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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ymj</journal-id><journal-title-group><journal-title xml:lang="ru">Якутский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Yakut Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1813-1905</issn><issn pub-type="epub">2312-1017</issn><publisher><publisher-name>ЯНЦ КМП</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">ymj-2147</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL RESEARCH</subject></subj-group></article-categories><title-group><article-title>Иммунологические показатели больных хроническим гастритом, ассоциированным с Helicobacter pylori в условиях Якутии</article-title><trans-title-group xml:lang="en"><trans-title>Immunological indicators of patients with chronic gastritis, associated with Helicobacter pylori in the conditions of Yakutia</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ефремова</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Efremova</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ефремова Аграфена Владимировна – лаборант-исследователь</p></bio><bio xml:lang="en"><p>Efremova Agrafena Vladimirovna – assistant-researcher of department studying the mechanisms of adaptation mechanisms</p></bio><email xlink:type="simple">a.efremova01@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гольдерова</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Golderova</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гольдерова Айталина Семеновна – к.м.н., гл.н.с.</p></bio><bio xml:lang="en"><p>Golderova Aytalina Semyonovna – candidate of medical science, senior researcher of department studying of adaptation mechanisms</p></bio><email xlink:type="simple">hoto68@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Миронова</surname><given-names>Г. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Mironova</surname><given-names>G. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Миронова Галина Егоровна – д.б.н., проф.;</p><p>вед.н.с.</p></bio><bio xml:lang="en"><p>Mironova Galina Egorovna – doctor of biological sciences, professor of department Macromolecular Compounds and Organic Chemistry;</p><p>leading researcher of department studying of adaptation mechanisms</p></bio><email xlink:type="simple">mirogalin@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Алексеева</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Alekseeva</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Алексеева Елизавета Алексеевна – м.н.с.</p></bio><bio xml:lang="en"><p>Alekseeva Elizaveta Alekseevna – junior researcher at the department study the mechanisms of adaptation</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Константинова</surname><given-names>Л. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Konstantinova</surname><given-names>L. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Константинова Лена Ивановна – лаборант-исследователь</p></bio><bio xml:lang="en"><p>Konstantinova Lena Ivanovna – assistant- researcher of department studying the mechanisms of adaptation mechanisms;</p><p>Postgraduate</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Олесова</surname><given-names>Л. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Olesova</surname><given-names>L. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Олесова Любовь Дыгыновна – к.б.н., с.н.с.</p></bio><bio xml:lang="en"><p>Olesova Lubov Dygynovna – head of laboratory studying the biochemical mechanisms of adaptation mechanisms</p></bio><email xlink:type="simple">atec@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Якутский научный центр комплексных медицинских проблем СО РАМН</institution><country>Россия</country></aff><aff xml:lang="en"><institution>YSC of complex medical problems of SB RAMS</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Якутский научный центр комплексных медицинских проблем СО РАМН;&#13;
СВФУ им. М.К. Аммосова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>North East Federal University M.K. Ammosov;&#13;
YSC of complex medical problems of SB RAMS</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Якутский научный центр комплексных медицинских проблем СО РАМН</institution><country>Россия</country></aff><aff xml:lang="en"><institution>YSC of complex medical problems of SB RAMS;&#13;
