ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМПymj-2144Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHСовременные направления в исследовании этиопатогенеза идиопатического сколиоза у детейModern directions in research of idiopathic scoliosis etiopathogenesis in childrenБороздунС. В.BorozdunS. V.

Бороздун Светлана Викторовна – к.м.н., врач педиатр

г. Красноярск

ПаничеваЕ. С.PanichevaE. S.

Паничева Елена Сергеевна – врач стоматолог, соискатель кафедры стоматологии

г. Красноярск

Krasnoyarsk

БоброваЕ. И.BobrovaE. I.

Боброва Елена Ивановна – м.н.с.

г. Красноярск

КузнецовВ. С.KuznetsovV. S.

Кузнецов Василий Сергеевич – студент

Krasnoyarsk

ЭвертЛ. С.EvertL. S.

Эверт Лидия Семеновна – д.м.н., вед.н.с.

lidiya_evert@mail.ruАртюховаТ. Ю.ArtjuhovaT. J.

Артюхова Татьяна Юрьевна – к. психол. н., доцент, зав. кафедрой

Лесосибирский педагогический институт – филиал Сибирского федерального университета

г. Лесосибирск

the rector - the candidate fiz-mat. nauk M.J.Reushev

Lesosibirsk

ИПО ГОУ ВПО КрасГМУ им. В.Ф. Войно-ЯсенецкогоРоссияScientific research institute of medical problems of the North FROM the Russian Academy of Medical ScienceRussian FederationИПО ГОУ ВПО КрасГМУ им. В.Ф. Войно-ЯсенецкогоРоссияV.F.Voino-Yasenetskiy State Educational Establishment of Higher Professional TrainingRussian FederationУРАМН НИИ медицинских проблем Севера СО РАМНРоссияScientific research institute of medical problems of the North FROM the Russian Academy of Medical ScienceRussian FederationГОУ ВПО КрасГМУ им. В.Ф. Войно-ЯсенецкогоРоссияV.F.Voino-Yasenetskiy State Educational Establishment of Higher Professional TrainingRussian FederationНИИ медицинских проблем Севера СО РАМНРоссияScientific research institute of medical problems of the North FROM the Russian Academy of Medical ScienceRussian FederationLesosibirsky pedagogical institute - branch SFURussian Federation201119102025031014Copyright © Бороздун С.В., Паничева Е.С., Боброва Е.И., Кузнецов В.С., Эверт Л.С., Артюхова Т.Ю., 20252025Бороздун С.В., Паничева Е.С., Боброва Е.И., Кузнецов В.С., Эверт Л.С., Артюхова Т.Ю.Borozdun S.V., Panicheva E.S., Bobrova E.I., Kuznetsov V.S., Evert L.S., Artjuhova T.J.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/2144

Дан обзор результатов проведенных исследований и существующих в настоящее время представлений об этиологии и патогенезе ювенильного идиопатического сколиоза (ЮИС) у детей и подростков. Обсуждаются нейро-анатомические взаимоотношения и роль системной дисфункции в патогенезе ЮИС. Отражены современные теории развития, основные факторы риска развития и прогрессирования ювенильного идиопатического сколиоза у детей, его основные компоненты. Подчеркивается важность продолжения исследований ЮИС на молекулярно-биохимическом уровне, необходимость выделения специфических параметров – маркеров развития идиопатического сколиоза для совершенствования подходов к диагностике, прогнозированию особенностей течения, профилактике и лечению данного заболевания у детей.

The review of results of the spent researches and now existing representations about etiology and pathogenesis of juvenile idiopathic scoliosis (JIS) in children and teenagers is given. Neuro-anatomic interrelations and a role of system dysfunction in JIS pathogenesis are discussed. Modern theories of development, major factors of risk of development and progressing of juvenile idiopathic scoliosis in children, its basic components are reflected. Importance of continuation of JIS researches at molecular-biochemical level, necessity of allocation of specific parameters - development markers of idiopathic scoliosis for perfection of approaches to diagnostics, forecasting of current features, prevention and treatment of the disease in children is underlined.

