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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ymj</journal-id><journal-title-group><journal-title xml:lang="ru">Якутский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Yakut Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1813-1905</issn><issn pub-type="epub">2312-1017</issn><publisher><publisher-name>ЯНЦ КМП</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">ymj-2155</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL RESEARCH</subject></subj-group></article-categories><title-group><article-title>Антибиотическая активность метаболитов грибов рода TRICHODERMA</article-title><trans-title-group xml:lang="en"><trans-title>Antibiotic activity of metabolites of TRICHODERMA fungi</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шариков</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Sharikov</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шариков Андрей Михайлович – н.с.</p></bio><bio xml:lang="en"><p>Andrew M. Sharikov, I have no degree, researcher at the laboratory of cell and molecular physiology and pathology</p><p>tel. sl. (391) 228-06-83; the institute: 660022, Krasnoyarsk, ul. Partizan Zheleznyaka, 3, block «G»; tel. house: (391) 268-37-99; house аddress: 660061, Krasnoyarsk, ul. Kalinina, d. 70, building «B», kv. 5</p></bio><email xlink:type="simple">loengrinionessi@bk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Новицкий</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Novitsky</surname><given-names>I. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Новицкий Иван Александрович – д.м.н., проф., вед.н.</p></bio><bio xml:lang="en"><p>Ivan A Novitsky, MD, Professor, Senior Researcher, Laboratory of Cellular and Molecular Physiology</p><p>tel. sl. (391) 228-06-83; the institute: 660022, Krasnoyarsk, ul. Partizan Zheleznyaka, 3, block «G»</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Манчук</surname><given-names>В. Т.</given-names></name><name name-style="western" xml:lang="en"><surname>Mantchuk</surname><given-names>V. T.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Манчук Валерий Тимофеевич – д.м.н., проф., член-кор. РАМН, директор института</p></bio><bio xml:lang="en"><p>Valery T Mantchuk, MD, professor, corresponding member of RAMS, Director</p><p>Krasnoyarsk. tel. sl. (391) 228-06-83; the institute: 660022, РФ, Krasnoyarsk, ul. Partizan Zheleznyaka, 3, block «G»</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>НИИ медицинских проблем Севера СО РАМН</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Medical Research Institute for Northern Problems of Medical Sciences</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>НИИ медицинских проблем Севера СО РАМН</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Institute of Pathology have medical problems of the North Medical Sciences</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2011</year></pub-date><pub-date pub-type="epub"><day>19</day><month>10</month><year>2025</year></pub-date><volume>0</volume><issue>3</issue><fpage>41</fpage><lpage>43</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Шариков А.М., Новицкий И.А., Манчук В.Т., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Шариков А.М., Новицкий И.А., Манчук В.Т.</copyright-holder><copyright-holder xml:lang="en">Sharikov A.M., Novitsky I.A., Mantchuk V.T.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://ymj.elpub.ru/jour/article/view/2155">https://ymj.elpub.ru/jour/article/view/2155</self-uri><abstract><p>Изучали методом лунок действие метаболитов грибов рода Trichoderma harzianum на ряд грампозитивных и грамнегативных микроорганизмов: Bacillus subtilis, Micrococcus luteus, Salmonella moskow, S. typhimurium. Показана антибиотическая активность метаболитов гриба T. charzianum в отношении M. luteus, S. moskow. Данные метаболиты перспективны как продуценты новых антибиотических препаратов.