<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ymj</journal-id><journal-title-group><journal-title xml:lang="ru">Якутский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Yakut Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1813-1905</issn><issn pub-type="epub">2312-1017</issn><publisher><publisher-name>ЯНЦ КМП</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">ymj-1765</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL RESEARCH</subject></subj-group></article-categories><title-group><article-title>Генетическая характеристика вируса гепатита С в Республике Саха (Якутия)</article-title><trans-title-group xml:lang="en"><trans-title>Genetic Characteristic of Virus C Hepatitis in the Republic of Sakha (Yakutia)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Никитина</surname><given-names>С. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Nikitina</surname><given-names>S. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Никитина Светлана Георгиевна – м.н.с.</p></bio><email xlink:type="simple">svetlana_nik77@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Слепцова</surname><given-names>С. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Sleptsova</surname><given-names>S. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Слепцова Снежана Спиридоновна – к.м.н., гл. внештат. Инфекционист</p></bio><email xlink:type="simple">ssslepsova@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Семенов</surname><given-names>С. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Semenov</surname><given-names>S. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Семенов Сергей Иннокентьевич – д.м.н., в.н.с.</p></bio><email xlink:type="simple">insemenov@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>НИИ здоровья СВФУ им. М.К. Аммосова</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-2"><institution>НИИ здоровья СВФУ им. М.К. Аммосова;&#13;
МЗ РС(Я)</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2013</year></pub-date><pub-date pub-type="epub"><day>30</day><month>09</month><year>2025</year></pub-date><volume>0</volume><issue>2</issue><fpage>31</fpage><lpage>33</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Никитина С.Г., Слепцова С.С., Семенов С.И., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Никитина С.Г., Слепцова С.С., Семенов С.И.</copyright-holder><copyright-holder xml:lang="en">Nikitina S.G., Sleptsova S.S., Semenov S.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://ymj.elpub.ru/jour/article/view/1765">https://ymj.elpub.ru/jour/article/view/1765</self-uri><abstract><p>Представлена генетическая характеристика вируса гепатита С в РС(Я). Генотипирование вируса гепатита С проводилось в лаборатории ЦНИИ эпидемиологии Роспотребнадзора РФ (г. Москва) с применением ПЦР-тест-системы. Данные тест-системы позволяют определять 4 генотипа ВГС: 1а, 1b, 2а, 3а. C 2007 по 2010 г. генотипированы 163 образца РНК вируса у больных хроническим гепатитом С из РС(Я), выделенные посредством ПЦР.</p></abstract><trans-abstract xml:lang="en"><p>A genetic characteristics of virus C hepatitis in the Republic Sakha (Yakutia) is presented. Genotyping of virus C hepatitis was carried out in the laboratory of the Central Research Institute of Epidemiology of the Federal Service of Supervision in the Sphere of Protection of the Rights and Well-being of Consumers (Rospotrebnadzor) of the Russian Federation (Moscow) with application of PCR-test-system. This test-system allows identification of 4 genotypes of virus C hepatitis: 1a, 1b, 2a, 3a. During 2007-2010 163 samples of viral RNA of the chronic hepatitis C patients from the Republic Sakha (Yakutia) were genotyped.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>хронический вирусный гепатит С</kwd><kwd>вирус гепатита С</kwd><kwd>полимеразная цепная реакция</kwd></kwd-group><kwd-group xml:lang="en"><kwd>chronic virus C hepatitis (ChHC)</kwd><kwd>hepatitis C virus (HCV)</kwd><kwd>polymerase chain reaction (PCR)</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Акимкин В.Г. Внутрибольничное инфицирование вирусами гепатитов В и С: эпидемиология и направление профилактики / В.