<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ymj</journal-id><journal-title-group><journal-title xml:lang="ru">Якутский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Yakut Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1813-1905</issn><issn pub-type="epub">2312-1017</issn><publisher><publisher-name>ЯНЦ КМП</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">ymj-1900</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL RESEARCH</subject></subj-group></article-categories><title-group><article-title>Совершенствование антибактериальной терапии инфицированного панкреонекроза в многопрофильном хирургическом стационаре</article-title><trans-title-group xml:lang="en"><trans-title>Improvement of antibacterial treatment of infected pancreatic necrosis in diversified surgical department</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Савельев</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Saveliev</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Савельев Вячеслав Васильевич – к.м.н., доцент ИПОВ</p></bio><email xlink:type="simple">vvsaveliev@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гоголев</surname><given-names>Н. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Gogolev</surname><given-names>N. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гоголев Николай Михайлович – к.м.н., доцент, зав. кафедрой ИПОВ</p></bio><email xlink:type="simple">gogrcemp@rambler.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шамаева</surname><given-names>С. Х.</given-names></name><name name-style="western" xml:lang="en"><surname>Shamaeva</surname><given-names>S. H.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шамаева Степанида Харитоновна – к.б.н., зав. лаб. клинической микробиологии</p></bio><email xlink:type="simple">stevas@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Потапов</surname><given-names>А. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Potapov</surname><given-names>A. F.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Потапов Александр Филиппович – д.м.н., проф., зав. кафедрой ИПОВ</p></bio><email xlink:type="simple">potapov-paf@mail.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Портнягина</surname><given-names>У. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Portnjagina</surname><given-names>U. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Портнягина Ульяна Семеновна – к.м.н., доцент ИПОВ</p></bio><email xlink:type="simple">ulyana-nsr@mail.ru</email><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>СВФУ им. М.К. Аммосова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>North-East federal university of M.K. Ammosov Institute after degree training of doctors Yakutsk</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>МИ СВФУ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>North-East federal university of M.K. Ammosov Institute after degree training of doctors Yakutsk</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ГУ «РБ№2-ЦЭМП»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>North-East federal university of M.K. Ammosov Institute after degree training of doctors Yakutsk</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>СВФУ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>North-East federal university of M.K. Ammosov Institute after degree training of doctors Yakutsk</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2012</year></pub-date><pub-date pub-type="epub"><day>06</day><month>10</month><year>2025</year></pub-date><volume>0</volume><issue>1</issue><fpage>36</fpage><lpage>40</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Савельев В.В., Гоголев Н.М., Шамаева С.Х., Потапов А.Ф., Портнягина У.С., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Савельев В.В., Гоголев Н.М., Шамаева С.Х., Потапов А.Ф., Портнягина У.С.</copyright-holder><copyright-holder xml:lang="en">Saveliev V.V., Gogolev N.M., Shamaeva S.H., Potapov A.F., Portnjagina U.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://ymj.elpub.ru/jour/article/view/1900">https://ymj.elpub.ru/jour/article/view/1900</self-uri><abstract><p>Проведен анализ результатов комплексного консервативного и хирургического лечения 50 больных с инфицированными формами панкреонекроза.В ходе исследования удалось адаптировать и усовершенствовать схему антибактериальной терапии, применяемую в лечении панкреатогенной инфекции в многопрофильном хирургическом стационаре.Выявлено, что проведение мониторинга антибиотикорезистентности и эффективности антибактериальной терапии в значительной степени повышает вероятность благоприятного исхода в лечении больных с панкреатогенной инфекцией.