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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ymj</journal-id><journal-title-group><journal-title xml:lang="ru">Якутский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Yakut Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1813-1905</issn><issn pub-type="epub">2312-1017</issn><publisher><publisher-name>ЯНЦ КМП</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.25789/YMJ.2020.69.15</article-id><article-id custom-type="elpub" pub-id-type="custom">ymj-2934</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>АКТУАЛЬНАЯ ТЕМА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ACTUAL TOPIC</subject></subj-group></article-categories><title-group><article-title>Показатели врожденного и адаптивного иммунитета при хроническом генерализованном пародонтите у больных пожилого и старческого возраста</article-title><trans-title-group xml:lang="en"><trans-title>Congenital and adaptive immunity indicators in chronic generalized periodontitis in elderly and senile patients</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пинелис</surname><given-names>И. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Pinelis</surname><given-names>I. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>ПИНЕЛИС Иосиф Семенович – д.м.н., проф., зав. кафедрой</p></bio><bio xml:lang="en"><p>PINELIS Iosif Semenovich - Professor, Head of the Department of Surgical Dentistry</p><p>39a, Gorkogo Str, 672000, Chita</p></bio><email xlink:type="simple">pinelis1@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пинелис</surname><given-names>Ю. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Pinelis</surname><given-names>Yu. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>ПИНЕЛИС Юрий Иосифович – д.м.н., проф.</p></bio><bio xml:lang="en"><p>PINELIS Yury Iosifovich - Professor of the Department of surgical Dentistry</p><p>39a, Gorkogo Str, 672000, Chita</p></bio><email xlink:type="simple">pinelisml@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Малежик</surname><given-names>М. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Malezhik</surname><given-names>M. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>МАЛЕЖИК Маргарита Сергеевна – к.м.н., ассистент кафедры</p></bio><bio xml:lang="en"><p>MALEZHIK Margarita Sergeevna − Assistant of the Department of Dentistry of Childhood</p><p>39a, Gorkogo Str, 672000, Chita</p></bio><email xlink:type="simple">rita.malezhik@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ушницкий</surname><given-names>И. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Ushnitsky</surname><given-names>I. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>УШНИЦКИЙ Иннокентий Дмитриевич – д.м.н., проф., зав. кафедрой</p></bio><bio xml:lang="en"><p>USHNITSKY Innokentiy Dmitrievich − MD, professor, head of the department of therapeutic, surgical, orthopedic dentistry and dentistry of children's age Medical institute</p></bio><email xlink:type="simple">incadim@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Читинская государственная медицинская академия</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Chita State Medical Academy</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>СВФУ им. М.К. Аммосова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>M.K. Ammosov North-Eastern federal university</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>21</day><month>11</month><year>2025</year></pub-date><volume>0</volume><issue>1</issue><fpage>63</fpage><lpage>68</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Пинелис И.С., Пинелис Ю.И., Малежик М.С., Ушницкий И.Д., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Пинелис И.С., Пинелис Ю.И., Малежик М.С., Ушницкий И.Д.</copyright-holder><copyright-holder xml:lang="en">Pinelis I.S., Pinelis Y.I., Malezhik M.S., Ushnitsky I.D.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://ymj.elpub.ru/jour/article/view/2934">https://ymj.elpub.ru/jour/article/view/2934</self-uri><abstract><p>Приведены результаты сравнительного исследования хронического генерализованного пародонтита (ХГП) средней степени тяжести у больных пожилого и старческого возраста. Развитие ХГП средней степени тяжести у людей пожилого и старческого возраста сопровождается активацией гуморального иммунитета с избыточным синтезом всех имму-ноглобулинов в крови и слюне, установлена подавленность комплементарной активности, анализ показателей общего и местного иммунитета указывает на отличия между больными пожилого и старческого возраста.</p></abstract><trans-abstract xml:lang="en"><p>The results of comparative study of chronic generalized periodontitis (CGP) of average severity in elderly and senile patients are reported. The development of CGP of medium severity in elderly and senile people is accompanied by activation of humoral immunity with excessive synthesis of all immunoglobulins in blood and saliva, the pressure of complementary activity is established, analysis of indicators of general and local immunity indicates differences between elderly and se-nile patients.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>пародонтит</kwd><kwd>ротовая жидкость</kwd><kwd>пожилой и старческий возраст</kwd><kwd>иммунитет</kwd><kwd>гемостаз</kwd></kwd-group><kwd-group xml:lang="en"><kwd>periodontitis</kwd><kwd>oral fluid</kwd><kwd>elderly and senile age</kwd><kwd>immunity</kwd><kwd>hemostasis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Блашкова С.Л. Разработка критериев качества патогенетической терапии хронического генерализованного пародонтита: автореф. дис. … д-ра. мед. наук / С.Л. 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