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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ymj</journal-id><journal-title-group><journal-title xml:lang="ru">Якутский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Yakut Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1813-1905</issn><issn pub-type="epub">2312-1017</issn><publisher><publisher-name>ЯНЦ КМП</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">ymj-1888</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL RESEARCH</subject></subj-group></article-categories><title-group><article-title>Роль болезнь-модифицирующих препаратов в лечении ограниченной склеродермии у детей</article-title><trans-title-group xml:lang="en"><trans-title>Role of disease modifying medications in treatment of children with sclerodermiacircumscripta</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Аммосова</surname><given-names>Е. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Ammosova</surname><given-names>E. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Аммосова Елена Петровна – к.м.н., научн. руковод. группы исследований болезней детского возраста</p></bio><email xlink:type="simple">ammosovael@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сивцева</surname><given-names>Е. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Sivtseva</surname><given-names>E. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сивцева Елена Николаевна – к.м.н., н.с.</p></bio><email xlink:type="simple">sivelya@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">НИИ здоровья СВФУ им. М.К. Аммосова<country>Россия</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2012</year></pub-date><pub-date pub-type="epub"><day>05</day><month>10</month><year>2025</year></pub-date><volume>0</volume><issue>1</issue><fpage>10</fpage><lpage>12</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Аммосова Е.П., Сивцева Е.Н., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Аммосова Е.П., Сивцева Е.Н.</copyright-holder><copyright-holder xml:lang="en">Ammosova E.N., Sivtseva E.N.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://ymj.elpub.ru/jour/article/view/1888">https://ymj.elpub.ru/jour/article/view/1888</self-uri><abstract><p>Проанализирована эффективность четырех схем базисной терапии у 97 детей с ограниченной склеродермией. В результате разработан дифференцированный подход к назначению той или иной базисной терапии с учетом клинического течения заболевания.</p></abstract><trans-abstract xml:lang="en"><p>The authors analyzed the effectiveness of therapy four schemes of basic therapy in 97 children with localized scleroderma. As a result, developed a different approach to the appointment of the basic therapy, taking into account the clinical current of disease.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ограниченная склеродермия</kwd><kwd>лечение</kwd><kwd>Д-пеницилламин</kwd><kwd>метотрексат</kwd></kwd-group><kwd-group xml:lang="en"><kwd>localized scleroderma</kwd><kwd>treatment</kwd><kwd>D-penicillamine</kwd><kwd>methotrexate</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Гребенюк В.Н. Ограниченная склеродермия у детей / В.Н. 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