<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ymj</journal-id><journal-title-group><journal-title xml:lang="ru">Якутский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Yakut Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1813-1905</issn><issn pub-type="epub">2312-1017</issn><publisher><publisher-name>ЯНЦ КМП</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.25789/YMJ.2022.80.16</article-id><article-id custom-type="elpub" pub-id-type="custom">ymj-288</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ГИГИЕНА, САНИТАРИЯ, ЭПИДЕМИОЛОГИЯ И МЕДИЦИНСКАЯ ЭКОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>HYGIENE, SANITATION, EPIDEMIOLOGY AND MEDICAL ECOLOGY</subject></subj-group></article-categories><title-group><article-title>Биохимические показатели крови населения в зоне повышенной естественной радиоактивности</article-title><trans-title-group xml:lang="en"><trans-title>Biochemical parameters of the blood of the population in the zone of increased natural radioactivity</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Олесова</surname><given-names>Л Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Olesova</surname><given-names>L. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Олесова Любовь Дыгыновна – к.б.н., в.н.с.-руковод. лаб.</p></bio><bio xml:lang="en"><p>Olesova Lyubov Dygynovna – PhD in Biology, external researcher, head of the lab.</p></bio><email xlink:type="simple">oles59@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Яковлева</surname><given-names>А. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Yakovleva</surname><given-names>A. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Яковлева Александра Ивановна – н.с.</p></bio><bio xml:lang="en"><p>Yakovleva Alexandra Ivanovna – research associate of the lab. biochemistry</p></bio><email xlink:type="simple">sashyak@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Охлопкова</surname><given-names>Е. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Okhlopkova</surname><given-names>E. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Охлопкова Елена Дмитриевна – к.б.н., в.н.с.– руковод. лаб.</p></bio><bio xml:lang="en"><p>Okhlopkova Elena Dmitrievna – PhD in Biology, external researcher, head of the Laboratory of Immunology</p></bio><email xlink:type="simple">elena_ohlopkova@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Софронова</surname><given-names>С. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Sofronova</surname><given-names>S. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Софронова Саргылана Ивановна – к.м.н., гл.н.с.–руковод. отдела</p></bio><bio xml:lang="en"><p>Sofronova Sargylana Ivanovna – PhD in Medicine, chief researcher</p></bio><email xlink:type="simple">sara2208@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Попова</surname><given-names>Т. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Popova</surname><given-names>T. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Попова Татьяна Егоровна – д.м.н., зам. директора по научной работе</p></bio><bio xml:lang="en"><p>Popova Tatiana Egorovna – MD, deputy director of scientific work</p></bio><email xlink:type="simple">tata2504@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Романова</surname><given-names>А. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Romanova</surname><given-names>A. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Романова Анна Николаевна – д.м.н., директор</p></bio><bio xml:lang="en"><p>Romanova Anna Nikolaevna –MD, Director</p></bio><email xlink:type="simple">ranik@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Якутский научный центр комплексных медицинских проблем<country>Россия</country></aff><aff xml:lang="en">Yakut Science Centre of Complex Medical Problems<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>06</day><month>02</month><year>2025</year></pub-date><volume>0</volume><issue>4</issue><fpage>59</fpage><lpage>65</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Олесова Л.Д., Яковлева А.И., Охлопкова Е.Д., Софронова С.И., Попова Т.Е., Романова А.Н., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Олесова Л.Д., Яковлева А.И., Охлопкова Е.Д., Софронова С.И., Попова Т.Е., Романова А.Н.</copyright-holder><copyright-holder xml:lang="en">Olesova L.D., Yakovleva A.I., Okhlopkova E.D., Sofronova S.I., Popova T.E., Romanova A.N.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://ymj.elpub.ru/jour/article/view/288">https://ymj.elpub.ru/jour/article/view/288</self-uri><abstract><p>Проведенный лабораторный анализ основных параметров крови населения, проживающего на территории с неблагополучной естественной радиоактивностью 222Rn, выявил у населения Алданского района изменения биохимического спектра сыворотки крови, указывающего на наличие признаков дизадаптации. Частота изменений липидного профиля сопряжена с гендерной принадлежностью и курением. Сдвиг липидного обмена в сторону атерогенности более выражен у мужчин за счет увеличения атерогенных фракций липидов в крови, подверженных перекисному окислению, и понижения уровня антиатерогенной фракции липидов. Сдвиг метаболических потоков в сторону катаболизма, активация гликолиза, дислипидемия указывают на напряжение углеводного и липидного метаболизма, что является признаком дизадаптации организма и риском развития экологически обусловленных заболеваний, в том числе новообразований.