ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.25789/YMJ.2022.80.26ymj-324Research ArticleНАУЧНЫЕ ОБЗОРЫ И ЛЕКЦИИSCIENTIFIC REVIEWS AND LECTURESРоль нейропилина-1 (NRP1) в развитии инфекции SARS-CoV-2The role of neuropilin-1 (NRP1) in the development of SARS-CoV-2 infectionМаркеловВ. А.MarkelovV. A.

Маркелов Виталий Андреевич – магистрант ФГБОУ ВО БашГУ; ст. лаборант ФГБОУ ВО БГМУ 

Markelov Vitaly Andreevich – graduate student of the FSBEI HE Bashkir State University; senior laboratory assistant of the FSBEI HE Bashkir State Medical University 

ДанилкоК. В.DanilkoA. V.

Данилко Ксения Владимировна – к.б.н., доцент ФГБОУ ВО БГМУ Минздрава России, с.н.с. ЦНИЛ ФГБОУ ВО БГМУ

Danilko Ksenia Vladimirovna – PhD, Associate Professor of the FSBEI HE Bashkir State Medical University of the Ministry of Health of Russia, senior researcher of the Central Research Institute 

ФГБОУ ВО БашГУ; ФГБОУ ВО БГМУ Минздрава РоссииРоссияFSBEI HE Bashkir State Universityж FSBEI HE Bashkir State Medical University of the Ministry of Health of RussiaRussian FederationФГБОУ ВО БГМУ Минздрава РоссииРоссияFSBEI HE Bashkir State Medical University of the Ministry of Health of RussiaRussian Federation20220702202504101103Copyright © Маркелов В.А., Данилко К.В., 20252025Маркелов В.А., Данилко К.В.Markelov V.A., Danilko A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/324

Представлен обзор литературы о роли нейропилина-1 в развитии инфекции SARS-CoV-2 и поиск вероятных связей полиморфных вариантов гена NRP1 c SARS-CoV-2. В данном обзоре приведены характеристики полиморфных вариантов гена NRP1, которые демонстрируют возможность их связи с течением инфекции SARS-CoV-2.

A review of the literature on the role of neuropilin-1 in the development of SARS-CoV-2 infection and a search for probable links between polymorphic variants of the NRP1 gene and SARS-CoV-2 are presented. This review presents the characteristics of polymorphic variants of the NRP1 gene, which demonstrate the possibility of their association with the course of SARS-CoV-2 infection.

