ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.25789/YMJ.2024.88.23ymj-229Research ArticleНАУЧНЫЕ ОБЗОРЫSCIENTIFIC REVIEWSМикробиом опухолей поджелудочной железыMicrobiome of pancreatic tumorsФедороваМ. С.FedorovaM. S.

 Федорова Мария Сергеевна – к.б.н., м.н.с.  

 Москва 

fedorowams@yandex.ruПавловВ. С.PavlovV. S.

 Павлов Владислав Сергеевич – к.б.н., м.н.с. 

vladislav1pavlov@gmail.comФилатоваА. А.FilatovaA. A.

 Филатова Алёна Алексеевна – врач-патологоанатом 

 Москва 

alyonafilatova17@gmail.comКалининД. В.KalininD. V.

 Калинин Дмитрий Валерьевич – к.м.н., зав. отд.  

dmitry.v.kalinin@gmail.comФГБУН Институт молекулярной биологии им. В.А. Энгельгардта РАНRussian FederationФГБУ «Национальный медицинский исследовательский центр хирургии им. А.В. Вишневского» МЗ РФRussian Federation2024060220250498102Copyright © Федорова М.С., Павлов В.С., Филатова А.А., Калинин Д.В., 20252025Федорова М.С., Павлов В.С., Филатова А.А., Калинин Д.В.Fedorova M.S., Pavlov V.S., Filatova A.A., Kalinin D.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/229

Рак поджелудочной железы (РПЖ) является одним из самых летальных типов злокачественных новообразований с очень низкой выживаемостью (5-7%), которая связана со сложностью его ранней диагностики и агрессивным течением. Прогрессия и метастазирование опухоли завязаны на множестве аспектов, одним из которых является её микробиом. Микробиота участвует в формировании иммунной толерантной среды, что способствует развитию рака, индуцируя процессы ангиогенеза, хеморезистентности, подавления иммунных клеток, инвазии и метастазирования опухоли. Изменения микробного состава опухоли и модуляция иммунной функции в конечном итоге могут повлиять на течение и исход заболевания. Расширение знаний о составе и путях попадания микроорганизмов в такие опухоли, как рак поджелудочной железы, позволит найти факторы, прогнозирующие их поведение и потенциальные таргеты для терапии. Цель обзора: обобщение известных к настоящему времени о составе микробиома и источниках микроорганизмов в опухолях поджелудочной железы.

Pancreatic cancer is one of the most lethal types of malignancies, with a very low survival rate (5-7%), which is related to the difficulty of early diagnosis and the aggressive nature of the disease. The progression of tumours and the process of metastasis are linked to a number of factors, one of which is the tumour microbiome. The microbiota plays a role in the formation of an immune-tolerant environment, which contributes to cancer development by inducing angiogenesis, chemoresistance, immune cell suppression, tumour invasion and metastasis. Modifications in the composition of tumour-associated microbes and alterations in immune function may ultimately influence the progression and outcome of the disease. Enhancing our understanding of the composition and pathways of microorganisms in tumours, such as pancreatic cancer, will facilitate the identification of predictive factors and potential therapeutic targets. The objective of this review to synthesise the current knowledge about the composition of the microbiota and its origins in pancreatic tumours.

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The authors declare that there are no conflicts of interest present.