</p></abstract><trans-abstract xml:lang="en"><p>An analysis of the main biochemical parameters of the population living in the territory with unfavorable natural radioactivity of 222Rn revealed changes in the biochemical spectrum of blood serum in the population of the Aldan region, indicating the presence of signs of disadaptation. Lipid profile changes are associated with gender and smoking. The shift of lipid metabolism towards atherogenicity is more pronounced in men due to an increase in the atherogenic fractions of lipids in the blood that are susceptible to peroxidation and a decrease in the level of the antiatherogenic fraction of lipids. The shift of metabolic flows towards catabolism, activation of glycolysis, dyslipidemia indicate the tension of carbohydrate and lipid metabolism, which is a sign of disadaptation of the body and the risk of developing environmentally conditioned diseases, including neoplasms.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>радон</kwd><kwd>метаболизм</kwd><kwd>липиды</kwd><kwd>углеводы</kwd><kwd>дизадаптация</kwd></kwd-group><kwd-group xml:lang="en"><kwd>radon</kwd><kwd>metabolism</kwd><kwd>lipids</kwd><kwd>carbohydrates</kwd><kwd>disadaptation</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Государственный доклад о состоянии и охране окружающей среды Республики Саха (Якутия) в 2021 году. URL: https://minpriroda.sakha.gov.ru/uploads/ckfinder/userfiles/2022/08/02/files/Preview%20(25).pdf</mixed-citation><mixed-citation xml:lang="en">Gosudarstvennyj doklad o sostoyanii i ohrane okruzhayushchej sredy Respubliki Saha (YAkutiya) v 2021 godu. [State report on the state and protection of the environment of the Republic of Sakha (Yakutia) in 2021. –URL: https://minpriroda.sakha.gov.ru/uploads/ckfinder/userfiles/2022/08/02/files/Preview%20(25).pdf (In Russ.).]</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">О состоянии здоровья населения и организации здравоохранения в Республике Саха (Якутия) по итогам деятельности за 2020 г. (рукопись). – Якутск: Министерство здравоохранения Республики Саха (Якутия), 2021. – 142 с.</mixed-citation><mixed-citation xml:lang="en">O sostoyanii zdorov'ya naseleniya i organizacii zdravoohraneniya v Respublike Saha (YAkutiya) po itogam deyatel'nosti za 2020 g. (rukopis') [On the state of health of the population and the organization of health care in the Republic of Sakha (Yakutia) based on the results of activities for 2020 (manuscript). Yakutsk: Ministry of Health of the Republic of Sakha (Yakutia), 2021: 142 (In Russ.).]</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Радиационная обстановка РГП территории Республики Саха (Якутия) за 2021 г. file:///C:/Users/Master/Desktop/Радиационная%20обстановка_РГП%20территории%20РС(Я)%20за%202021%20г.pdf</mixed-citation><mixed-citation xml:lang="en">Radiacionnaya obstanovka RGP territorii Respubliki Saha (YAkutiya) za 2021 g. [Radiation situation of the RSE of the territory of the Republic of Sakha (Yakutia) for 2021 (In Russ.).]</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Рослый И.М. Ферментемия-адаптивный механизм или маркер цитолиза / И.М. Рослый, С.В. Абрамов, В.И. Покровский // Вестник РАМН. 2002. -№8.С.3-8.</mixed-citation><mixed-citation xml:lang="en">Rosly I.M., Abramov S.V., Pokrovsky V.I. Roslyj I.M. Fermentemiya-adaptivnyj mekhanizm ili marker citoliza [Enzyme-adaptive mechanism or marker of cytolysis]. Vestnik RAMN [Bulletin of the Russian Academy of Medical Sciences. 2002; 8: 3-8 (In Russ.).]</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Фокина Е.Г. Энзимологическая часть биохимического паспорта человека / Е.Г. Фокина, И.М. Рослый // Эпидемиология и гигиена. – 2013. -№ 4.С.28-31.</mixed-citation><mixed-citation xml:lang="en">Fokina E.G., Rosly I.M. Enzimologicheskaya chast' biohimicheskogo pasporta cheloveka [Enzymological part of the human biochemical passport]. Epidemiologiya i gigiena [Epidemiology and hygiene]. 2013; 4: 28-31 [In Russ.).]</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Хочачка И. Биохимическая адаптация / И. Хочачка, Д. Сомеро. – М.: Мир, 1988. – 586 с.</mixed-citation><mixed-citation xml:lang="en">Khochachka I, Somero D. Biohimicheskaya adaptaciya [Biochemical adaptation]. Publishing house M.I.R. 1988: 586 (In Russ.).]</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Сравнительный анализ накопления радона в зданиях различного класса энергоэффективности на примере пяти российских городов / И.В. Ярмошенко, А.Д. Онищенко, Г.П. Малиновский [и др.] // Радиационная гигиена. 2020.Т. 13, № 2.С. 47-56.