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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ymj</journal-id><journal-title-group><journal-title xml:lang="ru">Якутский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Yakut Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1813-1905</issn><issn pub-type="epub">2312-1017</issn><publisher><publisher-name>ЯНЦ КМП</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.25789/YMJ.2024.85.01</article-id><article-id custom-type="elpub" pub-id-type="custom">ymj-296</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL RESEARCH</subject></subj-group></article-categories><title-group><article-title>Признаки полярного Т3 синдрома у молодых мужчин в Якутии</article-title><trans-title-group xml:lang="en"><trans-title>Signs of polar T3 syndrome in young men in Yakutia</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7129-6633</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Никанорова</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Nikanorova</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>НИКАНОРОВА Алена Афанасьевна – м.н.с.</p><p>г. Якутск</p></bio><bio xml:lang="en"><p>NIKANOROVA Alеna Afanasyevna – junior researcher, Laboratory of Molecular Genetics</p><p> </p></bio><email xlink:type="simple">nikanorova.alena@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6984-7934</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Барашков</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Barashkov</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>БАРАШКОВ Николай Алексеевич – к.б.н., в.н.с.-руковод. лаб.</p><p>г. Якутск</p></bio><bio xml:lang="en"><p>BARASHKOV Nikolay Alekseevich – Candidate of biological sciences, Head of laboratory of Molecular genetics</p><p> </p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6866-9462</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пшенникова</surname><given-names>В. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Pshennikova</surname><given-names>V. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>ПШЕННИКОВА Вера Геннадиевна – к.б.н., в.н.с.-руковод. лаб.</p><p>г. Якутск</p></bio><bio xml:lang="en"><p>PSHENNIKOVA Vera Gennadievna – Candidate of Biological Sciences, Head of laboratory of Populational Genetics</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6917-5760</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Находкин</surname><given-names>С. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Nakhodkin</surname><given-names>S. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>НАХОДКИН Сергей Сергеевич – н.с.</p><p>г. Якутск</p></bio><bio xml:lang="en"><p>NAKHODKIN Sergey Sergeyevich – scientific researcher of the Research Laboratory of Molecular Biology Institute of Natural Sciences</p><p> </p></bio><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6952-3868</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Федорова</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Fedorova</surname><given-names>S. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>ФЕДОРОВА Сардана Аркадьевна – д.б.н., зав. лаб.</p><p>г. Якутск</p></bio><bio xml:lang="en"><p>FEDOROVA Sardana Arkadievna – Doctor in Biology, Head of the Research Laboratory of Molecular Biology Institute of Natural Sciences</p><p> </p></bio><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ЯНЦ КМП</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal State Budgetary Scientific Institution Yakut Science Center of Complex Medical Problems</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ЯНЦ КМП</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal State Budgetary Scientific Institution Yakutsk Scientific Center of Complex Medical Problems</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ЯНЦ КМП</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal State Budgetary Scientific Institution Yakutsk Scientific Center for Complex Medical Problems</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>ИЕН СВФУ им. М.К. Аммосова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal State Autonomous Educational Institution of Higher Education M.K. Ammosov North-Eastern Federal University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>06</day><month>02</month><year>2025</year></pub-date><volume>0</volume><issue>1</issue><fpage>5</fpage><lpage>8</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Никанорова А.А., Барашков Н.А., Пшенникова В.Г., Находкин С.С., Федорова С.А., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Никанорова А.