ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.25789/YMJ.2024.86.20ymj-291Research ArticleТОЧКА ЗРЕНИЯPOINT OF VIEWОтношение показателя нейтрофилов к лимфоцитам и апоптоз лимфоцитов у больных HBV и HCV в зависимости от стадии фиброза печениRatio of neutrophils to lymphocytes and apoptosis of lymphocytes in patients with HBV and HCV depending on the stage of liver fibrosishttps://orcid.org/0000-0002-9227-5743ФараджеваН. А.FaradzhevaN. A.

Фараджева Натаван Алыш кызы – д.м.н., проф.

Faradzheva Natavan Alysh kizi – Doctor of Medical Sciences, Professor, Department of Therapy

nnatavan_n@mail.ruМахмудоваК. Дж.MahmudovaK. J.

Махмудова Конуль Джахангир кызы – врач-терапевт

Баку

Mahmudova Konul Jahangir kizi – therapist.

Baku

АхмедоваЛ. М.AhmedovaL. M.

Ахмедова Лeйли Мaмед кызы – к.м.н., с.н.с. Центральной науч.-исслед. лаб. Азербайджанского ГИУВ им. А. Алиева

Ahmadova Leyli Mamed kizi – PhD in Medicine, Senior Researcher at the Central Research Laboratory

Азербайджанский гос. ин-т усоверш. врачей им. А. АлиеваАзербайджанA. Aliyev Azerbaijan State Institute of Advanced Medical EducationAzerbaijanМедицинский центр “Medikus Сlinic”АзербайджанMedikus Clinic' Medical CenterAzerbaijan202406022025028487Copyright © Фараджева Н.А., Махмудова К.Д., Ахмедова Л.М., 20252025Фараджева Н.А., Махмудова К.Д., Ахмедова Л.М.Faradzheva N.A., Mahmudova K.J., Ahmedova L.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/291

Частым осложнением HBV и HCV является цирроз печени, в основе которого стоит хроническое системное воспаление, связанное с иммунной дисфункцией, влияющей на прогрессирование заболевания. Целью исследования было определение отношения нейтрофилов к лимфоцитам (ОНЛ) и показателя апоптоза лимфоцитов как маркера степени воспаления и системного иммуновоспалительного ответа при различных степенях фиброза печени у больных с HBV и HCV. Полученные результаты показали повышение абсолютного числа лимфоцитов со снижением показателя ОНЛ на фоне снижения маркера апоптоза лимфоцитов СВ95+ с различными степенями фиброза печени. Снижение этого маркера отражает повреждающее действие гепатотропных вирусов, косвенным подтверждением чего и является выявленный лейкоцитоз.

A common complication of HBV and HCV is liver cirrhosis, which is based on chronic systemic inflammation associated with immune dysfunction that affects the progression of the disease.

The purpose of the study

The purpose of the study. Determination of NLR and lymphocyte apoptosis index as a marker of the degree of inflammation and systemic immuno-inflammatory response in various degrees of liver fibrosis in patients with viral hepatitis.

Materials and methods

Materials and methods. 107 patients underwent the study, of which 53 patients were diagnosed with HBV and 54 with HCV. The blood levels of leukocytes, neutrophils, and lymphocytes were studied in the studied patients and the neutrophil/lymphocyte ratio (NEU/LYM) was determined. In order to verify structural changes in the liver, ultrasound elastometric examination was performed on a 2D – Supersonic Aixplorer SWE device (France) for all persons with esTableished viral hepatitis. The examination of patients was carried out according to the Cut–off scale, and liver fibrosis was determined by the METAVIR scale. A group of 10 practically healthy individuals was selected as a comparison group. The values of the indicators were expressed in kPa, the value of the indicator 7.1 kPa corresponded to F2, 9.2 kPa – F3, F4≥13.5 kPa. Verification of HBV and HCV was carried out by PCR on the device “Rotor Qene Q” (Germa

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The authors declare that there are no conflicts of interest present.