ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.25789/YMJ.2020.71.27ymj-2999Research ArticleНАУЧНЫЕ ОБЗОРЫ И ЛЕКЦИИSCIENTIFIC REVIEWS AND LECTURESНейротрофический фактор мозга (BDNF) и его диагностическая значимость при измерении в крови: аналитический обзорBrain neurotrophic factor (bdnf) and its diagnostic significance when measured in blood: analytical reviewШвайковскаяА. А.ShvaikovskayaA. A.

Швайковская Анна Андреевна – студент

a.a.shvaikovskaya@mail.ruЖанаеваС. Я.ZhanaevaS. Y.

Жанаева Светлана Яковлевна – к.б.н.

ЕвсюковаА. В.EvsyukovaA. V.

Евсюкова Александра Владиславовна – студент

ТихоноваМ. А.TikhonovaM. A.

Тихонова Мария Александровна – д.б.н., зав. лаб.

ДаниленкоК. В.DanilenkoK. V.

Даниленко Константин Васильевич – д.м.н., зам. директора по науч. и лечебной работе

АфтанасЛ. И.AftanasL. I.

Афтанас Любомир Иванович – д.м.н., проф., акад. РАН, директор института

Институт медицины и психологии В. Зельмана Новосибирского ГУRussian FederationНИИ физиологии и фундаментальной медициныRussian Federation20201112202503105110Copyright © Швайковская А.А., Жанаева С.Я., Евсюкова А.В., Тихонова М.А., Даниленко К.В., Афтанас Л.И., 20252025Швайковская А.А., Жанаева С.Я., Евсюкова А.В., Тихонова М.А., Даниленко К.В., Афтанас Л.И.Shvaikovskaya A.A., Zhanaeva S.Y., Evsyukova A.V., Tikhonova M.A., Danilenko K.V., Aftanas L.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/2999

В обзоре приведены основные сведения о биологической роли, содержании и регуляции нейротрофического фактора мозга (BDNF) в организме (раздел I), о концентрации BDNF в крови при нейропсихических заболеваниях (раздел II) и выполнен анализ сопряженности содержания BDNF в головном мозге и периферической крови (раздел III, основной).

The review provides basic information on the biological role, content and regulation of brain neurotrophic factor (BDNF) in the body (section I), on the concentration of BDNF in the blood in neuropsychiatric diseases (section II), and analyzes the relationship between the content of BDNF in the brain and peripheral blood (section III, main).

