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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ymj</journal-id><journal-title-group><journal-title xml:lang="ru">Якутский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Yakut Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1813-1905</issn><issn pub-type="epub">2312-1017</issn><publisher><publisher-name>ЯНЦ КМП</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">ymj-1935</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL RESEARCH</subject></subj-group></article-categories><title-group><article-title>Особенности системы гемостаза у пациентов с эрозивно-язвенными изменениями гастродуоденальной зоны и их значение для кардиальной патологии</article-title><trans-title-group xml:lang="en"><trans-title>Peculiarities of the hemostatic system in patients with erosive and ulcerative changes in gastroduodenalarea and their relevance to cardiac pathology</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сорокина</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Sorokina</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сорокина Елена Альбертовна – к.м.н., врач отделения рентгенохирургических методов диагностики и лечения</p></bio><bio xml:lang="en"><p>Sorokina Elena Albertovna – k.m.n. The physician of the X-ray-surgery diagnostic and treatment unit</p><p>Omsk</p></bio><email xlink:type="simple">destin2@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фокин</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Fokin</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Фокин Алексей Анатольевич – д.м.н., проф., зав. кафедрой ФП ДПО</p><p>засл. врач РФ</p></bio><bio xml:lang="en"><p>Fokin Aleksey Anatolievich – MD, professor, the chief of Surgery department</p><p>Cheliabinsk</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ахмедов</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Akhmedov</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ахмедов Вадим Адильевич – д.м.н., проф.</p></bio><bio xml:lang="en"><p>Akhmedov Vadim Adilevich – MD, professor of the Faculty Therapy Department</p></bio><email xlink:type="simple">v_akhmedov@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лоенко</surname><given-names>В. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Loenko</surname><given-names>V. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лоенко Виталий Борисович – к.м.н., зав. отделением</p></bio><bio xml:lang="en"><p>Loenko Vitaliy Borisovich - k.m.n, the chief of X-ray-surgery diagnostic and treatment unit</p><p>Omsk</p></bio><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Старжевская</surname><given-names>Л. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Starzhevskaya</surname><given-names>L. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Старжевская Лариса Евгеньевна – к.м.н., врач отделения кардиохирургии</p></bio><bio xml:lang="en"><p>Starzhevskaya Larisa Evgenievna – k.m.n. The physician of the heart-surgery unit</p></bio><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Файль</surname><given-names>И. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Fayil</surname><given-names>I. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Файль Ирина Леонидовна – к.м.н., врач отделения лаборатории гемостаза</p></bio><bio xml:lang="en"><p>Fayil Irina Leonidovna - k.m.n. The physician of the hemostasis laboritary unit</p><p>Omsk</p></bio><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Омская областная клиническая больница<country>Россия</country></aff><aff xml:lang="en">The Omsk Regional Clinical Hospital<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">Челябинская медицинская академия<country>Россия</country></aff><aff xml:lang="en">The Cheliabinsk National Medical Academy<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru">Челябинская медицинская академия<country>Россия</country></aff><aff xml:lang="en">Omsk State Medical Academy, Omsk<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru">Омская ОКБ<country>Россия</country></aff><aff xml:lang="en">The Omsk Regional Clinical Hospital<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru">Омская ОКБ<country>Россия</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2012</year></pub-date><pub-date pub-type="epub"><day>08</day><month>10</month><year>2025</year></pub-date><volume>0</volume><issue>2</issue><fpage>18</fpage><lpage>21</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Сорокина Е.А., Фокин А.А., Ахмедов В.А., Лоенко В.Б., Старжевская Л.Е., Файль И.Л., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Сорокина Е.А., Фокин А.А., Ахмедов В.А., Лоенко В.Б., Старжевская Л.Е., Файль И.Л.</copyright-holder><copyright-holder xml:lang="en">Sorokina E.A., Fokin A.A., Akhmedov V.A., Loenko V.B., Starzhevskaya L.E., Fayil I.L.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://ymj.elpub.ru/jour/article/view/1935">https://ymj.elpub.ru/jour/article/view/1935</self-uri><abstract><p>Изучено состояние свертывающей системы крови и фибринолиза у пациентов с эрозивно-язвенными изменениями гастродуоденальной зоны. Обосновано последовательное лечение данной категории пациентов, включающее эпителизацию эрозий и язв гастродуоденальной зоны и снижение тромбинемии. Отмечено, что стресс не является достоверно значимым фактором в отношении увеличения растворимого фибринмономерного комплекса у пациентов с кардиальной патологией на этапе подготовки к операции на сердце в условиях искусственного кровообращения.</p></abstract><trans-abstract xml:lang="en"><p>The condition of hemostasis and fibrinolis systems is studied in patients with erosive and ulcerous changes of gastroduodenal zone. The sequential treatment is validated in this category of patients, including erosions and ulcers of gastroduodenal zone epithelisation and decrease of thrombinemia. It is marked that the stress is non reliable significant factor for filamentous fibrin strands increase in patients with cardiac pathology in period of preparation for the heart surgery with cardiopulmonary bypass.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>тромбинемия</kwd><kwd>эрозивно-язвенные изменения гастродуоденальной зоны</kwd><kwd>операция на сердце</kwd><kwd>гемостаз</kwd></kwd-group><kwd-group xml:lang="en"><kwd>thrombinemia</kwd><kwd>erosive and ulcerous changes of gastroduodenal zone</kwd><kwd>heart surgery</kwd><kwd>hemostasis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Гончарова Н.С. Значение тромбинемии у пациентов с аортальным стенозом / Н.С. Гончарова, О.М. Моисеева, Г.М. Алешина, Е.В. Шляхто // Артериальная гипертензия. – 2009. – Т. 17. - №5. – С. 575-579.</mixed-citation><mixed-citation xml:lang="en">Goncharova N.S. 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