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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ymj</journal-id><journal-title-group><journal-title xml:lang="ru">Якутский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Yakut Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1813-1905</issn><issn pub-type="epub">2312-1017</issn><publisher><publisher-name>ЯНЦ КМП</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">ymj-2125</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL RESEARCH</subject></subj-group></article-categories><title-group><article-title>Концентрация интерлейкина-18 у больных острыми респираторными вирусными инфекциями</article-title><trans-title-group xml:lang="en"><trans-title>Interleukin-18 concentration in patients with acute respiratory viral infections</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шипилов</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Shipilov</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шипилов Михаил Васильевич – к.м.н., врач-эксперт</p></bio><email xlink:type="simple">mshipilov@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>ООО “Смоленскмединвест”</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2011</year></pub-date><pub-date pub-type="epub"><day>18</day><month>10</month><year>2025</year></pub-date><volume>0</volume><issue>2</issue><fpage>64</fpage><lpage>66</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Шипилов М.В., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Шипилов М.В.</copyright-holder><copyright-holder xml:lang="en">Shipilov M.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://ymj.elpub.ru/jour/article/view/2125">https://ymj.elpub.ru/jour/article/view/2125</self-uri><abstract><p>Обследованы больные ОРВИ средней тяжести в возрасте 15-54 лет с целью определения концентрации интерлейкина-18 в сыворотке крови. Установлено прогностическое значение высокого уровня ИЛ-18, прямо стимулирующего продукцию ИНФ-γ, в остром периоде тяжёлого течения гриппа pH1N1.</p></abstract><trans-abstract xml:lang="en"><p>Prognostic value of the high level of interleukin-18 is directly stimulating production of interferon-γ in the acute period of serious influenza pH1N1 was established.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>интерлейкин-18</kwd><kwd>грипп</kwd><kwd>парагрипп</kwd><kwd>аденовирусная инфекция</kwd><kwd>респираторно-синцитиальная вирусная инфекция</kwd><kwd>ОРВИ</kwd></kwd-group><kwd-group xml:lang="en"><kwd>interleukin-18</kwd><kwd>influenza</kwd><kwd>parainfluenza</kwd><kwd>adenoviral infection</kwd><kwd>respiratory syncytial virus infection</kwd><kwd>ARVI</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Иванов А.А. 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