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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ymj</journal-id><journal-title-group><journal-title xml:lang="ru">Якутский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Yakut Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1813-1905</issn><issn pub-type="epub">2312-1017</issn><publisher><publisher-name>ЯНЦ КМП</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.25789/YMJ.2022.79.08</article-id><article-id custom-type="elpub" pub-id-type="custom">ymj-26</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>МЕТОДЫ ДИАГНОСТИКИ И ЛЕЧЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>METHODS OF DIAGNOSIS AND TREATMENT</subject></subj-group></article-categories><title-group><article-title>Хирургичеcкое лечение первичной беспигментной меланомы толстой кишки: клинический случай</article-title><trans-title-group xml:lang="en"><trans-title>Surgical treatment of primary non-pigmented colon melanoma: a case report</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2748-0644</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Добродеев</surname><given-names>А. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Dobrodeev</surname><given-names>A. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Добродеев Алексей Юрьевич – д.м.н., в.н.с.</p><p>Томск</p></bio><bio xml:lang="en"><p>Dobrodeev Alexey Yuryevich – Doctor of Medical Sciences, Leading Researcher, Department of Abdominal Oncology, Research Institute of Oncology</p><p>Tomsk</p></bio><email xlink:type="simple">dobrodeev@oncology.tomsk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7375-9585</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Азовский</surname><given-names>Д. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Azovsky</surname><given-names>D. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Азовский Даниил Игоревич – ординатор отделения</p><p>Томск</p></bio><bio xml:lang="en"><p>Azovsky Daniil Igorevich – Resident doctor, Department of Abdominal Oncology, Research Institute of Oncology</p><p>Tomsk</p></bio><email xlink:type="simple">azovdaniil@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5691-2349</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Костромицкий</surname><given-names>Д. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Kostromitsky</surname><given-names>D. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Костромицкий Дмитрий Николаевич – к.м.н.</p><p>Томск</p></bio><bio xml:lang="en"><p>Kostromitsky Dmitry Nikolaevich – MD, PhD, Researcher, Department of Abdominal Oncology, Research Institute of Oncology</p><p>Tomsk</p></bio><email xlink:type="simple">d.n.kostromitsky@tomonco.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4213-9345</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Безгодова</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Bezgodova</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Безгодова Наталья Владимировна – врач-патологоанатом</p><p>Томск</p></bio><bio xml:lang="en"><p>Bezgodova Natalia Vladimirovna – Pathologist, Department of General and Molecular Pathology, Research Institute of Oncology</p><p>Tomsk</p></bio><email xlink:type="simple">natalia.bezgodova@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4701-0375</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Афанасьев</surname><given-names>С. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Afanasyev</surname><given-names>S. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Афанасьев Сергей Геннадьевич – д.м.н., проф., зав. отделением</p><p>Томск</p></bio><bio xml:lang="en"><p>Afanasyev Sergey Gennadievich – Doctor of Medical Sciences, Professor, Head of the Department of Abdominal Oncology, Research Institute of Oncology</p><p>Tomsk</p></bio><email xlink:type="simple">Afanasievsg@oncology.tomsk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7006-602X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тарасова</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Tarasova</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Тарасова Анна Сергеевна – к.м.н., н.с.