Г. Акимкин // Эпидемиология и инфекционные болезни.- 2006. - №6. – С.13-17.</mixed-citation><mixed-citation xml:lang="en">Akimkin V.G. Hospital–acquired Infection of Virus B and C Hepatitis: Epidemiology and Preventive Measures / V.G. Akimkin // Epidemiology and Infectious Diseases. – 2006. – №6. – P. 13–17.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Алейник М.Д. Эпидемиологические закономерности распространения гепатита В и пути совершенствования противоэпидемических мероприятий / М.Д. Алейник, Т.Ф. Рябикова, И.А. Бакаева, И.К. Макаревич // Вирусные гепатиты. – Горький, 1988. – С.5-9.</mixed-citation><mixed-citation xml:lang="en">Aleinik M.D. Epidemiologic Characteristic of Virus B Hepatitis Prevalence and Ways ofAntiepidemic Measures Perfection / M.D. Aleinik, T.F. Ryabikova, I.A. Bakaeva, I.K. Makarevich // Viral Hepatitis. – Gorkij, 1988. – P. 5–9.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Базарова М.В. Клинико-эпидемиологическая оценка эффективности вакцинации против гепатита В новорожденных детей, родившихся у женщин с НВ-вирусной инфекцией: автореф. дисс. канд. мед. наук / М.В. Базарова. – М., 2002. – 27 с.</mixed-citation><mixed-citation xml:lang="en">Bazarova M.V. Clinicoepidemiologic Estimation of Efficiency of Hepatitis B Vaccination in Newborns of Women Infected Virus B Hepatitis / M.V. Bazarova // Abstract of Cand.of Med. Siences Dissertation. – M., 2002. – 27 p.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Васильева Е.А. Сравнительная клиниколабораторная характеристика больных острыми формами вирусных гепатитов В и С / Е.А. Васильева, Т.В. Сологуб, С.Л. Мукомолов // Актуальные проблемы инфекционной патологии. – СПб., 1993. – Ч.2. – С.81.</mixed-citation><mixed-citation xml:lang="en">Vasilieva E.A. Comparative Clinico–laboratory Characteristic of Virus B and C Hepatitis Acute Form Patients / E.A. Vasilieva, T.V. Sologub, S.L. Mukomolov // Actual Problems of Infectious Pathology. – SPb., 1993. – V.2. – P. 81.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Вирусные гепатиты / А.Г. Рахманова, В.К. Пригожина, В.А. Неверов [и др.]. – СПб., 1995. – 35 с.</mixed-citation><mixed-citation xml:lang="en">Viral Hepatitis / A.G. Rakhmanova, V.K. Prigozhina, V.A. Neverov [et al.] // SPb. – 1995. – 35 p.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Вирусные гепатиты в Российской Федерации: аналитический обзор / Под ред. А.Б. Жебруна. – СПб., 2000. – Вып.3. – 256 с.</mixed-citation><mixed-citation xml:lang="en">Viral Hepatitis in the Russian Federation: Analytical Review / Ed. A.B. Zhebrun. – SPb., 2000. – Vol. 3. – 256 p.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Maertens G. Genotypes and variation of hepatitis C virus / G. Maertens, L. Stuyver // The molecular medicine of viral hepatitis / Ed. T.J. Harrison, A.J.Zuckerman. – 1977. – P. 183 – 233.</mixed-citation><mixed-citation xml:lang="en">Maertens G. Genotypes and variation of hepatitis C virus / G. Maertens, L. Stuyver // The molecular medicine of viral hepatitis / Ed. T.J. Harrison, A.J.Zuckerman. – 1977. – P. 183 – 233.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Sprengel R. Isolation and characterization of a hepatitis B virus endemic in herons / R. Sprengel, E.E. Kaleta, H. Will // J. Virl. – 1998. – Vol. 62, №10. – P.3832 – 3839.</mixed-citation><mixed-citation xml:lang="en">Sprengel R. Isolation and characterization of a hepatitis B virus endemic in herons / R. Sprengel, E.E. Kaleta, H. Will // J. Virl. – 1998. – Vol. 62, №10. – P.3832 – 3839.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Krugman S. Hepatitis virus: effect of heat on the infectivity and antigenicity of the MS1 and MS-2 strains / S. Krugman, J.P. Giles, J. Hammond // J. Infect. Dis. – 1970. – Vol.122, №5.– Р.432 – 436.</mixed-citation><mixed-citation xml:lang="en">Krugman S. Hepatitis virus: effect of heat on the infectivity and antigenicity of the MS1 and MS-2 strains / S. Krugman, J.P. Giles, J. Hammond // J. Infect. Dis. – 1970. – Vol.122, №5.– Р.432 – 436.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
