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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ymj</journal-id><journal-title-group><journal-title xml:lang="ru">Якутский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Yakut Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1813-1905</issn><issn pub-type="epub">2312-1017</issn><publisher><publisher-name>ЯНЦ КМП</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.25789/YMJ.2020.69.08</article-id><article-id custom-type="elpub" pub-id-type="custom">ymj-2924</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>МЕТОДЫ ДИАГНОСТИКИ И ЛЕЧЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>METHODS OF DIAGNOSIS AND TREATMENT</subject></subj-group></article-categories><title-group><article-title>Терапия больных раком молочной железы с тревожно-депрессивными расстройствами</article-title><trans-title-group xml:lang="en"><trans-title>Therapy of patients with breast cancer with anxiety and depressive disorders</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шушпанова</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Shushpanova</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>ШУШПАНОВА Ольга Владимировна – н.с.</p></bio><bio xml:lang="en"><p>SHUSHPANOVA Olga Vladimirovna – Researcher</p><p>34 Kashirskoye Shosse, 115522, Moscow</p></bio><email xlink:type="simple">sertraline@list.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Иванов</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Ivanov</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>ИВАНОВ Станислав Викторович – д.м.н., проф., гл.н.с.</p></bio><bio xml:lang="en"><p>IVANOV Stanislav Viktorovich – PhD, MD, Professor, Chief Researcher</p><p>34 Kashirskoye Shosse, 115522, Moscow</p></bio><email xlink:type="simple">stanislvi@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шушпанова</surname><given-names>Т. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Shushpanova</surname><given-names>T. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>ШУШПАНОВА Тамара Владимировна – к.м.н, в.н.с.</p></bio><bio xml:lang="en"><p>SHUSHPANOVA Tamara Vladimirovna – PhD., MD, Leading Scientific Researcher</p><p>634014, Tomsk, Aleutskaya 4</p></bio><email xlink:type="simple">shush59@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Научный центр психического здоровья РАН</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Mental Health Research Center of the Russian Academy of Sciences</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>НИИ психического здоровья Томского национального исследовательского медицинского центра РАН</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Mental Health Research Institute “Tomsk National Research Medical Center of the Russian Academy of Sciences”</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>21</day><month>11</month><year>2025</year></pub-date><volume>0</volume><issue>1</issue><fpage>34</fpage><lpage>38</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Шушпанова О.В., Иванов С.В., Шушпанова Т.В., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Шушпанова О.В., Иванов С.В., Шушпанова Т.В.</copyright-holder><copyright-holder xml:lang="en">Shushpanova O.V., Ivanov S.V., Shushpanova T.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://ymj.elpub.ru/jour/article/view/2924">https://ymj.elpub.ru/jour/article/view/2924</self-uri><abstract><p>Исследовались пациентки с гистологически верифицированным раком молочной железы, включая с впервые диагностированным РМЖ и с длительностью катамнеза 3–17 лет. В клинической картине у обследуемых выявлены депрессивные, тревожно–фобические и психосоматические расстройства, что в значительной степени снижало их качество жизни и отрицательно влияло на прогноз и выживаемость пациентов. Проведение специализированной фармакотерапии с применением антидепрессантов в комбинации с препаратами бензодиазепинового ряда и гипнотиками у больных РМЖ выявило высокие показатели эффективности проводимой комбинированной терапии.</p></abstract><trans-abstract xml:lang="en"><p>Female patients with histologically verified breast cancer, including newly diagnosed breast cancer and with a history of 3-17 years were under study. In the clinical picture of the examined patients, depressive, anxious-phobic and psycho-somatic disorders were identified, which significantly reduced their quality of life and adversely affected the prognosis and survival of patients. Conducting specialized pharmacotherapy with the use of antidepressants in combination with benzodiazepine drugs and hypnotics in breast cancer patients revealed high efficacy of the combination therapy.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>рак молочной железы</kwd><kwd>тревожность</kwd><kwd>депрессивное расстройство</kwd></kwd-group><kwd-group xml:lang="en"><kwd>breast cancer</kwd><kwd>anxiety</kwd><kwd>depressive disorder</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Володин Б.Ю. Психосоматические взаимоотношения у онкологических больных / Б.Ю. Володин // Паллиативная медицина и реабилитация. – 2007. – № 3. – С. 51-54.</mixed-citation><mixed-citation xml:lang="en">Volodin B.Yu. Psychosomatic relationships in cancer patients. /B.Yu. 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