ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.25789/YMJ.2023.82.22ymj-201Research ArticleНАУЧНЫЕ ОБЗОРЫ И ЛЕКЦИИSCIENTIFIC REVIEWS AND LECTURESЭндотелиопротекторные функции липопротеинов высокой плотностиEndothelial protective functions of high density lipoproteinshttps://orcid.org/0000-0003-1068-2431ПотеряеваО. Н.PoteryaevaO. N.

Ольга Николаевна Потеряева, д. м. н., в. н. с.

Новосибирск

Novosibirsk

olga_Poteryaeva@mail.ruhttps://orcid.org/0000-0003-1752-9034УсынинИ. Ф.UsyninI. F.

Иван Фёдорович Усынин, д. б. н., зав. лаб.

Новосибирск

Novosibirsk

НИИ биохимии ФИЦ фундаментальной и трансляционной медициныРоссияResearch Institute of Biochemistry of the Federal Research Center for Fundamental and Translational MedicineRussian Federation202305022025029095Copyright © Потеряева О.Н., Усынин И.Ф., 20252025Потеряева О.Н., Усынин И.Ф.Poteryaeva O.N., Usynin I.F.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/201

   Цель обзора – дать современные представления об участии липопротеинов высокой плотности (ЛПВП) в функционировании эндотелиальных клеток и предотвращении развития эндотелиальной дисфункции.

   Связываясь с различными рецепторами на эндотелиальных клетках, ЛПВП вызывают индукцию эндотелиальной синтазы оксида азота, повышают продукцию NO, стимулируют синтез простациклина, что приводит к снижению тонуса сосудов. Подавляя синтез молекул межклеточной адгезии, ЛПВП предотвращают миграцию лейкоцитов и моноцитов/макрофагов в сосудистую стенку, оказывая противовоспалительное действие. ЛПВП ингибируют продукцию активных форм кислорода, предотвращают апоптоз, стимулируют пролиферацию и миграцию эндотелиальных клеток.

   The goal of this review is to describe modern concepts concerning the involvement of HDLs in the functioning of endothelial cells and preventing the development of endothelial dysfunction.

   Upon binding to various receptors on endothelial cells, HDLs initiate the induction of endothelial nitric oxide synthase, enhance the production of NO, and stimulate the synthesis of prostacyclin, thus leading to vasorelaxation. By suppressing the synthesis of intercellular adhesion molecules, HDLs prevent the migration of leucocytes and monocytes/macrophages into the vascular wall, exerting anti-inflammatory action. HDLs inhibit the production of reactive oxygen species, prevent apoptosis, and stimulate the proliferation and migration of endothelial cells.

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The authors declare that there are no conflicts of interest present.