</p><p>Томск</p></bio><bio xml:lang="en"><p>Tarasova Anna Sergeevna – MD, PhD, Researcher, Department of Abdominal Oncology, Cancer Research Institute</p><p>Tomsk</p></bio><email xlink:type="simple">anna_tarasova@sibmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7301-7581</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Августинович</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Avgustinovich</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Августинович Александра Владимировна – к.м.н., с.н.с.</p><p>Томск</p></bio><bio xml:lang="en"><p>Avgustinovich Aleksandra Vladimirovna – MD, PhD, Senior Researcher, Department of Abdominal Oncology, Cancer Research Institute</p><p>Tomsk</p></bio><email xlink:type="simple">aov862@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">НИИ онкологии, Томский НИМЦ РАН<country>Россия</country></aff><aff xml:lang="en">Tomsk National Research Medical Center of the Russian Academy of Sciences<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>02</day><month>02</month><year>2025</year></pub-date><volume>0</volume><issue>3</issue><fpage>34</fpage><lpage>36</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Добродеев А.Ю., Азовский Д.И., Костромицкий Д.Н., Безгодова Н.В., Афанасьев С.Г., Тарасова А.С., Августинович А.В., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Добродеев А.Ю., Азовский Д.И., Костромицкий Д.Н., Безгодова Н.В., Афанасьев С.Г., Тарасова А.С., Августинович А.В.</copyright-holder><copyright-holder xml:lang="en">Dobrodeev A.Y., Azovsky D.I., Kostromitsky D.N., Bezgodova N.V., Afanasyev S.G., Tarasova A.S., Avgustinovich A.V.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://ymj.elpub.ru/jour/article/view/26">https://ymj.elpub.ru/jour/article/view/26</self-uri><abstract><p>В статье приводится описание клинического случая, который демонстрирует возможности хирургического лечения первичной беспигментной меланомы толстой кишки с удовлетворительными онкологическими результатами.</p></abstract><trans-abstract xml:lang="en"><p>Primary colonic melanoma is a rare malignant tumor with an aggressive course and a poor prognosis. The extremely low incidence of this pathology is due to the fact that there are no melanocytes in the mucosa of the gastrointestinal tract, from which the tumor develops. The development of non-pigmented melanoma are even rarer. Due to the lack of clinical guidelines for the treatment of primary colonic melanoma, therapy is mainly carried out empirically. The article describes a clinical case that demonstrates the possibilities of surgical treatment of primary non-pigmented melanoma of the colon with satisfactory oncological results.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>первичная беспигментная меланома</kwd><kwd>толстая кишка</kwd><kwd>хирургическое лечение</kwd></kwd-group><kwd-group xml:lang="en"><kwd>primary non-pigment melanoma</kwd><kwd>colon</kwd><kwd>surgical treatment</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Первичная меланома прямой кишки (клиническое наблюдение)/ Леонтьев А.В., Данилов М.А., Абдулатипова З.М. и др.// Тазовая хирургия и онкология. -2020;10(2):53-56. https://doi.org/10.17650/2686-9594-2020-10-2-53-56</mixed-citation><mixed-citation xml:lang="en">Primary rectal melanoma (a case report)/ Leontyev A.V., Danilov M.A., Abdulatipova Z.M. et all. // Pelvic Surgery and Oncology. - 2020;10(2):53-56. https://doi.org/10.17650/2686-9594-2020-10-2-53-56</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Титов К.С. Первичная меланома желудочно-кишечного тракта (обзор литературы)/ Титов К.С., Долгопятов И.А., Аскерова З.М., Атрощенко А.О. // Колопроктология.- 2017;2(60):94-99.</mixed-citation><mixed-citation xml:lang="en">Titov K.S. Primary melanoma of the gastrointestinal tract (literature review)/ Titov K.S., Dolgopyatov I.A., Askerova Z.M., Atroshchenko A.O. // Coloproctology. - 2017;2(60):94-99.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Amar A., Jougon J., Edouard A., Laban P., Marry J.P., Hillion G. Mélanome malin primitif de l'intestin grêle [Primary malignant melanoma of the small intestine]. Gastroenterol Clin Biol. 1992;16(4):365-7. French. PMID: 1397858.</mixed-citation><mixed-citation xml:lang="en">Amar A., Jougon J., Edouard A., Laban P., Marry J.P., Hillion G. Mélanome malin primitif de l'intestin grêle [Primary malignant melanoma of the small intestine]. Gastroenterol Clin Biol. 1992;16(4):365-7. French. PMID: 1397858.