А., Барашков Н.А., Пшенникова В.Г., Находкин С.С., Федорова С.А.</copyright-holder><copyright-holder xml:lang="en">Nikanorova A.A., Barashkov N.A., Pshennikova V.G., Nakhodkin S.S., Fedorova S.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://ymj.elpub.ru/jour/article/view/296">https://ymj.elpub.ru/jour/article/view/296</self-uri><abstract><p>Изучены сезонные колебания уровней тиреотропного гормона (ТТГ), свободного трийодтиронина (св.Т3) и свободного тироксина (св. Т4) у молодых мужчин в Якутии, где наблюдаются сильные изменения климатических параметров в зимне-весенний период (от -41,8 до -0,2°С). Сезонные колебания между зимним и весенним периодом были обнаружены для св.Т3: в зимнее время его уровни были ниже, чем в весеннее время. Статистически значимых сезонных колебаний для ТТГ и св.Т4 не выявлено. Обнаруженные в настоящем исследовании сезонные колебания св.Т3 в зимне-весенний период свидетельствуют о наличии признаков полярного Т3 синдрома у молодых мужчин в Якутии. Для поиска причин обнаруженных сезонных колебаний был проведен корреляционный анализ уровней ТТГ, св.Т3 и св.Т4 в зависимости от продолжительности светового дня и температуры атмосферного воздуха. В результате была обнаружена корреляционная связь св.Т3 и св.Т4 с долготой дня и температурой воздуха. Корреляционных связей не обнаружено между уровнями ТТГ и долготой дня, температурой воздуха. Таким образом, у жителей Якутии выявлены признаки полярного Т3 синдрома, которые могут быть связаны как с коротким световым днем, так и с низкими температурами атмосферного воздуха в зимнее время. Полученные результаты могут свидетельствовать о повышении поглощения Т3 на тканевом уровне при воздействии холода. </p></abstract><trans-abstract xml:lang="en"><p>The aim of the study was to search for seasonal variations in the levels of thyroid-stimulating hormone (TSH), free triiodothyronine (fT3) and free thyroxine (fT4) in young men in Yakutia, where there are strong changes in climatic parameters in the winter-spring period (from -41.8°C to -0.2°C). Seasonal variations between winter and spring were found for fT3, where in winter its levels were lower – 6.48±0.31 pmol/L than in spring 6.88±0.1 pmol/L (p=0.005). There were no statistically significant seasonal variations for TSH (U=97; p=0.914) and sv.T4 (U=47; p=0.112). Winter-spring seasonal variations of fT3 detected in this study there are signs of polar T3 syndrome in young men in Yakutia. To search for the causes of the detected seasonal variation, a correlation analysis of the levels of TSH, fT3 and fT4 was carried out depending on daylength and atmospheric air temperature. As a result, a correlation between fT3 and fT4 with the daylight (fT3: R=0.339, p=0.03; fT4: R=-0.346, p=0.01) and with air temperature (fT3: R=0.295, p=0.05; fT4: R=-0.296, p=0.04). No correlations were found with TSH levels (daylight: R=-0.06, p=0.69; air temperature: R=-0.09, p=0.559). Thus, the residents of Yakutia have signs of polar T3 syndrome, which can be associated with both a short light day and low atmospheric temperatures in winter. The results obtained may indicate an increase in the absorption of T3 at the tissue level when exposed to cold. </p></trans-abstract><kwd-group xml:lang="ru"><kwd>тиреотропный гормон (ТТГ)</kwd><kwd>свободный трийодтиронин (св.Т3)</kwd><kwd>свободный тироксин (св.Т4)</kwd><kwd>Якутия</kwd><kwd>полярный Т3 синдром</kwd></kwd-group><kwd-group xml:lang="en"><kwd>thyroid-stimulating hormone (TSH)</kwd><kwd>free triiodothyronine (fT3)</kwd><kwd>free thyroxine (fT4)</kwd><kwd>Yakutia</kwd><kwd>polar T3 syndrome</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Работа выполнена в рамках НИР ЯНЦ КМП «Изучение генетической структуры и груза наследственной патологии в популяциях Республики Саха (Якутия) и Государственного задания Министерства науки и высшего образования РФ (FSRG-2023- 0003).</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Alterations in the hypothalamic-pituitary-thyroid axis after prolonged residence in Antarctica / Reed H.L. [et al.] // Clinical Endocrinology. 1986. №1(25). 55-65. doi:10.1111/j.1365-2265.1986.tb03595.x</mixed-citation><mixed-citation xml:lang="en">Reed H.L. [et al.]. Alterations in the hypothalamic-pituitary-thyroid axis after prolonged residence in Antarctica. Clinical Endocrinology. 1986;1(25):55-65. doi:10.1111/j.1365-2265.1986. tb03595.