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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ymj</journal-id><journal-title-group><journal-title xml:lang="ru">Якутский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Yakut Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1813-1905</issn><issn pub-type="epub">2312-1017</issn><publisher><publisher-name>ЯНЦ КМП</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.25789/YMJ.2023.84.19</article-id><article-id custom-type="elpub" pub-id-type="custom">ymj-339</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>АКТУАЛЬНАЯ ТЕМА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ACTUAL TOPIC</subject></subj-group></article-categories><title-group><article-title>Клинический случай сочетанного течения новой коронавирусной инфекции COVID-19 и острого инфаркта миокарда</article-title><trans-title-group xml:lang="en"><trans-title>A clinical case of concurrent course of the novel coronavirus infection  COVID-19 and acute myocardial infarction</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кузнецова</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Kuznetsova</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кузнецова Амгалена Михайловна - аспирант кафедры</p><p>г. Якутск</p></bio><bio xml:lang="en"><p>Kuznetsova Amgalena Mikhailovna – a graduate student at the Department of Infectious Diseases, Phthisiology and Dermatovenerology</p><p>Yakutsk</p></bio><email xlink:type="simple">namgalena@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0103-4750</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Слепцова</surname><given-names>C. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Sleptsova</surname><given-names>S. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Слепцова Снежана Спиридоновна – д.м.н., доцент, зав. кафедрой</p></bio><bio xml:lang="en"><p>Sleptsova Snezhana  Spiridonovna – Doctor of Medical Sciences (MD), associate professor, Head of the Department of Infectious Diseases, Phthisiology and Dermatovenerology</p></bio><email xlink:type="simple">sssleptsova@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff xml:lang="en" id="aff-1"><institution>Ammosov NEFU Medical Institute</institution><country>Russian Federation</country></aff><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Мединститут СВФУ им. М. К. Аммосова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Ammosov NEFU Medical Institute</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>09</day><month>02</month><year>2025</year></pub-date><volume>0</volume><issue>4</issue><fpage>78</fpage><lpage>81</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Кузнецова А.М., Слепцова C.С., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Кузнецова А.М., Слепцова C.С.</copyright-holder><copyright-holder xml:lang="en">Kuznetsova A.M., Sleptsova S.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://ymj.elpub.ru/jour/article/view/339">https://ymj.elpub.ru/jour/article/view/339</self-uri><abstract><p>Проведен анализ клинического течения новой коронавирусной инфекции у пациентов с коморбидным состоянием и развитием поражения сердца, ассоциированного с COVID-19.</p><p>Описан клинический случай пациента, входящего в группу особого риска: наличие коморбидных заболеваний (таких как хроническая сердечная недостаточность, сахарный диабет 2 типа, артериальная гипертензия), возраст (77 лет), женский пол. Несмотря на позднее обращение пациентки за медицинской помощью, в связи с чем имеется утяжеление течения инфаркта миокарда, который протекал в сочетании НКВИ, на госпитальном этапе было проведено своевременное диагностирование риска сердечно-сосудистых осложнений и начата целенаправленная специфическая терапия. Вместе с тем, спустя 11 месяцев после выписки у пациентки случился второй инфаркт миокарда, еще через 3,5 месяца – третий (оба с благополучным исходом).</p><p>Представленный клинический случай подтверждает наличие патогенетического взаимодействия заболеваний сердечно-сосудистой системы и COVID-19, когда вирус SARS-CoV-2 проникает в клетки легких, сердца и других органов, в эндотелии кровеносных сосудов, вызывая частичное разрушение и повреждение сердечной ткани.</p></abstract><trans-abstract xml:lang="en"><p>COVID-19 is a severe acute respiratory infection caused by the SARS-CoV-2 coronavirus primarily affecting the respiratory system and leading to pathological changes in the cardiovascular system. The aim of the research is to analyze the clinical course of the new coronavirus infection in patients with comorbid conditions and the development of heart damage associated with COVID-19.