ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМП10.25789/YMJ.2022.79.04ymj-18Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHВлияние ожирения на половой диморфизм уровней ирисинаThe effect of obesity on sexual dimorphism of irisin levelshttps://orcid.org/0000-0002-7129-6633НиканороваА. А.NikanorovaA. A.

Никанорова Алена Афанасьевна – м.н.с.

 

Nikanorova Alеna Afanasyevna – junior researcher, Laboratory of Molecular Genetics

 

https://orcid.org/0000-0002-6984-7934БарашковН. А.BarashkovN. A.

Барашков Николай Алексеевич – к.б.н., в.н.с.-руковод. лаб.

 

Barashkov Nikolay Alekseevich – Candidate of biological sciences, Head of laboratory of Molecular genetics

 

barashkov2004@mail.ruhttps://orcid.org/0000-0001-6866-9462ПшенниковаВ. Г.PshennikovaV. G.

Пшенникова Вера Геннадиевна – к.б.н., в.н.с.руковод. лаб.

 

Pshennikova Vera Gennadievna – Candidate of Biological Sciences, Head of laboratory of Populational Genetics

 

pshennikovavera@mail.ruhttps://orcid.org/0000-0002-4710-1592ГотовцевН. Н.GotovtsevN. N.

Готовцев Ньургун Наумович – н.с.

 

Gotovtsev Nyurgun Naumovich – scientific researcher, Laboratory of Molecular Genetics

 

donzcrew@mail.ruhttps://orcid.org/0000-0002-2936-5818РомановГ. П.RomanovG. P.

Романов Георгий Прокопьевич – н.с., 

Якутск

Romanov Georgii Prokopievich – Researcher, Research Laboratory of Molecular Biology, Institute of Natural Sciences

 

gpromanov@gmail.comhttps://orcid.org/0000-0003-0914-3609СоловьевА. В.SolovyevA. V.

Соловьев Айсен Васильевич – к.б.н., с.н.с.

Якутск

Soloviev Aisen Vasilyevich – Candidate of Biological Sciences, Senior Researcher, Research Laboratory of Molecular Biology, Institute of Natural Sciences

 

nelloann@mail.ruhttps://orcid.org/0000-0002-4687-4868КузьминаС. С.KuzminaS. S.

Кузьмина Саргылана Семеновна – к.б.н., доцент

Якутск

Kuzmina Sargylana Semenovna – Candidate of Biological Sciences, Associate Professor, Department of Biology, 

 

sskuzmina@bk.ruСазоновН. Н.SazonovN. N.

Сазонов Николай Никитич – д.б.н., проф.

Якутск

Sazonov Nikolay Nikitich – Doctor of biological sciences, Professor, Department of Biology

 

nn.sazonov@s-vfu.ruhttps://orcid.org/0000-0002-6952-3868ФедороваС. А.FedorovaS. A.

Федорова Сардана Аркадьевна – д.б.н., зав. науч.-иссл. лаб.

Якутск

Fedorova Sardana Arkadievna – Doctor of biological sciences, Head of the Research Laboratory of Molecular Biology Institute of Natural Sciences

 

sardaanafedorova@mail.ruЯкутский научный центр комплексных медицинских проблемРоссияFederal State Budgetary Scientific Institution Yakut Science Center of Complex Medical ProblemsRussian FederationИнститут естественных наук СВФУ им. М.К. АммосоваRussian FederationИнститут естественных наук СВФУ им. М.К. АммосоваРоссияFederal State Budgetary Scientific Institution Yakut Science Center of Complex Medical ProblemsRussian FederationИнститут естественных наук СВФУ им. М.К. АммосоваРоссияFederal State Autonomous Educational Institution of Higher Education M.K. Ammosov Northeastern Federal UniversityRussian Federation202202022025031620Copyright © Никанорова А.А., Барашков Н.А., Пшенникова В.Г., Готовцев Н.Н., Романов Г.П., Соловьев А.В., Кузьмина С.С., Сазонов Н.Н., Федорова С.А., 20252025Никанорова А.А., Барашков Н.А., Пшенникова В.Г., Готовцев Н.Н., Романов Г.П., Соловьев А.В., Кузьмина С.С., Сазонов Н.Н., Федорова С.А.Nikanorova A.A., Barashkov N.A., Pshennikova V.G., Gotovtsev N.N., Romanov G.P., Solovyev A.V., Kuzmina S.S., Sazonov N.N., Fedorova S.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/18

Проведен сравнительный анализ средних уровней ирисина между женщинами и мужчинами (с нормальным весом и ожирением) для оценки полового диморфизма. В исследованной нами выборке якутов половой диморфизм обнаружен в группе лиц с нормальным весом: уровни ирисина были значимо выше у женщин по сравнению с мужчинами. Сравнительный анализ уровней ирисина в расширенной выборке обнаружил статистически значимый половой диморфизм только в группе лиц с ожирением, в группе лиц с нормальным весом половых отличий не было обнаружено. Таким образом, выявлено влияние ожирения на половой диморфизм.

