ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.25789/YMJ.2024.88.24ymj-233Research ArticleНАУЧНЫЕ ОБЗОРЫSCIENTIFIC REVIEWSПервично-множественные ненаследственные злокачественные новообразованияPrimary multiple non-hereditary malignant neoplasmshttps://orcid.org/0000-0003-2874-0193ПадеровЮ. М.PaderovYu. M.

 Падеров Юрий Михайлович – к.м.н., доцент  

 Томск 

 AuthorID (РИНЦ): 633353

yurii_paderov@mail.ruhttps://orcid.org/0009-0002-7714-788XМавидиХ. Л.MavidiKh. L.

 Мавиди Харлампий Леонидович – студент 5 курса 

 Томск 

mavidi.harik@mail.ruhttps://orcid.org/0000-0003-3536-8473ЖуйковаЛ. Д.ZhuikovaL. D.

 Жуйкова Лилия Дмитриевна – д.м.н., зав. лаб. НИИ онкологии 

 AuthorID (РИНЦ): 633353

ScopusID: 56626111900

Researcher ID (WOS): C-8293- 2012 

zhuikovalili@mail.ruhttps://orcid.org/0000-0003-1453-2254ПикаловаЛ. В.PikalovaL. V.

 Пикалова Лидия Валентиновна – к.м.н., н.с. 

AuthorID (РИНЦ): 917980

ScopusID: 57190937921

Researcher ID (WOS): E-5347-2017 

l.v.pikalova@tomonco.ruhttps://orcid.org/0000-0001-9429-9813ЗавьяловаМ. В.ZavyalovaM. V.

Завьялова Марина Викторовна – д.м.н., проф., в.н.с. НИИ онкологии Томского НИМЦ, зав. кафедрой ФГБОУ ВО СибГМУ 

AuthorID (РИНЦ): 323615

ScopusID: 36711031100

Researcher ID (WOS): С-8580-2012 

zavyalova.mv@ssmu.ruhttps://orcid.org/0000-0001-8973-8439ПисьменныйД. С.PismennyD. S.

Письменный Дмитрий Сергеевич – к.м.н., врач НИИ онкологии Томского НИМЦ, ассистент кафедры ФГБОУ 

AuthorID (РИНЦ): 913773

ScopusID: 57218625147 

https://orcid.org/0009-0009-0266-6707ЗавьяловА. В.ZavyalovA. V.

 Завьялов Александр Васильевич – студент 3 курса 

 AuthorID (РИНЦ): 1157261 

https://orcid.org/0000-0001-6010-6462КононоваГ. А,KononovaG. A.

 Кононова Галина Александровна – м.н.с. 

AuthorID (РИНЦ): 1104711

ScopusID: 57861019700

Researcher ID (WOS): GVU-3963-2022 

kononovaga@onco.tnimc.ruhttps://orcid.org/0000-0001-8002-3189АнанинаО. А.AnaninaO. A.

Ананина Ольга Александровна – к.м.н., с.н.с. 

AuthorID (РИНЦ): 555590

ScopusID: 56366338100

Researcher ID (WOS): D-8708- 2012 

ananina.olga@bk.ruФГБОУ ВО СибГМУ Минздрава РоссииРоссияТомский НИМЦРоссияНИИ онкологии Томского НИМЦРоссияНИИ онкологии Томского НИМЦ; ФГБОУ ВО СибГМУ Минздрава РоссииРоссияФГБОУ ВО «Сибирский государственный медицинский университет» МЗ РФРоссия20240602202504103106Copyright © Падеров Ю.М., Мавиди Х.Л., Жуйкова Л.Д., Пикалова Л.В., Завьялова М.В., Письменный Д.С., Завьялов А.В., Кононова Г.А., Ананина О.А., 20252025Падеров Ю.М., Мавиди Х.Л., Жуйкова Л.Д., Пикалова Л.В., Завьялова М.В., Письменный Д.С., Завьялов А.В., Кононова Г.А., Ананина О.А.Paderov Y.M., Mavidi K.L., Zhuikova L.D., Pikalova L.V., Zavyalova M.V., Pismenny D.S., Zavyalov A.V., Kononova G.A., Ananina O.A.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/233

В основе канцерогенеза первично-множественных злокачественных новообразований находится многоступенчатый процесс изменений, злокачественной трансформации и прогрессирования, что включает повреждение ДНК и нарушение функции иммунной системы. Повреждение определенных участков генов, участвующих в митозе, гибели клеток или репарации участков ДНК отражается в увеличении мутационной нагрузки. После накопления достаточного количества мутаций нарушается контроль над функцией клетки, что приводит к развитию рака. В последние годы отмечено увеличение частоты первично-множественных новообразований. В обзоре приведены основные факторы риска, в той или иной степени влияющие на развитие полинеоплазий.

Carcinogenesis is based on a multistage process of changes, malignant transformation and progression, which includes DNA damage and dysfunction of the immune system. Damage to certain parts of genes involved in mitosis, cell death or DNA repair is reflected in an increase in the mutation load. After accumulation of a sufficient number of mutations, control over cell function is disrupted, which leads to the development of cancer. In recent years, an increase in the frequency of multiple primary neoplasms has been noted. The review presents the main risk factors that to one degree or another affect the development of polyneoplasia.

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The authors declare that there are no conflicts of interest present.