детиидиопатический сколиозэтиологияпатогенезchildrenidiopathic scoliosisetiologypathogenesisReferencesAdolescents with idiopathic scoliosis are not osteoporotic / E.A. Szalay, P. Bosch, R.M. Schwend et al. //Spine (Phila Pa 1976). – 2008. - V. 33, N 7. - P. 802-806.Adolescents with idiopathic scoliosis are not osteoporotic / E.A. Szalay, P. Bosch, R.M. Schwend et al. //Spine (Phila Pa 1976). – 2008. - V. 33, N 7. - P. 802-806.Aggrecan gene expression disorder as aetiologic factor of idiopathic scoliosis / A.M. Zaidman, M.N. Zaidman, A.V. Korel et al. // Stud.Health Technol. Inform. – 2006. - V.123. - P. 14-17.Aggrecan gene expression disorder as aetiologic factor of idiopathic scoliosis / A.M. Zaidman, M.N. Zaidman, A.V. Korel et al. // Stud.Health Technol. Inform. – 2006. - V.123. - P. 14-17.A relook into the association of the estrogen receptor [alpha] gene (PvuII, XbaI) and adolescent idiopathic scoliosis: a study of 540 Chinese cases / N.L. Tang , H.Y. Yeung, K.M. Lee et al. // Spine (Phila Pa 1976). – 2006. - V. 31, N 21. - P. 2463-2468.A relook into the association of the estrogen receptor [alpha] gene (PvuII, XbaI) and adolescent idiopathic scoliosis: a study of 540 Chinese cases / N.L. Tang , H.Y. Yeung, K.M. Lee et al. // Spine (Phila Pa 1976). – 2006. - V. 31, N 21. - P. 2463-2468.Association between circulating leptin level and anthropometric parameters in girls with adolescent idiopathic scoliosis // Eur. Spine J. – 2007. - V.16, N 10. - P.1563-1569.Association between circulating leptin level and anthropometric parameters in girls with adolescent idiopathic scoliosis // Eur. Spine J. – 2007. - V.16, N 10. - P.1563-1569.Association between IL-6 and MMP-3 gene polymorphisms and adolescent idiopathic scoliosis: a case-control study / L. Aulisa, P. Papaleo, E. Pola et al. // Spine (Phila Pa 1976). – 2007. - V. 32, N 24. - P.2700-2702.Association between IL-6 and MMP-3 gene polymorphisms and adolescent idiopathic scoliosis: a case-control study / L. Aulisa, P. Papaleo, E. Pola et al. // Spine (Phila Pa 1976). – 2007. - V. 32, N 24. - P.2700-2702.Asymmetric evolution of anterior chest wall blood supply in female adolescents with progressive right-convex thoracic idiopathicscoliosis / P. Iliopoulos, P. Korovessis, G. Koureas et al. // Eur. Spine J. – 2007. - V.16, N 9. - P. 1343-1347.Asymmetric evolution of anterior chest wall blood supply in female adolescents with progressive right-convex thoracic idiopathicscoliosis / P. Iliopoulos, P. Korovessis, G. Koureas et al. // Eur. Spine J. – 2007. - V.16, N 9. - P. 1343-1347.Asymmetric expression of melatonin receptor mRNA in bilateral paravertebral muscles in adolescent idiopathic scoliosis / Y. Qiu , L. Wu,B. Wang et al. // Spine (Phila Pa 1976). – 2007. - V.32, N 6. - P. 667-672.Asymmetric expression of melatonin receptor mRNA in bilateral paravertebral muscles in adolescent idiopathic scoliosis / Y. Qiu , L. Wu,B. Wang et al. // Spine (Phila Pa 1976). – 2007. - V.32, N 6. - P. 667-672.Cerebral glucose metabolic abnormality in patients with congenital scoliosis / W.W. Park, K.T. Suh, J.I. Kim et al. // Eur. Spine J. – 2008. - V.17, N 7. - P.948-955.Cerebral glucose metabolic abnormality in patients with congenital scoliosis / W.W. Park, K.T. Suh, J.I. Kim et al. // Eur. Spine J. – 2008. - V.17, N 7. - P.948-955.CHD7 gene polymorphisms are associated with susceptibility to idiopathic scoliosis / X. Gao, D. Gordon, D. Zhang et al. // Am. J. Hum Genet. – 2007. - V.80, N 5. - P.:957-965.CHD7 gene polymorphisms are associated with susceptibility to idiopathic scoliosis / X. Gao, D. Gordon, D. Zhang