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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ymj</journal-id><journal-title-group><journal-title xml:lang="ru">Якутский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Yakut Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1813-1905</issn><issn pub-type="epub">2312-1017</issn><publisher><publisher-name>ЯНЦ КМП</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">ymj-2357</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL RESEARCH</subject></subj-group></article-categories><title-group><article-title>Изменение функции легких у больных с деструктивными формами туберкулеза легких в условиях Крайнего Севера</article-title><trans-title-group xml:lang="en"><trans-title>Change of lungs function in patients with the destructive forms of pulmonary tuberculosis in the conditions of the Far North</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сивцева</surname><given-names>А. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Sivtseva</surname><given-names>A. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сивцева Анна Иннокентьевна – д.м.н., зав. лаб.</p></bio><email xlink:type="simple">sannai@inbox.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пальшина</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Palshina</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Пальшина Аида Михайловна – к.м.н., зав. кафедрой</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хорунов</surname><given-names>А. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Horunov</surname><given-names>A. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Хорунов Алексей Николаевич – к.м.н., доцент</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Арбыкина</surname><given-names>М. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Arbykina</surname><given-names>M. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Арбыкина Маргарита Семеновна – врач функциональной диагностики высшей квалиф.категории</p></bio><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ФГНУ «Институт здоровья»<country>Россия</country></aff><aff xml:lang="en">Yakutsk State University<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">МИ СВФУ им.М.К. Аммосова<country>Россия</country></aff><aff xml:lang="en">Medical Institute<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru">ГУ НПЦ «Фтизиатрия»<country>Россия</country></aff><aff xml:lang="en">State Institution and Scientific Practical Center “Ftiziatriia”<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2010</year></pub-date><pub-date pub-type="epub"><day>26</day><month>10</month><year>2025</year></pub-date><volume>0</volume><issue>4</issue><fpage>27</fpage><lpage>29</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Сивцева А.И., Пальшина А.М., Хорунов А.Н., Арбыкина М.С., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Сивцева А.И., Пальшина А.М., Хорунов А.Н., Арбыкина М.С.</copyright-holder><copyright-holder xml:lang="en">Sivtseva A.I., Palshina A.M., Horunov A.N., Arbykina M.S.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://ymj.elpub.ru/jour/article/view/2357">https://ymj.elpub.ru/jour/article/view/2357</self-uri><abstract><p>У 46 больных жителей Якутии с деструктивными формами туберкулёза лёгких были исследованы изменения функции внешнего дыхания на фоне длительного лечения ингибитором АПФ энап 5мг. Было выявлено, что длительный приём (в течение 2 лет) энапа 5мг не вызывает бронхиальной обструкции, при компенсированном туберкулезе, при наличии исходно умеренных нарушений вентиляционной способности лёгких на фоне химиотерапии у 50% больных приводит к улучшению или частичному улучшению вентиляционной функции.</p></abstract><trans-abstract xml:lang="en"><p>In 46 patients residents of Yakutia with destructive forms of pulmonary tuberculosis changes of respiratory function on the background of longterm treatment with an ACE inhibitor Enap 5mg were studied. It was found that Enap 5mg prolonged use (over 2 years) does not cause bronchial obstruction during the compensated tuberculosis, in the presence of initially moderate violations of pulmonary ventilation capacity against the background of chemotherapy in 50% of patients leads to improvement or partial improvement of ventilatory function.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>деструктивные формы туберкулёза лёгких</kwd><kwd>вентиляционная функция лёгких</kwd></kwd-group><kwd-group xml:lang="en"><kwd>destructive forms of pulmonary tuberculosis</kwd><kwd>pulmonary ventilation</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Черниченко Н.В. Динамика вентиляционной и газообменной функции при применении препарата сурфанктанта у больных туберкулёзом лёгких / Н.В. Черниченко [и др.] // Проблемы туберкулёза и болезней лёгких. – М., 2006. – №6. – С.6-9.</mixed-citation><mixed-citation xml:lang="en">Thernithenko N.V. Dynamics of ventilation and gas exchange function in the application  preparatat surfanktankta in patients with pulm onary tuberculosis/ Thernithenko N.V. [et al.] //Problem of tuberculosis and Lung Disease. - М.,2006.- №6.- P.6-9</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Сатишур О.Е. Механическая вентиляция лёгких / О.Е. Сатишур. – М., 2006. – С.228, Satichur O.E. Mechanical ventilation of thelungs/ O.E. Satichur.-М., 2006.-P.228,229.</mixed-citation><mixed-citation xml:lang="en">Сатишур О.Е. Механическая вентиляция лёгких / О.Е. Сатишур. – М., 2006. – С.228,  Satichur O.E. Mechanical ventilation of thelungs/ O.E. Satichur.-М., 2006.-P.228,229.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Визель А.А. Оптимизация лекарственной коррекции функциональных нарушений кровообращения и дыхания у больных туберкулёзом лёгких: автореф. дис. … д-ра мед.наук / Визель А.А. – М., 1991.</mixed-citation><mixed-citation xml:lang="en">Vizel A.A. Optimization of drug correction of functional disorders of blood circulation and respiration in patients with pulmonary tuberculosis: Autoreferat for the degree of Doctor of Medical Sciences/ A.A. Vizel. -М., 1991.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Palevsky H.I., Fishman A.P. Chronic cor pulmonale / H.I. Palevsky, A.P. Fishman. Etiology and management // JAMA. – 1990. – May 2;263(17):2347-53.</mixed-citation><mixed-citation xml:lang="en">Palevsky H.I., Fishman A.P. Chronic cor pulmonale / H.I. Palevsky, A.P. Fishman. Etiology and management // JAMA. – 1990. – May 2;263(17):2347-53.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