человекнейротрофический фактор мозга (BDNF)нейропсихические заболеванияголовной мозгкровькорреляция между мозгом и кровьюhumanbrain-derived neurotrophic factor (BDNF)neuroplasticityneuropsychic diseasesbrainbloodcorrelation between brain and bloodБюджетное финансирование НИИФФМ на проведение поискового научного исследования 2016 года (результаты, относящиеся к рис. 1) и фундаментальных научных исследований (тема АААА-А16-116021010228-0).ReferencesЛевчук Л. А. Роль BDNF в патогенезе неврологических и психиатрических расстройств/ Л. А. Левчук //Современные проблемы науки и образования. – 2018. – №. 6. – С. 58.Levchuk L. A. The role of BDNF in the pathogenesis of neurological and psychiatric disorders / L. A. Levchuk // Modern problems of science and education. - 2018. - №6. - P. 58.Склероз гиппокампа: патогенез, клиника, диагностика, лечение/ Д.Н. Копачев [и др.] // Вопросы нейрохирургии» имени НН Бурденко. – 2016. – Т. 80, №. 4. – С. 109-116.Sclerosis of the hippocampus: pathogenesis, clinical picture, diagnosis, treatment / D.N. Kopachev [et al.] // J Questions of neurosurgery named after N.N. Burdenko. - 2016. - V. 80, №4. - P. 109-116.A 6-day combined wake and light therapy trial for unipolar depression / K. V. Danilenko, M. Y. Lebedinskaia, E. V. Gadetskaia [et al.] // Journal of affective disorders. – 2019. – V. 259. – P. 355-361.A 6-day combined wake and light therapy trial for unipolar depression / K. V. Danilenko, M. Y. Lebedinskaia, E. V. Gadetskaia [et al.] // Journal of affective disorders. – 2019. – V. 259. – P. 355-361.A method for reproducible measurements of serum BDNF: comparison of the performance of six commercial assays / A. Polacchini, G. Metelli, R. Francavilla [et al.] // Scientific reports. – 2015. – V. 5. – P. 17989.A method for reproducible measurements of serum BDNF: comparison of the performance of six commercial assays / A. Polacchini, G. Metelli, R. Francavilla [et al.] // Scientific reports. – 2015. – V. 5. – P. 17989.A study of brain and serum brain-derived neurotrophic factor protein in Wistar and Wistar-Kyoto rat strains after electroconvulsive stimulus / C. Kyeremanteng, J. James, J. Mackay [et al.] // Pharmacopsychiatry. – 2012. – V. 45. – № 06. – P. 244-249.A study of brain and serum brain-derived neurotrophic factor protein in Wistar and Wistar-Kyoto rat strains after electroconvulsive stimulus / C. Kyeremanteng, J. James, J. Mackay [et al.] // Pharmacopsychiatry. – 2012. – V. 45. – № 06. – P. 244-249.Acute low-dose ketamine produces a rapid and robust increase in plasma BDNF without altering brain BDNF concentrations / M. Le Nedelec, P. Glue, H. Winter [et al.] // Drug delivery and translational research. – 2018. – V. 8. – № 3. – P. 780-786.Acute low-dose ketamine produces a rapid and robust increase in plasma BDNF without altering brain BDNF concentrations / M. Le Nedelec, P. Glue, H. Winter [et al.] // Drug delivery and translational research. – 2018. – V. 8. – № 3. – P. 780-786.Altered expression of BDNF, BDNF pro-peptide and their precursor proBDNF in brain and liver tissues from psychiatric disorders: rethinking the brain–liver axis / B. Yang, Q. Ren, J.C. Zhang [et al.] //Translational psychiatry. – 2017. – V. 7. – № 5. – P. e1128-e1128.Altered expression of BDNF, BDNF pro-peptide and their precursor proBDNF in brain and liver tissues from psychiatric disorders: rethinking the brain–liver axis / B. Yang, Q. Ren, J.C. Zhang [et al.] //Translational psychiatry. – 2017. – V. 7. – № 5. – P. e1128-e1128.Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI) patients are characterized by increased BDNF serum levels / F. Angelucci, G. Spalletta, F. di Iulio [et al.] //Current Alzheimer Research. – 2010. – V. 7. – № 1. – P. 15-20.Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI) patients are characterized by increased BDNF serum levels / F. Angelucci, G. Spalletta, F. di Iulio [et al.] //Current Alzheimer Research. – 2010. – V. 7. – № 1. – P. 15-20.Barde Y. A., Edgar D., Thoenen H. Purification of a new neurotrophic factor from mammalian brain //The EMBO journal. – 1982. – V. 1. – № 5. – P. 549-553.Barde Y. A., Edgar D., Thoenen H. Purification of a new neurotrophic factor from mammalian brain //The EMBO journal. – 1982. – V. 1. – № 5. – P. 549-553.BDNF and epilepsy: too much of a good thing? / D. K. Binder, S. D. Croll, C.M. Gall [et al.] // Trends in neurosciences. – 2001. – V. 24. – № 1. – P. 47-53.BDNF and epilepsy: too much of a good thing? / D. K. Binder, S. D. Croll, C.M. Gall [et al.] // Trends in neurosciences. – 2001. – V. 24. – № 1. – P. 47-53.BDNF concentrations are decreased in serum and parietal cortex in immunotoxin 192 IgGSaporin rat model of cholinergic degeneration / F. Angelucci, F. Gelfo, P. De Bartolo [et al.] // Neurochemistry international. – 2011. – V. 59. – № 1. – P. 1-4.BDNF concentrations are decreased in serum and parietal cortex in immunotoxin 192 IgGSaporin rat model of cholinergic degeneration / F. Angelucci, F. Gelfo, P. De Bartolo [et al.] // Neurochemistry international. – 2011. – V. 59. – № 1. – P. 1-4.BDNF promoter I methylation correlates between post-mortem human peripheral and brain tissues / L. Stenz, S. Zewdie, T. Laforge-Escarra [et al.] // Neuroscience research. – 2015. – V. 91. – P. 1-7.BDNF promoter I methylation correlates between post-mortem human peripheral and brain tissues / L. Stenz, S. Zewdie, T. Laforge-Escarra [et al.] // Neuroscience research. – 2015. – V. 91. – P. 1-7.BDNF serum levels with respect to multidimensional assessment in amyotrophic lateral sclerosis / L. Tremolizzo, A. Pellegrini, E. Conti [et al.] //Neurodegenerative Diseases. – 2016. – V. 16. – № 3-4. – P. 192-198.BDNF serum levels with respect to multidimensional assessment in amyotrophic lateral sclerosis / L. Tremolizzo, A. Pellegrini, E. Conti [et al.] //Neurodegenerative Diseases. – 2016. – V. 16. – № 3-4. – P. 192-198.BDNF: a key factor with multipotent impact on brain signaling and synaptic plasticity / P. Kowiański, G. Lietzau, E. Czuba [et al] //Cellular and molecular neurobiology. – 2018. – V. 38. – №. 3. – P. 579-593.BDNF: a key factor with multipotent impact on brain signaling and synaptic plasticity / P. Kowiański, G. Lietzau, E. Czuba [et al] //Cellular and molecular neurobiology. – 2018. – V. 38. – №. 3. – P. 579-593.BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases / B. Lu, G. Nagappan, X. Guan [et al.] // Nature Reviews Neuroscience. – 2013. – V. 14. – № 6. – P. 401-416.BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases / B. Lu, G. Nagappan, X. Guan [et al.] // Nature Reviews Neuroscience. – 2013. – V. 14. – № 6. – P. 401-416.Benarroch E. E. Brain-derived neurotrophic factor Regulation, effects, and potential clinical relevance // Neurology. – 2015. – P. 10.1212/WNL.0000000000001507.Benarroch E. E. Brain-derived neurotrophic factor Regulation, effects, and potential clinical relevance // Neurology. – 2015. – P. 10.1212/WNL.0000000000001507.Blood BDNF concentrations reflect brain-tissue BDNF levels across species / A. B. Klein, R. Williamson, M. A. Santini [et al.] // International Journal of Neuropsychopharmacology. – 2011. – V. 14. – № 3. – P. 347-353.Blood BDNF concentrations reflect brain-tissue BDNF levels across species / A. B. Klein, R. Williamson, M. A. Santini [et al.] // International Journal of Neuropsychopharmacology. – 2011. – V. 14. – № 3. – P. 347-353.Brain-derived neurotrophic factor and antidepressive effect of electroconvulsive therapy: systematic review and meta-analyses of the preclinical and clinical literature / M. Polyakova, M. L. Schroeter, B. M. Elzinga [et al.] // PLoS one. – 2015. – V. 10. – № 11.Brain-derived neurotrophic factor and antidepressive effect of electroconvulsive therapy: systematic review and meta-analyses of the preclinical and clinical literature / M. Polyakova, M. L. Schroeter, B. M. Elzinga [et al.] // PLoS one. – 2015. – V. 10. – № 11.Brain-derived neurotrophic factor in adjuvant-induced arthritis in rats. Relationship with inflammation and endothelial dysfunction / M. Pedard, C. Demougeot, C. Prati [et al.] //Progress in Neuro-Psychopharmacology and Biological Psychiatry. – 2018. – V. 82. – P. 249-254.Brain-derived neurotrophic factor in adjuvant-induced arthritis in rats. Relationship with inflammation and endothelial dysfunction / M. Pedard, C. Demougeot, C. Prati [et al.] //Progress in Neuro-Psychopharmacology and Biological Psychiatry. – 2018. – V. 82. – P. 249-254.Brain-derived neurotrophic factor in brain disorders: focus on neuroinflammation / B. L. Giacobbo, J. Doorduin, H. C. Klein [et al.] // Molecular neurobiology. – 2019. – V. 56. – № 