References

ymj

Якутский медицинский журнал

Yakut Medical Journal

1813-19052312-1017

ЯНЦ КМП

10.25789/YMJ.2026.93.23

ymj-3206

Research Article

НАУЧНЫЕ ОБЗОРЫ

SCIENTIFIC REVIEWS

Влияние внутриопухолевого микробиома на терапию рака поджелудочной железы

The influence of the intratumor microbiome on pancreatic cancer therapy

https://orcid.org/0000-0002-6893-4673

Федорова

М. С.

Fedorova

M. S.

Федорова Мария Сергеевна – канд. биол. наук, мл. науч. сотр.,

ул. Вавилова, д. 32, г. Москва, 119991

fedorowams@yandex.ru

https://orcid.org/0009-0005-1904-7516

Филатова

А. А.

Filatova

A. A.

Филатова Алёна Алексеевна – врачпатологоанатом,

ул. Большая Серпуховская, д. 27, г. Москва, 117997

https://orcid.org/0000-0001-6247-9481

Калинин

Д. В.

Kalinin

D. V.

Калинин Дмитрий Валерьевич – канд. мед. наук, зав. патологоанатомическим отделением,

ул. Большая Серпуховская, д. 27, г. Москва, 117997

https://orcid.org/0000-0002-2942-6393

Павлов

В. С.

Pavlov

V. S.

Павлов Владислав Сергеевич – канд. биол. наук, мл. науч. сотр.,

ул. Вавилова, д. 32, г. Москва, 119991

ФГБУН «Институт молекулярной биологии имени В.А. Энгельгардта Российской академии наук»Россия

ФГБУ «Национальный медицинский исследовательский центр хирургии имени А.В. Вишневского» Министерства здравоохранения Российской ФедерацииРоссия

2026

28032026

01111115

2026

Федорова М.С., Филатова А.А., Калинин Д.В., Павлов В.С.

Fedorova M.S., Filatova A.A., Kalinin D.V., Pavlov V.S.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://ymj.elpub.ru/jour/article/view/3206

Рак поджелудочной железы (РПЖ) представляет собой одну из наиболее сложных проблем современной онкологии. Он отличается повышающимися с каждым годом показателями заболеваемости, крайне низкими показателями выживаемости, агрессивным и нередко бессимптомным течением, что ставит вопрос о необходимости поиска более эффективных терапевтических стратегий. В настоящее время манипуляция микробиомом рассматривается как мощный вспомогательный инструмент, который может повысить эффективность существующих методов лечения. Данный обзор обобщает современные данные о роли внутриопухолевого микробиома в терапии РПЖ, рассматривая его влияние на эффективность лечения и обсуждая потенциал таргетного воздействия на микробные сообщества как вспомогательного метода, способного улучшить исходы пациентов.

Pancreatic cancer represents one of the most challenging problems in modern oncology. It is characterized by annually increasing incidence rates, extremely low survival rates, and aggressive, often asymptomatic progression, raising the question of the need to search for more effective therapeutic strategies. Currently, microbiome manipulation is considered a powerful auxiliary tool that can enhance the effectiveness of existing treatments. This review summarizes current data on the role of the intratumoral microbiome in pancreatic cancer therapy, considering its influence on treatment efficacy and discussing the potential of targeted impact on microbial communities as an auxiliary method capable of improving patient outcomes.

микробиомрак поджелудочной железымикроокружение опухолихимиотерапияиммунотерапиятрансплантация фекальной микробиоты

microbiomepancreatic cancertumor microenvironmentchemotherapyimmunotherapyfecal microbiota transplantation

Работа выполнена в рамках проекта РНФ № 24-25-00460.

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The authors declare that there are no conflicts of interest present.