The aim of this study is to conduct a comparative analysis of average irisin levels between female and male (with normal weight and obese) to assess sexual dimorphism. Circulating levels of irisin in the blood of 279 Yakuts (185 female, 94 male, average age 19.8 ± 2.03 years) were determined. A comparative analysis of irisin levels between male and female in three BMI groups (underweight, normal weight, overweight/obesity) was carried out. The average level of irisin in the blood plasma in female was 8.33 ± 2.74 mcg/mL, and in male 7.76 ± 1.86 mcg/mL. Sexual dimorphism (p = 0.02) was detected in Yakuts with normal weight, where the level of irisin was higher in women (8.42 = 2.92 mcg/mL) compared to men (7.51 = 1.61 mcg/mL). Conducted a comparative analysis of irisin levels between male and female based on global data, were including this analysis are 2132 people. The age of the participants ranged from 18 to 61 years old. The meta-analysis was carried out for two different BMI groups: the first group included people with normal weight (18.5-24.9 kg/m2), the second group included people with varying degrees of obesity (>30 kg/m2). Comparative analysis of irisin levels in a large sample revealed statistically significant sexual dimorphism, where irisin levels were also higher in female compared to male, only in a sample of obese people (p = 0.02), in a sample of people with normal weight, no sexual differences were found (p = 0.09). Thus, the influence of obesity on sexual dimorphism was revealed.