</p><sec><title>Materials and Methods</title><p>Materials and Methods: A clinical case of a patient belonging to a high-risk group is described, having comorbidities (such as chronic heart failure, type 2 diabetes mellitus, arterial hypertension), an age of 77 years, and female gender. Despite the patient's late presentation for medical assistance, resulting in worsening of myocardial infarction, which occurred in combination with severe acute respiratory distress syndrome, timely identification of the risk of cardiovascular complications was carried out during the hospitalization stage, and specific targeted therapy was initiated. However, 11 months after discharge, the patient experienced a second myocardial infarction, followed by a third one after 3.5 months (both with favorable outcomes).</p></sec><sec><title>Results of the Study</title><p>Results of the Study: The presented clinical case confirms the existence of pathogenetic interaction between cardiovascular diseases and COVID-19, wherein the SARS-CoV-2 virus penetrates lung cells, heart, and other organs, affecting the endothelium of blood vessels, leading to partial destruction and damage to cardiac tissue.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>COVID-19</kwd><kwd>клинический случай</kwd><kwd>артериальная гипертензия</kwd><kwd>инфаркт миокарда</kwd><kwd>риски сердечно-сосудистых осложнений</kwd></kwd-group><kwd-group xml:lang="en"><kwd>COVID-19</kwd><kwd>clinical case</kwd><kwd>arterial hypertension</kwd><kwd>myocardial infarction</kwd><kwd>risks of cardiovascular complications</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Воробьева О.В., Ласточкин А.В. Острый инфаркт миокарда и коронавирусная инфекция (COVID-19) // Инфекционные болезни: новости, мнения, обучение. 2021. Т. 10, № 1. С. 93-97. DOI: https://doi.org/10.33029/2305-3496-2021-10-1-93-97</mixed-citation><mixed-citation xml:lang="en">Vorobieva O.V., Lastochkin A.V. Acute myocardial infarction and coronavirus infection (COVID-19) // Infectious diseases: news, opinions, training. 2021. T. 10, No. 1. P. 93-97. DOI: https://doi.org/10.33029/2305-3496-2021-10-1-93-97.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Ишемическая болезнь у женщин: патогенетические и патоморфологические особенности формирования и клинического течения / О.В. Цыганкова [и др.] // Проблемы женского здоровья. 2013; 4 (8): 50-59</mixed-citation><mixed-citation xml:lang="en">Ischemic disease in women: pathogenetic and pathomorphological features of formation and clinical course / Tsygankova O.V. [et al.] // Problems of women's health. 2013; 4 (8): 50-59.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Сердечно-сосудистые последствия перенесенного COVID-19: патогенез, диагностика и лечение / Л.В. Мельникова, Т.В. Лохина, Н.В. Беренштейн, М.Г. Иванчукова // 2021 – Электронный ресурс. URL: https://www.lvrach.ru/2021/07/15438017. Дата обращения 15.10.2023</mixed-citation><mixed-citation xml:lang="en">Cardiovascular consequences of COVID-19: pathogenesis, diagnosis and treatment. / Melnikova L.V., Lokhina T.V., Berenshtein N.V., Ivanchukova M.G. // 2021 – Electronic resource. URL: https://www.lvrach.ru/2021/07/15438017. Access date 10/15/2023.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Острое повреждение миокарда при коронавирусной болезни 2019 (COVID-19) (разбор клинического случая) / М.А. Бабаев, М.А. Петрушин, И.А. Дубровин, Н.С. Кострица, Н.А. Еременко // Журнал имени академика Б.В. Петровского DOI: 10.33029/2308-1198-2020-8-3-87-94.</mixed-citation><mixed-citation xml:lang="en">Acute myocardial injury during coronavirus disease 2019 (COVID-19) (clinical case analysis) / Babaev M.A., Petrushin M.A., Dubrovin I.A. Kostritsa N.S., Eremenko N.A. // B.V. Petrovsky Journal DOI: 10.33029/2308-1198-2020-8-3-87-94</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Cardiovascular Complications of COVID-19: Pharmacotherapy Perspective / Talasaz AH, Kakavand H, Van Tassell B, Aghakouchakzadeh M, Sadeghipour P, Dunn S, Geraiely B // Cardiovasc. Drugs Ther. 2021 Apr;35(2):249-259. doi: 10.1007/s10557-020-07037-2. Epub 2020 Jul 15. PMID: 32671601; PMCID: PMC7360896.- https://pubmed.ncbi.nlm.nih.gov/32671601/ Date of application: 14.10.2023.</mixed-citation><mixed-citation xml:lang="en">Cardiovascular Complications of COVID-19: Pharmacotherapy Perspective / Talasaz AH, Kakavand H, Van Tassell B, Aghakouchakzadeh M, Sadeghipour P, Dunn S, Geraiely B // Cardiovasc. Drugs Ther. 2021 Apr;35(2):249-259. doi: 10.1007/s10557-020-07037-2. Epub 2020 Jul 15. PMID: 32671601; PMCID: PMC7360896.- https://pubmed.ncbi.nlm.nih.gov/32671601/ Date of application: 14.10.2023.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Riccardo M. Inciardi, MD; Laura Lupi, MD; Gregorio Zaccone, et al. JAMA Cardiol. doi:10.1001/jamacardio.2020.1096. Published online March 27, 2020.</mixed-citation><mixed-citation xml:lang="en">Riccardo M. Inciardi, MD; Laura Lupi, MD; Gregorio Zaccone, et al. JAMA Cardiol. doi:10.1001/jamacardio.2020.1096. Published online March 27, 2020.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