</p></abstract><trans-abstract xml:lang="en"><p>Effect of metabolites of fungi Trichoderma harzianum on the number of gram-positive and gram-negative microorganisms: Bacillus subtilis, Micrococcus luteus, Salmonella moskow, S. typhimurium was studied by the method of holes. Antibiotic activity of metabolites of the fungus T. charzianum against M. luteus, S. moskow is shown. These metabolites are perspective as producers of new antibiotic drugs.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>бактерицидное действие</kwd><kwd>несовершенные грибы</kwd><kwd>метаболиты грибов рода Trichoderma</kwd><kwd>метод лунок</kwd><kwd>грамнегативные и грампозитивные микроорганизмы</kwd></kwd-group><kwd-group xml:lang="en"><kwd>bactericidal effect</kwd><kwd>imperfect fungi</kwd><kwd>metabolites of fungi of the genus Trichoderma</kwd><kwd>the method of holes</kwd><kwd>gram-negative and grampositive microorganisms</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ершова Е.Ю. Поиск продуцентов антибиотиков грибного происхождения, эффективных в отношении метициллинрезистентных стафилококков: автореф. дисс. …канд. биол. наук / Е.Ю. Ершова. – М., 2003. – 26с.</mixed-citation><mixed-citation xml:lang="en">Ershova E.J. Search for producers of antibiotics of fungal origin that are effective against methicillin resistant staphylococci: author. diss. ... Candidate. Biol. Science / E.J. Ershova.- M., 2003. – 26 p.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Ооржак У.С. Научно-практические аспекты рационального использования плодовых тел Fomitopsis officinalis (Vill.: Fr.) Bond. et. Sing: автореф. дисс. …канд. биол. наук / У.С. Ооржак. – Красноярск, 2006. – 18с.</mixed-citation><mixed-citation xml:lang="en">Oorzhak U.S. Scientific and practical aspects of management of fruiting bodies of Fomitopsis officinalis (Vill.: Fr.) Bond. et. Sing: author. diss. ... Candidate. Biol. Science / U.S. Oorzhak. - Krasnoyarsk, 2006. – 18p.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Сейкетов Г.Ш. Грибы рода Trichoderma и их использование в практике / Г.Ш. Сейкетов. – Алма-Ата: Наука, 1982. – 245с.</mixed-citation><mixed-citation xml:lang="en">Seyketov G.Sh. Trichoderma fungi and their use in practice / Seyketov G.Sh. - Alma-Ata: Nauka, 1982. – 245p.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Филиппова И.А. Естественное лекарство нового тысячелетия: грибы против рака / И.А. Филиппова. СПб.: Диля, 2005. – 128с.</mixed-citation><mixed-citation xml:lang="en">Filippova I.A. The natural medicine of the new millennium: fungi against cancer / I.A. Filippova. -SPb.: Diehla, 2005. -128p.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Чхенкели В.А. Антимикробное действие дереворазрушающего гриба Coriolus pubescens (Shum.: Fr.) Quel. / В.А.Чхенкели; Т.И. Никифорова; Р.Г. Скворцова // Микол. и фитопатол. – 1998. – Т.32, Вып. 1. – С. 69-72.</mixed-citation><mixed-citation xml:lang="en">Chkhenkeli V.A., Nikiforova T.I., Skvortsova R.G. Antimicrobial action of wood-destroying fungi Coriolus pubescens (Shum.: Fr.) Quel. / V.A. Chkhenkeli, T.I. Nikiforova, R.G. Skvortsova // Mikol. i fitopatol. - 1998. - V.32, Is. 1. - P. 69-72.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Чхенкели В.А. Некоторые аспекты медико-биологических исследований высших дереворазрушающих базидиомицетов как источника биологически активных веществ / В.А. Чхенкели; Г.Д. Чхенкели; Е.Д. Агапова и др. // Сибирский медицинский журнал. – 2001. – №1. – С. 59-65.</mixed-citation><mixed-citation xml:lang="en">Chkhenkeli V.A. Some aspects of biomedical research of higher wood-destroying basidiomycetes as a source of biologically active compounds / V.A. Chkhenkeli, G.D. Chkhenkeli, E.D. Agapova [et al.] // Sibirsk. Med. Zhurnal. - 2001. - № 1. - P. 59-65.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Чхенкели В.