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Chang A.E., Karnell L.H., Menck H.R. The National Cancer Data Base report on cutaneous and noncutaneous melanoma: a summary of 84,836 cases from the past decade. The American College of Surgeons Commission on Cancer and the American Cancer Society. Cancer. 1998 Oct 15;83(8):1664-78. doi: 10.1002/(sici)1097-0142(19981015)83:83.0.co;2-g. PMID: 9781962.</mixed-citation><mixed-citation xml:lang="en">Chang A.E., Karnell L.H., Menck H.R. The National Cancer Data Base report on cutaneous and noncutaneous melanoma: a summary of 84,836 cases from the past decade. The American College of Surgeons Commission on Cancer and the American Cancer Society. Cancer. 1998 Oct 15;83(8):1664-78. doi: 10.1002/(sici)1097-0142(19981015)83:83.0.co;2-g. PMID: 9781962.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Krausz M.M., Ariel I., Behar A.J. Primary malignant melanoma of the small intestine and the APUD cell concept. J Surg Oncol. 1978;10(4):283-8. doi: 10.1002/jso.2930100402. PMID: 29168.</mixed-citation><mixed-citation xml:lang="en">Krausz M.M., Ariel I., Behar A.J. Primary malignant melanoma of the small intestine and the APUD cell concept. J Surg Oncol. 1978;10(4):283-8. doi: 10.1002/jso.2930100402. PMID: 29168.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Manouras A., Genetzakis M., Lagoudianakis E., Markogiannakis H., Papadima A., Kafiri G., Filis K., Kekis P.B., Katergiannakis V. Malignant gastrointestinal melanomas of unknown origin: should it be considered primary? World J Gastroenterol. 2007 Aug 7;13(29):4027-9. doi: 10.3748/wjg.v13.i29.4027. PMID: 17663525; PMCID: PMC4171183.</mixed-citation><mixed-citation xml:lang="en">Manouras A., Genetzakis M., Lagoudianakis E., Markogiannakis H., Papadima A., Kafiri G., Filis K., Kekis P.B., Katergiannakis V. Malignant gastrointestinal melanomas of unknown origin: should it be considered primary? World J Gastroenterol. 2007 Aug 7;13(29):4027-9. doi: 10.3748/wjg.v13.i29.4027. PMID: 17663525; PMCID: PMC4171183.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Miliaras S., Ziogas I.A., Mylonas K.S., Papadopoulos V.N. Primary malignant melanoma of the ascending colon. BMJ Case Rep. 2018 Mar 9;2018:bcr2017223282. doi: 10.1136/bcr-2017-223282. PMID: 29523612; PMCID: PMC5847959.</mixed-citation><mixed-citation xml:lang="en">Miliaras S., Ziogas I.A., Mylonas K.S., Papadopoulos V.N. Primary malignant melanoma of the ascending colon. BMJ Case Rep. 2018 Mar 9;2018:bcr2017223282. doi: 10.1136/bcr-2017-223282. PMID: 29523612; PMCID: PMC5847959.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Mishima Y. Melanocytic and nevocytic malignant melanomas. Cellular and subcellular differentiation. Cancer. 1967 May;20(5):632-49. doi: 10.1002/1097-0142(1967)20:53.0.co;2-7. PMID: 6024276.</mixed-citation><mixed-citation xml:lang="en">Mishima Y. Melanocytic and nevocytic malignant melanomas. Cellular and subcellular differentiation. Cancer. 1967 May;20(5):632-49. doi: 10.1002/1097-0142(1967)20:53.0.co;2-7. PMID: 6024276.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Raja J., Hegde R., Srodon M., Katoch A., Kurtzman S., Zhang Z. A Case of Primary Melanoma of the Transverse Colon. Cureus. 2017 Oct 26;9(10):e1803. doi: 10.7759/cureus.1803. PMID: 29308331; PMCID: PMC5749940.</mixed-citation><mixed-citation xml:lang="en">Raja J., Hegde R., Srodon M., Katoch A., Kurtzman S., Zhang Z. A Case of Primary Melanoma of the Transverse Colon. Cureus. 2017 Oct 26;9(10):e1803. doi: 10.7759/cureus.1803. PMID: 29308331; PMCID: PMC5749940.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Yi N.H., Lee S.H., Lee S.H., Kim J.H., Jee S.R., Seol S.Y. Primary malignant melanoma without melanosis of the colon. Intest Res. 2019 Oct;17(4):561-564. doi: 10.5217/ir.2019.00020. Epub 2019 Aug 5. PMID: 31302994; PMCID: PMC6821945</mixed-citation><mixed-citation xml:lang="en">Yi N.H., Lee S.H., Lee S.H., Kim J.H., Jee S.R., Seol S.Y. Primary malignant melanoma without melanosis of the colon. Intest Res. 2019 Oct;17(4):561-564. doi: 10.5217/ir.2019.00020. Epub 2019 Aug 5. PMID: 31302994; PMCID: PMC6821945</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
