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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ymj</journal-id><journal-title-group><journal-title xml:lang="ru">Якутский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Yakut Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1813-1905</issn><issn pub-type="epub">2312-1017</issn><publisher><publisher-name>ЯНЦ КМП</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">ymj-1964</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>СЛУЧАЙ ИЗ ПРАКТИКИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL CASE</subject></subj-group></article-categories><title-group><article-title>Протоковая карцинома IN SITU молочной железы с мультифокальным ростом</article-title><trans-title-group xml:lang="en"><trans-title>Breast ductal carcinoma IN CITU with the multifocal growth</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Коростелева</surname><given-names>Л. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Korostyleva</surname><given-names>N. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Коростелева Любовь Никифоровна – к.м.н., доцент</p></bio><bio xml:lang="en"><p>Lyubov Nikiforovna Korostyleva, Candidate of Medical Sciences, Associate Professor, Department of Surgical Pathology and Dentistry</p></bio><email xlink:type="simple">korln@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Макаров</surname><given-names>А. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Makarov</surname><given-names>A. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Макаров Альберт Дмитриевич – к.м.н., доцент</p></bio><bio xml:lang="en"><p>Albert Dmitrievich Makarov, Candidate of Medical Sciences, Associate Professor, Department of Hospital Surgery</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гурьева</surname><given-names>З. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Gurieva</surname><given-names>Z. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гурьева Зинаида Дмитриевна – врач онколог-маммолог</p></bio><bio xml:lang="en"><p>Zinaida Dmitrievna Gurieva, oncologist-mammologist, Candidate of Medical Sciences</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Слепцова</surname><given-names>Н. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Sleptsova</surname><given-names>N. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Слепцова Наталья Михайловна – к.м.н., врач рентгенолог</p></bio><bio xml:lang="en"><p>Natalia Mikhailovna Sleptsova, radiologist</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Корякина</surname><given-names>Н. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Koryakina</surname><given-names>N. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Корякина Надежда Николаевна – зав. рентгенотделением</p></bio><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Иннокентьева</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Innokentieva</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Иннокентьева Александра Степановна – врач патоморфолог</p></bio><bio xml:lang="en"><p>Alexandra Stepanovna Innokentieva, pathomorphologist</p></bio><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ИПОВ СВФУ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Institute for Post-graduate Medical Studies, North-Eastern Federal University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>МИ СВФУ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Medical Institute, North-Easter Federal University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>РБ № 1 – НЦМ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>the Republic's Hospital № 1 – Center of Medicine</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>РБ №1-НЦМ МЗ РС(Я)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>the Republic's Hospital № 1 – Center of Medicine</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2012</year></pub-date><pub-date pub-type="epub"><day>11</day><month>10</month><year>2025</year></pub-date><volume>0</volume><issue>2</issue><fpage>101</fpage><lpage>103</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Коростелева Л.Н., Макаров А.Д., Гурьева З.Д., Слепцова Н.М., Корякина Н.Н., Иннокентьева А.С., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Коростелева Л.Н., Макаров А.Д., Гурьева З.Д., Слепцова Н.М., Корякина Н.Н., Иннокентьева А.С.</copyright-holder><copyright-holder xml:lang="en">Korostyleva N.K., Makarov A.D., Gurieva Z.D., Sleptsova N.M., Koryakina N.N., Innokentieva A.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://ymj.elpub.ru/jour/article/view/1964">https://ymj.elpub.ru/jour/article/view/1964</self-uri><abstract><p>Карцинома in situ является неинвазивной формой рака молочной железы, представленной злокачественными клетками, ограниченными эпителием, без вовлечения в процесс базальной мембраны, но имеющими потенциальную способность к инвазии. Современные достижения молекулярной генетики, открытие онкогенов, генов-супрессоров опухолевого роста подтверждают мнение о карциноме in situ как ранней фазе истинного рака молочной железы. Эти опухоли имеют разные биологические свойства, отличаются риском развития инвазивного рака и методами лечения.</p></abstract><trans-abstract xml:lang="en"><p>The carcinoma in situ is a noninvasive form of the mammary gland cancer presented by malignant cells localized in the epithelium and not penetrating the basement membrane, but potentially, capable of invasion. The latest developments in the molecular genetics, discovery of oncogenes and tumor growth suppressing genes confirm the opinion that the carcinoma in situ is an early phase of the genuine breast cancer. These neoplacms possess various biological properties and differ in the risk of progressing into invasive cancer and treatment practices.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>протоковая карцинома in situ (DCIS)</kwd><kwd>маммография</kwd><kwd>ультрасонография</kwd><kwd>биопсия опухоли</kwd><kwd>секторальная резекция</kwd><kwd>мастэктомия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>ductal carcinoma in situ (DCIS)</kwd><kwd>mammography</kwd><kwd>ultrasonography</kwd><kwd>tumor biopsy</kwd><kwd>lumpectomy</kwd><kwd>mastectomy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Нейштадт Э.Л. Мастопатия. Есть ли повод для беспокойства? / Э.Л. Нейштадт// Проблемы диагностики и лечения рака молочной железы: материалы 1-й междунар. онкологич. конф. – СПб., 2004. – С.80 – 82.</mixed-citation><mixed-citation xml:lang="en">Neischtadt, E.L. Mastopathy. 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