инфекция SARS-CoV-2нейропилин-1полиморфные варианты гена NRP1SARS-CoV-2 infectionneuropilin-1polymorphic variants of the NRP1 geneРабота выполнена при финансовой поддержке программы стратегического академического лидерства «Приоритет 2030».The work was supported by the strategic academic leadership «Program Priority 2030».ReferencesAckermann M, Verleden SE, Kuehnel M, et al. Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in COVID-19. N Engl J Med. 2020 Jul 9; 383(2):120-128. doi: 10.1056/NEJMoa2015432.Ackermann M, Verleden SE, Kuehnel M, et al. Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in COVID-19. N Engl J Med. 2020 Jul 9; 383(2):120-128. doi: 10.1056/NEJMoa2015432.Alnomasy SF. Virus-receptor interactions of SARS-CoV-2 spike receptor-binding domain and human neuropilin-1 b1 domain. Saudi J Biol Sci. 2021 Jul; 28(7):3926-3928. doi: 10.1016/j.sjbs.2021.03.074.Alnomasy SF. Virus-receptor interactions of SARS-CoV-2 spike receptor-binding domain and human neuropilin-1 b1 domain. Saudi J Biol Sci. 2021 Jul; 28(7):3926-3928. doi: 10.1016/j.sjbs.2021.03.074.Burks SM, Rosas-Hernandez H, Alejandro Ramirez-Lee M, et al. Can SARS-CoV-2 infect the central nervous system via the olfactory bulb or the blood-brain barrier? Brain Behav Immun. 2021 Jul;95:7-14. doi: 10.1016/j.bbi.2020.12.031.Burks SM, Rosas-Hernandez H, Alejandro Ramirez-Lee M, et al. Can SARS-CoV-2 infect the central nervous system via the olfactory bulb or the blood-brain barrier? Brain Behav Immun. 2021 Jul;95:7-14. doi: 10.1016/j.bbi.2020.12.031.Buzhdygan TP, DeOre BJ, Baldwin-Leclair A, et al. The SARS-CoV-2 spike protein alters barrier function in 2D static and 3D microfluidic in-vitro models of the human blood-brain barrier. Neurobiol Dis. 2020 Dec;146:105131. doi: 10.1016/j.nbd.2020.105131.Buzhdygan TP, DeOre BJ, Baldwin-Leclair A, et al. The SARS-CoV-2 spike protein alters barrier function in 2D static and 3D microfluidic in-vitro models of the human blood-brain barrier. Neurobiol Dis. 2020 Dec;146:105131. doi: 10.1016/j.nbd.2020.105131.Bruder D, Probst-Kepper M, Westendorf AM, et al. Neuropilin-1: a surface marker of regulatory T cells. Eur J Immunol. 2004 Mar;34(3):623-630. doi: 10.1002/eji.200324799.Bruder D, Probst-Kepper M, Westendorf AM, et al. Neuropilin-1: a surface marker of regulatory T cells. Eur J Immunol. 2004 Mar;34(3):623-630. doi: 10.1002/eji.200324799.Cantuti-Castelvetri L, Ojha R, Pedro LD, et al. Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity. Science. 2020 Nov 13;370(6518):856-860. doi: 10.1126/science.abd2985.Cantuti-Castelvetri L, Ojha R, Pedro LD, et al. Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity. Science. 2020 Nov 13;370(6518):856-860. doi: 10.1126/science.abd2985.Daly JL, Simonetti B, Klein K, et al. Neuropilin-1 is a host factor for SARS-CoV-2 infection. Science. 2020 Nov 13;370(6518):861865. doi: 10.1126/science.abd3072.Daly JL, Simonetti B, Klein K, et al. Neuropilin-1 is a host factor for SARS-CoV-2 infection. Science. 2020 Nov 13;370(6518):861-865. doi: 10.1126/science.abd3072.Duran I, Tenney J, Warren CM, et al. NRP1 haploinsufficiency predisposes to the development of Tetralogy of Fallot. Am J Med Genet A. 2018 Mar;176(3):649-656. doi: 10.1002/ajmg.a.38600.Duran I, Tenney J, Warren CM, et al. NRP1 haploinsufficiency predisposes to the development of Tetralogy of Fallot. Am J Med Genet A. 2018 Mar;176(3):649-656. doi: 10.1002/ajmg.a.38600.Girija ASS. Fox3+ CD25+ CD4+ T-regulatory cells may transform the nCoV's final destiny to CNS! J Med Virol. 