</p></abstract><trans-abstract xml:lang="en"><p>The presented work is based on the analysis results of complex conservative and surgical treatment 50 patients with the infected forms of pancreatic necrosis, were on treatment in surgical branches of Republican hospital №2 - Center of emergency Republic of Sakha (Yakutia) during the period with 2008 for 2011.During research it was possible to adapt and improve the scheme of antibacterial therapy applied in treatment pancreatogenic infections in a versatile surgical hospital.Monitoring carrying out antibacterialresistens and efficiency of antibacterial therapy substantially raises probability of a favorable outcome in treatment of patients with pancreatogenic an infection.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>панкреонекроз</kwd><kwd>антибактериальная терапия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>pancreatic necrosis</kwd><kwd>antibacterial therapy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Брехов Е.И. Современные технологии в диагностике и лечении панкреонекроза / Е.И. Брехов, А.С. Миронов // Эндоскопическая хирургия. – 2006. – №1. – С.24.</mixed-citation><mixed-citation xml:lang="en">Brehov E.I. Modern of technology in diagnostics and treatment pancreatic necrosis / E.I. Brehov, A.S. Mironov // Endoskopic. surgery. - 2006. - №1. - P. 24.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Галимзянов Ф.В. Первичная диагностика инфицированного панкреонекроза / Ф.В. Галимзянов // Хирургия. – 2006. – №6. – С. 8–10.</mixed-citation><mixed-citation xml:lang="en">Galimzynov F.V. Primary diagnostics of infected pancreatic necrosis / F.V. Galimzynov // Surgery. - 2006. - № 6. - P. 8-10.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Голуб А.В. Антибактериальная терапия осложненных интраабдоминальных инфекций: от чего зависит успех? / А.В. Голуб, А.В. Дехнич, Р.С. Козлов // Клиническая микробиология и антимикробная химиотерапия. – 2011. – №2. – С. 158–162.</mixed-citation><mixed-citation xml:lang="en">Golub A.V. Antibacterial therapy of complicated intraperitoneal infections: what the success depends? / A.V. Golub, A.V. Dehnich, R.S. Kozlov // Clinical microbiology and antimicrobic chemotherapy. - 2011. - №2. - P. 158-162.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Грувер К.П. Клиническое значение бактериемии у больных сепсисом / К.П. Грувер, В.Б. Белобородов // Клиническая микробиология и антимикробная химиотерапия. – 2011. – №1. – С. 90–96.</mixed-citation><mixed-citation xml:lang="en">Gruver K.P. Clinical significance of bacteremia at patient of sepsis / K.P. Gruver, V.B. Beloborodov // Clinical microbiology and antimicrobic chemotherapy. - 2011. - №1. - P. 90-96.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Гучев И.А. Панкреонекроз, возможности антибактериальной терапии и профилактики / И.А. Гучев, И.П. Волков, А.М. Иванова // Русский медицинский журнал. – 2007. – № 12. – С. 965–972.</mixed-citation><mixed-citation xml:lang="en">Guchev I.A. Pancreatic necrosis, possibilities of antibacterial therapy and preventive maintenance / I.A. Guchev, I.P. Volkov, A.M. Ivanova // Russian medical journal. - 2007. - № 12. - P. 965-972.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Деструктивный панкреатит. Доказательные методы диагностики и лечения / Б.Р. Гельфанд, [и др.] // Методические рекомендации под редакцией академика РАН и РАМН В.С. Савельева. – Москва, 2008. – С. 8.</mixed-citation><mixed-citation xml:lang="en">The destructive a pancreatitis. Demonstrative methods of diagnostics and treatment / B.R. Gelfand, [et al.] // Methodical recommendations of the academician Russian Academy of Sciences and Russian Academy of Medical Science V.S. Saveliev. - Moscow, 2008. - P. 8.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Панкреонекроз / И.И. Затевахин [и др.]. – М., 2007. – С. 125–137.</mixed-citation><mixed-citation xml:lang="en">Pancreatic necrosis / I.I. Zatevahin, [et al.]. - Moscow, 2007. - P. 125-137.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Лобанов С.Л. Современные подходы к лечению острого панкреатита / С.Л. Лобанов, А.В. Степанов, Л.С. Лобанов. – Чита, 2008. – С. 87–93.</mixed-citation><mixed-citation xml:lang="en">Lobanov S.L. Modern approaches to treatment of acute pancreatitis / S.L. Lobanov, A.V. Stepanov, L.S. Lobanov. - Chita, 2008. - P. 87-93.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Малахова М.Я. Лабораторная диагностика эндогенной интоксикации / М.