et al. // Am. J. Hum Genet. – 2007. - V.80, N 5. - P.:957-965.Dastych, M. Changes of selenium, copper, and zinc content in hair and serum of patients with idiopathic scoliosis / M. Dastych, J. Cienciala, M. Krbec // J. Orthop. Res. – 2008. - V.26, N 9. - P. 1279-1282.Dastych, M. Changes of selenium, copper, and zinc content in hair and serum of patients with idiopathic scoliosis / M. Dastych, J. Cienciala, M. Krbec // J. Orthop. Res. – 2008. - V.26, N 9. - P. 1279-1282.Durmala, J. Prevalence of subtle cardiac electrical abnormalities in children with idiopathic scoliosis / J. Durmala, M. Sosnowska, M. Sosnowski // Stud. Health Technol. Inform. – 2006. - V.123. - P. 425-430.Durmala, J. Prevalence of subtle cardiac electrical abnormalities in children with idiopathic scoliosis / J. Durmala, M. Sosnowska, M. Sosnowski // Stud. Health Technol. Inform. – 2006. - V.123. - P. 425-430.Elevated soluble receptor activator of nuclear factor-kappaB ligand and reduced bone mineral density in patients with adolescent idiopathic scoliosis / K.T. Suh, S.S. Lee , S.H. Hwang et al. // Eur. Spine J. – 2007. - V. 16, N 10. - P. 1563-1569.Elevated soluble receptor activator of nuclear factor-kappaB ligand and reduced bone mineral density in patients with adolescent idiopathic scoliosis / K.T. Suh, S.S. Lee , S.H. Hwang et al. // Eur. Spine J. – 2007. - V. 16, N 10. - P. 1563-1569.Estimation of the centre of mass for the study of postural control in Idiopathic Scoliosis patients: a comparison of two techniques / K.F. Zabjek, C. Coillard, C.H. Rivard et al. // Eur. Spine J. – 2008. - V.17, N 3. - P. 355-60.Estimation of the centre of mass for the study of postural control in Idiopathic Scoliosis patients: a comparison of two techniques / K.F. Zabjek, C. Coillard, C.H. Rivard et al. // Eur. Spine J. – 2008. - V.17, N 3. - P. 355-60.Etiologic theories of idiopathic scoliosis: enantiomorph disorder concept of bilateral symmetry, physeally-created growth conflicts and possible prevention / R.G. Burwell, B.J. Freeman, P.H. Dangerfield et al. // Stud. Health Technol. Inform. – 2006. - V.123. - P. 391-397.Etiologic theories of idiopathic scoliosis: enantiomorph disorder concept of bilateral symmetry, physeally-created growth conflicts and possible prevention / R.G. Burwell, B.J. Freeman, P.H. Dangerfield et al. // Stud. Health Technol. Inform. – 2006. - V.123. - P. 391-397.Etiologic theories of idiopathic scoliosis: neurodevelopmental concept of maturational delay of the CNS body schema (“body-inthe-brain”) / R.G. Burwell, B.J. Freeman, P.H. Dangerfield et al. // Stud. Health Technol. Inform. – 2006. - V.123. - P. 72-79.Etiologic theories of idiopathic scoliosis: neurodevelopmental concept of maturational delay of the CNS body schema (“body-inthe-brain”) / R.G. Burwell, B.J. Freeman, P.H. Dangerfield et al. // Stud. Health Technol. Inform. – 2006. - V.123. - P. 72-79.Etiopathogenesis of adolescent idiopathic scoliosis and new molecular concepts / K. Letellier, B. Azeddine, S. Blain et al. // Med. Sci (Paris). – 2007. - V.23, N 11. - P. 910-916.Etiopathogenesis of adolescent idiopathic scoliosis and new molecular concepts / K. Letellier, B. Azeddine, S. Blain et al. // Med. Sci (Paris). – 2007. - V.23, N 11. - P. 910-916.Experimental scoliosis in melatonindeficient C57BL/6J mice without pinealectomy / M Machida, J. Dubousset, T. Yamada et al. // J. Pineal Res. – 2006. - V.41, N 1. - P. 1-7.Experimental scoliosis in melatonindeficient C57BL/6J mice without pinealectomy / M Machida, J. Dubousset, T. Yamada et al. // J. Pineal Res. – 2006. - V.41, N 1. - P. 