ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.25789/YMJ.2024.86.22ymj-294Research ArticleСЛУЧАЙ ИЗ ПРАКТИКИCLINICAL CASEКлинический случай развития синдрома Свита у пациентки с миелодиспластическим синдромомClinical case of the development of Sweet's syndrome in a patient with myelodysplastic syndromeСеменоваУ. В.SemenovaU. V.

Семенова Уйгулаана Васильевна – студентка

M.K. Ammosov North-Eastern Federal University

seelru@bk.ruБорисовА. И.BorisovA. I.

Борисов Алексей Иннокентьевич – студент

M.K. Ammosov North-Eastern Federal University

seelru@bk.ruАлександроваТ. Н.AlexandrovaT. N.

Александрова Туйара Никоновна – врач-гематолог

Aleksandrova Tuiara Nikonovna – hematologist, department of hematology

alexandrova_tuyara@mail.ruМулинаИ. И.MulinaI. I.

Мулина Инна Ивановна – зав. Отделением

Mulina Inna Ivanovna – head of department of hematology

ЯдрихинскаяВ. Н.YadrikhinskayaV. N.

Ядрихинская Вера Николаевна – к.м.н., доцент

Yadrikhinskaya Vera Nikolaevna – PhD in Medicine, associate professor of the department Hospital therapy, professional diseases, clinical pharmacology

yadrvera@mail.ruМединститут СВФУ им. М.К. АммосоваРоссияSemenova Uigulana Vasilevna – student of the Medical InstituteRussian FederationМединститут СВФУ им. М.К. АммосоваРоссияBorisov Alexey Innokentievich – student of the Medical InstituteRussian FederationРБ№1-Национальный центр медициныРоссияNational Center of MedicineRussian FederationМединститут СВФУ им. М.К. АммосоваРоссияMedical Institute of M.K. Ammosov North-Eastern Federal UniversityRussian Federation202406022025029497Copyright © Семенова У.В., Борисов А.И., Александрова Т.Н., Мулина И.И., Ядрихинская В.Н., 20252025Семенова У.В., Борисов А.И., Александрова Т.Н., Мулина И.И., Ядрихинская В.Н.Semenova U.V., Borisov A.I., Alexandrova T.N., Mulina I.I., Yadrikhinskaya V.N.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/294

В статье представлено описание клинического случая синдрома Свита, ассоциированного с применением гипометилирующих агентов в терапии миелодиспластического синдрома. Рецидивирующее течение синдрома Свита, неэффективность поддерживающих доз преднизолона потребовали пересмотра тактики терапии миелодиспластического синдрома с отменой гипометилирующих агентов.

Терапевтическая тактика пациентов с редким заболеванием, синдромом Свита, должна подбираться индивидуально с учетом формы заболевания и сопутствующей патологии.

Sweet's syndrome is a rare type of dermatoses, which characterized by a recurrent course, painful bright red papules, inflammatory plaques, fever and neutrophilic leukocytosis. The article demonstrates a clinical case of Sweet's syndrome associated with hypomethylating agents in patient with myelodysplastic syndrome. The diagnosis was verified based on clinical features which included purplish-red colored skin plaques with ulcerative-necrotic defects right after azacitidine and decitabine therapy; profound therapeutic effect from steroids, plasmapheresis, ineffectiveness of antibiotics, antifungal drugs; increasing the level of neutrophils. The concurrent severe course of the diseases was complicated by extensive necrotic skin lesions of the lower extremities, which required surgical intervention. The recurrent course of Sweet's syndrome and the ineffectiveness of maintenance doses of prednisolone required a consideration of changing treatment approach of myelodysplastic syndrome with the discontinuation of hypomethylating agents.

Therapeutic tactics for patients with a rare disease, Sweet's syndrome, should be selected individually, taking into account the form of the disease and concomitant pathology.