5. – P. 3295-3312.Brain-derived neurotrophic factor in brain disorders: focus on neuroinflammation / B. L. Giacobbo, J. Doorduin, H. C. Klein [et al.] // Molecular neurobiology. – 2019. – V. 56. – № 5. – P. 3295-3312.Brain-derived neurotrophic factor is stored in human platelets and released by agonist stimulation / H. Fujimura, C. A. Altar, R. Chen [et al.] // Thrombosis and haemostasis. – 2002. – V. 87. – № 04. – P. 728-734.Brain-derived neurotrophic factor is stored in human platelets and released by agonist stimulation / H. Fujimura, C. A. Altar, R. Chen [et al.] // Thrombosis and haemostasis. – 2002. – V. 87. – № 04. – P. 728-734.Brunoni A. R., Lopes M., Fregni F. A systematic review and meta-analysis of clinical studies on major depression and BDNF levels: implications for the role of neuroplasticity in depression // International Journal of Neuropsychopharmacology. – 2008. – V. 11. – № 8. – P. 1169-1180.Brunoni A. R., Lopes M., Fregni F. A systematic review and meta-analysis of clinical studies on major depression and BDNF levels: implications for the role of neuroplasticity in depression // International Journal of Neuropsychopharmacology. – 2008. – V. 11. – № 8. – P. 1169-1180.Castrén E., Kojima M. Brain-derived neurotrophic factor in mood disorders and antidepressant treatments // Neurobiology of disease. – 2017. – V. 97. – P. 119-126.Castrén E., Kojima M. Brain-derived neurotrophic factor in mood disorders and antidepressant treatments // Neurobiology of disease. – 2017. – V. 97. – P. 119-126.Correlations and discrepancies between serum and brain tissue levels of neurotrophins after electroconvulsive treatment in rats / A. Sartorius, R. Hellweg, J. Litzke [et al.] //Pharmacopsychiatry. – 2009. – V. 42. – № 06. – P. 270-276.Correlations and discrepancies between serum and brain tissue levels of neurotrophins after electroconvulsive treatment in rats / A. Sartorius, R. Hellweg, J. Litzke [et al.] //Pharmacopsychiatry. – 2009. – V. 42. – № 06. – P. 270-276.de Assis G. G., Almondes K. M. Exercise-dependent BDNF as a modulatory factor for the executive processing of individuals in course of cognitive decline. A systematic review //Frontiers in psychology. – 2017. – V. 8. – P. 584.de Assis G. G., Almondes K. M. Exercise-dependent BDNF as a modulatory factor for the executive processing of individuals in course of cognitive decline. A systematic review //Frontiers in psychology. – 2017. – V. 8. – P. 584.Decreased serum brain-derived neurotrophic factor (BDNF) levels in patients with Alzheimer’s disease (AD): A systematic review and meta-analysis / T.K.S. Ng, C.S.H. Ho, W.W.S. Tam [et al.] //International journal of molecular sciences. – 2019. – V. 20. – № 2. – P. 257.Decreased serum brain-derived neurotrophic factor (BDNF) levels in patients with Alzheimer’s disease (AD): A systematic review and meta-analysis / T.K.S. Ng, C.S.H. Ho, W.W.S. Tam [et al.] //International journal of molecular sciences. – 2019. – V. 20. – № 2. – P. 257.Duman R. S. A neurotrophic model for stress-related mood disorders / R. S. Duman, L. M. Monteggia // Biological psychiatry. – 2006. – V. 59. – № 12. – P. 1116-1127.Duman R. S. A neurotrophic model for stress-related mood disorders / R. S. Duman, L. M. Monteggia // Biological psychiatry. – 2006. – V. 59. – № 12. – P. 1116-1127.Early diagnosis of Alzheimer’s disease from elevated olfactory mucosal miR-206 level / J. Moon, S. T. Lee, I. G. Kong [et al.] // Scientific reports. – 2016. – V. 6. – № 1. – P. 1-9.Early diagnosis of Alzheimer’s disease from elevated olfactory mucosal miR-206 level / J. Moon, S. T. Lee, I. G. Kong [et al.] // Scientific reports. – 2016. – V. 6. – № 1. – P. 1-9.Effect of social isolation stress on saliva BDNF in rat / Y. Nakagawa, M. To, J. Saruta, Y. Yamamoto [et al.] //Journal of oral science. – 2019. – V. 61. – № 4. – P. 516-520.Effect of social isolation stress on saliva BDNF in rat / Y. Nakagawa, M. To, J. Saruta, Y. Yamamoto [et al.] //Journal of oral science. – 2019. – V. 61. – № 4. – P. 516-520.Estradiol and striatal dopamine receptor antagonism influence memory system bias in the female rat / M. G. Quinlan, A. Almey, M. Caissie [et al.] // Neurobiology of learning and memory. – 2013. – V. 106. – P. 221-229.Estradiol and striatal dopamine receptor antagonism influence memory system bias in the female rat / M. G. Quinlan, A. Almey, M. Caissie [et al.] // Neurobiology of learning and memory. – 2013. – V. 106. – P. 221-229.Expression analysis of GRIN2B, BDNF, and IL-1β genes in the whole blood of epileptic patients / A. Zhand, A. Sayad, S. Ghafouri-Fard [et al.] // Neurological Sciences. – 2018. – V. 39. – №. 