1-7.Expression of calmodulin in the articular process of vertebrae of adolescent idiopathic scoliosis patients] / G.X. Qiu , J. Li , Y. Liu et al. // Zhonghua Yi Xue Za Zhi. – 2006. - V.86, N 29. - P. 2017-2020.Expression of calmodulin in the articular process of vertebrae of adolescent idiopathic scoliosis patients] / G.X. Qiu , J. Li , Y. Liu et al. // Zhonghua Yi Xue Za Zhi. – 2006. - V.86, N 29. - P. 2017-2020.Facet asymmetry in normal vertebral growth: characterization and etiologic theory of scoliosis / Y.M. Masharawi, S. Peleg, H.B. Albert et al. // Spine (Phila Pa 1976). – 2008. - V.33, N 8. - P. 898-902.Facet asymmetry in normal vertebral growth: characterization and etiologic theory of scoliosis / Y.M. Masharawi, S. Peleg, H.B. Albert et al. // Spine (Phila Pa 1976). – 2008. - V.33, N 8. - P. 898-902.Genetic association study of growth hormone receptor and idiopathic scoliosis / X.S. Qiu, N.L. Tang , H.Y. Yeung et al. // Clin Orthop Relat Res. – 2007. - V.462. - P. 53-58.Genetic association study of growth hormone receptor and idiopathic scoliosis / X.S. Qiu, N.L. Tang , H.Y. Yeung et al. // Clin Orthop Relat Res. – 2007. - V.462. - P. 53-58.Genetic association study of insulin-like growth factor-I (IGF-I) gene with curve severity and osteopenia in adolescent idiopathic scoliosis/ H.Y. Yeung , N.L. Tang , K.M. Lee et al. / Stud. Health Technol. Inform. – 2006. - V.123. - P. 18-24.Genetic association study of insulin-like growth factor-I (IGF-I) gene with curve severity and osteopenia in adolescent idiopathic scoliosis/ H.Y. Yeung , N.L. Tang , K.M. Lee et al. / Stud. Health Technol. Inform. – 2006. - V.123. - P. 18-24.Geographic latitude and prevalence of adolescent idiopathic scoliosis / T.B. Grivas, E. Vasiliadis, O. Savvidou et al. // Stud. Health Technol. Inform. – 2006. - V.123. - P. 84-89.Geographic latitude and prevalence of adolescent idiopathic scoliosis / T.B. Grivas, E. Vasiliadis, O. Savvidou et al. // Stud. Health Technol. Inform. – 2006. - V.123. - P. 84-89.Geometric and electromyographic assessments in the evaluation of curve progression in idiopathic scoliosis / J. Cheung, A.G. Veldhuizen, J.P. Halberts et al. // Spine (Phila Pa 1976). – 2006. - V.31, N 3. - P. 322-329.Geometric and electromyographic assessments in the evaluation of curve progression in idiopathic scoliosis / J. Cheung, A.G. Veldhuizen, J.P. Halberts et al. // Spine (Phila Pa 1976). – 2006. - V.31, N 3. - P. 322-329.Handedness and spinal deformity / C.J. Goldberg, D.P. Moore, E.E. Fogarty et al. //Stud. Health Technol. Inform. – 2006. - V.123. - P. 442- 448.Handedness and spinal deformity / C.J. Goldberg, D.P. Moore, E.E. Fogarty et al. //Stud. Health Technol. Inform. – 2006. - V.123. - P. 442- 448.Histomorphological study of the spinal growth plates from the convex side and the concave side in adolescent idiopathic scoliosis / S. Wang, Y. Qiu , Z. Zhu et al. // J.Orthop. Surg Res. – 2007. - V.2. - P.19.Histomorphological study of the spinal growth plates from the convex side and the concave side in adolescent idiopathic scoliosis / S. Wang, Y. Qiu , Z. Zhu et al. // J.Orthop. Surg Res. – 2007. - V.2. - P.19.Human platelet Ca2+-ATPases: new markers of cell differentiation as illustrated in idiopathic scoliosis / R. Bredoux, E. Corvazier, S. Dally et al. // Platelets. – 2006. - V.17, N 6. - P. 421-433.Human platelet Ca2+-ATPases: new markers of cell differentiation as illustrated in idiopathic scoliosis / R. Bredoux, E. Corvazier, S. Dally et al. // Platelets. – 2006. - V.17, N 6. - P. 421-433.Idiopathic scoliosis: identification of candidate regions