А. Противотуберкулёзная активность базидиомицета CORIOLUS PUBESCENS (SHUM.: FR.) QUEL. и препарата, получаемого на его основе / В.А.Чхенкели; Н.А. Шкиль // Сибирский медицинский журнал. – 2005. – №1. – С. 67-71.</mixed-citation><mixed-citation xml:lang="en">Chkhenkeli V.A. Antituberculosis activity of basidiomycete CORIOLUS PUBESCENS (SHUM.: FR.) QUEL. and drug, obtained on its basis / V.A. Chkhenkeli, N.A. Shkil // Ibid. - 2005. - № 1. - P. 67-71.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Шариков А.М. Выраженность бактерицидной активности гриба INONOTUS OBLIQUUS PILAT в отношении FRANCISELLA TULARENSIS линии 15 НИИЭГ / А.М. Шариков, Н.В. Пашенова, И.А. Новицкий // Сибирское медицинское обозрение. – 2008. – №1(49). – С. 19-21.</mixed-citation><mixed-citation xml:lang="en">Sharikov A.M. Intensity of bactericidal activity of the fungus INONOTUS OBLIQUUS PILAT against FRANCISELLA TULARENSIS line 15 NIIEG / A.M. Sharikov, N.V. Pashenova, I.A. Novitsky // Sib. Med. obozr. - 2008. - № 1 (49). - P. 19-21.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Шариков А.М. Исследование антибиотической активности гриба чаги в отношении возбудителя туляремии / А.М. Шариков, Н.В. Пашенова, Д.А. Нешумаев, И.А. Новицкий. // Тихоокеанский медицинский журнал. – 2010. – №1. – С. 64-65.</mixed-citation><mixed-citation xml:lang="en">Sharikov A.M. Investigation of antibiotic activity of the shelf fungus against the pathogen of tularemia / A.M. Sharikov, N.V. Pashenova, D.A. Neshumaev, I.A. Novitsky // Tikhook. Med. Zhurnal. - 2010. - № 1. - P. 64-65.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Howell C.R. Relevance of mycoparasitism in the biological control of Rhizoctonia solani by Glioclaafum virens / C.R. Howell // Phytopathology, 1987. - 77 .- P. 992-994.</mixed-citation><mixed-citation xml:lang="en">Howell C.R. Relevance of mycoparasitism in the biological control of Rhizoctonia solani by Glioclaafum virens / C.R. Howell // Phytopathology, 1987. - 77 .- P. 992-994.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Lumsden R.D., Lewis I.A., Locke J.C. Managing soilbome plant pathogens with fungal antagonists / R.D. Lumsden, I.A. Lewis, J.C. Locke // Pest Management: Biologically Based Technologies (ed. R.D. Lumsden &amp; J.L.Vaughn), 1993. - P. 196-203.</mixed-citation><mixed-citation xml:lang="en">Lumsden R.D., Lewis I.A., Locke J.C. Managing soilbome plant pathogens with fungal antagonists / R.D. Lumsden, I.A. Lewis, J.C. Locke // Pest Management: Biologically Based Technologies (ed. R.D. Lumsden &amp; J.L.Vaughn), 1993. - P. 196-203.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Chlebicki A. Fomitopsis officinalis on Sibirian Larch in the Urals / A. Chlebicki, V. Mukhin, N. Ushakova // Mycologist. – 2003. – Vol. 17, 3. – P. 116-120.</mixed-citation><mixed-citation xml:lang="en">Chlebicki A. Fomitopsis officinalis on Sibirian Larch in the Urals / A. Chlebicki, V. Mukhin, N. Ushakova // Mycologist. – 2003. – Vol. 17, 3. – P. 116-120.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Molitoris H.P. Mushrooms in medicine / H.P. Molitoris // Folia Mikrobiol. – 1994. – V. 39. – N. 2. – P. 91-98.</mixed-citation><mixed-citation xml:lang="en">Molitoris H.P. Mushrooms in medicine / H.P. Molitoris // Folia Mikrobiol. – 1994. – V. 39. – N. 2. – P. 91-98.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Mukhin V.A. Distribution, frequency and biology of Laricifomes officinalis in the Asian part of Russia / V.A. Mukhin, H. Kotiranta, H. Knudsen [et al.] // Mycology and Phytopathology. - 2005. - V. 39, No. 5. - P. 34-42.</mixed-citation><mixed-citation xml:lang="en">Mukhin V.A. Distribution, frequency and biology of Laricifomes officinalis in the Asian part of Russia / V.A. Mukhin, H. Kotiranta, H. Knudsen [et al.] // Mycology and Phytopathology. - 2005. - V. 39, No. 5. - P. 34-42.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