</mixed-citation><mixed-citation xml:lang="en">Yarmoshenko I.V., Onishchenko A.D., Malinovskij G.P. [et al.] Sravnitel'nyj analiz nakopleniya radona v zdaniyah razlichnogo klassa energoeffektivnosti na primere pyati rossijskih gorodov [Comparative analysis of radon accumulations in buildings of different energy efficiency classes on the example of five Russian cities]. Radiacionnaya gigiena [Radiation hygiene. 2020; 13 (2): 47-56 (In Russ.).]</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Akram M. Mini-review on glycolysis and cancer. J Cancer Educ. 2013 Sep;28(3):4547. doi: 10.1007/s13187-013-0486-9. PMID: 23728993.</mixed-citation><mixed-citation xml:lang="en">Akram M. Mini-review on glycolysis and cancer. J Cancer Educ. 2013 Sep;28(3):4547. doi: 10.1007/s13187-013-0486-9. PMID: 23728993.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Bräuner EV, Andersen ZJ, Andersen CE, Pedersen C, Gravesen P, Ulbak K, Hertel O, Loft S, Raaschou-Nielsen O. Residential radon and brain tumour incidence in a Danish cohort. PLoS One. 2013 Sep 16;8(9):e74435. doi: 10.1371/journal.pone.0074435. PMID: 24066143; PMCID: PMC3774631.</mixed-citation><mixed-citation xml:lang="en">Bräuner EV, Andersen ZJ, Andersen CE, Pedersen C, Gravesen P, Ulbak K, Hertel O, Loft S, Raaschou-Nielsen O. Residential radon and brain tumour incidence in a Danish cohort. PLoS One. 2013 Sep 16;8(9):e74435. doi: 10.1371/journal.pone.0074435. PMID: 24066143; PMCID: PMC3774631.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Cao Y. Adipocyte and lipid metabolism in cancer drug resistance. J Clin Invest. 2019 Jul 2;129(8):3006-3017. doi: 10.1172/JCI127201. PMID: 31264969; PMCID: PMC6668696.</mixed-citation><mixed-citation xml:lang="en">Cao Y. Adipocyte and lipid metabolism in cancer drug resistance. J Clin Invest. 2019 Jul 2;129(8):3006-3017. doi: 10.1172/JCI127201. PMID: 31264969; PMCID: PMC6668696.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Darby S, Hill D, Auvinen A, Barros-Dios JM et al. Radon in homes and risk of lung cancer: collaborative analysis of individual data from 13 European case-control studies. BMJ. 2005 Jan 29;330(7485):223. doi: 10.1136/ mj.38308.477650.63. Epub 2004 Dec 21. PMID: 15613366; PMCID: PMC546066.</mixed-citation><mixed-citation xml:lang="en">Darby S, Hill D, Auvinen A, Barros-Dios JM et al. Radon in homes and risk of lung cancer: collaborative analysis of individual data from 13 European case-control studies. BMJ. 2005 Jan 29;330(7485):223. doi: 10.1136/bmj.38308.477650.63. Epub 2004 Dec 21. PMID: 15613366; PMCID: PMC546066.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Grzywa-Celińska A, Krusiński A, Mazur J, Szewczyk K, Kozak K. Radon-The Element of Risk. The Impact of Radon Exposure on Human Health. Toxics. 2020 Dec 14;8(4):120. doi: 10.3390/toxics8040120. PMID: 33327615; PMCID: PMC7765099.</mixed-citation><mixed-citation xml:lang="en">Grzywa-Celińska A, Krusiński A, Mazur J, Szewczyk K, Kozak K. Radon-The Element of Risk. The Impact of Radon Exposure on Human Health. Toxics. 2020 Dec 14;8(4):120. doi: 10.3390/toxics8040120. PMID: 33327615; PMCID: PMC7765099.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Henshaw DL, Eatough JP, Richardson RB. Radon as a causative factor in induction of myeloid leukaemia and other cancers. Lancet. 1990 Apr 28;335(8696):1008-12. doi: 10.1016/01406736(90)91071-h. PMID: 1970069.</mixed-citation><mixed-citation xml:lang="en">Henshaw DL, Eatough JP, Richardson RB. Radon as a causative factor in induction of myeloid leukaemia and other cancers. Lancet. 1990 Apr 28;335(8696):1008-12. doi: 10.1016/01406736(90)91071-h. PMID: 1970069.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Lammert, E.; Zee, M. Metabolism of Human Diseases: Organ Physiology and Pathophysiology; Springer: Berlin, Germany, 2014.</mixed-citation><mixed-citation xml:lang="en">Lammert, E.; Zee, M. Metabolism of Human Diseases: Organ Physiology and Pathophysiology; Springer: Berlin, Germany, 2014.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Mattes, R.D. Fat taste and lipid metabolism in humans. Physiol. Behav. 2005, 86, 691– 697.</mixed-citation><mixed-citation xml:lang="en">Mattes, R.D. Fat taste and lipid metabolism in humans. Physiol. Behav. 2005, 86, 691– 697.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Zaballa I, Eidemüller M. Mechanistic study on lung cancer mortality after radon exposure in the Wismut cohort supports important role of clonal expansion in lung carcinogenesis. Radiat Environ Biophys. 2016 Aug;55(3):299-315. doi: 10.1007/s00411-016-0659-0. Epub 2016 Jun 22. PMID: 27334643.</mixed-citation><mixed-citation xml:lang="en">Zaballa I, Eidemüller M. Mechanistic study on lung cancer mortality after radon exposure in the Wismut cohort supports important role of clonal expansion in lung carcinogenesis. Radiat Environ Biophys. 2016 Aug;55(3):299-315. doi: 10.1007/s00411-016-0659-0. Epub 2016 Jun 22. PMID: 27334643.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
