ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.25789/YMJ.2023.81.16ymj-184Research ArticleАКТУАЛЬНАЯ ТЕМАACTUAL TOPICВирусная нагрузка SARS-CoV-2 у новорожденных с COVID-19SARS-CoV-2 viral load in newborns with COVID-19https://orcid.org/0000-0002-1458-2385ПаршинаА. А.ParshinaA. A.

Паршина Анастасия Анатольевна – к.м.н., н.с.

г. Иркутск

Parshina Anastasiya A. – MD, PhD, Research Officer of the Laboratory of Infectology and Immune Prophylaxis in Pediatrics

a.parshina.csma@yandex.ruhttps://orcid.org/0000-0003-4196-0713МоскалёваЕ. В.MoskalevaYe. V.

Москалёва Екатерина Владимировна – к.м.н., н.с.

г. Иркутск

Moskaleva Yekaterina V. – MD, PhD, Research Officer of the Laboratory of Infectology and Immune Prophylaxis in Pediatrics

mkatena@mail.ruhttps://orcid.org/0000-0002-7965-8061ПетроваА. Г.PetrovaA. G.

Петрова Алла Германовна – д.м.н., проф., гл.н.с., руковод. лаб.

г. Иркутск

Petrova Alla G. – MD, PhD, DSc, Chief Research Officer, the Head of the Laboratory of Infectology and Immune Prophylaxis in Pediatrics

rudial75@gmail.comhttps://orcid.org/0000-0002-0117-2563РычковаЛ. В.RychkovaL. V.

Рычкова Любовь Владимировна – д.м.н., член-кор. РАН, проф. РАН, директор

 г. Иркутск

Rychkova Lyubov V. – MD, PhD, chief researcher, corresponding member of the Russian Academy of Sciences, Professor of the Russian Academy of Sciences, Director

iphr@sbamsr.irk.ruhttps://orcid.org/0000-0002-3168-1983ОгарковО. Б.OgarkovO. B.

Огарков Олег Борисович – д.м.н., зав. отделом

г. Иркутск

Ogarkov Oleg B. – MD, Head of the Department of epidemiology and microbiology

obogarkov@mail.ruhttps://orcid.org/0000-0003-2169-0242ОрловаЕ. А.OrlovaE. A.

Орлова Елизавета Андреевна – м.н.с., аспирант

г. Иркутск

Orlova Elizaveta A. – MD, Research Assistant, Graduate Student of the Laboratory of epidemiologically and socially significant infections

elizaveta.a.orlova@gmail.comhttps://orcid.org/0000-0001-8434-1600ВаняркинаА. С.VanyarkinaA. S.

Ваняркина Анастасия Сергеевна – к.м.н., н.с.

г. Иркутск

Vanyarkina Anastasiya S. – PhD, Research Officer of the Laboratory of Infectology and Immune Prophylaxis in Pediatrics

avanyarkina@yahoo.comhttps://orcid.org/0000-0002-9353-7928НовиковаЕ. А.NovikovaE. A.

Новикова Евгения Анатольевна – м.н.с.

г. Иркутск

Novikova Evgenia A. – MD, Research Assistant of the Laboratory of Infectology and Immunoprophylaxis in Pediatrics

europe411@mail.ruhttps://orcid.org/0000-0003-0692-2295КазанцеваЕ. Д.KasantsevaE. D.

Казанцева Екатерина Дмитриевна – аспирант, лаборант-исследователь

г. Иркутск

Kasantseva Ekaterina D. – MD, Graduate Student of the Laboratory of Infectology and Immune Prophylaxis in Pediatrics

kat.smile7@yandex.ruФГБНУ «Научный центр проблем здоровья семьи и репродукции человека»РоссияScientific Centre for Family Health and Human Reproduction ProblemsRussian Federation202305022025016366Copyright © Паршина А.А., Москалёва Е.В., Петрова А.Г., Рычкова Л.В., Огарков О.Б., Орлова Е.А., Ваняркина А.С., Новикова Е.А., Казанцева Е.Д., 20252025Паршина А.А., Москалёва Е.В., Петрова А.Г., Рычкова Л.В., Огарков О.Б., Орлова Е.А., Ваняркина А.С., Новикова Е.А., Казанцева Е.Д.Parshina A.A., Moskaleva Y.V., Petrova A.G., Rychkova L.V., Ogarkov O.B., Orlova E.A., Vanyarkina A.S., Novikova E.A., Kasantseva E.D.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/184

В статье представлены результаты исследования уровня вирусной нагрузки SARS-CoV-2 у новорожденных детей с подтвержденной COVID-19 инфекцией различной степени тяжести. Установлено, что количество вирусной РНК SARS-CoV-2 на слизистой оболочке носоглотки новорожденных детей выше данного показателя для детей более старшего возраста и не имеет связи с тяжестью течения болезни и наличием поражения легочной ткани.

The aim

The aim. Investigation of nasopharyngeal SARS-CoV-2 viral load in newborns with COVID-19 of different severity.

Materials and methods

Materials and methods. The main group was composed of 44 newborns with RT-PCR confirmed COVID-19. 168 children aged from 1 month to 17 years old with RT-PCR confirmed COVID-19 were included in the group of comparison. SARS-CoV-2 viral load was measured as amount of viral RNA copies in 1 ml of nasopharyngeal mucosa using the regression model and presented as lg of the amount. The results presented as Me[Q1;Q3].

Results

Results. SARS-CoV-2 viral load in newborns was detected significantly higher as compared to children aged 1-17 years: 3,2×106[5,7×104; 7,8×107] and 1,3×105[2,6×104; 1,2×107] respectively and no association has been revealed between nasopharyngeal SARS-CoV-2 viral load and disease severity, lung injury and the type of feeding.

Discussion

Discussion. Nasopharyngeal SARS-CoV-2 viral load presumably reflects epidemiological circumstances and tends to decrease as the disease develops. It can be due to virus dissemination to lung tissue, vessel walls and other organs that followed by fall of number of viral particles in upper respiratory tract. While elimination of virus from mucosa on the early stages after infection probably depends on efficiency of innate immunity (which mechanisms can kill and/or impede virus invasion before immune response develops), viral load in blood and internal organs tissues, as well as favorable course of the disease, mainly depends on ‘proportionate’ immune response. So that, assessing the viral load and its significance for disease development should be performed considering the day after infection.

Conclusions

Conclusions. High level of nasopharyngeal SARS-CoV-2 viral load in newborns along with mostly mild COVID-19 course can be based on age-correlated features such as: immature immunity mechanisms, low expression of ACE2 receptors, the absence of comorbidity and intake of innate immunity factors while breastfeeding.

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The authors declare that there are no conflicts of interest present.