ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.25789/YMJ.2026.93.20ymj-3202Research ArticleНАУЧНЫЕ ОБЗОРЫSCIENTIFIC REVIEWSПатогенетическое обоснование преконцепционной подготовки для женщин с ожирениемPathogenetic rationale for preconception preparation for obese womenhttps://orcid.org/0000-0002-6779-7566ВинокуроваЕ. А.VinokurovaE. A.

Винокурова Елена Александровна – д-р мед. наук, проф., проф. кафедры акушерства и гинекологии лечебного факультета Института материнства и детства,

ул. Одесская, д. 54, г. Тюмень, 625023

vinokurovaelena@mail.ruhttps://orcid.org/0009-0005-8629-8809КолесоваИ. П.KolesovaI. P.

Колесова Ирина Павловна – студент Института клинической медицины, 

ул. Одесская, д. 54, г. Тюмень, 625023

https://orcid.org/0009-0007-2089-5621ХарлапановаА. В.KharlapanovaA. V.

Харлапанова Анастасия Владимировна – врач акушер-гинеколог, 

ул. Народная 6/1, г. Тюмень, 625046

ФГБОУ ВО «Тюменский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииRussian FederationГАУЗ Тюменской области «Городская поликлиника №12»Russian Federation202628032026019599Copyright © Винокурова Е.А., Колесова И.П., Харлапанова А.В., 20262026Винокурова Е.А., Колесова И.П., Харлапанова А.В.Vinokurova E.A., Kolesova I.P., Kharlapanova A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/3202

В литературном обзоре представлен анализ современных данных о влиянии ожирения на репродуктивную функцию женщин и частоту невынашивания беременности. Рассмотрены эпидемиологические аспекты проблемы, показывающие, что в России избыточную массу тела, имеют около 60% женщин репродуктивного возраста, а ожирение — более 30%. Особое внимание уделено анализу патогенетических механизмов, включающих инсулинорезистентность и гиперандрогению, хроническое системное воспаление и оксидативный стресс, дисфункцию эндометрия и снижение качества ооцитов. На основе анализа литературных данных обоснована необходимость комплексного междисциплинарного подхода к прегравидарной подготовке женщин с ожирением, включающего модификацию образа жизни, медикаментозную коррекцию метаболических нарушений и психологическую поддержку.

This literature review analyzes current data on the impact of obesity on female reproductive function and miscarriage of pregnancy rates. It examines epidemiological aspects revealing that in Russia approximately 60% of women of reproductive age are overweight and over 30% have obesity. Particular attention is given to the analysis of pathogenetic mechanisms including insulin resistance and hyperandrogenism chronic systemic inflammation and oxidative stress as well as endometrial dysfunction and impaired oocyte quality. Based on the analyzed data the review substantiates the necessity for a comprehensive multidisciplinary approach to the preconception care of women with obesity encompassing lifestyle modification pharmacological management of metabolic disorders and psychological support.

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The authors declare that there are no conflicts of interest present.