2021 Oct;93(10):5673-5675. doi: 10.1002/jmv.26482.Girija ASS. Fox3+ CD25+ CD4+ T-regulatory cells may transform the nCoV's final destiny to CNS! J Med Virol. 2021 Oct;93(10):56735675. doi: 10.1002/jmv.26482.Gerger A, El-Khoueiry A, Zhang W, et al. Pharmacogenetic angiogenesis profiling for first-line Bevacizumab plus oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer. Clin Cancer Res. 2011 Sep 1;17(17):5783-92. doi: 10.1158/1078-0432.CCR11-1115.Gerger A, El-Khoueiry A, Zhang W, et al. Pharmacogenetic angiogenesis profiling for first-line Bevacizumab plus oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer. Clin Cancer Res. 2011 Sep 1;17(17):5783-92. doi: 10.1158/1078-0432.CCR11-1115.Grage-Griebenow E, Löseke S, Kauth M, et al. Anti-BDCA-4 (neuropilin-1) antibody can suppress virus-induced IFN-alpha production of plasmacytoid dendritic cells. Immunol Cell Biol. 2007 Jul;85(5):383-90. doi: 10.1038/sj.icb.7100048.Grage-Griebenow E, Löseke S, Kauth M, et al. Anti-BDCA-4 (neuropilin-1) antibody can suppress virus-induced IFN-alpha production of plasmacytoid dendritic cells. Immunol Cell Biol. 2007 Jul;85(5):383-90. doi: 10.1038/sj.icb.7100048.Guo HF, Vander Kooi CW. Neuropilin Functions as an Essential Cell Surface Receptor. J Biol Chem. 2015 Dec 4; 290(49):29120-6. doi: 10.1074/jbc.R115.687327.Guo HF, Vander Kooi CW. Neuropilin Functions as an Essential Cell Surface Receptor. J Biol Chem. 2015 Dec 4; 290(49):29120-6. doi: 10.1074/jbc.R115.687327.Hopkins C, Lechien JR, Saussez S. More than ACE2? NRP1 may play a central role in the underlying pathophysiological mechanism of olfactory dysfunction in COVID-19 and its association with enhanced survival. Med Hypotheses. 2021 Jan;146:110406. doi: 10.1016/j.mehy.2020.110406.Hopkins C, Lechien JR, Saussez S. More than ACE2? NRP1 may play a central role in the underlying pathophysiological mechanism of olfactory dysfunction in COVID-19 and its association with enhanced survival. Med Hypotheses. 2021 Jan;146:110406. doi: 10.1016/j.mehy.2020.110406.Hamming I, Timens W, Bulthuis ML, et al. Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis. J Pathol. 2004 Jun;203(2):631-7. doi: 10.1002/path.1570.Hamming I, Timens W, Bulthuis ML, et al. Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis. J Pathol. 2004 Jun;203(2):631-7. doi: 10.1002/path.1570.Hippensteel JA, LaRiviere WB, Colbert JF, et al. Heparin as a therapy for COVID-19: current evidence and future possibilities. Am J Physiol Lung Cell Mol Physiol. 2020 Aug 1;319(2):L211-L217. doi: 10.1152/ajplung.00199.2020.Hippensteel JA, LaRiviere WB, Colbert JF, et al. Heparin as a therapy for COVID-19: current evidence and future possibilities. Am J Physiol Lung Cell Mol Physiol. 2020 Aug 1;319(2):L211-L217. doi: 10.1152/ajplung.00199.2020.Hashemi SMA, Thijssen M, Hosseini SY, et al. Human gene polymorphisms and their possible impact on the clinical outcome of SARS-CoV-2 infection. Arch Virol. 2021 Aug;166(8):2089-2108. doi: 10.1007/s00705021-05070-6.Hashemi SMA, Thijssen M, Hosseini SY, et al. Human gene polymorphisms and their possible impact on the clinical outcome of SARS-CoV-2 infection. Arch Virol. 2021 Aug;166(8):2089-2108. doi: 10.1007/s00705021-05070-6.Hancock JT, Rouse RC, Stone E, Greenhough A. Interacting Proteins, Polymorphisms and the Susceptibility of Animals to SARS-CoV-2. Animals (Basel). 2021 Mar 12;11(3):797. doi: 10.3390/ani11030797.Hancock JT, Rouse RC, Stone E, Greenhough A. Interacting Proteins, Polymorphisms and the Susceptibility of Animals to SARSCoV-2. Animals (Basel). 2021 Mar 12;11(3):797. doi: 10.3390/ani11030797.Jobe A, Vijayan R. Characterization of peptide binding to the SARS-CoV-2 host factor neuropilin. Heliyon. 