Я. Малахова // Медицинские лабораторные технологии. – Спб., Интермедика, 1999. – Т. 2. – С. 618–647.</mixed-citation><mixed-citation xml:lang="en">Malakhova M.J. Laboratory diagnostics endogenic intoxications / M.J. Malakhova // Medical laboratory technologies. – Spb.: Intermedica, 1999. - Vol. 2. - P. 618-647.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Рогожин В.В. Методы биохимических исследований / В.В. Рогожин. – Якутск, 1998. – С. 8–27.</mixed-citation><mixed-citation xml:lang="en">Rogozhin V.V. Metody of biochemical researches / V.V. Rogozhin. - Yakutsk, 1998. - P. 8-27.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Савельев B.C. Панкреонекрозы / В.С. Савельев, М.И. Филимонов, С.З. Бурневич. – Москва, 2008. – С. 5–20.</mixed-citation><mixed-citation xml:lang="en">Saveliev V.S. Pancreatic necrosis / V.S. Saveliev, M.I. Filimonov, S.Z. Burnevich. – M., 2008. - P. 5-20.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Сидоренко С.В. Этиология тяжелых госпитальных инфекций в отделениях реанимации и антибиотикорезистентность среди их возбудителей / С.В. Сидоренко, С.П. Резван, Л.В. Еремина // Антибиотики и химиотерапия. – 2005. – №2. – С. 33–41.</mixed-citation><mixed-citation xml:lang="en">Sidorenko S.V. Heavy hospital infections in branches of resuscitation and antibiotic resistance among their activators / S.V. Sidorenko, S.P. Rezvan, L.V. Eremina // Antibiotics and chemotherapy. - 2005. - №2. - P. 33-41.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Потапов А.Ф. Комплексная оценка интенсивной терапии хирургической абдоминальной инфекции в специализированном Центре экстренной медицинской помощи Республики Саха (Якутия): автореф. дисс…. д-ра мед. наук / А.Ф. Потапов. – М., 2004. – С. 3–25.</mixed-citation><mixed-citation xml:lang="en">Potapov A.F. Complex an estimation of intensive therapy surgical abdominal infections in the specialised Center of emergency Republics Sakha (Yakutia): avtoref. dis. …doc. of medical-sciences / A.F. Potapov. - М, 2004. - P. 3-25.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Шестопалов А.Е. Метронидазол в антибактериальной терапии гнойно-септических заболеваний в абдоминальной хирургии / А.Е. Шестопалов, А.В. Бутров // Русский медицинский журнал. – 2007. – №12. – С. 986–987.</mixed-citation><mixed-citation xml:lang="en">Shestopalov A.E. Metronidazole in antibacterial therapy of purulent-septic diseases in abdominal surgeries / A.E. Shestopalov, A.V. Butrov // Russian medical journal. - 2007. - №12. - P. 986-987.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">APACHE II-acute physiology and chronic health evaluation: physiologically based classification system / W.A. Knaus [et. al] // Crit. Care Med, – 1981; 9: P. 591–597.</mixed-citation><mixed-citation xml:lang="en">APACHE II-acute physiology and chronic health evaluation: physiologically based classification system / W.A. Knaus [et. al] // Crit. Care Med, – 1981; 9: P. 591–597.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Lankisch P.G. The role of antibiotics prophylaxis in the treatment of acute pancreatitis / P.G. Lankisch, M.M. Lerch // J. Clin. Gastroenterol. – 2006. – V.40. – (2). – P. 149–155.</mixed-citation><mixed-citation xml:lang="en">Lankisch P.G. The role of antibiotics prophylaxis in the treatment of acute pancreatitis / P.G. Lankisch, M.M. Lerch // J. Clin. Gastroenterol. – 2006. – V.40. – (2). – P. 149–155.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Mayerle J. Conservative treatment of acute pancreatitis / J. Mayerle, P. Simon, M. Kraft // Med. Klin (Munich). – 2003; 98: 12: P. 744–749.</mixed-citation><mixed-citation xml:lang="en">Mayerle J. Conservative treatment of acute pancreatitis / J. Mayerle, P. Simon, M. Kraft // Med. Klin (Munich). – 2003; 98: 12: P. 744–749.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Olakowski M. Management of necrotizing pancreatitis / M. Olakowski, D. Dranka– Bojarowska // Acta Chir. Belgr. – 2006. – V. 106. – №2. – P. 172–176.</mixed-citation><mixed-citation xml:lang="en">Olakowski M. Management of necrotizing pancreatitis / M. Olakowski, D. Dranka– Bojarowska // Acta Chir. Belgr. – 2006. – V. 106. – №2. – P. 172–176.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Ranson J.H.C. Acute pancreatitis: pathogenesis, outcome and treatment / J.H.C. Ranson // Clin. Gastroenterol. – 1984; 13(9): P. 843–863.</mixed-citation><mixed-citation xml:lang="en">Ranson J.H.C. Acute pancreatitis: pathogenesis, outcome and treatment / J.H.C. Ranson // Clin. Gastroenterol. – 1984; 13(9): P. 843–863.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
