ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.25789/YMJ.2024.86.09ymj-235Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHАссоциация полиморфизма rs9939609 гена FTO с индексом массы тела в популяции якутовAssociation of the FTO gene polymorphism (rs9939609) with body mass index in the Yakut populationhttps://orcid.org/0009-0008-5414-4102БочуровА. А.BochurovA. A.

Бочуров Алексей Алексеевич – м.н.с.

Якутск

Bochurov Alexey Alekseevich – junior researcher of the Laboratory of Hereditary Pathology, Department of Molecular Genetics

binbaher@mail.ruhttps://orcid.org/0000-0001-7862-1876ПавловаН. И.PavlovaN. I.

Павлова Надежда Ивановна – к.б.н., в.н.с.-руковод. лаб.

Якутск

Pavlova Nadezhda Ivanovna – PhD in Biology, leading researcher Head of the Laboratory of Hereditary Pathology, Department of Molecular Genetics

solnishko_84@inbox.ruhttps://orcid.org/0009-0005-5977-5518КрыловА. В.KrylovA. V.

Крылов Алексей Васильевич – м.н.с.

Якутск

Krylov Alexey Vasilievich – junior researcher of the Laboratory of Hereditary Pathology, Department of Molecular Genetics

alexkrulovwork@gmail.comhttps://orcid.org/0000-0002-2143-0021КононоваС. К.KononovaS. K.

Кононова Сардана Кононовна – к.б.н., гл.н.с.-руковод. отдела.

Якутск

Kononova Sardana Kononovna – PhD in Biology, chief researcher, head of the Department of Molecular Genetics

konsard@rambler.ruФГБНУ «Якутский научный центр комплексных медицинских проблем» ЯкутскРоссияFederal State Budgetary Scientific Institution Yakut Science Centre of Complex Medical ProblemsRussian Federation202406022025023538Copyright © Бочуров А.А., Павлова Н.И., Крылов А.В., Кононова С.К., 20252025Бочуров А.А., Павлова Н.И., Крылов А.В., Кононова С.К.Bochurov A.A., Pavlova N.I., Krylov A.V., Kononova S.K.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/235

Исследование посвящено изучению взаимосвязи полиморфизма rs9939609 гена FTO с индексом массы тела (ИМТ) в популяции якутов. Выборка состояла из участников якутской национальности без сахарного диабета. Был проведен анализ распределения частот встречаемости аллелей и генотипов, а также анализ показателей ИМТ в группах с различными генотипами полиморфизма rs9939609 гена FTO, в ходе которого обнаружено сходство в соотношениях частот аллелей с популяциями Восточной и Южной Азии. Установлена слабая связь ожирения с аллелем риска А при сравнивании группы с нормальным ИМТ и объединенной группой ожирение+предожирение.

The study is devoted to studying the relationship between the rs9939609 polymorphism of the FTO gene and body mass index (BMI) in the Yakut population. The sample consisted of 521 participants of Yakut nationality without diabetes mellitus and not registered with a dispensary, aged from 18 to 75 years, 222 women and 299 men. An analysis of the distribution of frequencies of occurrence of alleles and genotypes was carried out, as well as an analysis of BMI indicators in groups with different genotypes of the rs9939609 polymorphism of the FTO gene, during which similarities were found in the ratios of allele frequencies with populations of East and South Asia. Statistical analysis using the Kruskal-Wallis test with multiple analysis Dunn's test with Bonferroni correction and the odds ratio (OR) with the significance test with Yates' correction within the study showed a weak association of obesity with the risk allele A when comparing the group with normal BMI and the combined group of obesity + pre-obesity p = 0.043.

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The authors declare that there are no conflicts of interest present.