т.И., Ларионова Н.А., Стручкова М.С.Afanasyeva L.N., Filippov E.V., Filippova G.V., Nikiforov P.V., Nikolaeva T.I., Larionova N.A., Struchkova M.S.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/352

В результате проведенного скринингового исследования женского населения впервые были получены данные по распространению основных генотипов вируса папилломы человека высокого канцерогенного риска (ВПЧ ВКР) в 10 районах Республики Саха (Якутия). Наибольшая инфицированность, в том числе интегрированными формами, выявлена в возрастных группах 20-30 и 31-40 лет. Показано, что инфицирование ВПЧ ВКР более чем в 4 раза увеличивает риск интраэпителиальных поражений плоского эпителия. Выявлена связь интеграции ВПЧ и высокой вирусной нагрузки с риском развития цервикальных интраэпителиальных неоплазий. Основной вклад (50%) в CIN поражения вносит интегрированная форма ВПЧ-16.

The study was conducted in 2022 as part of the implementation of the second stage of the pilot project "ОНКОПОИСКСАХА.РФ" (ONCO-SEARCH) at the Yakut Republican Oncology Dispensary, which is part of the national project "Healthcare". The project involved 798 women from 10 districts of the Republic of Sakha (Yakutia). The comprehensive examination included cytological testing, detection and genotyping of high carcinogenic risk human papillomavirus (HСR-HPV) using polymerase chain reaction, and assessment of viral load. The territorial distribution of HСR-HPV types was demonstrated. The overall infection rate among women ranged from 6.9% (Tomponsky district) to 25.0% (Oymyakon district), with an average of 14.8%. The majority of infections were of the episomal - non-integrated form of HPV. Differences in infection rates among women of different age groups were observed. The highest pro-portion of HCR-HPV carriers, including integrated forms, was found in the age groups of 20-30 and 31-40 years. High-grade squamous intraepithelial lesions (HSIL) were diagnosed in 2.5% of the examined women, while low-grade squamous intraepithelial lesions (LSIL) were found in 1.8%. One woman was diagnosed with squamous cell carcinoma. The study showed a correlation between viral load, integrated forms of HPV, and cervical intraepithelial neoplasia (CIN). The integrated form of genotype 16 made the largest contribution (50%) to CIN lesions among HCR-HPV-infected individuals.

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The authors declare that there are no conflicts of interest present.