on chromosome 19p13 / K.J. Alden, B. Marosy, N. Nzegwu et al. // Spine (Phila Pa 1976). – 2006. - V.31, N 16. – P. 1815-1819.Idiopathic scoliosis: identification of candidate regions on chromosome 19p13 / K.J. Alden, B. Marosy, N. Nzegwu et al. // Spine (Phila Pa 1976). – 2006. - V.31, N 16. – P. 1815-1819.Karski, T. Recent observations in the biomechanical etiology of so-called idiopathic scoliosis. New classification of spinal deformity--I-st, II-nd and III-rd etiopathological groups / T. Karski // Stud. Health Technol. Inform. – 2006. - V.123. - P. 473-482.Karski, T. Recent observations in the biomechanical etiology of so-called idiopathic scoliosis. New classification of spinal deformity--I-st, II-nd and III-rd etiopathological groups / T. Karski // Stud. Health Technol. Inform. – 2006. - V.123. - P. 473-482.Kulis, A. Concentration of estradiol in girls with idiophatic scoliosis / A. Kulis, D. Zarzycki, J. Jaśkiewicz // Ortop., Traumatol., Rehabil. – 2006. - V.8, N 4. - P. 455-459.Kulis, A. Concentration of estradiol in girls with idiophatic scoliosis / A. Kulis, D. Zarzycki, J. Jaśkiewicz // Ortop., Traumatol., Rehabil. – 2006. - V.8, N 4. - P. 455-459.Lower degree of mineralization found in cortical bone of adolescent idiopathic scoliosis (AIS) / H.Y. Yeung, L. Qin, V.W. Hung et al. // Stud. Health Technol. Inform. – 2006. - V.123. - P. 599-604.Lower degree of mineralization found in cortical bone of adolescent idiopathic scoliosis (AIS) / H.Y. Yeung, L. Qin, V.W. Hung et al. // Stud. Health Technol. Inform. – 2006. - V.123. - P. 599-604.Mac-Thiong, J.M. Comparison of sacropelvic morphology between normal adolescents and subjects with adolescent idiopathic scoliosis / J.M. Mac-Thiong, H. Labelle, J.A. de Guise // Stud. Health Technol. Inform. – 2006. - V.123. - P. 195-200.Mac-Thiong, J.M. Comparison of sacropelvic morphology between normal adolescents and subjects with adolescent idiopathic scoliosis / J.M. Mac-Thiong, H. Labelle, J.A. de Guise // Stud. Health Technol. Inform. – 2006. - V.123. - P. 195-200.Molecular determinants of melatonin signaling dysfunction in adolescent idiopathic scoliosis / Azeddine B, Letellier K, Wang da S et al.// Clin. Orthop. Relat. Res. – 2007. - V. 462. - 45-52.Molecular determinants of melatonin signaling dysfunction in adolescent idiopathic scoliosis / Azeddine B, Letellier K, Wang da S et al.// Clin. Orthop. Relat. Res. – 2007. - V. 462. - 45-52.Morphometric analysis for pathological abnormality detection in the skull vaults of adolescent idiopathic scoliosis girls / L. Shi , P.A. Heng , T.T. Wong et al. // Med. Image Comput. Comput.- Assist. Interv. – 2006. - V. 9, Pt 1. - P. 175-182.Morphometric analysis for pathological abnormality detection in the skull vaults of adolescent idiopathic scoliosis girls / L. Shi , P.A. Heng , T.T. Wong et al. // Med. Image Comput. Comput.- Assist. Interv. – 2006. - V. 9, Pt 1. - P. 175-182.Ostrowska, B. Recovery of dynamic following external posture disturbance in children with idiopathic scoliosis / B. Ostrowska, K. RozekPiechura, T. Skolimowski // Ortop.Traumatol. Rehabil. – 2006. - V.8, N 3. - P. 300-307.Ostrowska, B. Recovery of dynamic following external posture disturbance in children with idiopathic scoliosis / B. Ostrowska, K. RozekPiechura, T. Skolimowski // Ortop.Traumatol. Rehabil. – 2006. - V.8, N 3. - P. 300-307.Patterns of extra-spinal left-right skeletal asymmetries and proximo-distal disproportion in adolescent girls with lower spine scoliosis: iliofemoral length asymmetry & bilateral tibial/foot length disproportion / R.G. Burwell, R.K. Aujla, B.J. Freeman