ymjЯкутский медицинский журналYakut Medical Journal1813-19052312-1017ЯНЦ КМПymj-1743Research ArticleСОВЕРШЕНСТВОВАНИЕ ПРОТИВОТУБЕРКУЛЕЗНОЙ ПОМОЩИTUBERCULOSIS CARE IMPROVEMENTСравнительный анализ генотипов Mycobacterium tuberculosis в Республике Саха (Якутия) и Иркутской областиComparative analysis of Mycobacterium tuberculosis genotypes in the Republic Sakha (Yakutia) and the Irkutsk regionЖдановаС. Н.ZhdanovaS. N.

Жданова Светлана Николаевна – к.м.н., с.н.с.

Zhdanova Svetlana Nikolaevna – Cand.Med.Sc., Senior Researcher

Irkutsk

svetnii@mail.ruАлексееваГ. И.AlexeevaG. I.

Алексеева Галина Ивановна – д.м.н., зав. бактериологич. лаб.

Alexeeva Galina Ivanovna – Dr.Med.Sc., Head of Bacteriological Laboratory

Yakutsk, Sakha Republic (Yakutia)

ОгарковО. Б.OgarkovO. B.

Огарков Олег Борисович – к.б.н., зав. лаб.

Ogarkov Oleg Borisovich – Cand.Biol.Sc., Laboratory Head; Irkutsk Regional TBPrevention Dispensary

Irkutsk

КравченкоА. Ф.KravchenkoA. F.

Кравченко Александр Федорович – д.м.н., директор

Kravchenko Alexander Fedorovich – Dr.Med.Sc., Director

Yakutsk, Sakha Republic (Yakutia)

ЗоркальцеваЕ. Ю.ZorkaltsevaE. Yu.

Зоркальцева Елена Юльевна – д.м.н., зав. кафедрой

Zorkaltseva Elena Yulievna – Dr.Med.Sc., Department Chair

ВинокуроваМ. К.VinokurovaM. K.

Винокурова Мария Константиновна – д.м.н., зам. директора по науке

Vinokurova Maria Konstantinovna – Dr.Med.Sc., Deputy Director for Science

Yakutsk, Sakha Republic (Yakutia)

СавиловЕ. Д.SavilovE. D.

Савилов Евгений Дмитриевич – д.м.н., проф., зав. кафедрой

Savilov Eugeniy Dmitrievich – Dr.Med.Sc., Professor, Department Chair

ФБГУ «Научный центр проблем семьи и репродукции человека СО РА МН»РоссияScientific Center for Family Health and Human Reproduction Problems, Siberian Branch, Russian Academy of Medical SciencesRussian FederationГБУ РС (Я) НПЦ «Фтизиатрия»РоссияResearch Practice Center for PhthisiatryRussian FederationГБУЗ «Иркутский областной противотуберкулезный диспансер». ГОУ ДПО «Иркутская ГМА последипломного образования»РоссияIrkutsk State Medical Continuing Education AcademyRussian Federation201327092025016871Copyright © Жданова С.Н., Алексеева Г.И., Огарков О.Б., Кравченко А.Ф., Зоркальцева Е.Ю., Винокурова М.К., Савилов Е.Д., 20252025Жданова С.Н., Алексеева Г.И., Огарков О.Б., Кравченко А.Ф., Зоркальцева Е.Ю., Винокурова М.К., Савилов Е.Д.Zhdanova S.N., Alexeeva G.I., Ogarkov O.B., Kravchenko A.F., Zorkaltseva E.Y., Vinokurova M.K., Savilov E.D.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ymj.elpub.ru/jour/article/view/1743

Изоляты микобактерий туберкулеза, полученные от больных с впервые выявленным туберкулезом из Иркутской области и Республики Саха (Якутия) за ноябрь 2008 - май 2010 гг., протестированы на лекарственную устойчивость и генотипированы с использованием метода MIRU-12. С помощью филогенетической реконструкции определены основные эпидемические генотипы туберкулеза с множественной лекарственной устойчивостью (МЛУ). На филогенетических моделях продемонстрированы четкие региональные различия проявления первичного туберкулеза с МЛУ, требующие территориально обоснованных стратегий диагностики и лечения.

Multidrug-resistant tuberculosis without prior treatment (primary MDR-TB) is a major problem in the Russian Federation, and also in Eastern Siberia and Far East. Mycobacterium tuberculosis isolates from patients with primary TB at two referral sites in Irkutsk oblast and the Sakha Republic (Yakutia) were tested for conventional susceptibility and genotyped using MIRU-12. Outcomes from primary MDR-TB were compared between sites. Phylogenetic reconstruction was used to determined basic epidemic genotypes with MDR. Primary MDR-TB was common in both regions and phylogenetic patterns; drug-resistance and outcomes carried regionally distinct differences, emphasizing the need for locally informed diagnosis and treatment strategies.

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The authors declare that there are no conflicts of interest present.