North East Federal University M.K. Ammosov</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2011</year></pub-date><pub-date pub-type="epub"><day>19</day><month>10</month><year>2025</year></pub-date><volume>0</volume><issue>3</issue><fpage>21</fpage><lpage>24</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ефремова А.В., Гольдерова А.С., Миронова Г.Е., Алексеева Е.А., Константинова Л.И., Олесова Л.Д., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Ефремова А.В., Гольдерова А.С., Миронова Г.Е., Алексеева Е.А., Константинова Л.И., Олесова Л.Д.</copyright-holder><copyright-holder xml:lang="en">Efremova A.V., Golderova A.S., Mironova G.E., Alekseeva E.A., Konstantinova L.I., Olesova L.D.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://ymj.elpub.ru/jour/article/view/2147">https://ymj.elpub.ru/jour/article/view/2147</self-uri><abstract><p>Обследовано 88 больных хроническим гастритом, коренной национальности (якуты) в возрасте от 30 до 50 лет. Выявлена зависимость уровня иммуноглобулинов и цитокинов от степени обсемененности Нelicobacter pylori в сыворотке крови больных хроническим гастритом.</p></abstract><trans-abstract xml:lang="en"><p>Our research presents the immunological characteristics of 88 patients with chronic gastritis type B, indigenous (Yakuts), age range 30-50 years. In research the dependence of the levels of immunoglobulins and cytokines on the degree of Helicobacter pylori contamination in the blood serum of patients with chronic gastritis is revealed.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>хронический гастрит</kwd><kwd>Helicobacter pylori</kwd><kwd>иммуноглобулины</kwd><kwd>цитокины</kwd></kwd-group><kwd-group xml:lang="en"><kwd>chronic gastritis</kwd><kwd>Helicobacter pylori</kwd><kwd>immunoglobulins</kwd><kwd>cytokines</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Александрова В.А. Иммунный ответ инфекции Helicobacter pylori/ В.А. Александрова, И.П. Козлова// Лечащий врач. – 2002. – №11. – С. 13 – 16.</mixed-citation><mixed-citation xml:lang="en">Alexandrova V.A. Immune response of Helicobacter pylori infection/ V.A. Aleksandrova, I.P. Kozlova // Treating physician (Russian). – 2002. – № 11. –P. 13 – 16.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Андросов В.Т. Клинико-патогенетические варианты хронического гастрита в условиях Крайнего Севера (Якутская АССР): автореф. дис. …канд. мед. наук./ В.Т. Андросов – Якутск, 1984. – 18с.</mixed-citation><mixed-citation xml:lang="en">Androsov V.T. Clinico-pathogenetic variants of chronic gastritis in the Far North (Yakut ASSR): abstract. dis. ... candidate. med. science. / V.T. Androsov – Yakutsk, 1984. – 18p.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Антитела к Helicobacter pylori при болезнях желудка/ Л.Б. Лазебник, Т.М. Царегородцева, Т.И. Серова [и др.]// Терапевт.арх. – 2006. – Т. 78, № 2. – С. 15 – 19.</mixed-citation><mixed-citation xml:lang="en">Antibodies to Helicobacter pylori for stomach diseases (Russian) / L.B. Lazebnik, T.M. Tsaregorodtseva, T.I. Serova [et al.] // Terapevt. arh. – 2006. – V. 78, № 2. – P.15 – 19.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Аруин Л.И. Морфологическая диагностика болезней желудка и кишечника/ Л.И. Аруин, Л.Л. Капуллер, В.А.Исаков – М.: Триада -Х – 1998. – 496с.</mixed-citation><mixed-citation xml:lang="en">Aruin L.I. Morphological diagnosis of the stomach and intestine diseases/ L.I. Aruin, L.L. Kapuller, V.A. Isakov – M.: Triada-X – 1998. – 496p.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Емельянова Э.А. Хронический гастрит и язвенная болезнь в условиях Севера/ Э.А. Емельянова, С.Л. Сафонова. – Якутск. – 2000.– 96с.</mixed-citation><mixed-citation xml:lang="en">Emelyanova E.A. Chronic gastritis and peptic ulcer disease in the North (Russian) / E.A. Emelianova, S.L. Safonova. – Yakutsk. – 2000. – 96p.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Кононов А.В. Воспаление как основа Helicobacter pylori-ассоциированных болезней/ А.В. Кононов//Архив патологии. – 2006. – Т.68., № 5 - С. 3 – 5.</mixed-citation><mixed-citation xml:lang="en">Kononov A.V. Inflammation as a basis for Helicobacter pylori-associated diseases/ A.V. Kononov // Archives of Pathology. – 2006. – T.68., № 5 – P. 3 – 5.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Лоскутова К.С. Изменения слизистой оболочки антрального отдела желудка при Helicobacter pylori-ассоциированном гастритеу населения Якутии/К.С. Лоскутова//Вестник ЯГУ. – 2006. – Т.3., №2. – С. 22 – 26.</mixed-citation><mixed-citation xml:lang="en">Loskutova K.S. Changes in the mucous membrane of antrum in Helicobacter pyloriassociated gastritis in the population of Yakutia / K.S. Loskutova // Vestnik of YGU. – 2006. – V.3., № 2. – P. 22 – 26.