ирисиножирениежировая тканьпопуляция якутовirisinobesityadipose tissueYakut populationReferencesA PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis / Boström P., Wu J., Jedrychowski M.P. [et al.] // Nature. 2012: 7382(481): 463-468. doi:10.1038/nature10777A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis / Boström P., Wu J., Jedrychowski M.P. [et al.] // Nature. 2012: 7382(481): 463-468. doi:10.1038/nature10777A transient elevated irisin blood concentration in response to prolonged, moderate aerobic exercise in young men and women / Kraemer R.R., Shockett P., Webb N.D. [et al.] //Hormone and metabolic research. 2014. 46(2): 150-154.A transient elevated irisin blood concentration in response to prolonged, moderate aerobic exercise in young men and women / Kraemer R.R., Shockett P., Webb N.D. [et al.] //Hormone and metabolic research. 2014. 46(2): 150-154.Adipose Tissue Secretion Pattern Influences β-Cell Wellness in the Transition from Obesity to Type 2 Diabetes / Biondi G., Marrano N., Borrelli A. [et al.] //International Journal of Molecular Sciences. 2022. 23(10): 5522.Adipose Tissue Secretion Pattern Influences β-Cell Wellness in the Transition from Obesity to Type 2 Diabetes / Biondi G., Marrano N., Borrelli A. [et al.] //International Journal of Molecular Sciences. 2022. 23(10): 5522.Association between serum irisin levels and non-alcoholic fatty liver disease in health screen examinees / Choi E.S., Kim M.K., Song M.K. [et al.] // PloS one. 2014. 9(10): e110680.Association between serum irisin levels and non-alcoholic fatty liver disease in health screen examinees / Choi E.S., Kim M.K., Song M.K. [et al.] // PloS one. 2014. 9(10): e110680.Association of circulating irisin and cardiopulmonary exercise capacity in healthy volunteers: results of the Study of Health in Pomerania / Kerstholt N., Ewert R., Nauck M. [et al.] // BMC pulmonary medicine. 2015. 15(1): 1-9.Association of circulating irisin and cardiopulmonary exercise capacity in healthy volunteers: results of the Study of Health in Pomerania / Kerstholt N., Ewert R., Nauck M. [et al.] // BMC pulmonary medicine. 2015. 15(1): 1-9.Association of plasma irisin with bone mineral density in a large Chinese population using an extreme sampling design / Wu L.F., Zhu D.C., Tang C.H. [et al.] //Calcified tissue international. 2018. 103(3): 246-251.Association of plasma irisin with bone mineral density in a large Chinese population using an extreme sampling design / Wu L.F., Zhu D.C., Tang C.H. [et al.] //Calcified tissue international. 2018. 103(3): 246-251.Association of serum irisin with metabolic syndrome in obese Chinese adults / Yan B., Shi X., Zhang H. [et al.] //PloS one. 2014. 9(4): e94235.Association of serum irisin with metabolic syndrome in obese Chinese adults / Yan B., Shi X., Zhang H. [et al.] //PloS one. 2014. 9(4): e94235.Biological Response of Irisin Induced by Different Types of Exercise in Obese Subjects: A Non-Inferiority Controlled Randomized Study / D’Amuri A., Raparelli V., Sanz J.M. [et al.] // Biology. 2022. 11(3): 392.Biological Response of Irisin Induced by Different Types of Exercise in Obese Subjects: A Non-Inferiority Controlled Randomized Study / D’Amuri A., Raparelli V., Sanz J.M. [et al.] // Biology. 2022. 11(3): 392.Christensen A.A., Gannon M. The beta cell in type 2 diabetes //Current diabetes reports. 2019. 19(9): 1-8.Christensen A.A., Gannon M. The beta cell in type 2 diabetes //Current diabetes reports. 2019. 19(9): 1-8.Circulating irisin concentrations are associated with a favourable lipid profile in the general population / Oelmann S., Nauck M., Völzke H. et al. //PloS one. 2016. 11(4): e0154319.Circulating irisin concentrations are associated with a favourable lipid profile in the general population / Oelmann S., Nauck M., Völzke H. et al. //PloS one. 2016. 11(4): e0154319.Circulating irisin in healthy adults: Changes after acute exercise, correlation with body composition, and energy expenditure parameters in cross-sectional study / Lagzdina R., Rumaka M., Gersone G., et al. //Medicina. 2020. 56(6): 274.Circulating irisin in healthy adults: Changes after acute exercise, correlation with body composition, and energy expenditure parameters in cross-sectional study / Lagzdina R., Rumaka M., Gersone G., et al. //Medicina. 2020. 56(6): 274.Circulating irisin in healthy, young individuals: day-night rhythm, effects of food intake and exercise, and associations with gender, physical activity, diet, and body composition / Anastasilakis A.D., Polyzos S.A., Saridakis Z.G. [et al.] // The Journal of Clinical Endocrinology & Metabolism. 