ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.25789/YMJ.2022.80.06ymj-232Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHОсобенности микробиома эндометрия бесплодных женщин и его влияние на ремоделирование в фазу «имплантационного окна»Features of the endometrial microbiome of infertile women and its effect on the viability of the "implantation window" phaseПолинаМ. Л.PolinaM. I.

Полина Мирослава Леонидовна – к.м.н., Медицинский центр женского здоровья (Москва), ассистент кафедры Медицинского института Российского университета Дружбы народов

Polina Miroslava Leonidovna – PhD in Medical Sciences, Assistant Professor of the Department of Obstetrics and Gynaecology, Medical Center for Women's Health (Moscow), Medical Institute of the Peoples' Friendship University of Russia

polina.ml@mail.ruВитязеваИ. И.VityazevaI. I.

итязева Ирина Ивановна – д.м.н., зав. отделением

Vityazeva Irina Ivanovna – MD, Head. Department 

ЗахароваП. Н.ZakharovaP. N.

Захарова  Прасковья  Николаевна – аспирант Медицинского института 

Zakharova Praskovya Nikolaevna – post-graduate student of the of the Department of Obstetrics and Gynecology, Faculty of Postgraduate Training of Doctors, Medical Institute 

ДугласН. И.DouglasN. I.

Дуглас Наталья Ивановна – д.м.н., зав. кафедрой МИ

Douglas Natalya Ivanovna – MD, head. Department of Obstetrics and Gynecology, Medical Institute 

Медицинский центр женского здоровья (Москва); Российскbq университета Дружбы народовРоссияMedical Center for Women's Health (Moscow), Peoples' Friendship University of RussiaRussian FederationНациональный медицинский исследовательский центр эндокринологии МЗ РФРоссияNational Medical Research Center of Endocrinology of the Ministry of Health of the Russian FederationRussian FederationСеверо-Восточный федеральный университет им. М.К. АммосоваРоссияM.K. Ammosov North-Eastern Federal UniversityRussian Federation202206022025042328Copyright © Полина М.Л., Витязева И.И., Захарова П.Н., Дуглас Н.И., 20252025Полина М.Л., Витязева И.И., Захарова П.Н., Дуглас Н.И.Polina M.I., Vityazeva I.I., Zakharova P.N., Douglas N.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/232

С целью изучения микробиоты и морфологических характеристик эндометрия в фазу «имплантационного окна» обследовали женщин с бесплодием неясного генеза (БНГ), трубно-перитонеальным (ТПБ), на фоне хронического эндометрита (ХЭ) в сочетании с полипом эндометрия (ПЭ), хронического эндометрита в целом (с ПЭ и без него).

По данным гистологического исследования образцы с несоответствием темпов созревания эндометрия средней стадии фазы секреции отмечали чаще в группе с ХЭ, чем с БНГ и ТПБ. При дисхронизме желез и стромы эндометрия в фазу «имплантационного окна» женщины имели дисбиотический тип микробиоты достоверно чаще, чем женщины с секреторными изменениями. Полученные данные позволяют предполагать влияние лактобациллярного типа эндометрия на полноценное ремоделирование эндометрия в фазу «имплантационного окна». Дисбиотический тип микробиоты представляется маркером нарушения морфологических характеристик эндометрия в фазу «имплантационного окна», преимущественно на фоне хронического воспалительного процесса.

Changes in the endometrial microbiome (dysbiotic type) were more often combined with dyschronism phenomena (inconsistency in the rate of the gland maturation with the secretory phase of the menstrual cycle) in women than with secretory changes. The data obtained allow us to state the dysbiotic type of microbiota appears to be a marker of violation of the morphological characteristics of the endometrium during the "implantation window" phase, mainly against the background of a chronic inflammatory process. The dysbiotic profile of the endometrium in infertile women is the cause of a violation of molecular mechanisms necessary for adequate blastocyst implantation. The studying endometrial microbiota increases the likelihood of predicting reproductive outcomes before embryo transfer and choosing an effective treatment strategy when changing quantitative and qualitative species characteristics

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The authors declare that there are no conflicts of interest present.