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Особенности течения язвенной болезни у коренных жителей Севера /С.С.Сосина, П.М. Иванов, А.И. Иванов и [др.] //Актуальные проблемы клинической онкологии и преканцерогенеза: материалы межрегион. конф. – Якутск. – 2005. – С.75-76.</mixed-citation><mixed-citation xml:lang="en">Features of ulcer disease in the indigenous population of the North / S.S. Sosina, P.M. Ivanov,  A.I. Ivanov [et al.] //Actual problems of clinicaloncology and precancerogenesis: interreg. conf. materials. – Yakutsk. – 2005. – P.75-76.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Останин А.А. Характеристика апоптической и функциональной активности лимфоцитов у больных язвенной болезнью/ А.А. Останин, А.И. Пальцев, А.Г. Лебедев//Бюллетень СО РАМН. – 2004. – №1 (111). – С. 129 – 134.</mixed-citation><mixed-citation xml:lang="en">Ostanin A.A. Characteristics of apoptosis and the functional activity of lymphocytes in patients with peptic ulcer disease / A.A. Ostanin, A.I. Paltsev, A.G. Lebedev // Bulletin of Siberian Branch of RAMS. – 2004. – № 1 (111). – P. 129 – 134.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Петрова П.Г. Экология, адаптация, здоровье/П.Г. Петрова; по ред. Н.А. Агаджаняна. – Якутск: Сахаполиграфиздат – 1996. – 269с.</mixed-citation><mixed-citation xml:lang="en">Petrova P.G. Ecology, adaptation, health / P.G. Petrova; in red. of N.A. Aghajanian. – Yakutsk: Sakhapoligrafizdat. – 1996. – 269p.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Тихонов Д.Г. Болезни пищевода, желудка и двенадцатиперстной кишки в Республике Саха (Якутия). (Клинико-эпидемиологическое обследование. Амбулаторно-поликлиническая помощь): автореф. дис…. д-ра мед. наук/ Д.Г. Тихонов – М., 1993. – 39с.</mixed-citation><mixed-citation xml:lang="en">Tikhonov D.G. Diseases of the esophagus, stomach and duodenum in the Republic Sakha  (Yakutia) (Clinical and epidemiological study. Outpatient care): abstract. dis.... dr. med. science /D.G. Tikhonov – M., 1993. – 39p.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Федоров А.И. Особенности иммуноглобулинового статуса населения Якутии в зависимости от географических широт места проживания/ А.И.Федоров, В.Л. Осаковский//Якутский медицинский журнал. – 2008. – №4(24). – С.29 – 31.</mixed-citation><mixed-citation xml:lang="en">Fedorov A.I. Features of the immunoglobulin status of the population of Yakutia, depending on the geographic latitude of residence (Russian)/ A.I. Fedorov, V.L. Osakovsky //Yakutsk Medical Journal. – 2008. - № 4(24). – P.29 – 31.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Activation of the complement system during and after cardiopulmonary bypass surgery: postsurgery activation involves C-reactive proteinand is associated with postoperative arrhythmia/P. Bruins, H. te Velthuis, A. P. Yazdanbakhsh [et al.] //Circulation. – 1997. – Vol. 96. – P. 3542-3548.</mixed-citation><mixed-citation xml:lang="en">Activation of the complement system during and after cardiopulmonary bypass surgery:  postsurgery activation involves C-reactive proteinand is associated with postoperative arrhythmia/P. Bruins, H. te Velthuis, A. P. Yazdanbakhsh [et al.] //Circulation. – 1997. – Vol. 96. – P. 3542-3548.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Local cytokine response in Helicobacter pylori-infected subjects/ C. Lindholm, M. QuidingJarbink, H. Lonroth [et. al.]//Infect. and Immun. –1998.– Vol. 66. –№12. – P. 5964–597</mixed-citation><mixed-citation xml:lang="en">Local cytokine response in Helicobacter pylori-infected subjects/ C. Lindholm, M. QuidingJarbink, H. Lonroth [et. al.]//Infect. and Immun. –1998.– Vol. 66. –№12. – P. 5964–597</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Validation of a serological test for the diagnosis of Helicobacter pylori infection and the immune response to urease and CagA in children/ M. Camorlinga-Ponce, J. Torres, J. Perez-Perez [et. al.]// Am. J. Gastroenterol. – 1998. – Vol. 93. – P. 1264 – 1270.</mixed-citation><mixed-citation xml:lang="en">Validation of a serological test for the diagnosis of Helicobacter pylori infection and the immune response to urease and CagA in children/ M. Camorlinga-Ponce, J. Torres, J. Perez-Perez [et. al.]// Am. J. Gastroenterol. – 1998. – Vol. 93. – P. 1264 – 1270.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