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Brown adipose tissue thermogenesis among young adults in northeastern Siberia and Midwest United States and its relationship with other biological adaptations to cold climates / Levy S.B. [et al.] //American Journal of Human Biology. 2022. №6(34). e23723. doi:10.1002/ajhb.23723</mixed-citation><mixed-citation xml:lang="en">Levy S.B. [et al.]. Brown adipose tissue thermogenesis among young adults in northeastern Siberia and Midwest United States and its relationship with other biological adaptations to cold climates. American Journal of Human Biology. 2022; 6(34): e23723. doi:10.1002/ajhb.23723</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Brown adipose tissue, energy expenditure, and biomarkers of cardio-metabolic health among the Yakut (Sakha) of northeastern Siberia / Levy S.B. [et al.] //American Journal of Human Biology. 2018. №6(30). e23175. doi:10.1002/ajhb.23175</mixed-citation><mixed-citation xml:lang="en">Levy S.B. [et al.]. Brown adipose tissue, energy expenditure, and biomarkers of cardio-metabolic health among the Yakut (Sakha) of northeastern Siberia. American Journal of Human Biology. 2018; 6(30): e23175. doi:10.1002/ajhb.23175</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Brown fat thermogenesis in cold-acclimated rats is not abolished by the suppression of thyroid function / Zaninovich A.A. [et al.] // American Journal of Physiology-Endocrinology and Metabolism. 2002. №3(283). E496-E502. doi:10.1152/ajpendo.00540.2001</mixed-citation><mixed-citation xml:lang="en">Reed H.L. [et al.]. Changes in serum triiodothyronine (T3) kinetics after prolonged Antarctic residence: the polar T3 syndrome. The Journal of Clinical Endocrinology &amp; Metabolism. 1990; 4(70): 965-974. doi:10.1210/jcem-70-4-965</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Changes in serum triiodothyronine (T3) kinetics after prolonged Antarctic residence: the polar T3 syndrome / Reed H.L. [et al.] //The Journal of Clinical Endocrinology &amp; Metabolism. 1990. №4(70). 965-974. doi:10.1210/jcem-70-4-965</mixed-citation><mixed-citation xml:lang="en">Chen N. [et al.]. Different adaptations of Chinese winter-over expeditioners during prolonged Antarctic and sub-Antarctic residence. International journal of biometeorology. 2016; 60: 737-747. doi:10.1007/s00484015-1069-8</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Different adaptations of Chinese winter-over expeditioners during prolonged Antarctic and sub-Antarctic residence / Chen N. [et al.] //International journal of biometeorology. 2016. №60. 737-747. doi:10.1007/s00484-015-1069-8</mixed-citation><mixed-citation xml:lang="en">Fernandez J.A. [et al.]. Direct assessment of brown adipose tissue as a site of systemic tri-iodothyronine production in the rat. Biochemical Journal. 1987; 1(243): 281-284. doi:10.1042/ bj2430281</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Direct assessment of brown adipose tissue as a site of systemic tri-iodothyronine production in the rat / Fernandez J.A. [et al.] //Biochemical Journal. 1987. №1(243). 281-284. doi:10.1042/bj2430281</mixed-citation><mixed-citation xml:lang="en">Zaninovich A.A. [et al.]. Mitochondrial respiration in muscle and liver from cold-acclimated hypothyroid rats. Journal of Applied Physiology. 2003; 4(95): 1584-1590. doi:10.1152/japplphysiol.00363.2003</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Mitochondrial respiration in muscle and liver from cold-acclimated hypothyroid rats / Zaninovich A.A. [et al.] //Journal of Applied Physiology. 2003. №4(95). 1584-1590. doi:10.1152/japplphysiol.00363.2003</mixed-citation><mixed-citation xml:lang="en">Mullur R., Liu Y.Y., Brent G.A. Thyroid hormone regulation of metabolism. Physiological reviews. 2014; 2(94): 355-382. doi:10.1152/physrev.00030.2013</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Mullur R., Liu Y.Y., Brent G.A. Thyroid hormone regulation of metabolism //Physiological reviews. 2014. №2(94). 355-382. doi:10.1152/physrev.00030.2013</mixed-citation><mixed-citation xml:lang="en">Pirahanchi Y., Toro F., Jialal I. Physiology, Thyroid Stimulating Hormone. StatPearls. Treasure Island (FL). 2022.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Pirahanchi Y., Toro F., Jialal I. Physiology, Thyroid Stimulating Hormone. StatPearls. Treasure Island (FL). 2022.</mixed-citation><mixed-citation xml:lang="en">Reed H.L. [et al.]. Pituitary and peripheral hormone responses to T3 administration during Antarctic residence. American Journal of Physiology-Endocrinology and Metabolism. 