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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ymj</journal-id><journal-title-group><journal-title xml:lang="ru">Якутский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Yakut Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1813-1905</issn><issn pub-type="epub">2312-1017</issn><publisher><publisher-name>ЯНЦ КМП</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.25789/YMJ.2023.82.01</article-id><article-id custom-type="elpub" pub-id-type="custom">ymj-32</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL RESEARCH</subject></subj-group></article-categories><title-group><article-title>Моделирование гипоксии печени в эксперименте in vivo</article-title><trans-title-group xml:lang="en"><trans-title>Modeling of liver hypoxia in an in vivo experiment</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гончарова</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Goncharova</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Анна Сергеевна Гончарова, к. б. н., зав. центром</p><p>испытательный лабораторный центр</p><p>Ростов-на-Дону</p></bio><bio xml:lang="en"><p>Rostov-on-Don</p></bio><email xlink:type="simple">fateyeva_a_s@list.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гурова</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Gurova</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Софья Валерьевна Гурова, м. н. с.</p><p>Ростов-на-Дону</p></bio><bio xml:lang="en"><p>Rostov-on-Don</p></bio><email xlink:type="simple">gurova.sophie@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ходакова</surname><given-names>Д. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Khodakova</surname><given-names>D. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дарья Владиславовна Ходакова, м. н. с.</p><p>Ростов-на-Дону</p></bio><bio xml:lang="en"><p>Rostov-on-Don</p></bio><email xlink:type="simple">khodakovaDV@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кечерюкова</surname><given-names>Т. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Kecheryukova</surname><given-names>T. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Тахмина Мажитовна Кечерюкова, врач по рентгенэндоваскулярным методам диагностики и лечения</p><p>Ростов-на-Дону</p></bio><bio xml:lang="en"><p>Rostov-on-Don</p></bio><email xlink:type="simple">tkecheryukova@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Максимов</surname><given-names>А. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Maksimov</surname><given-names>A. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Алексей Юрьевич Максимов, д. м. н., зам. генерального директора по перспективным научным разработкам</p><p>Ростов-на-Дону</p></bio><bio xml:lang="en"><p>Rostov-on-Don</p></bio><email xlink:type="simple">m.d.n.maksimov@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лаптева</surname><given-names>Т. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Lapteva</surname><given-names>T. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Татьяна Олеговна Лаптева, зав. отделением</p><p>патологоанатомическое отделение</p><p>Ростов-на-Дону</p></bio><bio xml:lang="en"><p>Rostov-on-Don</p></bio><email xlink:type="simple">lto-96@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Романова</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Romanova</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мария Вадимовна Романова, м. н. с.</p><p>Ростов-на-Дону</p></bio><bio xml:lang="en"><p>Rostov-on-Don</p></bio><email xlink:type="simple">m.v.mindar@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Аллилуева</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Allilueva</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Екатерина Владиславовна Аллилуева, м. н. с.</p><p>Ростов-на-Дону</p></bio><bio xml:lang="en"><p>Rostov-on-Don</p></bio><email xlink:type="simple">katherine_bio@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «Национальный медицинский исследовательский центр онкологии» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal State Budgetary Institution "National Medical Research Center of Oncology" of the Ministry of Health of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>03</day><month>02</month><year>2025</year></pub-date><volume>0</volume><issue>2</issue><fpage>5</fpage><lpage>8</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Гончарова А.С., Гурова С.В., Ходакова Д.В., Кечерюкова Т.М., Максимов А.Ю., Лаптева Т.О., Романова М.В., Аллилуева Е.В., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Гончарова А.С., Гурова С.В., Ходакова Д.В., Кечерюкова Т.М., Максимов А.Ю., Лаптева Т.О., Романова М.В., Аллилуева Е.В.</copyright-holder><copyright-holder xml:lang="en">Goncharova A.S., Gurova S.V., Khodakova D.V., Kecheryukova T.M., Maksimov A.Y., Lapteva T.O., Romanova M.V., Allilueva E.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://ymj.elpub.ru/jour/article/view/32">https://ymj.elpub.ru/jour/article/view/32</self-uri><abstract><p>   Проведено исследование влияния редукции кровотока портальной триады на уровень ферментов печени, ее состояние и выживаемость лабораторных мышей. Уровни аланинаминотрансферазы и аспартатаминотрансферазы в обеих группах с редукцией кровотока были статистически значимо выше, чем в контрольной, а также статистически значимо выше в группе с забором крови через 24 ч после реперфузии по сравнению с группой с забором крови через 2 ч после реперфузии. Гистологическое исследование показало признаки ишемического повреждения тканей, также наблюдалось увеличение количества сосудов в препаратах печени животных с редукцией кровотока по сравнению с контролем. Уровень выживаемости животных после выполнения процедуры составил более 80 %, что является удовлетворительным, но, тем не менее, указывает на необходимость такого количества животных, которое позволит выполнить статистическую обработку результатов даже в случае гибели некоторых особей. Результаты исследования показали, что полученная модель является важным инструментом для исследований в области изучения патологических состояний печени, связанных с ишемическими и гипоксическими условиями.</p></abstract><trans-abstract xml:lang="en"><p>   The effect of portal triad blood flow reduction on liver enzyme levels, liver condition, and survival in laboratory mice was studied. Alanine aminotransferase and aspartate aminotransferase levels in both blood flow reduction groups were statistically significantly higher than in the control group, and statistically significantly higher in the blood sampling group 24 hours after reperfusion compared to the blood sampling group 2 hours after reperfusion. Histological examination showed signs of ischemic tissue damage, and an increase in the number of vessels in liver preparations from animals with blood flow reduction compared to the control group was observed. The survival rate of animals after the procedure was more than 80 %, which is satisfactory, but nevertheless indicates the need for a number of animals that will allow statistical processing of the results even in the event of death of some individuals. The results of the study showed that the obtained model is an important tool for research in the field of studying pathological conditions of the liver associated with ischemic and hypoxic conditions.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>гипоксия</kwd><kwd>оксигенация</kwd><kwd>печень</kwd><kwd>заболевания печени</kwd><kwd>модели in vivo</kwd></kwd-group><kwd-group xml:lang="en"><kwd>hypoxia</kwd><kwd>oxygenation</kwd><kwd>liver</kwd><kwd>liver diseases</kwd><kwd>in vivo models</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Кит О.И., Гончарова А.С., Лукбанова Е.А. 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