2021 Oct;7(10):e08251. doi: 10.1016/j.heliyon.2021.e08251.Jobe A, Vijayan R. Characterization of peptide binding to the SARS-CoV-2 host factor neuropilin. Heliyon. 2021 Oct;7(10):e08251. doi: 10.1016/j.heliyon.2021.e08251.Kirschenbaum D, Imbach LL, Ulrich S, et al. Inflammatory olfactory neuropathy in two patients with COVID-19. Lancet. 2020 Jul 18;396(10245):166. doi: 10.1016/S01406736(20)31525-7.Kirschenbaum D, Imbach LL, Ulrich S, et al. Inflammatory olfactory neuropathy in two patients with COVID-19. Lancet. 2020 Jul 18;396(10245):166. doi: 10.1016/S01406736(20)31525-7.Klaewkla M, Charoenwongpaiboon T, Mahalapbutr P. Molecular basis of the new COVID-19 target neuropilin-1 in complex with SARS-CoV-2 S1 C-end rule peptide and small-molecule antagonists. J Mol Liq. 2021 Aug 1;335:116537. doi: 10.1016/j.molliq.2021.116537.Klaewkla M, Charoenwongpaiboon T, Mahalapbutr P. Molecular basis of the new COVID-19 target neuropilin-1 in complex with SARS-CoV-2 S1 C-end rule peptide and small-molecule antagonists. J Mol Liq. 2021 Aug 1;335:116537. doi: 10.1016/j.molliq.2021.116537.Li ZL, Buck M. Neuropilin-1 assists SARSCoV-2 infection by stimulating the separation of spike protein domains S1 and S2. bioRxiv [Preprint]. 2021 Jan 19:2021.01.06.425627. doi: 10.1101/2021.01.06.425627. Update in: Biophys J. 2021 Jul 20;120(14):2828-2837.Li ZL, Buck M. Neuropilin-1 assists SARSCoV-2 infection by stimulating the separation of spike protein domains S1 and S2. bioRxiv [Preprint]. 2021 Jan 19:2021.01.06.425627. doi: 10.1101/2021.01.06.425627. Update in: Biophys J. 2021 Jul 20;120(14):2828-2837.Lyu Z, Jin H, Yan Z, et al. Effects of NRP1 on angiogenesis and vascular maturity in endothelial cells are dependent on the expression of SEMA4D. Int J Mol Med. 2020 Oct;46(4):13211334. doi: 10.3892/ijmm.2020.4692.Lyu Z, Jin H, Yan Z, et al. Effects of NRP1 on angiogenesis and vascular maturity in endothelial cells are dependent on the expression of SEMA4D. Int J Mol Med. 2020 Oct;46(4):13211334. doi: 10.3892/ijmm.2020.4692.Lorés-Motta L, van Asten F, Muether PS, et al. A genetic variant in NRP1 is associated with worse response to ranibizumab treatment in neovascular age-related macular degeneration. Pharmacogenet Genomics. 2016 Jan;26(1):207. doi: 10.1097/FPC.0000000000000180.Lorés-Motta L, van Asten F, Muether PS, et al. A genetic variant in NRP1 is associated with worse response to ranibizumab treatment in neovascular age-related macular degeneration. Pharmacogenet Genomics. 2016 Jan;26(1):207. doi: 10.1097/FPC.0000000000000180.Moutal A, Martin LF, Boinon L, et al. SARS-CoV-2 spike protein co-opts VEGF-A/ neuropilin-1 receptor signaling to induce analgesia. Pain. 2021 Jan;162(1):243-252. doi: 10.1097/j.pain.0000000000002097.Moutal A, Martin LF, Boinon L, et al. SARS-CoV-2 spike protein co-opts VEGF-A/ neuropilin-1 receptor signaling to induce analgesia. Pain. 2021 Jan;162(1):243-252. doi: 10.1097/j.pain.0000000000002097.Mayi BS, Leibowitz JA, Woods AT, et al. The role of Neuropilin-1 in COVID-19. PLoS Pathog. 2021 Jan 4;17(1):e1009153. doi: 10.1371/journal.ppat.1009153.Mayi BS, Leibowitz JA, Woods AT, et al. The role of Neuropilin-1 in COVID-19. PLoS Pathog. 2021 Jan 4;17(1):e1009153. doi: 10.1371/journal.ppat.1009153.Men M, Chen DN, Li JD, et al. Analysis of PLXNA1, NRP1, and NRP2 variants in a cohort of patients with isolated hypogonadotropic hypogonadism. Mol Genet Genomic Med. 2021 Nov;9(11):e1816. doi: 10.1002/mgg3.1816.Men M, Chen DN, Li JD, et al. Analysis of PLXNA1, NRP1, and NRP2 variants in a cohort of patients with isolated hypogonadotropic hypogonadism. Mol Genet Genomic Med. 2021 Nov;9(11):e1816. doi: 10.1002/mgg3.1816.Nakamura F, Tanaka M, et al. Neuropilin-1 extracellular domains mediate semaphorin D/ III-induced growth cone collapse. Neuron. 