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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ymj</journal-id><journal-title-group><journal-title xml:lang="ru">Якутский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Yakut Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1813-1905</issn><issn pub-type="epub">2312-1017</issn><publisher><publisher-name>ЯНЦ КМП</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.25789/YMJ.2020.69.21</article-id><article-id custom-type="elpub" pub-id-type="custom">ymj-2940</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>АРКТИЧЕСКАЯ МЕДИЦИНА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ARCTIC MEDICINE</subject></subj-group></article-categories><title-group><article-title>Активность ферментов крови у коренных и приезжих жителей Республики Саха (Якутия)</article-title><trans-title-group xml:lang="en"><trans-title>Enzyme activity in the indigenous and non-indigenous population of the Republic Sakha (Yakutia)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Олесова</surname><given-names>Л. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Olesova</surname><given-names>L. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>ОЛЕСОВА Любовь Дыгыновна - к.б.н., в.н.с.- руковод. лаб., oles59@mail.ru</p></bio><bio xml:lang="en"><p>OLESOVA Lyubov Dygynovna – Ph.D., Leading Researcher head of the laboratory of Biochemistry</p></bio><email xlink:type="simple">oles59@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Яковлева</surname><given-names>А. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Yakovleva</surname><given-names>A. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>ЯКОВЛЕВА Александра Ивановна - н.с.</p></bio><bio xml:lang="en"><p>YAKOVLEVA Alexandra Ivanovna – Research fellow at the laboratory of biochemistry</p></bio><email xlink:type="simple">sashyak@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Семенова</surname><given-names>Е. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Semenova</surname><given-names>E. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>СЕМЕНОВА Евгения Ивановна - к.б.н., с.н.с.</p></bio><bio xml:lang="en"><p>SEMENOVA Evgenia Ivanovna – Ph.D., Senior Researcher at the laboratory of biochemistry</p></bio><email xlink:type="simple">kunsuntar@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кривошапкина</surname><given-names>З. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Krivoshapkina</surname><given-names>Z. H.</given-names></name></name-alternatives><bio xml:lang="ru"><p>КРИВОШАПКИНА Зоя Николаевна - к.б.н.</p></bio><bio xml:lang="en"><p>KRIVOSHAPKINA Zoya Nikolaevna – Ph.D.</p></bio><email xlink:type="simple">zoyakriv@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Миронова</surname><given-names>Г. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Mironova</surname><given-names>G. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>МИРОНОВА Галина Егоровна - д.б.н., проф.</p></bio><bio xml:lang="en"><p>MIRONOVA Galina Egorovna – Doctor of Biological Sciences, Professor, Institute of Natural Sciences (INS)</p></bio><email xlink:type="simple">mirogalin@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Охлопкова</surname><given-names>Е. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Okhlopkova</surname><given-names>E. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>ОХЛОПКОВА Елена Дмитриевна – к.б.н., в.н.с.-руковод. лаб.</p></bio><bio xml:lang="en"><p>OKHLOPKOVA Elena Dmitrievna – Ph.D., Leading Researcher, head of the laboratory of Immunology</p></bio><email xlink:type="simple">elena_ohlopkova@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Константинова</surname><given-names>Л. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Konstantinova</surname><given-names>L. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>КОНСТАНТИНОВА Лена Ивановна – н.с.</p></bio><bio xml:lang="en"><p>KONSTANTINOVA Lena Ivanovna – Research fellow at the laboratory of biochemistry</p></bio><email xlink:type="simple">konstanta.l@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ефремова</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Efremova</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>ЕФРЕМОВА Аграфена Владимировна – к.б.н., с.н.с.</p></bio><bio xml:lang="en"><p>EFREMOVA Agrafena Vladimirovna – Ph.D., Senior Researcher at the laboratory of biochemistry</p></bio><email xlink:type="simple">a.efremova@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Григорьева</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Grigorieva</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>ГРИГОРЬЕВА Анастасия Анатольевна – н.с.</p></bio><bio xml:lang="en"><p>GRIGORYEVA Anastasia Anatolyevna – Research fellow at the laboratory of biochemistry</p></bio><email xlink:type="simple">Nastiagrigoryeva@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ЯНЦ КМП</institution><country>Россия</country></aff><aff xml:lang="en"><institution>FSBSI "YSC CMP"</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>СВФУ им. М.К. Аммосова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>North-eastern Federal University named after M.K. Ammosov (NEFU named after M.K. Ammosov)</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>24</day><month>11</month><year>2025</year></pub-date><volume>0</volume><issue>1</issue><fpage>87</fpage><lpage>91</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Олесова Л.Д., Яковлева А.И., Семенова Е.И., Кривошапкина З.Н., Миронова Г.Е., Охлопкова Е.Д., Константинова Л.И., Ефремова А.В., Григорьева А.А., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Олесова Л.Д., Яковлева А.И., Семенова Е.И., Кривошапкина З.Н., Миронова Г.Е., Охлопкова Е.Д., Константинова Л.И., Ефремова А.В., Григорьева А.А.</copyright-holder><copyright-holder xml:lang="en">Olesova L.D., Yakovleva A.I., Semenova E.I., Krivoshapkina Z.H., Mironova G.E., Okhlopkova E.D., Konstantinova L.I., Efremova A.V., Grigorieva A.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://ymj.elpub.ru/jour/article/view/2940">https://ymj.elpub.ru/jour/article/view/2940</self-uri><abstract><p>С целью оценки состояния метаболизма коренного и некоренного населения проведено определение активности некоторых ферментов в сыворотке крови у населения Республики Саха (Якутия). Различия в активности ферментов сыворотки крови у коренного и некоренного населения Якутии связаны, прежде всего, с различными потребностями организма в энергии. Значимо более высокая активность ферментов, участвующих в биоэнергетике у коренных жителей, согласуется с мнением исследователей о более интенсивном энергетическом обмене коренного населения, приобретенном в процессе длительной адаптации к суровым условиям Севера.</p></abstract><trans-abstract xml:lang="en"><p>In order to assess the metabolic state of the indigenous and non-indigenous population, the activity of certain enzymes in the blood serum was determined in people living in rural, industrial and Arctic groups of the regions of the Republic of Sakha (Yakutia). Differences in the activity of serum enzymes in the indigenous and non-indigenous population of Yakutia are associated primarily with the various energy needs of the body. Significantly higher activity of enzymes involved in bioenergy among indigenous population is consistent with the opinion of researchers about amore intense energy exchange of the indigenous population, acquired in the process of long-term adaptation to the harsh conditions of the North.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>Север</kwd><kwd>коренное и некоренное население</kwd><kwd>адаптация</kwd><kwd>ферменты</kwd></kwd-group><kwd-group xml:lang="en"><kwd>North</kwd><kwd>indigenous and non-indigenous population</kwd><kwd>adaptation</kwd><kwd>enzymes</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Биохимия / Под ред. Е.С. Северина. – 2003. – 779 с.</mixed-citation><mixed-citation xml:lang="en">Biochemistry / Ed. E.S. 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