11. – P. 1945-1953.Expression analysis of GRIN2B, BDNF, and IL-1β genes in the whole blood of epileptic patients / A. Zhand, A. Sayad, S. Ghafouri-Fard [et al.] // Neurological Sciences. – 2018. – V. 39. – №. 11. – P. 1945-1953.Gan K. J. Dendritic and axonal mechanisms of Ca2+ elevation impair BDNF transport in Aβ oligomer–treated hippocampal neurons / K. J. Gan, M. A. Silverman // Molecular biology of the cell. – 2015. – V. 26. – №. 6. – P. 1058-1071.Gan K. J. Dendritic and axonal mechanisms of Ca2+ elevation impair BDNF transport in Aβ oligomer–treated hippocampal neurons / K. J. Gan, M. A. Silverman // Molecular biology of the cell. – 2015. – V. 26. – №. 6. – P. 1058-1071.Hashimoto K. Molecular mechanisms of the rapid-acting and long-lasting antidepressant actions of (R)-ketamine / K. Hashimoto // Biochemical Pharmacology. – 2020. – V. 177, 113935 doi: 10.1016/j.bcp.2020.113935Hashimoto K. Molecular mechanisms of the rapid-acting and long-lasting antidepressant actions of (R)-ketamine / K. Hashimoto // Biochemical Pharmacology. – 2020. – V. 177, 113935 doi: 10.1016/j.bcp.2020.113935Higher brain BDNF gene expression is associated with slower cognitive decline in older adults / A. S. Buchman, L.Yu, P. A. Boyle [et al.] // Neurology. – 2016. – V. 86. – №. 8. – P. 735-741.Higher brain BDNF gene expression is associated with slower cognitive decline in older adults / A. S. Buchman, L.Yu, P. A. Boyle [et al.] // Neurology. – 2016. – V. 86. – №. 8. – P. 735-741.Huang Y. Peripheral BDNF/TrkB protein expression is decreased in Parkinson’s disease but not in Essential tremor / Y. Huang, C. Huang, W. Yun // Journal of Clinical Neuroscience. – 2019. – V. 63. – P. 176-181.Huang Y. Peripheral BDNF/TrkB protein expression is decreased in Parkinson’s disease but not in Essential tremor / Y. Huang, C. Huang, W. Yun // Journal of Clinical Neuroscience. – 2019. – V. 63. – P. 176-181.Human hippocampal neurogenesis persists throughout aging / M. Boldrini, C. A. Fulmore, A. N. Tartt [et al.] // Cell stem cell. – 2018. – V. 22. – №. 4. – P. 589-599. e5.Human hippocampal neurogenesis persists throughout aging / M. Boldrini, C. A. Fulmore, A. N. Tartt [et al.] // Cell stem cell. – 2018. – V. 22. – №. 4. – P. 589-599. e5.Hyperammonemia compromises glutamate metabolism and reduces BDNF in the rat hippocampus / F. Galland, E. Negri, C. Da Ré [et al.] // Neurotoxicology. – 2017. – V. 62. – P. 46-55.Hyperammonemia compromises glutamate metabolism and reduces BDNF in the rat hippocampus / F. Galland, E. Negri, C. Da Ré [et al.] // Neurotoxicology. – 2017. – V. 62. – P. 46-55.Illness severity and biomarkers in depression: using a unidimensional rating scale to examine BDNF / M. A. Caldieraro, E. A. Vares, L. H. Souza [et al.] // Comprehensive psychiatry. – 2017. – V. 75. – P. 46-52.Illness severity and biomarkers in depression: using a unidimensional rating scale to examine BDNF / M. A. Caldieraro, E. A. Vares, L. H. Souza [et al.] // Comprehensive psychiatry. – 2017. – V. 75. – P. 46-52.Increased hippocampal BDNF immunoreactivity in subjects treated with antidepressant medication / B. Chen, D. Dowlatshahi, G. M. MacQueen [et al.] // Biological psychiatry. – 2001. – V. 50. – №. 4. – P. 260-265.Increased hippocampal BDNF immunoreactivity in subjects treated with antidepressant medication / B. Chen, D. Dowlatshahi, G. M. MacQueen [et al.] // Biological psychiatry. – 2001. – V. 50. – №. 4. – P. 260-265.Karege F. Postnatal developmental profile of brain-derived neurotrophic factor in rat brain and platelets / F. Karege, M. Schwald, M. Cisse //Neuroscience letters. – 2002. – V. 328. – №. 3. – P. 261-264.Karege F. Postnatal developmental profile of brain-derived neurotrophic factor in rat brain and platelets / F. Karege, M. Schwald, M. Cisse //Neuroscience letters. – 2002. – V. 328. – №. 3. – P. 261-264.Libman-Sokołowska M. BDNF as a biomarker in the course and treatment of schizophrenia / M. Libman-Sokołowska, E. Drozdowicz, T. Nasierowski // Psychiatr. Pol. – 2015. – V. 49. – №. 