ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.25789/YMJ.2023.84.02ymj-271Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHАнализ полиморфных вариантов генов рецепторов серотонина и гамма-аминомасляной кислоты у больных сахарным диабетом 2 типаAnalysis of polymorphic variants of serotonin and gamma-aminobutyric acid receptor genes in patients with type 2 diabetes mellitushttps://orcid.org/0000-0003-2071-0969КочетоваО. В.KochetovaO. V.

Кочетова Ольга Владимировна – к.б.н., с.н.с. 

г. Уфа

Web of Science ResearcherID A-2035-2014

Kochetova Olga Vladimirovna – PhD in Biology, Senior Researcher

 Ufa

 Web of Science Researcher ID A-2035-2014

Olga_mk78@mail.ruhttps://orcid.org/0000-0002-1590-6433АвзалетдиноваД. Ш.AvzaletdinovaD. S.

 Авзалетдинова  Диана Шамилевна – к.м.н., доцент 

г. Уфа

Avzaletdinova Diana Shamilevna – PhD, Associate Professor 

 Ufa

ecolab_203@mail.ruhttps://orcid.org/0000-0002-1695-5173КорытинаГ. Ф.KorytinaG. F.

Корытина Гульназ Фаритовна – д.б.н., доцент, гл.н.с.

Web of Science ResearcherID A-1688-2014 

Korytina Gulnaz Faritovna – Doctor of Biological Sciences, Associate Professor, chief researcher

Web of Science ResearcherID A-1688-2014

Ecolab_203@mail.ruhttps://orcid.org/0000-0001-8900-2480ВиктороваТ. В.ViktorovaT. V.

Викторова Татьяна Викторовна – д.м.н., проф., зав. кафедрой

 AuthorID: 90113.  

Viktorova Tatyana Viktorovna – MD, Professor, Head of the Department  

 Author ID: 90113

ecolab_203@mail.ruИБГ УФИЦ РАНРоссияInstitute of Biochemistry and Genetics of Ufa Federal Research Centre of the Russian Academy of ScienceRussian FederationБашкирский ГМУРоссияBashkir State Medical UniversityRussian Federation20230602202504912Copyright © Кочетова О.В., Авзалетдинова Д.Ш., Корытина Г.Ф., Викторова Т.В., 20252025Кочетова О.В., Авзалетдинова Д.Ш., Корытина Г.Ф., Викторова Т.В.Kochetova O.V., Avzaletdinova D.S., Korytina G.F., Viktorova T.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/271

Проведен анализ полиморфных вариантов генов рецепторов серотонина HTRD rs674386, HTR1F rs56398417, HTR2A rs6313, HTR3A rs1062613, HTR2C rs6318 и гена GABRA2 rs279845 у больных сахарным диабетом 2 типа (СД2), проживающих в Республике Башкортостан. В результате изучения 6 локусов генов нейротрансмиттеров были выявлены протективные маркеры генотипы CT и СС локуса rs1062613 гена HTR3A (OR= 0,73, Pcor_FDR=0,0007) и генотипы риска GC и CC локуса rs6318 гена HTR2C (OR=2,21, Pcor_FDR=0,0045) среди женщин, генотип СС является рисковым и для мужчин (R=4,05, Pcor_FDR=0,0045). Анализ сочетаний генотипов и аллелей выявил комбинации повышенного и пониженного риска СД2. Проведенный анализ ROC-кривых показал, что исследуемые локусы и такие переменные, как пол, возраст обследуемых и ИМТ, можно использовать для оценки прогностической значимости СД2 (AUC=83,4% (95% CI 83,5-87,4).

An analysis of polymorphic variants of the serotonin receptor genes HTRD rs674386, HTR1F rs56398417, HTR2A rs6313, HTR3A rs1062613, HTR2C rs6318 and the GABRA2 rs279845 gene in T2D patients living in the Republic of Belarus was carried out. As a result of the study of 6 loci of neurotransmitter genes, protective markers CT and CC genotypes of the rs1062613 locus of the HTR3A gene (OR= 0.73, Pcor_FDR=0.0007) and GC and CC risk genotypes of the rs6318 locus of the HTR2C gene (OR=2.21, Pcor_FDR=0.0045) among women, the CC genotype is also risky for men (R=4.05, Pcor_FDR=0.0045). Analysis of combinations of genotypes and alleles revealed combinations of increased and decreased risk of T2D. The analysis of ROC curves showed that the studied loci and such variables as sex, age of the examined and BMI can be used to assess the prognostic significance of T2D AUC=83.4% (95% CI 83.5-87.4).

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The authors declare that there are no conflicts of interest present.