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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ymj</journal-id><journal-title-group><journal-title xml:lang="ru">Якутский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Yakut Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1813-1905</issn><issn pub-type="epub">2312-1017</issn><publisher><publisher-name>ЯНЦ КМП</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">ymj-2145</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL RESEARCH</subject></subj-group></article-categories><title-group><article-title>Состояние здоровья подростков с гипоталамическим синдромом пубертатного периода</article-title><trans-title-group xml:lang="en"><trans-title>The health status of adolescents with the pubertal period hypothalamic syndrome</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ракицкая</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Rakitskaya</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ракицкая Елена Викторовна – к.м.н., доцент</p></bio><bio xml:lang="en"><p>Rakitskaya Elena Viktorovna, M.D., Assistant Professor at the Pediatric Department, tel.: +7(4212)980-591</p><p>680000, Khabarovsk, ul.Muravyova-Amurskogo, 35. Tel./Fax: 8(4212) 326-393</p></bio><email xlink:type="simple">iomid@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Учакина</surname><given-names>Р. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Uchakina</surname><given-names>R. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Учакина Раиса Владимировна – д.б.н., проф., гл.н.с.</p></bio><bio xml:lang="en"><p>Uchakina Raisa Vladimirovna – Ph.D., Professor, Main scientific researcher</p><p>680022, Khabarovsk, ul.Voronezghskaya. 49, bldg.1.Tel.: 8(4212) 980-591</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Козлов</surname><given-names>В. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Kozlov</surname><given-names>V. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Козлов Владимир Кириллович – д.м.н., проф., засл. деятель науки, чл.-корр. РАМН, директор</p></bio><bio xml:lang="en"><p>Kozlov Vladimir Kirillovich – M.D., Ph.D. Professor, Honorable scientific researcher, Deputy Member of the RAMS, Director, tel.: +7(4212)980-335</p><p>680022, Khabarovsk, ul.Voronezghskaya. 49, bldg.1.Tel.: 8(4212) 980-591</p></bio><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ДВГМУ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Far-Eastern state medical university</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>НИИ охраны материнства и детства СО РАМН</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Mother and child care institute at SB RAMS</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>НИИ охраны материнства и детства</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Mother and child care institute at SB RAMS</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2011</year></pub-date><pub-date pub-type="epub"><day>19</day><month>10</month><year>2025</year></pub-date><volume>0</volume><issue>3</issue><fpage>14</fpage><lpage>17</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ракицкая Е.В., Учакина Р.В., Козлов В.К., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Ракицкая Е.В., Учакина Р.В., Козлов В.К.</copyright-holder><copyright-holder xml:lang="en">Rakitskaya E.V., Uchakina R.V., Kozlov V.K.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://ymj.elpub.ru/jour/article/view/2145">https://ymj.elpub.ru/jour/article/view/2145</self-uri><abstract><p>Обследовано 74 здоровых и 142 с гипоталамическим синдромом (ГС) подростка. Изучены показатели белкового, липидного и углеводного обменов, гормональный статус, изучены психологические особенности, качество жизни, особенности физического развития и становления репродуктивной функции. Выявленные клинико-лабораторные изменения свидетельствуют о раннем дебюте метаболического синдрома (МС) у подростков с ГС. Полиморфизм метаболических и эндокринных нарушений у подростков с ГС свидетельствует о высокой степени риска развития раннего атеросклероза, сахарного диабета 2 типа, прогрессирующей полиэндокринной патологии, приводящих к нарушению репродуктивного здоровья.</p></abstract><trans-abstract xml:lang="en"><p>74 healthy adolescents and 142 patients with the pubertal period hypothalamic syndrome were examined. The indexes of protein, lipid and carbohydrate metabolic processes, hormone state, psychological peculiarities, quality of life, physical development peculiarities and reproductive function formation were investigated. Detected clinical and laboratory changes represent the early debut of the metabolic syndrome (MS) in the adolescents with hypothalamic syndrome (HS). The polymorphism of metabolic and endocrine disorders in the adolescents with HS reflects the high risk of early atherosclerosis and diabetes mellitus type 2 developments, progression of poly-endocrine pathology, resulting in reproductive disabilities.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>подростки</kwd><kwd>гипоталамический синдром</kwd><kwd>состояние здоровья</kwd><kwd>качество жизни</kwd></kwd-group><kwd-group xml:lang="en"><kwd>adolescents</kwd><kwd>hypothalamic syndrome</kwd><kwd>health status</kwd><kwd>quality of life</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Аверьянов А. П. Нейровегетативные нарушения у детей с ожирением в период пубертата и их коррекция / А. П. Аверьянов, Н. В. 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