6. – P. 1149-1158.Libman-Sokołowska M. BDNF as a biomarker in the course and treatment of schizophrenia / M. Libman-Sokołowska, E. Drozdowicz, T. Nasierowski // Psychiatr. Pol. – 2015. – V. 49. – №. 6. – P. 1149-1158.Lima S. M. A. Neurogenesis in the hippocampus of adult humans: controversy "fixed" at last / S. M. A. Lima, W. Gomes-Leal // Neural regeneration research. – 2019. – V. 14. – №. 11. – P. 1917.Lima S. M. A. Neurogenesis in the hippocampus of adult humans: controversy "fixed" at last / S. M. A. Lima, W. Gomes-Leal // Neural regeneration research. – 2019. – V. 14. – №. 11. – P. 1917.McGregor C. E., English A. W. The role of BDNF in peripheral nerve regeneration: activity-dependent treatments and Val66Met / C. E. McGregor, A. W. English // Frontiers in cellular neuroscience. – 2018. – V. 12.McGregor C. E., English A. W. The role of BDNF in peripheral nerve regeneration: activity-dependent treatments and Val66Met / C. E. McGregor, A. W. English // Frontiers in cellular neuroscience. – 2018. – V. 12.Meta-analyses of comparative efficacy of antidepressant medications on peripheral BDNF concentration in patients with depression / C. Zhou, J. Zhong, B. Zou [et al.] // PLoS One. – 2017. – V. 12. – №. 2.Meta-analyses of comparative efficacy of antidepressant medications on peripheral BDNF concentration in patients with depression / C. Zhou, J. Zhong, B. Zou [et al.] // PLoS One. – 2017. – V. 12. – №. 2.Murer M.G. Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease / M.G. Murer, Q. Yanb, R. Raisman-Vozari // Progress in Neurobiology. – 2001. – V. 63. – P. 71-124. DOI: 10.1016/s0301-0082(00)00014-9Murer M.G. Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease / M.G. Murer, Q. Yanb, R. Raisman-Vozari // Progress in Neurobiology. – 2001. – V. 63. – P. 71-124. DOI: 10.1016/s0301-0082(00)00014-9Neurotrophin expression in lymphocytes: a powerful indicator of degeneration in Parkinson’s disease, amyotrophic lateral sclerosis and ataxia / A. Sadanand, A. Janardhanan, A.J. Vanisree [et al.] //Journal of Molecular Neuroscience. – 2018. – V. 64. – №. 2. – P. 224-232.Neurotrophin expression in lymphocytes: a powerful indicator of degeneration in Parkinson’s disease, amyotrophic lateral sclerosis and ataxia / A. Sadanand, A. Janardhanan, A.J. Vanisree [et al.] //Journal of Molecular Neuroscience. – 2018. – V. 64. – №. 2. – P. 224-232.Novkovic T. BDNF contributes to the facilitation of hippocampal synaptic plasticity and learning enabled by environmental enrichment / T. Novkovic, T. Mittmann, D. Manahan-Vaughan // Hippocampus. – 2015. – V. 25. – №. 1. – P. 1-15.Novkovic T. BDNF contributes to the facilitation of hippocampal synaptic plasticity and learning enabled by environmental enrichment / T. Novkovic, T. Mittmann, D. Manahan-Vaughan // Hippocampus. – 2015. – V. 25. – №. 1. – P. 1-15.Peripheral brain-derived neurotrophic factor levels in Alzheimer’s disease and mild cognitive impairment: a comprehensive systematic review and meta-analysis / B.Y. Kim, S.H. Lee, P.L. Graham [et al.] //Molecular neurobiology. – 2017. – V. 54. – №. 9. – P. 7297-7311Peripheral brain-derived neurotrophic factor levels in Alzheimer’s disease and mild cognitive impairment: a comprehensive systematic review and meta-analysis / B.Y. Kim, S.H. Lee, P.L. Graham [et al.] //Molecular neurobiology. – 2017. – V. 54. – №. 9. – P. 7297-7311Plasma brain-derived neurotrophic factor daily variations in men: correlation with cortisol circadian rhythm / S. Begliuomini, E. Lenzi, F Ninni [et al.] // Journal of Endocrinology. – 2008. – V. 197. – №. 2. – P. 429-436.Plasma brain-derived neurotrophic factor daily variations in men: correlation with cortisol circadian rhythm / S. Begliuomini, E. Lenzi, F Ninni [et al.] // Journal of Endocrinology. – 2008. – V. 197. – №. 2. – P. 429-436.Postmortem brain, cerebrospinal fluid, and blood neurotrophic factor levels in Alzheimer’s disease: a systematic review and meta-analysis / Y. Du, H. T. Wu, X. Y. Qin [et al.] // Journal of Molecular Neuroscience. – 2018. – V. 65. – №. 3. – P. 289-300.Postmortem brain, cerebrospinal fluid, and blood neurotrophic factor levels in Alzheimer’s disease: a systematic review and meta-analysis / Y. Du, H. T. Wu, X. Y. Qin [et al.] // Journal of Molecular Neuroscience. – 2018. – V. 65. – №. 