et al. // Stud. Health Technol. Inform. – 2006. - V.123. - P. 101-108.Patterns of extra-spinal left-right skeletal asymmetries and proximo-distal disproportion in adolescent girls with lower spine scoliosis: iliofemoral length asymmetry & bilateral tibial/foot length disproportion / R.G. Burwell, R.K. Aujla, B.J. Freeman et al. // Stud. Health Technol. Inform. – 2006. - V.123. - P. 101-108.Pingot, M. Assessment of muscle strength of hip joints in children with idiopathic scoliosis / M. Pingot, J. Czernicki, J. Kubacki // Ortop. Traumatol. Rehabil. – 2007. - V.9, N 6. - P. 636-643.Pingot, M. Assessment of muscle strength of hip joints in children with idiopathic scoliosis / M. Pingot, J. Czernicki, J. Kubacki // Ortop. Traumatol. Rehabil. – 2007. - V.9, N 6. - P. 636-643.Quantitative analysis of types I and II collagen in the disc annulus in adolescent idiopathic scoliosis / Y. He, Y. Qiu , F. Zhu et al. // Stud. Health Technol. Inform. – 2006. - V.123. - P. 123-128.Quantitative analysis of types I and II collagen in the disc annulus in adolescent idiopathic scoliosis / Y. He, Y. Qiu , F. Zhu et al. // Stud. Health Technol. Inform. – 2006. - V.123. - P. 123-128.Raczkowski, J.W. The concentrations of testosterone and estradiol in girls with adolescent idiopathic scoliosis / J.W. Raczkowski // Neuro Endocrinol. Lett. – 2007. - V. 28, N 3. - P. 302-304.Raczkowski, J.W. The concentrations of testosterone and estradiol in girls with adolescent idiopathic scoliosis / J.W. Raczkowski // Neuro Endocrinol. Lett. – 2007. - V. 28, N 3. - P. 302-304.Raggio, C.L. Sexual dimorphism in adolescent idiopathic scoliosis / C.L. Raggio // Orthop. Clin. North Am. – 2006. - V. 37, N 4. - P. 555-558.Raggio, C.L. Sexual dimorphism in adolescent idiopathic scoliosis / C.L. Raggio // Orthop. Clin. North Am. – 2006. - V. 37, N 4. - P. 555-558.Relative shortening and functional tethering of spinal cord in adolescent scoliosis - Result of asynchronous neuro-osseous growth, summary of an electronic focus group debate of the IBSE / W.C. Chu, W.M. Lam, B.K. Ng et al. // Scoliosis. – 2008. - V.3. - P. 8.Relative shortening and functional tethering of spinal cord in adolescent scoliosis - Result of asynchronous neuro-osseous growth, summary of an electronic focus group debate of the IBSE / W.C. Chu, W.M. Lam, B.K. Ng et al. // Scoliosis. – 2008. - V.3. - P. 8.Right hip adduction deficit and adolescent idiopathic scoliosis / K.M. Cheung, A.C. Cheng, Cheung WY et al. //J. Orthop. Surg (Hong Kong). – 2008. - V.16, N 1. - P. 24-26.Right hip adduction deficit and adolescent idiopathic scoliosis / K.M. Cheung, A.C. Cheng, Cheung WY et al. //J. Orthop. Surg (Hong Kong). – 2008. - V.16, N 1. - P. 24-26.Van der Plaats, A. Numerical simulation of asymmetrically altered growth as initiation mechanism of scoliosis / A. Van der Plaats, A.G. Veldhuizen, G.J. Verkerke // Ann. Biomed. Eng. - 2007. - V. 35, N 7. - P. 1206-1215.Van der Plaats, A. Numerical simulation of asymmetrically altered growth as initiation mechanism of scoliosis / A. Van der Plaats, A.G. Veldhuizen, G.J. Verkerke // Ann. Biomed. Eng. - 2007. - V. 35, N 7. - P. 1206-1215.Vitamin D receptor gene polymorphisms in female adolescent idiopathic scoliosis patients / C.W. Xia, Y. Qiu, X Sun et al. // Zhonghua Yi XueZa Zhi. – 2007. - V.87, N 21. - P. 1465-1469.Vitamin D receptor gene polymorphisms in female adolescent idiopathic scoliosis patients / C.W. Xia, Y. Qiu, X Sun et al. // Zhonghua Yi XueZa Zhi. – 2007. - V.87, N 21. - P. 1465-1469.

The authors declare that there are no conflicts of interest present.