2014: 99(9): 3247-3255. doi:10.1210/jc.2014-1367Circulating irisin in healthy, young individuals: day-night rhythm, effects of food intake and exercise, and associations with gender, physical activity, diet, and body composition / Anastasilakis A.D., Polyzos S.A., Saridakis Z.G. [et al.] // The Journal of Clinical Endocrinology & Metabolism. 2014: 99(9): 3247-3255. doi:10.1210/jc.2014-1367Circulating irisin in relation to insulin resistance and the metabolic syndrome / Park K., Zaichenko L., Brinkoetter M. [et al.] //The journal of clinical endocrinology & metabolism. 2013. 98(12): 4899-4907.Circulating irisin in relation to insulin resistance and the metabolic syndrome / Park K., Zaichenko L., Brinkoetter M. [et al.] //The journal of clinical endocrinology & metabolism. 2013. 98(12): 4899-4907.Circulating irisin is reduced in male patients with type 1 and type 2 myotonic dystrophies / Dozio E., Passeri E., Cardani R. [et al.] // Frontiers in endocrinology. 2017. 8: 320.Circulating irisin is reduced in male patients with type 1 and type 2 myotonic dystrophies / Dozio E., Passeri E., Cardani R. [et al.] // Frontiers in endocrinology. 2017. 8: 320.Circulating irisin levels in response to acute and chronic exercise in obese adults / Winn N.C., Liu Y., Heden T.D. [et al.] //International Journal of Exercise Science: Conference Proceedings. 2013. 11(1): 42.Circulating irisin levels in response to acute and chronic exercise in obese adults / Winn N.C., Liu Y., Heden T.D. [et al.] //International Journal of Exercise Science: Conference Proceedings. 2013. 11(1): 42.Circulating levels of irisin in patients with anorexia nervosa and different stages of obesity-Correlation with body mass index / Stengel A., Hofmann T., Goebel-Stengel M. [et al.] // Peptides. 2013. 39: 125-130.Circulating levels of irisin in patients with anorexia nervosa and different stages of obesity-Correlation with body mass index / Stengel A., Hofmann T., Goebel-Stengel M. [et al.] // Peptides. 2013. 39: 125-130.Circulating sclerostin and irisin are related and interact with gender to influence adiposity in adults with prediabetes / Klangjareonchai T., Nimitphong H., Saetung S. [et al.] //International Journal of Endocrinology. 2014. 2014.Circulating sclerostin and irisin are related and interact with gender to influence adiposity in adults with prediabetes / Klangjareonchai T., Nimitphong H., Saetung S. [et al.] //International Journal of Endocrinology. 2014. 2014.Circulating serum irisin levels in obesity and type 2 diabetes mellitus / Shoukry A., Shalaby S.M., El-Arabi Bdeer S. [et al] //IUBMB life. 2016. 68(7): 544-556.Circulating serum irisin levels in obesity and type 2 diabetes mellitus / Shoukry A., Shalaby S.M., El-Arabi Bdeer S. [et al] //IUBMB life. 2016. 68(7): 544-556.Effects of obesity, diabetes and exercise on Fndc5 gene expression and irisin release in human skeletal muscle and adipose tissue: In vivo and in vitro studies. / Kurdiova T., Balaz M., Vician M. [et al.] //J. Physiol. 2014. 592: 1091– 1107. doi: 10.1113/jphysiol.2013.264655.Effects of obesity, diabetes and exercise on Fndc5 gene expression and irisin release in human skeletal muscle and adipose tissue: In vivo and in vitro studies. / Kurdiova T., Balaz M., Vician M. [et al.] //J. Physiol. 2014. 592: 1091– 1107. doi: 10.1113/jphysiol.2013.264655.Effects of swimming exercise on serum irisin and bone FNDC5 in rat models of high-fat diet-induced osteoporosis / Kang Y.S., Kim J.C., Kim J.S. [et al.] //Journal of sports science & medicine. 2019. 18(4): 596.Effects of swimming exercise on serum irisin and bone FNDC5 in rat models of high-fat diet-induced osteoporosis / Kang Y.S., Kim J.C., Kim J.S. [et al.] //Journal of sports science & medicine. 2019. 18(4): 596.Espes D., Lau J., Carlsson P.O. Increased levels of irisin in people with long-standing Type 1 diabetes //Diabetic medicine. 2015. 32(9): 1172-1176.Espes D., Lau J., Carlsson P.O. Increased levels of irisin in people with long-standing Type 1 diabetes //Diabetic medicine. 2015. 32(9): 1172-1176.Expression of the irisin precursor FNDC5 in skeletal muscle correlates with aerobic exercise performance in patients with heart failure / Lecker S.H., Zavin A., Cao P., [et al.] //Circulation: Heart Failure. 2012. 5(6): 812-818.Expression of the irisin precursor FNDC5 in skeletal muscle correlates with aerobic exercise performance in patients with heart failure / Lecker S.H., Zavin A., Cao P., [et al.] //Circulation: Heart Failure. 2012. 5(6): 812-818.FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise / Huh J.Y., Panagiotou G., Mougios V. [et al.] // Metabolism. 2012: 61(12): 1725-1738. doi:10.1016/j.metabol.2012.09.002FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise / Huh J.Y., Panagiotou G., Mougios V. [et al.] // Metabolism. 