3. – P. 289-300.Pradhan J. The role of altered BDNF/ TrkB signalling in amyotrophic lateral sclerosis / J. Pradhan, P. G. Noakes, M. C. Bellingham // Frontiers in cellular neuroscience. – 2019. – V. 13. – P. 368.Pradhan J. The role of altered BDNF/ TrkB signalling in amyotrophic lateral sclerosis / J. Pradhan, P. G. Noakes, M. C. Bellingham // Frontiers in cellular neuroscience. – 2019. – V. 13. – P. 368.Presence of brain-derived neurotrophic factor in brain and human and rat but not mouse serum detected by a sensitive and specific immunoassay / S.F. Radka, P.A. Hoist, M. Fritsche [et al.] //Brain research. – 1996. – V. 709. – №. 1. – P. 122-130.Presence of brain-derived neurotrophic factor in brain and human and rat but not mouse serum detected by a sensitive and specific immunoassay / S.F. Radka, P.A. Hoist, M. Fritsche [et al.] //Brain research. – 1996. – V. 709. – №. 1. – P. 122-130.Robust changes in expression of brain-derived neurotrophic factor (BDNF) mRNA and protein across the brain do not translate to detectable changes in BDNF levels in CSF or plasma / T.A. Lanz, S.E. Bove, C.D. Pilsmaker [et al.] //Biomarkers. – 2012. – V. 17. – №. 6. – P. 524-531.Robust changes in expression of brain-derived neurotrophic factor (BDNF) mRNA and protein across the brain do not translate to detectable changes in BDNF levels in CSF or plasma / T.A. Lanz, S.E. Bove, C.D. Pilsmaker [et al.] //Biomarkers. – 2012. – V. 17. – №. 6. – P. 524-531.Selective endovascular cooling for stroke entails brain-derived neurotrophic factor and splenic IL-10 modulation / S. Corey, D.I. Abraham, Y. Kaneko [et al.] // Brain Research. – 2019. – V. 1722, Art 146380. DOI: 10.1016/j.brainres.2019.146380Selective endovascular cooling for stroke entails brain-derived neurotrophic factor and splenic IL-10 modulation / S. Corey, D.I. Abraham, Y. Kaneko [et al.] // Brain Research. – 2019. – V. 1722, Art 146380. DOI: 10.1016/j.brainres.2019.146380Serum BDNF concentrations as peripheral manifestations of depression: evidence from a systematic review and meta-analyses on 179 associations (N= 9484) / M. L. Molendijk, P. Spinhoven, M. Polak [et al.] // Molecular psychiatry. – 2014. – V. 19. – №. 7. – P. 791-800.Serum BDNF concentrations as peripheral manifestations of depression: evidence from a systematic review and meta-analyses on 179 associations (N= 9484) / M. L. Molendijk, P. Spinhoven, M. Polak [et al.] // Molecular psychiatry. – 2014. – V. 19. – №. 7. – P. 791-800.Serum BDNF concentrations show strong seasonal variation and correlations with the amount of ambient sunlight / M.L. Molendijk, J.P. Haffmans, B.A. Bus [et al.] //PloS one. – 2012. – V. 7. – №. 11.Serum BDNF concentrations show strong seasonal variation and correlations with the amount of ambient sunlight / M.L. Molendijk, J.P. Haffmans, B.A. Bus [et al.] //PloS one. – 2012. – V. 7. – №. 11.Serum Levels of Brain-Derived Neurotrophic Factor and Insulin-Like Growth Factor 1 Are Associated With Autonomic Dysfunction and Impaired Cerebral Autoregulation in Patients With Epilepsy / S.F. Chen, S.B. Jou, N.C. Chen [et al.] //Frontiers in neurology. – 2018. – V. 9. – P. 969.Serum Levels of Brain-Derived Neurotrophic Factor and Insulin-Like Growth Factor 1 Are Associated With Autonomic Dysfunction and Impaired Cerebral Autoregulation in Patients With Epilepsy / S.F. Chen, S.B. Jou, N.C. Chen [et al.] //Frontiers in neurology. – 2018. – V. 9. – P. 969.Shetty A. K. Hippocampal neurotrophin levels in a kainate model of temporal lobe epilepsy: a lack of correlation between brain-derived neurotrophic factor content and progression of aberrant dentate mossy fiber sprouting / A. K. Shetty, V. Zaman, G. A. Shetty // Journal of neurochemistry. – 2003. – V. 87. – №. 1. – P. 147-159.Shetty A. K. Hippocampal neurotrophin levels in a kainate model of temporal lobe epilepsy: a lack of correlation between brain-derived neurotrophic factor content and progression of aberrant dentate mossy fiber sprouting / A. K. Shetty, V. Zaman, G. A. Shetty // Journal of neurochemistry. – 2003. – V. 87. – №. 1. – P. 147-159.Stressful life events and the brain-derived neurotrophic factor gene in bipolar disorder / G. M. Hosang, R. Uher, R. Keers [et al.] // Journal of affective disorders. – 2010. – V. 125. – №. 