1998 Nov;21(5):1093-100. doi: 10.1016/s08966273(00)80626-1.Nakamura F, Tanaka M, et al. Neuropilin-1 extracellular domains mediate semaphorin D/III-induced growth cone collapse. Neuron. 1998 Nov;21(5):1093-100. doi: 10.1016/s08966273(00)80626-1.Parker MW, Xu P, Li X, Vander Kooi CW. Structural basis for selective vascular endothelial growth factor-A (VEGF-A) binding to neuropilin-1. J Biol Chem. 2012 Mar 30;287(14):11082-9. doi: 10.1074/jbc.M111.331140.Parker MW, Xu P, Li X, Vander Kooi CW. Structural basis for selective vascular endothelial growth factor-A (VEGF-A) binding to neuropilin-1. J Biol Chem. 2012 Mar 30;287(14):11082-9. doi: 10.1074/jbc.M111.331140.Pollock CE, Sutherland HG, Maher BH, et al. The NRP1 migraine risk variant shows evidence of association with menstrual migraine. J Headache Pain. 2018 Apr 18;19(1):31. doi: 10.1186/s10194-018-0857-z.Pollock CE, Sutherland HG, Maher BH, et al. The NRP1 migraine risk variant shows evidence of association with menstrual migraine. J Headache Pain. 2018 Apr 18;19(1):31. doi: 10.1186/s10194-018-0857-z.Pellet-Many C, Frankel P, et al. Neuropilins: structure, function and role in disease. Biochem J. 2008 Apr 15;411(2):211-26. doi: 10.1042/BJ20071639.Pellet-Many C, Frankel P, et al. Neuropilins: structure, function and role in disease. Biochem J. 2008 Apr 15;411(2):211-26. doi: 10.1042/ BJ20071639.Siri M, Dastghaib S, Zamani M, et al. Autophagy, unfolded protein response, and neuropilin-1 cross-talk in SARS-CoV-2 infection: what can be learned from other coronaviruses. Int J Mol Sci. 2021 Jun 1;22(11):5992. doi: 10.3390/ijms22115992.Siri M, Dastghaib S, Zamani M, et al. Autophagy, unfolded protein response, and neuropilin-1 cross-talk in SARS-CoV-2 infection: what can be learned from other coronaviruses. Int J Mol Sci. 2021 Jun 1;22(11):5992. doi: 10.3390/ijms22115992.Sun B, Wu XY, Nie M. [SARS-CoV-2 damages male fertility: How and why]. Zhonghua Nan Ke Xue. 2021 Aug;27(8):738-741. Chinese. PMID: 34914248.Sun B, Wu XY, Nie M. [SARS-CoV-2 damages male fertility: How and why]. Zhonghua Nan Ke Xue. 2021 Aug;27(8):738-741. Chinese. PMID: 34914248.Vander Kooi CW, Jusino MA, Perman B, et al. Structural basis for ligand and heparin binding to neuropilin B domains. Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6152-7. doi: 10.1073/pnas.0700043104.Vander Kooi CW, Jusino MA, Perman B, et al. Structural basis for ligand and heparin binding to neuropilin B domains. Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6152-7. doi: 10.1073/pnas.0700043104.Xu J, Qi L, Chi X, et al. Orchitis: a complicationofsevereacuterespiratorysyndrome (SARS). Biol Reprod. 2006 Feb;74(2):410-6. doi: 10.1095/biolreprod.105.044776.Xu J, Qi L, Chi X, et al. Orchitis: a complication of severe acute respiratory syndrome (SARS). Biol Reprod. 2006 Feb;74(2):410-6. doi: 10.1095/biolreprod.105.044776.Zhao Y, Zhu R, Xiao T, Liu X. Genetic variants in migraine: a field synopsis and systematic re-analysis of meta-analyses. J Headache Pain. 2020 Feb 11;21(1):13. doi: 10.1186/s10194-020-01087-5.Zhao Y, Zhu R, Xiao T, Liu X. Genetic variants in migraine: a field synopsis and systematic re-analysis of meta-analyses. J Headache Pain. 2020 Feb 11;21(1):13. doi: 10.1186/s10194-020-01087-5.

The authors declare that there are no conflicts of interest present.