2012: 61(12): 1725-1738. doi:10.1016/j.metabol.2012.09.002FNDC5/irisin is not only a myokine but also an adipokine / Roca-Rivada A., Castelao C., Senin L.L. [et al.] // PloS one. 2013: 8(4): e60563. doi:10.1371/journal.pone.0060563FNDC5/irisin is not only a myokine but also an adipokine / Roca-Rivada A., Castelao C., Senin L.L. [et al.] // PloS one. 2013: 8(4): e60563. doi:10.1371/journal.pone.0060563FNDC5: a novel player in metabolism and metabolic syndrome / Cao R.Y., Zheng H., Redfearn D. [et al.] //Biochimie. 2019. 158: 111-116.FNDC5: a novel player in metabolism and metabolic syndrome / Cao R.Y., Zheng H., Redfearn D. [et al.] //Biochimie. 2019. 158: 111-116.Geer E.B., Shen W. Gender differences in insulin resistance, body composition, and energy balance //Gender medicine. 2009. 6: 60-75.Geer E.B., Shen W. Gender differences in insulin resistance, body composition, and energy balance //Gender medicine. 2009. 6: 60-75.High circulating irisin levels are associated with insulin resistance and vascular atherosclerosis in a cohort of nondiabetic adult subjects / Sesti G., Andreozzi F., Fiorentino T.V. [et al.] //Acta diabetologica. 2014. 51(5): 705-713.High circulating irisin levels are associated with insulin resistance and vascular atherosclerosis in a cohort of nondiabetic adult subjects / Sesti G., Andreozzi F., Fiorentino T.V. [et al.] //Acta diabetologica. 2014. 51(5): 705-713.Increased FNDC 5 is associated with insulin resistance in high fat-fed mice / Guilford B.L., Parson J.C., Grote C.W. [et al.] //Physiological reports. 2017. 5(13): e13319.Increased FNDC 5 is associated with insulin resistance in high fat-fed mice / Guilford B.L., Parson J.C., Grote C.W. [et al.] //Physiological reports. 2017. 5(13): e13319.International Obesity Task Force. Obesity: Managing the Global Epidemic: Report of the World Health Organization (WHO) Consultation; World Health Organization: Geneva, Switzerland, 1997.International Obesity Task Force. Obesity: Managing the Global Epidemic: Report of the World Health Organization (WHO) Consultation; World Health Organization: Geneva, Switzerland, 1997.Irisin and exercise training in humans–results from a randomized controlled training trial / Hecksteden A., Wegmann M., Steffen A. [et al.] //BMC medicine. 2013. 11(1): 1-8.Irisin and exercise training in humans–results from a randomized controlled training trial / Hecksteden A., Wegmann M., Steffen A. [et al.] //BMC medicine. 2013. 11(1): 1-8.Irisin and leptin concentrations in relation to obesity, and developing type 2 diabetes: a cross sectional and a prospective case-control study nested in the Normative Aging Study / Sahin-Efe A., Upadhyay J., Ko B.J. [et al.] //Metabolism. 2018. 79: С. 24-32.Irisin and leptin concentrations in relation to obesity, and developing type 2 diabetes: a cross sectional and a prospective case-control study nested in the Normative Aging Study / Sahin-Efe A., Upadhyay J., Ko B.J. [et al.] //Metabolism. 2018. 79: С. 24-32.Irisin and markers of metabolic derangement in non-diabetic Caucasian subjects with stage I-II obesity during early aging / Campolo J., Corradi E., Rizzardi A. [et al.] // PloS one. 2020. 15(2): e0229152.Irisin and markers of metabolic derangement in non-diabetic Caucasian subjects with stage I-II obesity during early aging / Campolo J., Corradi E., Rizzardi A. [et al.] // PloS one. 2020. 15(2): e0229152.Irisin is elevated in skeletal muscle and serum of mice immediately after acute exercise / Brenmoehl J., Albrecht E., Komolka K. [et al] //International journal of biological sciences. 2014. 10(3): 338.Irisin is elevated in skeletal muscle and serum of mice immediately after acute exercise / Brenmoehl J., Albrecht E., Komolka K. [et al] //International journal of biological sciences. 2014. 10(3): 338.Sex-Dependent Association between Circulating Irisin Levels and Insulin Resistance in Healthy Adults / Jameel F., Thota R.N., Wood L.G. [et al.] // Journal of Nutrition & Intermediary Metabolism. 2015. 2(3): 86–92. https://doi.org/10.1016/j.jnim.2015.10.001.Sex-Dependent Association between Circulating Irisin Levels and Insulin Resistance in Healthy Adults / Jameel F., Thota R.N., Wood L.G. [et al.] // Journal of Nutrition & Intermediary Metabolism. 2015. 2(3): 86–92. https://doi.org/10.1016/j.jnim.2015.10.001.The PRISMA 2020 statement: an updated guideline for reporting systematic reviews / Page M.J., McKenzie J.E., Bossuyt P.M. [et al.] // Systematic reviews. 2021. 10(1): 1-11.The PRISMA 2020 statement: an updated guideline for reporting systematic reviews / Page M.J., McKenzie J.E., Bossuyt P.M. [et al.] // Systematic reviews. 2021. 10(1): 1-11.

The authors declare that there are no conflicts of interest present.