ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.25789/YMJ.2024.86.01ymj-216Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHАнализ уровня экспрессии циркулирующих микрорнк в крови у пациентов с болезнью АльцгеймераAnalysis of the expression level of circulating micrornas in the blood of patients with Alzheimer's diseaseНиколаевВ. М.NikolaevV. M.

Николаев Вячеслав Михайлович – к.б.н., с.н.с.

Nikolaev Vyacheslav Mikhailovich – Candidate of Biological Sciences, senior researcher

Nikolaev1126@mail.ruКрасноваН. М.KrasnovaN. M.

Краснова Наталья Михайловна – к.м.н., доцент

Krasnova Natalia Mikhailovna – Candidate of Medical Sciences, Associate Professor

АсекритоваА. С.AsekritovaA. S.

Асекритова Александра Степановна – к.м.н., доцент СВФУ им. М.К. Аммосова, зав. Центром предиктивной медицины и биоинформатики Республиканской клинич. б-цы №3

Asekritova Alexandra Stepanovna – Candidate of Medical Sciences, Associate Professor at the M.K. Ammosov Northeastern Federal University, Head of The Center for Predictive Medicine and Bioinformatics of the Republican Clinical Hospital No. 3

ТатариноваО. В.TatarinovaO. V.

Татаринова Ольга Викторовна – д.м.н., с.н.с.

Tatarinova Olga Viktorovna – Doctor of Medical Sciences, senior researcher at the YSC of Complex Medical Problems, chief physician of the RCH No. 3

БурeИ. В.BureI. V.

Буре Ирина Владимировна – к.б.н., с.н.с.

Bure Irina Vladimirovna – Candidate of Biological Sciences, Senior Researcher

СычевД. А.SychevD. A.

Сычев Дмитрий Алексеевич – д.м.н., проф., проф. РАН, акад. РАН, ректор ДПО РМАНПО МЗ РФ

Sychev Dmitry Alekseevich – Doctor of Medical Sciences, Prof., Prof. RAS, acad. RAS, Rector

ЯНЦ комплексных медицинских проблемРоссияYSC of Complex Medical ProblemsRussian FederationСеверо-Восточный федеральн. ун-та им. М.К. АммосоваРоссияM.K. Ammosov Northeastern Federal UniversityRussian FederationСВФУ им. М.К. Аммосова; Республиканская клинич. б-ца №3РоссияM.K. Ammosov Northeastern Federal University; Republican Clinical Hospital No. 3Russian FederationЯНЦ КМП, гл. врач РКБ№3РоссияRCH No. 3Russian FederationНИИ молекулярной и персонализированной медицины Российской медицинской академии непрерывного проф. образования МЗ РФРоссияResearch Institute of Molecular and Personalized Medicine of the Russian Medical Academy of Continuing Education of the Ministry of Health of the Russian FederationRussian FederationДПО РМАНПО МЗ РФ.РоссияRussian Academy of Medical Sciences of the Ministry of Health of the Russian FederationRussian Federation2024050220250258Copyright © Николаев В.М., Краснова Н.М., Асекритова А.С., Татаринова О.В., Бурe И.В., Сычев Д.А., 20252025Николаев В.М., Краснова Н.М., Асекритова А.С., Татаринова О.В., Бурe И.В., Сычев Д.А.Nikolaev V.M., Krasnova N.M., Asekritova A.S., Tatarinova O.V., Bure I.V., Sychev D.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/216

Проведено исследование с целью определить уровень экспрессии циркулирующих микроРНК: hsa-mir-483, hsa-miR-132, hsa-mir-29c, hsa-mir-193b в сыворотке крови у лиц пожилого и старческого возраста, страдающих болезнью Альцгеймера.

Полученные нами данные свидетельствуют, что в организме пациентов, страдающих болезнью Альцгеймера, уровни данных микроРНК зависели от возраста и степени когнитивных нарушений. У лиц старческого возраста, страдающих умеренной степенью деменции, в сыворотке крови выявлена циркулирующая микроРНК mir-132-5p, в отличие от лиц пожилого возраста с легкой степенью деменции.

Over the past few decades, there has been a steady decline in fertility worldwide, while life expectancy has been increasing. This is leading to an ageing population. In today's aging world, cognitive disorders and dementia in the elderly are key problems. Thus studying the regulation of the molecular mechanisms of age-related cognitive impairment is an urgent task. Fourteen elderly and senile individuals with Alzheimer's disease participated in this study. The expression of circulating microRNAs at all stages was determined using kits from Qiagen (Germany).

A study was conducted to determine the expression level of circulating microRNAs: hsa-mir-483, hsa-miR-132, hsa-mir-29c, hsa-mir-193b in the blood serum of elderly and senile people suffering from Alzheimer's disease.

The data obtained by us indicates that in patients suffering from Alzheimer's disease, the levels of these micro-RNAs depended on age and the degree of cognitive impairment. Circulating mir-132-5p microRNA was detected in the blood serum of senile people suffering from moderate dementia, in contrast to elderly people with mild degree of dementia.

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The authors declare that there are no conflicts of interest present.