Currently, the search for effective methods of reconstructive interventions aimed at increasing alveolar ridge height and thickness remains a pressing issue in dentistry. However, the results of studies on the comparative assessment of the effectiveness of the use of autogenic bone from various donor sites are extremely small and ambiguous. Aim. Substantiate the effectiveness of using the optimal composition of autogenic bone chips (ABC) and xenogenic bone material (XBM) taking into account the anatomical localization of the donor zone in guided bone regeneration (GBR) according to the data of microhemodynamics of the experiment. Research materials and methods. The object of the study in the research was 84 sexually mature male rabbits of the chinchilla breed weighing 2500-3200 g. The materials of Cardioplant LLC (Penza) with registration certificates: Xenogenous bone material (XBM) “Xenograft Mineral” (medical device registration certificate No. RZN 2015/3086 dated 16.09.2015) and bioresorbable membrane “BioPLATE Barrier” (medical device registration certificate No. RZN 2016/4808 dated 26.01.2021). A defect in the mandible area was formed in the animals under study, which was then filled with osteoplastic material. Laser Doppler flowmetry (LDF) was used to monitor the state of microhemodynamics of gingival tissues in the area of surgery using a laser analyzer of capillary blood flow "LAKK-02," (NPP "Lazma," Moscow). Results and discussion. It was established that within the first two weeks after the intervention, optimal rates of microcirculation recovery in the surgical area are characteristic of osteoplasty using a mixture of XBM (75%) and ABC (25%) from the oral donor zone. On the 14th day after the operation, capillary blood flow was stabilized, which was manifested by a decrease in the studied parameters in all observation groups. However, the normalization of microvessel functioning was not the same in the study groups. At the same time, the normalization of capillary blood flow was optimal in animals of subgroup 3 in group II, with the microcirculation indicator at the level of 20,59±1,18 perf. units, and its intensity at the level of 2,31±0,12 perf. units by the 14th day. Starting from the 30th day of observation, microcirculation recovery proceeded at the same pace in all groups of animals, with the exception of a slight lag in animals of subgroup 3 in group III, however, by the 90th day and by the end of the observation period, significant differences in capillary blood flow levels could not be found.

Conclusion. The obtained results should be taken into account in outpatient dental practice when performing manipulations related to the use of the GBR technique