ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.25789/YMJ.2022.80.21ymj-306Research ArticleАКТУАЛЬНАЯ ТЕМАACTUAL TOPICДисбаланс липидов у жителей г. Якутска при инфицировании вирусом SARS-COV-2 и в постковидный периодLipid imbalance in Yakutsk residents when infected with the SARS-CoV-2 virus and in the post-covid periodЯковлеваА. И.YakovlevaA. I.

Яковлева Александра Ивановна – н.с.

akovleva Alexandra Ivanovna – researcher, Laboratory of Biochemical and Immunological Research

sashyak@mail.ruОлесоваЛ. Д.OlesovaL D.

Олесова Любовь Дыгыновна – в.н.с.

Olesova Lyubov Dygynovna – external researcher, Laboratory of Biochemical and Immunological Research

oles59@mail.ruОхлопковаЕ. Д.OkhlopkovaE. D.

Охлопкова Елена Дмитриевна – с.н.с.

Okhlopkova Elena Dmitrievna – senior researcher, Laboratory of Biochemical and Immunological Research

elena_okhlopkova@mail.ruЯкутский научный центр комплексных медицинских проблемРоссияYakut Science Centre for Complex Medical ProblemsRussian Federation202207022025047983Copyright © Яковлева А.И., Олесова Л.Д., Охлопкова Е.Д., 20252025Яковлева А.И., Олесова Л.Д., Охлопкова Е.Д.Yakovleva A.I., Olesova L.D., Okhlopkova E.D.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/306

Проведено исследование липидного обмена у жителей г. Якутска в возрасте от 20 до 72 лет, перенесших заболевание новой коронавирусной инфекцией SARS-CoV-2 сроком от 3 до 12 месяцев назад. Целью работы явилось изучение изменения показателей фракций липидов у пациентов, перенесших COVID-19, в зависимости от срока и тяжести заболевания.

По результатам исследования при инфицировании вирусом SARS-CoV-2 происходит нарушение метаболизма липидов: уровень общего холестерина снижается в остром и значимо повышается в постковидном периоде. Наиболее выраженный сдвиг липидного профиля в сторону атерогенности происходит у переболевших COVID-19 три месяца назад за счет снижения антиатерогенной фракции липидов. Дислипидемия наиболее выражена у пациентов, перенесших инфекцию с тяжелым поражением легких (50-75%), вследствие повышения атерогенных фракций липидов, что повышает риск развития кардиоваскулярных заболеваний.

According to the results of the study, when infected with the SARS-CoV-2 virus, lipid metabolism is disturbed: in the acute period of infection, the level of total cholesterol decreases, in the post-COVID period, its level significantly increases. The most pronounced shift in the lipid profile towards atherogenicity occurs in patients who recovered from COVID-19 three months ago due to a decrease in the antiatherogenic fraction of lipids. Dyslipidemia is most pronounced in patients who have had an infection with severe lung damage (50-75%) due to an increase in atherogenic lipid fractions that create a risk of atherosclerosis.

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The authors declare that there are no conflicts of interest present.