миелодиспластический синдромкожный васкулитсиндром Свитаострый нейтрофильный дерматозMyelodysplastic syndromeskin vasculitisSweet's syndromeacute neutrophilic dermatosisReferencesИдиопатическая форма синдрома Свита / О.Ю. Олисова [и др.] // Российский ж-л кожных и венерич. болезней. 2016. Т. 19, №1. С. 27-31. doi: 10.18821/1560-9588-2016-19-1-27-31The idiopathic form of Sweet’s syndrome / O.Yu. Olisova [et al.].russian Journal of Skin and Venereal Diseases. 2016; 19(1): 27-31. doi: 10.18821/1560-9588-2016-19-1-27-31Клинические рекомендации. Миелодиспластический синдром / Национальное гематологическое общество. М., 2020. URL: https://cr.minzdrav.gov.ru/recomend/141/. Дата обращения: 16.01.2024Clinical guidelines. Myelodysplastic syndrome / National hematology society. M., 2020. https://cr.minzdrav.gov.ru/recomend/141/. Assess date: 16.01.2024Autoimmune disorders are common in myelodysplastic syndrome patients and confer an adverse impact on outcomes / J. Montoro [et al.] // Ann Hematol. 2018. Vol. 97, No. 8. Р.1349-1356. doi: 10.1007/s00277-018-3302-0.Autoimmune disorders are common in myelodysplastic syndrome patients and confer an adverse impact on outcomes / J. Montoro [et al.] // Ann Hematol. 2018. Vol. 97, No. 8. Р.1349-1356. doi: 10.1007/s00277-018-3302-0.Barcellini W, Giannotta JA, Fattizzo B. Autoimmune Complications in Hematologic Neoplasms // Cancers (Basel). 2021. Vol. 13, №7. Р.1532. doi: 10.3390/cancers13071532Barcellini W, Giannotta JA, Fattizzo B. Autoimmune Complications in Hematologic Neoplasms // Cancers (Basel). 2021. Vol. 13, №7. Р.1532. doi: 10.3390/cancers13071532Berry WA, Kelly R. A case of polycyclic Sweet's syndrome arising from azacitidine injection sites in myelodysplasia. Ann Hematol. 2020 Jan;99(1):201-202. doi: 10.1007/s00277-019-03873-x.Berry WA, Kelly R. A case of polycyclic Sweet's syndrome arising from azacitidine injection sites in myelodysplasia. Ann Hematol. 2020 Jan;99(1):201-202. doi: 10.1007/s00277-019-03873-x.Chronic immune stimulation might act as a trigger for the development of acute myeloid leukemia or myelodysplastic syndromes /s. Y. Kristinsson [et al.] // 2011. Vol. 29, No. 21. P. 2897-2903. DOI: 10.1200/JCO.2011.34.8540Chronic immune stimulation might act as a trigger for the development of acute myeloid leukemia or myelodysplastic syndromes /s. Y. Kristinsson [et al.] // 2011. Vol. 29, No. 21. P. 2897-2903. DOI: 10.1200/JCO.2011.34.8540Complete remission of Sweet's syndrome after azacytidine treatment for concomitant myelodysplastic syndrome /s. Martinelli [et al.] // Int J Hematol. – 2014. Vol. 99, No. 5. Р. 663-7. doi: 10.1007/s12185-014-1527-9.Complete remission of Sweet's syndrome after azacytidine treatment for concomitant myelodysplastic syndrome /s. Martinelli [et al.] // Int J Hematol. – 2014. Vol. 99, No. 5. Р. 663-7. doi: 10.1007/s12185-014-1527-9.New Practical Aspects of Sweet Syndrome / T.P. Joshi, S.K. Friske, D.A. Hsiou [et al] // Am J Clin Dermatol. 2022. Vol. 23. No 3. Р. 301-318. doi: 10.1007/s40257-022-00673-4New Practical Aspects of Sweet Syndrome / T.P. Joshi, S.K. Friske, D.A. Hsiou [et al] // Am J Clin Dermatol. 2022. Vol. 23. No 3. Р. 301-318. doi: 10.1007/s40257-022-00673-4Paraneoplastic Dermatoses: A Brief General Review and an Extensive Analysis of Paraneoplastic Pemphigus and Paraneoplastic Dermatomyositis / D. Didona [et al.] // Int J Mol Sci. 2020. Vol. 21, No. 6. Р. 2178. doi: 10.3390/ijms21062178Paraneoplastic Dermatoses: A Brief General Review and an Extensive Analysis of Paraneoplastic Pemphigus and Paraneoplastic Dermatomyositis / D. Didona [et al.] // Int J Mol Sci. 2020. Vol. 21, No. 6. Р. 2178. doi: 10.3390/ijms21062178Response of autoimmune and inflammatory disorders in myelodysplastic syndromes to 5-azacytidine: report of two cases and literature review/ D.Y. Wu, J. Wang, R. Zhang [et al.] // Ann Palliat Med. 2021. Vol. 10, No. 8. Р. 9276-9280. doi: 10.21037/apm-21-1416.Response of autoimmune and inflammatory disorders in myelodysplastic syndromes to 5-azacytidine: report of two cases and literature review/ D.Y. Wu, J. Wang, R. Zhang [et al.] // Ann Palliat Med. 2021. Vol. 10, No. 8. Р. 9276-9280. doi: 10.21037/apm-21-1416.Sweet Syndrome Associated with Myelodysplastic Syndrome-A Review of a Multidisciplinary Approach / C.R. Ferea, S.N. Mihai, G. Balan [et al.] // Life (Basel). 2023. Vol. 13, No. 3. Р. 809. DOI: 10.3390/life13030809Sweet Syndrome Associated with Myelodysplastic Syndrome-A Review of a Multidisciplinary Approach / C.R. Ferea, S.N. Mihai, G. Balan [et al.] // Life (Basel). 2023. Vol. 13, No. 3. Р. 809. DOI: 10.3390/life13030809Sweet syndrome: long-term follow-up of 138 patients / Clinical and Experimental Dermatology / J. Marcoval, C. Martín-Callizo, F. Valentí-Medina [et al.] // 2016. Vol. 41, No. 7. Р. 741–746. doi: 10.1111/ced.12899.Sweet syndrome: long-term follow-up of 138 patients / Clinical and Experimental Dermatology / J. Marcoval, C. Martín-Callizo, F. Valentí-Medina [et al.] // 2016. Vol. 41, No. 7. Р. 741–746. doi: 10.1111/ced.12899.Vasculitis in Myelodysplastic Syndrome and Chronic Myelomonocytic Leukemia: A Report of Two Cases / J. Jacobse, Y. W. J. Sijpkens, J.W. van 't Wout [et al.] // J Hematol. 2018. Vol. 7. No. 4. Р. 158-162. doi: 10.14740/jh461wVasculitis in Myelodysplastic Syndrome and Chronic Myelomonocytic Leukemia: A Report of Two Cases / J. Jacobse, Y. W. J. Sijpkens, J.W. van 't Wout [et al.] // J Hematol. 2018. Vol. 7. No. 4. Р. 158-162. doi: 10.14740/jh461wVashisht P, Goyal A, Hearth Holmes MP. Sweet Syndrome. 2022 Sep 12. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 28613704.Vashisht P, Goyal A, Hearth Holmes MP. Sweet Syndrome. 2022 Sep 12. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 28613704.

The authors declare that there are no conflicts of interest present.