1-3. – P. 345-349.Stressful life events and the brain-derived neurotrophic factor gene in bipolar disorder / G. M. Hosang, R. Uher, R. Keers [et al.] // Journal of affective disorders. – 2010. – V. 125. – №. 1-3. – P. 345-349.Sun H. S. Epigenetics of the depressed brain: role of histone acetylation and methylation / H. S. Sun, P. J. Kennedy, E. J. Nestler // Neuropsychopharmacology. – 2013. – V. 38. – №. 1. – P. 124-137.Sun H. S. Epigenetics of the depressed brain: role of histone acetylation and methylation / H. S. Sun, P. J. Kennedy, E. J. Nestler // Neuropsychopharmacology. – 2013. – V. 38. – №. 1. – P. 124-137.Tanila H. The role of BDNF in Alzheimer's disease. – 2017.Tanila H. The role of BDNF in Alzheimer's disease. – 2017.The human BDNF gene: peripheral gene expression and protein levels as biomarkers for psychiatric disorders / A. Cattaneo, N. Cattane, V. Begni [et al.] // Translational psychiatry. – 2016. – V. 6. – №. 11. – P. e958-e958.The human BDNF gene: peripheral gene expression and protein levels as biomarkers for psychiatric disorders / A. Cattaneo, N. Cattane, V. Begni [et al.] // Translational psychiatry. – 2016. – V. 6. – №. 11. – P. e958-e958.The impact of antidepressant treatment on brain-derived neurotrophic factor level: An evidence-based approach through systematic review and meta-analysis / V. Arumugam, V. S. John, N. Augustine [et al.] // Indian journal of pharmacology. – 2017. – V. 49. – №. 3. – P. 236The impact of antidepressant treatment on brain-derived neurotrophic factor level: An evidence-based approach through systematic review and meta-analysis / V. Arumugam, V. S. John, N. Augustine [et al.] // Indian journal of pharmacology. – 2017. – V. 49. – №. 3. – P. 236The Level of proBDNF in Blood Lymphocytes Is Correlated with that in the Brain of Rats with Photothrombotic Ischemic Stroke / H. Y. Luo, M. Rahman, L. Bobrovskaya [et al.] // Neurotoxicity research. – 2019. – V. 36. – №. 1. – P. 49-57.The Level of proBDNF in Blood Lymphocytes Is Correlated with that in the Brain of Rats with Photothrombotic Ischemic Stroke / H. Y. Luo, M. Rahman, L. Bobrovskaya [et al.] // Neurotoxicity research. – 2019. – V. 36. – №. 1. – P. 49-57.The Role of the Microenvironmental Niche in Declining Stem-Cell Functions Associated with Biological Aging / N.A. DeCarolis, E.D. Kirby, T. Wyss-Coray [et al.] // Cold Spring Harbor Perspectives in Medicine. – 2015. – V. 5. – pii: a025874.The Role of the Microenvironmental Niche in Declining Stem-Cell Functions Associated with Biological Aging / N.A. DeCarolis, E.D. Kirby, T. Wyss-Coray [et al.] // Cold Spring Harbor Perspectives in Medicine. – 2015. – V. 5. – pii: a025874.Tongiorgi E. What is the biological significance of BDNF mRNA targeting in the dendrites? / E. Tongiorgi, L. Domenici, M. Simonato // Molecular neurobiology. – 2006. – V. 33. – №. 1. – P. 17-32.Tongiorgi E. What is the biological significance of BDNF mRNA targeting in the dendrites? / E. Tongiorgi, L. Domenici, M. Simonato // Molecular neurobiology. – 2006. – V. 33. – №. 1. – P. 17-32.Transport of brain-derived neurotrophic factor across the blood–brain barrier / W. Pan, W. A. Banks, M. B. Fasold [et al.] // Neuropharmacology. – 1998. – V. 37. – №. 12. – P. 1553-1561.Transport of brain-derived neurotrophic factor across the blood–brain barrier / W. Pan, W. A. Banks, M. B. Fasold [et al.] // Neuropharmacology. – 1998. – V. 37. – №. 12. – P. 1553-1561.Walsh J.J. Exercise and circulating BDNF: Mechanisms of release and implications for the design of exercise interventions / J.J. Walsh, M.E. Tschakovsky // Appl Physiol Nutr Metab. – 2018. –V. 43, N11. – Pp. 1095-1104. doi: 10.1139/apnm2018-0192.Walsh J.J. Exercise and circulating BDNF: Mechanisms of release and implications for the design of exercise interventions / J.J. Walsh, M.E. Tschakovsky // Appl Physiol Nutr Metab. – 2018. –V. 43, N11. – Pp. 1095-1104. doi: 10.1139/apnm2018-0192.West A. E., Pruunsild P., Timmusk T. Neurotrophins: transcription and translation / A. E. West, P. Pruunsild, T. Timmusk // Neurotrophic factors. – Springer, Berlin, Heidelberg, 2014. – P. 67-100.West A. E., Pruunsild P., Timmusk T. Neurotrophins: transcription and translation / A. E. West, P. Pruunsild, T. Timmusk // Neurotrophic factors. – Springer, Berlin, Heidelberg, 2014. – P. 67-100.

The authors declare that there are no conflicts of interest present.