ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.25789/YMJ.2024.88.26ymj-241Research ArticleНАУЧНЫЕ ОБЗОРЫSCIENTIFIC REVIEWSГенетические факторы, влияющие на здоровье кожиGenetic factors affecting skin healthhttps://orcid.org/0000-0001-7862-1876ПавловаН. И,PavlovaN. I.

 Павлова Надежда Ивановна – к.б.н., в.н.с. – руковод. лаб. 

 Якутск 

solnishko_84@inbox.ruЯНЦ КМПРоссия20240602202504111114Copyright © Павлова Н.И., 20252025Павлова Н.И.Pavlova N.I.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/241

Кожа является самым большим органом в организме человека, выполняющим барьерную функцию для поддержания гомеостаза организма. Старение кожи — сложный процесс, на который влияют наследственные и экологические факторы. Такие свойства, как увлажненность, эластичность и антиоксидантная способность, играют ключевую роль в процессе старения кожи. Генетические вариации могут влиять на выработку коллагена и эластина, уровень антиоксидантов и целостность барьерной функции кожного покрова. Выявление генетических маркеров, влияющих на состояние кожи, позволит разработать рекомендации для коррекции признаков старения, а также может стать эффективным и доступным методом лечения многих кожных заболеваний в будущем. В данном обзоре обобщены и представлены современные данные о генетических факторах и молекулярных механизмах, влияющих на здоровье и внешний вид кожи.

Skin is the largest organ in the human body, performing a barrier function to maintain homeostasis of the body. Skin aging is a complex process influenced by hereditary and environmental factors. Properties such as hydration, elasticity and antioxidant capacity play a key role in the skin aging process. Genetic variations can affect the production of collagen and elastin, the level of antioxidants and the integrity of the barrier function of the skin. Identification of genetic markers that affect skin condition will allow us to develop recommendations for correcting signs of aging, and may also become an effective and affordable method for treating many skin diseases in the future. This review summarizes and presents current data on genetic factors and molecular mechanisms affecting the health and appearance of the skin.

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The authors declare that there are no conflicts of interest present.