1988; 6(254): E733-E739. doi:10.1152/ajpendo.1988.254.6.E733</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Pituitary and peripheral hormone responses to T3 administration during Antarctic residence / Reed H.L. [et al.] //American Journal of Physiology-Endocrinology and Metabolism. 1988. №6(254). E733-E739. doi:10.1152/ajpendo.1988.254.6.E733</mixed-citation><mixed-citation xml:lang="en">Levy S.B. [et al.]. Seasonal and socioeconomic influences on thyroid function among the Yakut (Sakha) of Eastern Siberia. American Journal of Human Biology. 2013; 6(25): 814-820. doi:10.1002/ajhb.22457</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Seasonal and socioeconomic influences on thyroid function among the Yakut (Sakha) of Eastern Siberia / Levy S.B. [et al.] //American Journal of Human Biology. 2013. №6(25). 814820. doi:10.1002/ajhb.22457</mixed-citation><mixed-citation xml:lang="en">Evseeva S.A. [et al.]. Seasonal changes in the pituitary-thyroid system in children of the Arctic region of Yakutia. Yakut medical journal. 2021; 2(71): 89-91. doi:10.25789/YMJ.2021.74.23</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Seasonal changes in the pituitary-thyroid system in children of the Arctic region of Yakutia / Evseeva S.A. [et al.] // Yakut medical journal. 2021. №2(71). 89-91. doi:10.25789/YMJ.2021.74.23</mixed-citation><mixed-citation xml:lang="en">Leonard W.R. [et al.]. Seasonal variation in basal metabolic rates among the Yakut (Sakha) of Northeastern Siberia. American Journal of Human Biology. 2014; 4(26): 437-445. doi:10.1002/ajhb.22524</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Seasonal variation in basal metabolic rates among the Yakut (Sakha) of Northeastern Siberia / Leonard W.R. [et al.] //American Journal of Human Biology. 2014. №4(26). 437-445. doi:10.1002/ajhb.22524</mixed-citation><mixed-citation xml:lang="en">Silva J.E. Thermogenic mechanisms and their hormonal regulation. Physiological reviews. 2006; 2(86): 435-464. doi:10.1152/physrev.00009.2005</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Silva J.E. Thermogenic mechanisms and their hormonal regulation //Physiological reviews. 2006. №2(86). 435-464. doi:10.1152/physrev.00009.2005</mixed-citation><mixed-citation xml:lang="en">Silva J.E., Larsen P.R. Potential of brown adipose tissue type II thyroxine 5'-deiodinase as a local and systemic source of triiodothyronine in rats. The Journal of clinical investigation. 1985; 6(76): 2296-2305. doi:10.1172/JCI112239</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Silva J.E., Larsen P.R. Potential of brown adipose tissue type II thyroxine 5'-deiodinase as a local and systemic source of triiodothyronine in rats //The Journal of clinical investigation. 1985. №6(76). 2296-2305. doi:10.1172/JCI112239</mixed-citation><mixed-citation xml:lang="en">Leonard W.R. [et al.].The pituitary-thyroid axis in healthy men living under subarctic climatological conditions. Journal of endocrinology. 2001; 1(169):195. doi:10.1677/joe.0.1690195</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">The pituitary-thyroid axis in healthy men living under subarctic climatological conditions / Hassi J. [et al.] //Journal of endocrinology. 2001. №1(169). 195. doi:10.1677/joe.0.1690195</mixed-citation><mixed-citation xml:lang="en">Tsibulnikov S. [et al.]. Thyroid hormones and the mechanisms of adaptation to cold. Hormones. 2020; 19: 329-339. doi:10.1007/s42000020-00200-2</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Thyroid hormones and the mechanisms of adaptation to cold / Tsibulnikov S. [et al.] // Hormones. 2020. №19. 329-339. doi:10.1007/s42000-020-00200-2</mixed-citation><mixed-citation xml:lang="en">Andersen S. [et al.]. Thyroid hyperactivity with high thyroglobulin in serum despite sufficient iodine intake in chronic cold adaptation in an Arctic Inuit hunter population. European journal of endocrinology. 2012; 3(166): 433-440. doi:10.1530/EJE-11-0888</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Thyroid hyperactivity with high thyroglobulin in serum despite sufficient iodine intake in chronic cold adaptation in an Arctic Inuit hunter population / Andersen S. [et al.] //European journal of endocrinology. 2012. 3(166). 433-440. doi:10.1530/EJE-11-0888</mixed-citation><mixed-citation xml:lang="en">Thyroid hyperactivity with high thyroglobulin in serum despite sufficient iodine intake in chronic cold adaptation in an Arctic Inuit hunter population / Andersen S. [et al.] //European journal of endocrinology. 2012. 3(166). 433-440. doi:10.1530/EJE-11-0888</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
